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Soc Psychiatry Psychiatr Epidemiol (2000) 35: 248±254 Ó Steinkop€-Verlag 2000

ORIGINAL PAPER

K. Bhui á D. Bhugra á D. Goldberg

Cross-cultural validity of the Amritsar Depression Inventory


and the General Health Questionnaire amongst English
and Punjabi primary care attenders

Accepted: 21 January 2000

Abstract Background: In order to estimate the health Pakistani; Commander et al. 1997). `Asians' are re-
needs of cultural groups, the cross-cultural validity of ported to repeatedly present to their GPs with physical
instruments requires investigation in distinct cultural complaints (Gillam et al. 1980); even if psychological
rather than ethnic or racial groups. Method: We complaints are presented, `Asians' more often receive a
screened `Punjabi' and `English' primary care attenders physical diagnosis (Wilson and McCarthy 1994). The
in South London (UK), using the General Health routine use of cross-culturally validated screening in-
Questionnaire (GHQ-12), an English origin instrument, struments might signi®cantly improve GPs detection of
and the Amritsar Depression Inventory (ADI), which common mental disorders. Diculties in accurately de-
was developed in the Punjab in India. The criterion tecting disorders include the questionable sensitivity of
measure was the Clinical Interview Schedule (CIS-R). existing Euro-American instruments, cultural di€erences
We calculated the validity coecients, optimal thresh- in concepts of mental health that are at variance with
olds and the area under the `Receive Operating Char- psychiatric nosology, and the aggregation of culturally
acteristic' curve to compare cross-cultural performance. distinct social groups into `apparently' similar ethnic
We identi®ed items on each questionnaire that contrib- and racial groups (Helman 1990; Nazroo 1997; Singh
ute to performance of the instruments. Results: The 1997). Although much work examines the use of British
GHQ-12 has high validity coecients in both cultural and American screening instruments amongst samples
groups. The ADI performs as well amongst English from the Indian subcontinent, it is unusual for epide-
subjects, but among Punjabis it is poorer than the GHQ- miological instruments developed entirely in India to be
12. Among Punjabis who have been resident in the UK used in the UK and for comparisons to be made of their
for over 30 years, the ADI performs no better than validity amongst British samples of `British' and `Asian'
chance. Few items on the ADI or the GHQ are strongly general practice attenders. We compare the performance
predictive of case status. Conclusions: The GHQ-12 of two instruments where their cultural origins were
shows good validity in both cultures. Expressions of concordant and discordant to the culture of English and
distress may change due to acculturation. `Culturally Punjabi primary care attenders. We emphasise the use of
sensitive' screening instruments need to re¯ect this. cultural groups rather than aggregated ethnic groups.
Further work might attend to the changing expressions
of distress following migration.
Subjects and methods
General practices and subjects
Introduction
The subjects were attenders of ®ve general practices in a single
General practitioners (GPs) in the UK less often detect, London electoral ward that includes signi®cant numbers of resident
Punjabi-Asian and White-English people. Consecutive subjects
treat or o€er a specialist referral for common mental were approached if, on arrival for their doctor's appointment, they
disorder among `Asians' (Indian, Bangladeshi, and were of White-European or Asian-Indian sub-continent appear-
ance. The ®rst phase included a cultural screen. The Punjabis af-
®rmed themselves to be of Punjabi cultural origin and of a family
originally from the Indian subcontinent.
K. Bhui (&) á D. Bhugra á D. Goldberg Punjabis form a well-circumscribed cultural group with com-
Institute of Psychiatry, De Crespigny Park, mon language, music, foods, dress and homeland. Punjabis can
London SE5 8AF, UK however be Hindu, Muslim or Sikh, but all share Punjabi as a
e-mail: K.S.Bhui@mds.qmw.ac.uk language. The English group were those who were white, English
249

speaking and identi®ed themselves to be of English identity. Any- interviews. These were `probable cases'. One-third of those who
one who was uncertain about their identity or who was from an- scored less than 2 on the GHQ and less than 5 on the ADI
other cultural group (for example, Scottish, Irish, Gujarati or (`probable non-cases') also proceeded to the second phase. Two
Bangladeshi origin) was excluded. Patients with learning dicul- research assistants helped with the ®rst stage. One of them was
ties, severe hearing impairment, or a psychosis were also excluded. Punjabi, and spoke Punjabi and English, and completed interviews
in Punjabi. The other was Asian, but not Punjabi, and so com-
pleted only English interviews. The two assistants helped for up to
Instruments one-®fth of the weekly surgery time. The majority of the ®rst stage
and all the second stage interviews were conducted by a single
The General Health Questionnaire (GHQ-12) is a 12-item ques- bilingual psychiatrist (K.B.). Smoking habits, alcohol use, medi-
tionnaire that has been used extensively in the detection of non- cation and physical illnesses were identi®ed in the second phase; the
psychotic morbidity in many cultural contexts (Goldberg et al. CIS-R was completed in the second phase.
1997), but it has been criticised for under-detection of disorders in
some demographic groups (Lewis and Araya 1995; Williams and
Hunt 1997). The Amritsar Depression Inventory (ADI) is a 30-item Statistical analysis
(yes/no) questionnaire, which was developed in the Punjab (Singh
et al. 1974) from 50 statements that are commonly used expressions Data analysis was conducted using SPSS 6.0 and STATA 5.0. The
among Punjabi patients with depressive states. Patients were re- expansion weights used were the reciprocals of the sampling frac-
cruited from outpatient clinics over a 5-year period. Commonly tions. The conventional threshold value to de®ne cases on the CIS-
described signs and symptoms of depression in the psychiatric lit- R is 11/12, and unless speci®ed otherwise, `case' and `caseness' refer
erature and commonly used `illness statements' were also included. to this threshold de®nition. The performance of the ADI may vary
The questions were suitable for uneducated rural workers as well as with the severity of the disorder as de®ned along a continuum of
literate groups. The developing questionnaire was administered to the CIS-R score. Consequently, we also examined the CIS-R
75 patients, of whom 25 had severe depression, 25 had reactive thresholds that de®ne the 25th, 50th, and 75th percentile cut-points
depression and 25 had an anxiety disorder; 25 normals were also for the distribution of CIS-R scores. Stratum-speci®c estimates of
added. The 30 items of the ADI di€erentiated patients with `de- performance overcome the shortfalls of applying a ®xed threshold.
pression and anxiety' from those with no disorder. The construct These strata were de®ned by thresholds of 4/5, 11/12 and 21/22,
validity using a psychiatrist's clinical diagnosis was 0.75, and the which are the quartile thresholds. The 50th centile threshold was
reliability was 0.82. the same as the conventional CIS-R threshold. The centile points
The Clinical Interview Schedule (Revised; CIS-R) is a standard did not di€er by more than one CIS-R point for each cultural
semi-structured interview to assess non-psychotic disorders. It is group, hence the overall centile points were adopted.
suitable for use by lay interviewers, as it minimises observer bias Data on both GHQ-12 and ADI for all screened subjects was
(Lewis and Pelosi 1990). The `category fallacy argument' criticises available to investigate the split-half reliability of the GHQ-12 and
the application of diagnostic nosological categorisation developed the ADI, correlation between the forms (split-half) and Cronbach's
in one cultural group to members of another culture (Kleinman a (standardised). The validity coecients and the `Area Under the
1980; Littlewood 1990). We used the CIS-R total symptom score, Receiver Operating Characteristic Curve' (AUC) were calculated
and individual symptom scores, to measure morbidity. This as- using STATA 5.0. The AUC is a measure of the performance of a
sumes that symptoms rather than diagnostic groups are universally screening test (see Mari and Williams 1985; Swets and Pickett
associated with common non-psychotic mental disorders (Jacob 1982). An AUC of 0.5 indicates that the screen performs no better
et al. 1998a; Nazroo 1997). than chance, and the better the performance the nearer the AUC is
to 1.0. The AUC is calculated for all possible threshold values of
the GHQ-12 and ADI for any one case de®ning threshold value on
Questionnaire design and preparation the CIS-R. Optimal threshold values are then identi®ed, and
comparisons made of the validity coecients for the GHQ and the
All the questionnaires were translated and back translated by two ADI when concordant and discordant with the cultural origins of
bilingual psychiatrists and a social services worker in order to the sample. The di€erence between the areas under the ROC curves
achieve direct and conceptual equivalence with minimum alteration were calculated using the ROC Curve Analyser programme. We
to the structure of the sentence. The questionnaires were piloted in also examined the strength of the association of each of the GHQ
two practices and discussed with a local Asian voluntary organi- and ADI items with caseness on the CIS-R (11/12) using weighted
sation worker/user, a Punjabi bilingual local social services worker, multiple logistic regression. Data for items that were associated
and a few members of the public. This ensured the translations with case status at a P-value of less than 0.1 are presented.
were understandable and sought only necessary information. Psy-
chologically `threatening' questions were asked after giving assur-
ance of con®dentiality, asking about demographics and asking
about physical ill-health; one ADI question about sexual function Results
was omitted after objections to this question in pilot studies. The
order of the two screens was reversed half way through the survey. Sample characteristics

Interview procedure and sampling strategy Of 561 individuals eligible for inclusion, 58 (10.4%) re-
fused to participate either at the ®rst or second stage.
All questionnaires related to the preceding 7 days; they were read Hence a total of 209 Punjabis and 185 English attenders
out to subjects but completed by the research interviewer. Inter- completed the second stage, of which 36 and 27 re-
views were conducted in English, Punjabi or a mixture of the two
depending on the subject's preference. A two-phase sampling spectively were `probable non-cases'. There were no
procedure was used to maximise eciency of data collection di€erences in age distribution, marital status, gender,
(Newman et al. 1990; Pickles et al. 1995). The ®rst phase included religion, accommodation, occupation, social class or
®xed choice questions about cultural identity, demographics and source general practice between refusers and non-refus-
the two screening instruments: the General Health Questionnaire
(12 items) and the Amritsar Depression Inventory (29 items;
ers. Completers had a signi®cantly lower GHQ score
Goldberg 1972; Singh et al. 1974). Those scoring 2 or more on the (mean: refusers 4.28 vs completers 3.00, F = 5.05
GHQ or 5 or more on the ADI proceeded to the second phase df = 1, 539, P = 0.03), but similar ADI scores as
250

refusers (refusers 9.12 vs completers 8.76, df 1, 538 Face, content and conceptual validity of the ADI
F = 0.05, P = 0.83). There were no age di€erences
between the two cultural groups (English mean age: These observations were made during piloting of the
46.0 years vs Punjabi mean age: 45.5 years; t = 0.26, questionnaires and during the study. The content of the
df = 392, P = 0.79). Punjabis born outside the UK questionnaires was meaningful, and there were few items
(n = 174) had lived in the UK for an average of 24.3 that created diculties of understanding; the items
years (range 1±43 years). Age at migration was not as- seemed appropriate to tap experiences of common
sociated with a caseness rating on the CIS-R [mean age mental disorders (content validity). Subjects in both
at migration (SE) for non cases: 23.3 (1.05) years vs cultural groups readily identi®ed that the questions re-
cases: 25.5 (0.84) years; t = )1.60, P = 0.11]. Of lated to distress, depression, illness, and disabilities.
Punjabi subjects, 90 chose to complete interviews in Subjects often advanced that the questions were `de-
English, 108 preferred Punjabi and 11 used a mixture of pressing', whilst also expressing concern that some in-
English and Punjabi. dividuals su€ered with such feelings. The underlying
constructs appeared to be the same, but one can not
assume this, as illustrated by the following observations.
Ethnic and cultural characteristics The absence of interpersonal a€ection (an ADI item)
might be part of a depressive picture in Punjabis but not
Ninety-seven percent (181/185) of English and 15.8% among all English subjects. Or at least, if present, this is
(33/209) of Punjabi subjects were born in the UK, while not a common expression of depressive feelings in the
7.7% of Punjabis were born in Pakistan, 62.4% in India, English language. Feelings of inferiority (a GHQ item)
12.9% in Africa and 1.4% in other countries. In terms of seems depressive in English subjects, but among some
ethnic origin, 60.8% of Punjabis classi®ed themselves as Punjabis these were regarded as expressions of humility
Asian Indian, 7.7% as Asian Pakistani, 23.4% as Asian and to be a desirable way of relating. Most items on the
British, 1.9% as Asian African and 6.2% as `other'. instruments such as sleep loss, worry, panic, hopeless-
Among English subjects, 99% were of White UK ethnic ness, depressive feelings, suicidal ideas all made sense in
origin. Among Punjabis, 85% were Sikh, 8.1% were both cultures and were identi®ed as part of the response
Muslim, 6.2% were Hindu, and 0.5% were Christian. to distress and speci®cally depression. Nonetheless, even
Sixty-®ve percent of English subjects were Christian and where items were not readily identi®ed as being linked to
29% had no religious aliation, with the remainder a common mental disorder, the disability that the item
having `other' religious beliefs. tapped was recognised by subjects as a possible con-
Punjabis were less often in the ®fth age pentile (61.3- comitant of mental distress.
to 85.9-year-old group; OR = 0.31, 95% CI = 0.15±
0.66, P = 0.002). There were no gender ratio di€erences
across cultural groups (OR = 0.91, 95% CI = 0.58± Validity coecients and Area under ROC Curve
1.42, P = 0.68). Punjabis were more often married
(OR = 3.4, 95% CI = 1.83±1.42, P < 0.001). Punjabis The sensitivity and speci®city data are presented in
were less often in rented accommodation (local author- Table 1. Firstly, using the conventional CIS-R threshold
ity: OR = 0.2, 95% CI = 0.11±0.35, P < 0.001; of 11/12 to de®ne caseness, the optimal threshold value
private rented: OR = 0.1, 95% CI = 0.04±0.26, for the GHQ is the same amongst Punjabis and English
P < 0.001), less likely to be unemployed (OR = 0.25, subjects, namely 2/3. However, the optimal threshold for
95% CI = 0.1±0.26, P = 0.002) and less likely to be the ADI di€ers across cultures: 6/7 for English subjects
retired (OR = 0.17, 95% CI = 0.08±0.35, P < 0.001). and 11/12 for Punjabis. Signi®cant ®ndings are that on
There were no cultural di€erences in social class distri- using the ADI, the AUC amongst Punjabis (0.78) is
butions or in the number of body systems a€ected by a signi®cantly less than that for English subjects (0.87;
physical illness. P = 0.01). Unexpectedly, this indicates the ADI to be a
poorer case detector amongst Punjabis. Amongst Pun-
jabis the GHQ is a better case detector (AUC = 0.88)
Reliability than the ADI (AUC = 0.78; P < 0.01).
In order to explore how exposure to English culture
The Guttman split-half reliability was the same for both might in¯uence the validity of the ADI amongst Pun-
cultural groups. It was 0.92 for ADI scores, and for GHQ jabis, we examined validity coecients for subgroups of
scores it was 0.87. The correlation between forms (split- Punjabi patients. Those who were interviewed in English
half ADI) was 0.85 and 0.86 among Punjabi and English (AUC = 0.79; Sens = 67.84%; Spec = 78.79%), those
subjects respectively. The same statistic using GHQ who preferred an interview in Punjabi (AUC = 0.73;
scores was 0.77 for both Punjabi and English subjects. Sens = 65.83%; Spec = 71.45%), those born in the
Finally Cronbach's a (standardised) using ADI scores UK (AUC = 0.75; Sens = 37.18%; Spec = 88.16%),
was 0.92 (0.93) and 0.91 (0.92) among Punjabi and En- those born outside the UK (AUC = 0.74;
glish subjects respectively. The same statistic for GHQ Sens = 42.58%; Spec = 89.37%), those who had ar-
scores was 0.87 (0.88) for Punjabi and English subjects. rived in the UK less than 19 years ago (AUC = 0.71;
251

Table 1 Validity coecients for the 12-item General Health Questionnaire (GHQ-12) and Amritsar Depression Inventory (ADI) at
di€erent thresholds of the Clinical Interview Schedule (CIS) (PPV Positive predictive validity, NPV Negative predictive validity,
AUC Area Under Receiver Operating Characteristic Curve)

CIS Instrument Culture Best Sensitivity Speci®city PPV NPV % correct AUC
threshold threshold

4/5 GHQ-12 English 1/2 66.54 80.92 85.83 58.2 71.79 0.74
Punjabi 1/2 74.06 75.9 86.5 58.38 74.65 0.75
ADI English 4/5 69.13 88.78 91.45 62.34 76.3 0.79
Punjabi 6/7 79.03 64.0 81.5 56.14 72.13 0.70
11/12 GHQ-12 English 2/3 74.19 80.00 69.00 83.78 77.82 0.84
Punjabi 2/3 78.10 77.55 71.30 83.21 81.75 0.88
ADI English 6/7 72.04 87.18 74.68 83.95 81.53 0.87
Punjabi 11/12 70.19 72.79 62.93 77.54 71.71 0.78
21/22 GHQ-12 English 4/5 68.89 86.93 54.39 92.51 83.60 0.78
Punjabi 6/7 67.34 86.63 54.03 91.93 82.99 0.77
ADI English 9/10 75.56 85.42 53.97 93.92 83.6 0.81
Punjabi 18/19 60.87 89.36 58.33 90.78 84.33 0.75

Sens = 20%; Spec = 94.3%) and those who had lived about the validity of the ADI among this Punjabi
in the UK for over 30 years (AUC = 0.57; Sens: sample.
38.54%; Spec: 72.18%). None of these coecients in-
dicate better validity of the ADI. However, the ADI was
no better than chance among Punjabis who had been Discussion
resident in the country for over 30 years.
Methodological limitations

Validity of the instruments for di€ering severity The survey was conducted on consecutive attenders in
of disorder primary care, and hence the ®ndings are not necessarily
generalisable to population samples of Punjabis and
The prevalence of common mental disorders, using the English subjects. A common complication in research
conventional threshold of 11/12 for the CIS-R, is the exploring the cultural expression of distress is the ag-
same in each cultural group (Bhui et al. 1999). There- gregation of distinct cultural groups into ethnic or even
fore, the variable thresholds are not accounted for by racial groups (Singh 1997). Black/white di€erences are
prevalence variations. We wished to investigate whether still reported in psychiatric literature, giving rise to ra-
the performance of an instrument was di€erent across cially based interpretation of research ®ndings rather
cultures at di€erent severities of disorder. For more than cultural interpretations. We addressed this by
severe disorders (higher CIS-R threshold), the optimal studying discrete cultural groups. Those with more ill-
threshold on the GHQ is higher among Punjabi than ness (on the GHQ) were less likely to participate, per-
English subjects. For less severe disorders (CIS-R haps leading to a sampling bias towards lower GHQ
threshold of 4/5) the optimal GHQ threshold is the scores. The Clinical Interview Schedule (CIS-R; Lewis
same in both cultural groups. However, the ADI and Pelosi 1990) has stable psychometric properties and
threshold consistently di€ers between the two cultures its semi-structured nature eliminates observer bias.
at all levels of severity. Punjabis consistently require a However, well-known instruments (in this instance the
higher threshold, and the more severe the morbidity GHQ and the CIS-R) may consistently be at variance
(higher CIS-R threshold), the greater is the di€erence with `culturally sensitive' instruments (ADI).
between the optimal threshold for Punjabis and English
subjects.
Explaining the ®ndings

ADI and GHQ items and their association There are four possible explanations for our ®ndings.
with CIS-R case status (11/12) Firstly, one might consider that the development of the
ADI was not as rigorous as that of the GHQ. However,
The items that independently predict caseness on the both screening instruments perform well amongst En-
CIS-R (threshold of 11/12) are distinct for each cultural glish subjects, suggesting that the ADI is not simply a
group (see Table 2). Only three items are important case poor instrument but, unlike the GHQ-12, its perfor-
predictors in both cultural groups: Feel unhappy most of mance is not culturally invariant. A second possibility is
the time, Lost much sleep over worry, and Felt con- that the ADI may be a good instrument amongst Pun-
stantly under strain. Only three items of the ADI were jabis in the Punjab, but not Punjabis living in the UK.
predictive of case status among Punjabis, raising doubts This might arise because of acculturation and altering
252

Table 2 ADI Items and their association with caseness (CIS rative acquisition of the host population's popular
threshold 11/12; weighted multiple logistic regression; P < 0.1) expressions.
Instrument Culture Items OR 95% CI P value A third possibility is that common mental disorders
are fundamentally di€erent in the two cultural groups. It
ADI Punjabi 1 1.91 0.93±3.91 0.08 is possible that the ADI and GHQ tap di€erent experi-
13a 2.42 0.97±6.11 0.06 ential constructions and symptom pro®les of `a common
16 0.35 0.13±0.89 0.03
English 4 2.68 0.96±7.48 0.06 mental disorder' in the two cultural groups. The ADI,
5 2.75 0.85±8.93 0.09 for example, has items about interpersonal a€ection,
6 2.81 0.98±8.08 0.06 hope, physical symptoms, community burden and mo-
13a 3.15 1.07±9.28 0.04 tivation as well as depressive items. The GHQ tends to
17 5.93 1.08±32.67 0.04
20 2.57 0.83±7.94 0.1
tap thinking capacity, depressive cognition, ability to
21 3.72 1.34±10.31 0.01 tolerate and overcome problems and sleep. Hence, if one
22 26.15 0.89±767.7 0.06 posits that the GHQ acts as a detector of psychological
27 0.02 0.0007±0.53 0.02 manifestations of distress (Patel et al. 1998), and the
GHQ Punjabi 1 1.65 0.95±2.86 0.07 ADI is better at tapping interpersonal, social and so-
2a 1.60 1.01±2.52 0.05 matic items, it is possible that the two instruments detect
5a 2.61 1.52±4.49 0.001 di€erent experiential dimensions of the same disorder.
9 1.74 1.06±2.86 0.03
12 2.37 1.09±5.15 0.03 The ADI and GHQ perform equally well among English
English 2a 1.75 1.12±2.72 0.01 subjects. One explanation is that these dimensions
5a 1.67 0.93±2.98 0.08 (psychological and social) are better correlated in En-
6 2.1 1.09±4.05 0.03 glish subjects' expressions of distress. The implication is
8 2.13 0.94±4.87 0.07
10 2.41 1.17±4.96 0.02
that these dimensions are di€erently correlated among
Punjabi subjects, perhaps accounting for the diculties
ADI item
1 I am unable to fully commit myself to anything
in the detection of disorder among Punjabi-Asians.
4 I am unable to carry on and complete new tasks A ®nal possible explanation for these ®ndings is that,
5 I do not have enough energy to carry on and while the ADI was developed in the Punjab, it used
complete new tasks psychiatric epidemiological concepts rather than local
6 When anything goes wrong, I am unable to put it ethnographies. One can still argue that the ADI is a
right
13a I feel unhappy most of the time psychiatric instrument, and therefore is ethnocentric,
16 I feel that I am inferior to others omitting important aspects of distress associated with
17 I feel that I am unable to do things as quickly mental illness among Punjabis. This might explain its
and eciently as other people value amongst English subjects. Comparison across
20 I feel sad because of aches and pains
21 I am a burden on society cultures using bi-culturally validated instruments, per-
22 I feel unhappy about the mistakes I made in the past haps by developing a hybrid between the GHQ-12 and
27 Deep down I regard myself a worthless person ADI, will selectively include symptoms that are common
GHQ item to the cultures under investigation. Such bi-culturally (or
1 Able to concentrate on what you're doing multi-culturally) valid instruments risk omission of items
2a Lost much sleep over worry that may not have epidemiological validity in accord
5a Felt constantly under strain with a criterion measure. These `omitted items' may
6 Felt you couldn't overcome things
8 Been able to face up to problems constitute an essential part of the illness experience of
9 Been feeling unhappy or depressed individuals. `Omitted items' might help de®ne mental
10 Been losing con®dence in yourself disorders in accord with lay and local ethnographic
12 Feeling reasonably happy approaches. If these are not meaningfully related to
a
Items common to both cultural groups `distress experiences' de®ned by psychiatric criteria, then
a revision of commonly used psychiatric criteria is un-
likely to be helpful.
health beliefs and lifestyle following exposure to the
dominant culture. One explanation is that the London-
resident Punjabi subjects' expressions of distress have Previous work on the GHQ-12
been shaped by exposure to English culture, and that
these expressions are di€erent from those of Punjabis The GHQ-12 yields high validity coecients when ad-
living in the Punjab. However, the validity coecients ministered in several languages and countries including
were no better for those Punjabis born outside the Bangalore in India (Goldberg et al. 1997). The GHQ-12
UK, for those arriving in this country more recently or has high validity coecients among Hindi speaking
for those clearly preferring to speak in Punjabi. How- women in West London, Bengali speakers in Calcutta,
ever, the ADI was no better than chance in the detection and Karnataka speakers in South India (Bandyo-
of a common mental disorder among Punjabis resident padhyay et al. 1988; Jacob et al. 1998a; Sriram et al.
in the UK for over 30 years. Hence, culturally engrained 1989). The GHQ-12 also had stable stratum-speci®c
expressions of distress may attenuate with accultu- likelihood ratios across 15 centres in a World Health
253

Organisation study (Furukawa and Goldberg 1999). Acknowledgements The authors wish to thank Dr. Gurjinder
However, Williams and Hunt (1997) conclude that the Malhi, Puspha Patel and Surinder Sandhu for assistance with
translations and screening procedures; all patients who gave will-
GHQ-12 underestimates distress amongst South Asians, ingly of their time and their general practitioners. Dr. Bhui is
and especially amongst women. There are cultural dif- supported by the Wellcome Trust grant no: 043815/Z/95.
ferences in the optimal threshold values, and these re-
¯ect variability in the severity and the prevalence of
disorders (Goldberg et al. 1997). There are also some References
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