Product Information

S1019 CI-1033
HER2

Novel Life Science Reagents

for Cell Signaling Research

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F O HN N O O N HN N Cl

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 485.94 C24H25ClFN5O3 DMSO 99% at -20 2 years 267243-28-7

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Tech Support
tech@selleckchem.com

Synonyms: Canertinib,

PD-183805

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
Canertinib (CI-1033, PD 183805) is a pan-erbB tyrosine kinase inhibitor. It selectively inhibits erbB1 (epidermal growth factor receptor), erbB2, erbB3, and erbB4 without blocking tyrosine kinase activity of many other receptors such as platelet-derived growth factor receptor, fibroblast growth factor receptor, and insulin receptor.[1] Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms. [2] Canertinib inhibited erbB receptor phosphorylation and induced growth inhibition and apoptosis at concentrations of 1 M or more.[3]

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Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

References
[1] Slichenmyer WJ et al. Semin. Oncology. 2001 October;28(16): 80-85 [2] Ami Citri et al. The EMBO Journal. 2002,21:2407-2417 [3] Dennis P.M. Hughes et al. Pediatric Blood & Cancer .2005 Jul 8;46: 614-623

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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