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PAPER NAME : Minor 8

1) Glutethimide synthesis can be started with& ..

A) Benzyl cyanide

B) Benzene

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C) Aniline

D) Propyl cyanide

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Correct Answer is A

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2) 7 Choloro 1,3 dihydo,1methyl 5 phenyl 2H 1,4 benzodiazepine 2 one is& ..

A) Diazepam

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B) Zolipidem

C) Lorazepam m
D) Clonazepam

Correct Answer is A
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3) 3- Chlorophenylamide in presence of S/Iodine gives intermediate compound(X) which on treatment

NaNH2 and Cl(CH2)N(CH3)2 give final product(Z). X & B is& ..

ph

A) Chloro diphenylamine & Droperidol respectively

B) 3-Chloro phenzothiazine & & Chloropromazine respectively

.b

C) 2- Chloro phenzothiazine & Chloropromazine respectively

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D) Chloro phenzothiazine & Chlorprothixene respectively

Correct Answer is C
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4) N-demethylation of mephobarbital gives

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A) Pentobarbital

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B) Methobarbital

C) Phenobarbital

D) Vinbarbital

Correct Answer is C

5) Which of the anticonvulsant drug undergoes Knoevanagel condensation.

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A) Primidone

B) Phenytoin

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C) Paramethadione

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D) Phensuximide

Correct Answer is D

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6) Solution having a greater concentration of impermeable solutes on the external side of the
membrane

results in& ..
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A) Isotonicity
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B) Hypotonicity

C) Hypertonicity
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D) None of these

Correct Answer is C
.b

7) The final result of dipping a cell in hypotonic solution& &

A) Cell Shrinkage
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B) Swelling of the cell

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C) No effect

D) Cytolysis
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Correct Answer is D

8) Select the best suited statement for caffine.

A) Pseudo Alkaloid and Steroidal derivative

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B) True Alkaloid and Terpenoidal derivative

C) Pseudo Alkaloid and Purine derivative

D) Cytolysis

Correct Answer is C

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9) Select the true statement& .

A) Caffine, a pseudo-alkaloid: Water insoluble & Gives negative standard qualitative test of true alkaloids

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B) Caffine, a pseudo-alkaloid: Water soluble & Gives positive standard qualitative test of true alkaloids

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C) Homatropine , a pseudo-alkaloid: Ether soluble & Gives negative standard qualitative test of true
alkaloids

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D) Colchicine, a pseudo-alkaloid: Not soluble in both ether & water & Gives positive standard qualitative
test

of true alkaloids m
Correct Answer is B

10) Select the adultrants of European belladonna

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A) Ailanthus
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B) Phytolacca

C) Both a & b
.b

D) Indian belladonna

Correct Answer is C
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11) Lanatoside C contains aglycon& .

A) Digoxigenin
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B) Digitoxigenin
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C) Gitaloxigenin

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D) Gitoxigenin

Correct Answer is A

12) Select the best distinguishing microscopical character for European belladonna over Alianthus.

A) Wavy epidermis with striated cutical

B) Microsphenoidal Sandy crystals of Ca-Oxallate

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C) Both a & b

D) Stometa

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Correct Answer is B

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13) Select Tryptophen derived alkaloids

A) Emetine, Quinidine, Strychine, Ajmaline

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B) Reserpine, Quinidine, Strychine, Ajmaline

C) Emetine, Cephaelin, Quinidine, Strychine m

D) All of these

Correct Answer is B
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14) Ipecacuanha root contain& .
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A) Cephaelin, a Tryptophan derived alkaloids

B) Cephaelin, a Tetrahydroisoqinoline derived alkaloids

C) Cephaelin and Emetine, Tetrahydroisoqinoline derived alkaloids

.b

D) Cephaelin and Emetine, Tryptophan derived alkaloids

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Correct Answer is C

15) Strychnine, is derived from& .

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A) Tryptophan
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B) Lysine

C) Phenylalanine

D) Purine
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Correct Answer is A

16) Cinchona Red is& ..

A) Decomposed product of Cinchotannic acid

B) Decomposed product of Tannic acid

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C) Decomposed product of Quinine

D) Condensed product of Cinchotannic acid

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Correct Answer is A

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17) Distinguish character of African Rouwolfia is& .

A) Group of sclereids in the bark

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B) Stratified cork

C) Larger vessels m
D) Both a & c

Correct Answer is D
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18) Select the best suited analytical technique for 2%w/v & 20%w/v suspension of Aspirin.

A) Nephlometry & Turbidimetry respectively

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B) Turbidimetry & Nephlometry respectively

C) Any method from Nephlometry & Turbidimetry

.b

D) Nephlometry & Turbidimetry are not suitable for suspensions

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Correct Answer is A

19) Select the false statement for FLOURIMETRY& .

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A) Measurements are based upon Transmitted light

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B) Scattered light is of higher wavelength than incident light

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C) Wavelength of incident light is greater than scattered light

D) Both a & b

Correct Answer is B

20) Select the true statement for optical active compound& .

A) Contain Chiral Carbon

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B) Their solution can rotate plain polarized light

C) Often exhibit circular birefringence

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D) All of these

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Correct Answer is D

21) Nephlometic measurments are based on& .

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A) Scattered light

B) Transmitted light m
C) Absorbed light

D) Both a & b
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Correct Answer is A
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22) Single coil radiofrequency receiver for NMR works on the principal of&

A) Photoelectric

B) WSB
.b

C) Black body
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D) None of these

Correct Answer is B
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23) Select the suitable electric field strength for methane to analyze under 2 unit radius mass
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spectrometer with 10 unit magnetic field. (All units are same)?

A) 1.25e- unit

B) 125e- unit
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C) 12.5e- unit

D) None of these

Correct Answer is C

24) Molecular ion peakof Marsh gas will come in mass spectrum at&

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A) 15 & 16

B) 16 & 17

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C) Only 16

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D) Only 15

Correct Answer is C

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25) Conversion of Angiotensin I to Angiotensin II is caused by ACE which is chemically

A) Dipeptidyl Carboxy Peptidase m

B) Angiotensinases

C) Kininase I
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D) Peptidyl Carboxy Peptidase

Correct Answer is A
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26) A case of brassy cough occur while using captopril, it is due to breakdown of

A) Angiotensin III
.b

B) Subsatance P
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C) Neuropeptide Y

D) Degradation of captopril
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Correct Answer is B
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27) The following is an example of bradykinin antagonist

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A) Icatibant

B) Enalaprilat

C) Telmisartan

D) Kininase I

Correct Answer is A

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28) Amrinone; an inodilator acts via

A) Increasing cAMP

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B) Decreasing cAMP

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C) Increasing Na/K/ATPase

D) Decreasing Na/K/ATPase

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Correct Answer is A

29) Prolongation of _____________ interval is a sign of Torsades de pointes

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A) Q-T

B) Q-S
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C) P-Q
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D) S-T

Correct Answer is A

30) N type voltage sensitive calcium channel is blocked by

.b

A) conotoxin
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B) Diltiazem

C) Mibefradil
w

D) Ethosuximide
w

Correct Answer is A

31) Torsades de pointes causes

A) Triggered arrhythmia
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B) Sick sinus

C) Atrial fibrillation

D) Reentrant arrhythmia

Correct Answer is A

m
32) Ringing in ear, deafness, vertigo are signs in patients suffering from cinchonism which is side effect

of

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A) Procainamide

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B) Quinidine

C) Digitoxin

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D) Cinnamic acid

Correct Answer is B m
33) A patient under disopyramide treatment shows sign of dry mouth, constipation, urinary retention,

blurred vision. The symptoms are due to

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A) Anticholinergic activity

B) Cholinergic activity
ph

C) Arrhythmia potentiation

D) Local anesthetic effect

.b

Correct Answer is A
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34) Class IV antiarrhythmic drugs act via

A) Inhibiting Ca++ mediated channel

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B) Inhibiting Na+ mediated channel

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C) Prolong repolarization

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D) Increasing K+ level

Correct Answer is A

35) A patient undergoing angina pectoris s therapy use a phosphodiesterases inhibitor for erectile

dysfunction; death of patient occurs what will be possible reason for it

A) Hypotension

m
B) Hypertension

C) Arrhythmia

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D) Methemoglobinemia

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Correct Answer is A

36) Which of the following is not true. Pyrogens may be removed from parenterals/containers

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A) By autoclaving at 121 degree C for 30 minutes in a normal cycle

B) Adsorption on surface using selected adsorbents m

C) Selective solvent extraction method

D) Ultrafiltration
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Correct Answer is A
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37) Which of the following is a Non aqueous water immiscible solvent for parenterals:

A) Dimethyl acetamide

B) Isopropyl myristate
.b

C) Both a and b
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D) Glycerin

Correct Answer is B
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38) The usual concentration (percent) of Phenyl Mercuric Nitrate used in parenterals is:
w

A) 0.01

B) 0.4

C) 0.001
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D) 0.5

Correct Answer is C

39) Which of the following is not used as antioxidant in sterile products:

A) Sodium bisulfite

m
B) Mannitol

C) Sodium formaldehyde sulfoxylate

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D) Both B and C

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Correct Answer is B

40) Which of the following is false for intravenous nutrient emulsions:

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A) Lecithin may be used as emulsifier

B) The droplet size should be less than 0.1 micron m

C) Cottonseed oil may be added up to 15% concentration

D) None of the above

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Correct Answer is D

41) Which of the following may be used as protective colloid in parenteral product of Cortisone acetate :
ph

A) Mannitol

B) EDTA
.b

C) Sodium CMC
w

D) Both B and C

Correct Answer is C
w

42) Sodium Chloride intravenous infusion, IP contains which of the following preservative:
w

A) Phenyl Mercuric nitrate

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B) Benzyl alcohol

C) Methyl or propyl paraben

D) None of the above

Correct Answer is D

43) In accordance with IP 2007, which one of the following animal is used for systemic injection method

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in testing of plastic containers for parenteral use:

A) Guinea pig

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B) Rat

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C) Mice

D) Any one of the above may be used if it is healthy and free from any disease

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Correct Answer is C

44) The administration of depot preparations usually are preferred by which of the following route
m
A) Intracutaneous

B) Intramuscular
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C) Intravenous
ph

D) Intraspinal

Correct Answer is B

45) Accorrding to IP 2007, Packaging material suitable for non aqueous parenteral preparations
.b

(generally) isA) Type 1 glass

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B) Type II amber colored glass

C) Type III glass

w

D) both a and c
w

Correct Answer is D

46) Sodium hydroxide (40 g) when dissolved in water and volume made up to 1000 ml the resultant

solution is of following strength

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A) 2 Mole

B) 1.5 Mole

C) 0.5 Mole

D) 1 Mole

m
Correct Answer is D

47) Wurster Process is concerned with

o
A) Tunnel Dryer

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B) Rotary Dryer

C) Fluidized Bed Dryer

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D) None of the above

Correct Answer is C m
48) Simultaneously use of norepinephrine and atropine causes

A) Decreased blood sugar

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B) Increased heart rate

C) Increased skin temperature

ph

D) Reduced pupil size

Correct Answer is B
.b

49) A. niger is used in the production of& & .

w

A) Citric acid

B) Penicillin
w

C) Streptomycin
w

D) All of these

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Correct Answer is A

50) Which of the following is centrally acting antihypertensive drug:

A) Captopri

B) Verapamil

C) Clonidine

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D) Amlodipine

Correct Answer is C

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EXP :

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