Gpat 1

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PAPER NAME : MINOR 1
1) Drug-exciepient intrection can be studied using....
m
A) XRD
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B) FT-IR
f.c
C) DSC
D) All of the above
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Correct Answer is D
2) In the name of the polymer EUDRAGIT E PO" PO stands for?
A) Powdered form of Eudragit E grade

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B) Polished form of Eudragit E grade
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C) Moisture protected form of Eudragit E grade
D) Powdered form of any Eudragit grade

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Correct Answer is A
3) Aerosil is :
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A) Carboxy Methyl Cellulose
B) Colloidal silica
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C) Hydroxy Propyl Cellulose

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D) Methyl cellulose
Correct Answer is B
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4) Tween 80 is :
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A) Sorbitan monooleate
B) Ploxyethylene acetate
C) Polyoxyethylene sorbitan mono oleate
m
D) Ployoxypropylene sorbitan monooleate
o
Correct Answer is C
f.c
5) The environmental conditions for accelerated stability studies according to ICH guidelines are
(Temp/Relative Humidity, time):
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A) 40/60, 6 months
B) 30/65, 12 months
C) 30/75, 3 month
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D) 40/75, 6 months
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Correct Answer is D
6) Sta Rx 1500 is
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A) A binder
B) A lubricant
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C) A diluent
D) A directly compressible diluent

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Correct Answer is D
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7) Choose the correct excepient for enhancing solubility in tablet manufacture:
A) PEG
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B) Talc
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C) Lactose
D) MCC
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Correct Answer is A
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8) Glidant would be used to eliminate the following problem occurs during tablet manufacturing
f.c
A) Picking
B) Sticking
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C) Weight variation
D) Mottling
Correct Answer is C
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EXP : For picking antiadhesive, sticking-lubricant is used. Glidant would enhance flow of powder or
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granules that facilitate the proper and uniform die filling so that weight variation problem could be
eliminated.
ph
9) Cellutab is the commercial name of
A) Lactose
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B) Colloidal Silica
C) HPMC
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D) Starch
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Correct Answer is D
10) A person is taking vegetables rich in vitamin K along with warfarin. The activity of warfarin would
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be:
A) Increased

B) There would be no effect
C) Decreased
D) Warfarin and food like spinach has not to do anything with each other
m
Correct Answer is C
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EXP : Components of food may antagonize the desired effect of the drug, as in the case of warfarin.
f.c
Foods which are high in vitamin K, or which enhance vitamin K production by intestinal
microorganisms, can reduce the effectiveness of warfarin in diminishing th
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11) Alprazolam is taken by a patient with grapefruit juice. The activity of the drug would be :
A) Increased
B) Decreased
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C) There would be no effect
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D) Juice taken with drug may cause colic pain
Correct Answer is A
ph
EXP : The interaction between grapefruit juice and a variety of drugs has been widely reported. It
appears that one or more flavonoids found in grapefruit juice inhibit some of the enzymes in the
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cytochrome P450 system. This results in reduced metabolism of dru
12) Which of the following combination would enhance the duration of action of drug:
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A) Amines in food- Disulfiram

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B) Alcohol- MAO inhibitor
C) Cefaxime-Probenecid
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D) All would enhance duration of action of drug

Correct Answer is C
13) Which of the following theory is associated with crystal growth:
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A) Griffin
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B) Ficks theory
f.c
C) Noyes Whitney equation
D) Ostwald ripining
stu
Correct Answer is D
14) Reynold's no is associated with
A) Fluid viscosity
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B) Solid content in fluid
ar
C) Flow of fluid
D) All of above
ph
Correct Answer is C
15) 0.1% dispersion of HPMC in water will follow:

.b
A) Plastic flow
B) Dilatant flow
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C) Newtonian flow
w
D) Pseudoplastic flow
Correct Answer is C
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16) Drug interaction between terefenadine and ketoconazole is due to
A) Enzyme inhibition

B) Enzyme induction
C) Increase in renal excretion
D) Both a and c
m
Correct Answer is A
o
EXP : Ketoconazole inhibit CYP3A a ssubfamily of Cytochrome P-450 enzyme and cause Increased
f.c
level of Terefenadine result in cardiac arrythamia.
17) According to ICH guidlines,the photostability testing of drug to provide informations necessary for
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handelling, packaging & labeling is known as.........
A) Forced degradation testing
B) Confirmatory testing
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C) Phototesting
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D) All of these
Correct Answer is B
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18) According to ICH guidelines for photostability testing of drugs ,the light source may be....
A) UV flourscence lamp
.b
B) Micro wave lamp
C) UV-visible flourscence lamp

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D) IR lamp
w
Correct Answer is C
19) The form of Lactose which does not undergo Maillard reaction is
w
A) Hydrous lactose
B) Anhydrous. Lactose
C) Spray dried lactose
m
D) All of these
o
Correct Answer is C
f.c
20) Adaptogens are....
A) Natural substances which increases the specific &nonspecific resistance of the body
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B) Natural substances which increases the specific resistance of the body
C) Natural substances which increases the non-specific resistance of the body
D) Natural substances which increases the quality of body

m
Correct Answer is C
ar
21) "BHASMA" preparation involves following steps....
A) Sodhana & Marana

ph
B) Marana & Sodhana
C) Only Sodhana
.b
D) Only Marana
Correct Answer is A
w
22) Ayurvedic system of medicine describes the concept of "RASAYANA" & the medicinal plants
w
described under the concept promote the quality of body tissue through....
A) Poshaka rasa
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B) Agni
C) Srotasas

D) All of these
Correct Answer is D
23) Marine cytotoxic agent is....
m
A) Ara-C
o
B) ATX II
f.c
C) Spongosine
D) Both a and c
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Correct Answer is A
24) Select the marine cardiovascular active agent....
A) Eldosin
m
B) ATX II
ar
C) Laminine
D) All of the above

ph
Correct Answer is D
25) Maran (one of the step for the preparation of BHASMA) means....
.b
A) A change is brought about in the chemical form or state of the metal
B) Remove unwanted part from the raw material and separate out impurities
w
C) Several water washes

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D) Ignition
Correct Answer is A
w
26) Ge68 -Ge98 parent daughter system is used for the

A) Brain scanning
B) Thyroid studies
m
C) Bone studies
o
D) Kidney function
f.c
Correct Answer is C
27) Iodine-132 having very short half life so the preffered method for sterilization is
stu
A) Filtration
B) Radiation
C) Chemical
m
D) None of the above
ar
Correct Answer is A
28) Technetium 99m isotopic is used for brain scanning, which of the statement is true
ph
A) Have short half life
B) Does not emit beta radiation

.b
C) Produce gamma photons
D) All of the above

w
Correct Answer is D
w
29) Select the right statement for "carrier mediated transport mechenism".........
A) Drugs can show the mechenism at increased or multiple dose

w
B) Follow mixed order kinetics
C) Required ATP

D) All of the above
Correct Answer is D
30) Gold Au(198) is used as....
m
A) Neoplastic suppesment
o
B) Blood volume determination
f.c
C) Thyroid function
D) Renography
stu
Correct Answer is A
31) In acid catalysed hydrolysis of ester, the actual catalyst is....
A) Hydroxonium ion
m
B) Oxonium ion
ar
C) Methoxy ion
D) Enolate ion
ph
Correct Answer is A
32) Base catalysed hydrolysis of an ester is started with....

.b
A) The attack of hydroxide nucleophiles at the electrophilic C of the ester C=O
B) The attack of hydroxide electrophiles at the electrophilic C of the ester C=O

w
C) The attack of hydroxide nucleophiles at the electrophilic O of the ester C=O

w
D) The attack of hydroxide electrophiles at the neucleophilic C of the ester C=O
Correct Answer is A
w
33) Select the formula to calculate steady state concentration follow I/V infusion model....
A) Css= Infusion rate/Clearance
B) Css= Clearance/ Infusion rate
m
C) Css= Infusion rate x Clearance
o
D) Css= Infusion rate + Clearance
f.c
Correct Answer is A
34) Under compartment modeling, Wegner-Nelson-Method involves....
stu
A) Determination of absorption rate constant (Ka) from %ARA Vs time curve
B) Determination of elimination rate constant (Ka) from % ARA Vs time curve
C) Determination of absorption rate constant (Ke) from %ARA Vs Concentration curve

m
D) Determination of plasma half life
ar
Correct Answer is A
35) I/V infusion model follow....

ph
A) Zero order absorption & first order elimination kinetics
B) No absorption & first order elimination kinetics

.b
C) No absorption & zero order elimination kinetics
D) First order absorption & first order elimination kinetics

w
Correct Answer is A
w
36) Under non compartmental analysis the following formula is used for the calculations....
A) AUMC=MRT/AUC
w
B) MRT=AUC/AUMC
C) AUC= AUMC/MRT

D) MRT=AUMC/AUC
Correct Answer is D
37) In compartment modeling the term "open" indicates....
m
A) Unidirectional input & output
o
B) Body is open
f.c
C) All compartments are open
D) None of these
stu
Correct Answer is A
38) Under the concept of biopharmaceutics,hydrophobic drugs are.....
A) Permeation rate limited

m
B) Dissolution rate limite
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C) Both a & b
D) Initially permeation & then dissolution rate limited

ph
Correct Answer is B
39) In anisocytic stomata.....

.b
A) 2 guard cells covered by 3 subsidiary cells
B) 3 guard cells covered by 3 subsidiary cells

w
C) 2 guard cells covered by 2 subsidiary cells

w
D) many guard cells coverd by many subsidiary cells
Correct Answer is A
w
40) Sand, soil attached with a plant represents.....

A) Physiological ash
B) Non-Physiological ash
m
C) Fiber value
o
D) Both a & b
f.c
Correct Answer is B
41) Select the rational statement for polyploidy.....
stu
A) More than one genome
B) Occurs in multiple series
C) Causes disturbance to mitotic spindle

m
D) All of these
ar
Correct Answer is D
42) Immunosupressants are used

ph
A) To supress rejection of transplanted prgans
B) to supress graft versus host disease in bone marrow transplantation

.b
C) to treat autoimmume diseases
D) All of above
w
Correct Answer is D
w
43) Serious unwanted effect of ciclosporin is
A) Hepatotoxicity
w
B) Nephrotoxicity
C) Hyperlipedemia

D) Thrombocytopenia
Correct Answer is B
44) Which of the following is true about Azathioprine
m
A) It converts into mercaptopurine in body
o
B) It is used in treatment of rheumatoid artheritis
f.c
C) Interefere with purine synthesis
D) All are true
stu
Correct Answer is D
EXP : Azathioprine interfere with purine synthesis and is cytotoxic.It is widely used to treat
autoimmune diseases. It converts to mercaptopurine and interefere with DNA synthesis

m
45) Immunosuppressant with additive inhibitory action on prostaglandin and leukotriene synthesis is
ar
A) Mercaptopurine
B) Prednisolone
ph
C) Cyclosporine
D) Infliximab
.b
Correct Answer is B
46) . __________ inhibit de novo purine synthesis and suppress T cells and cells.
w
A) Mycophenolate mofetil
w
B) Methotrexate
C) Tacrolimus
w
D) Tacrolimus
Correct Answer is A
47) A patient is prescribed cyclosporine as immunosuppressant in renal transplantation, what would be
m
mechanism of action
o
A) Activation of NK cells
f.c
B) Increased catabolism of IgG Antibodies
C) Interference with antigen recognization
stu
D) Inhibit gene transcription of interleukins
Correct Answer is D
48) ____________ is also one of the side effects of sirolimus

m
A) Thrombocytopenia
ar
B) Hypertension
C) Osteoporosis
ph
D) Psorosis
Correct Answer is A
.b
49) Which type of interferon is used for treatment of Hepatitis B
A) Alpha
w
B) Beta
w
C) gama
D) All
w
Correct Answer is A
50) ______________ is an example of immunomodulater?

A) Arnica
B) Ginseng
C) Neem
m
D) All of these
o
Correct Answer is D
f.c
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stu
m
ar
ph
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Send any Pharma related material :admin@bpharmstuf.

PAPER NAME : MINOR 1

1) Drug-exciepient intrection can be studied using....

D) All of the above

2) In the name of the polymer EUDRAGIT E PO" PO stands for?

A) Powdered form of Eudragit E grade

D) Powdered form of any Eudragit grade

A) Carboxy Methyl Cellulose

C) Hydroxy Propyl Cellulose

To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on

C) Polyoxyethylene sorbitan mono oleate

(Temp/Relative Humidity, time):

D) A directly compressible diluent

7) Choose the correct excepient for enhancing solubility in tablet manufacture:

9) Cellutab is the commercial name of

To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on

microorganisms, can reduce the effectiveness of warfarin in diminishing th

cytochrome P450 system. This results in reduced metabolism of dru

A) Amines in food- Disulfiram

B) Alcohol- MAO inhibitor

D) All would enhance duration of action of drug

13) Which of the following theory is associated with crystal growth:

14) Reynold's no is associated with

15) 0.1% dispersion of HPMC in water will follow:

16) Drug interaction between terefenadine and ketoconazole is due to

To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on

C) Increase in renal excretion

A) Forced degradation testing

B) Micro wave lamp

C) UV-visible flourscence lamp

C) Spray dried lactose

C) Natural substances which increases the non-specific resistance of the body

D) Natural substances which increases the quality of body

A) Sodhana & Marana

B) Marana & Sodhana

To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on

23) Marine cytotoxic agent is....

24) Select the marine cardiovascular active agent....

D) All of the above

A) A change is brought about in the chemical form or state of the metal

C) Several water washes

26) Ge68 -Ge98 parent daughter system is used for the

A) Have short half life

B) Does not emit beta radiation

C) Produce gamma photons

D) All of the above

A) Drugs can show the mechenism at increased or multiple dose

B) Follow mixed order kinetics

To receive free Pharma GPAT,NIPER, Preparation Sms/Guidance & ADMISSION NOTIFICATIONS on

30) Gold Au(198) is used as....

31) In acid catalysed hydrolysis of ester, the actual catalyst is....

32) Base catalysed hydrolysis of an ester is started with....

A) The attack of hydroxide nucleophiles at the electrophilic C of the ester C=O

B) The attack of hydroxide electrophiles at the electrophilic C of the ester C=O

C) The attack of hydroxide nucleophiles at the electrophilic O of the ester C=O

D) The attack of hydroxide electrophiles at the neucleophilic C of the ester C=O

A) Css= Infusion rate/Clearance

B) Css= Clearance/ Infusion rate

34) Under compartment modeling, Wegner-Nelson-Method involves....

B) Determination of elimination rate constant (Ka) from % ARA Vs time curve

C) Determination of absorption rate constant (Ke) from %ARA Vs Concentration curve

35) I/V infusion model follow....

A) Zero order absorption & first order elimination kinetics