Here are the defaults that come with AutoCAD:

F1: Displays Help

F2: Toggles the Text Window

F3: Toggles OSNAP

F4: Toggles Tablet mode

F5: Toggles ISOPLANE

F6: Toggles Dynamic UCS

F7: Toggles GRID mode

F8: Toggles ORTHO mode

F9: Toggles SNAP mode

F10: Toggles Polar Tracking

F11: Toggles Object Snap Tracking

F12: Toggles Dynamic Input

CTRL+0: Toggles Clean Screen

CTRL+1: Toggles the Properties palette

CTRL+2: Toggles the DesignCenter palette

CTRL+3: Toggles the Tool Palettes Window

CTRL+4: Toggles the Sheet Set Manager

CTRL+6: Toggles the dbConnect Manager

CTRL+7: Toggles the Markup Set Manager

CTRL+8: Toggles the QuickCalc calculator palette

CTRL+9: Toggles the command window

CTRL+A: Selects all objects in the drawing

CTRL+SHIFT+A: Toggles Groups

CTRL+B: Toggles Snap mode

CTRL+C: Copies objects to Clipboard

CTRL+SHIFT+C: Copies objects to Clipboard with Base Point

CTRL+D: Toggles Dynamic UCS

CTRL+E: Cycles through isometric planes

CTRL+F: Toggles running object snaps

CTRL+G: Toggles the grid

CTRL+H: Toggles PICKSTYLE

CTRL+I: Toggles COORDS

CTRL+J; CTRL+M: Repeats the last command (pressing Enter does the same)

CTRL+L: Toggles Ortho mode

CTRL+N: Creates a new drawing

CTRL+O: Opens an existing drawing

CTRL+P: Prints/plots thecurrent drawing

CTRL+R: Cycles through layout viewports

CTRL+S: Saves the current drawing

CTRL+SHIFT+S: Opens the Save As dialog box

CTRL+T: Toggles TABLET mode

CTRL+V: Pastes data from the Clipboard

CTRL+SHIFT+V: Pastes data from the Clipboard as a Block

CTRL+X: Cuts objects to Clipboard

CTRL+Y: Cancels the preceding Undo action

CTRL+Z: Reverses the last action

CTRL+[; CTRL+\: Cancels the current command (pressing Esc does the same)

CTRL+PAGE UP: Moves to the next layout tab to the left of the current tab

CTRL+PAGE DOWN: Moves to the next layout tab to the right of the current tab
ALT+F11: Displays the Visual Basic Editor

ALT+F8: Displays the Macros dialog box

Read more:
http://www.ellenfinkelstein.com/autocadtips/AutoCAD_tips_keyboard_shortcuts.html#ixzz1I3f0p4QS

Create a custom keyboard shortcut

Would you like to create a keyboard shortcut to your favorite command-option combination? For
example, I use Zoom Extents an awful lot, but it's hidden on the Zoom flyout. I could put it on a
custom toolbar, but another option is to create a keyboard shortcut. Here are the steps:
1. Enter cui to open the Customize User Interface dialog box.
2. In the Command List pane, click the New button.
3. In the Properties pane, you can now specify your new command. Enter a name and a macro. My
macro was zoom e
 4. In the Customizations In pane at the top, expand Partial CUI Files, then Custom, then Keyboard
Shortcuts, so you can see the Shortcut Keys item.
5. Find your new command in the Command List pane (it's listed under the name you gave it) and
drag it to the Shortcut Keys item in the top pane.
6. Click the command where it appears in the top pane. Its Properties pane now shows a Key(s)
item. Click that item and then click its Ellipsis button. The Shortcut Keys dialog box opens.

Press the shortcut key combination you want to use and you can see if it's unassigned -- or assigned to
something you never use. Click OK.
7. Click OK to close the Customize User Interface dialog box.
8. Try out your new shortcut!

Read more: http://www.ellenfinkelstein.com/AutoCAD_tips_custom_shortcut.html#ixzz1I3hy6Wm2