Altered Repolarization of

the Myocardium

Release of Lysosomal Enzymes

Anaerobic Lactic Acid

Glycolysis Production

Myocardial Irritability

Decreased Contractility ANGINA

DYSRHYTHMI
A

 Ventricular
Function

 Preload  CO

 Blood Flow to
Brain

LOSS OF CONS-
CIOUSNESS

3
 Occlusive Thrombus
WEAKNESS/FATIGUE

Ischemia of Tissue in Region

PALPITATIONS
Supplied by Artery

 O2
Coronary Blood Supply
Less Than Demand

 CO2 levels
MYOCARDIAL CELL DEATH (NECROSIS)

 Bld
pH

DEEP & Stimulation of

LABORED Sympathetic NS
BREATHING

 O2 need  Afterload
 HR

Vasoconstriction
 Epinephrine &
Norepinephrine
Production
HTN
 BMR

 Blood Supply to
ARRHYTHMI
GI Tract
A

DIAPHORESIS N/V

2
 PATHOPHYSIOLOGY OF ACUTE MI

ACUTE MYOCARDIAL INFARCTION

.

MODIFIABLE FACTORS: NONMODIFIABLE

FACTORS:
Hypertension
Smoking (+) Family Hx of AMI
 levels of triglyceride, total cholesterol & LDL Aging
DM Men and Postmenopausal
Obesity Women
Excessive intake of saturated fats, carbohydrates
or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Drug Abuse

Change in the Condition of

Plaque in the Coronary Artery

Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of Platelet
Claudi- Mass
cation
ATHERO- THROMBOSIS
SCLEROSIS

N/V
Release of Thromboplastin

Fainting
Platelet release Thromboxane A2,
Serotonin, Platelet Factors 3 & 4

Sweating
Coagulation and Vasospasm

Cool
extremities
Enlargement of Thrombus