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a
Departamento de Quı́mica Inorgánica y Orgánica, Universitat Jaume I, Avda, Vicente Sos Baynat s/n, Castellón E-12071, Spain
b
Departamento de Quı́mica Inorgánica, Universitat de Valencia, C/Dr. Moliner s/n, Burjassot-Valencia E-46100, Spain
Received 31 May 2005; received in revised form 27 June 2005; accepted 4 July 2005
Available online 11 August 2005
Abstract
0022-328X/$ - see front matter Ó 2005 Elsevier B.V. All rights reserved.
doi:10.1016/j.jorganchem.2005.04.060
E. Mas-Marzá et al. / Journal of Organometallic Chemistry 690 (2005) 5576–5580 5577
The reaction of 1,1-carbonyldiimidazole and 2-pyri- Fig. 1. Molecular diagram of compound 2. (Hydrogen atoms and
counter-anions have been omitted for clarity). Selected bond lengths
dinecarboxaldehyde at 80 °C in the presence of (Å) and angles (°): C(1)–C(2) 1.505(8), C(1)–N(2) 1.470(7), C(1)–N(4)
CoCl2 Æ 6H2O as catalyst, affords the preparation of 1.461(7), N(2)–C(1)–N(4) 109.2(4), N(4)–C(1)–C(2) 111.9(4).
(2-pyridine)bis(imidazolyl)methane (1), which had been
previously obtained by a different method [26]. The reac-
tion of 1 with MeI gives the corresponding methylated ubility of the complex at all. The compound could only
compound, (2-pyridine)bis(3-methylimidazolium-1-yl)me- be dissolved in DMSO, yielding compound 4 (Scheme
thane diiodide, [H2PYBIMMe]I2 (2), in high yield 2). The 1H NMR spectrum of 4 in DMSO-d6 shows that
(Scheme 1). This procedure is similar to the one that the twofold symmetry of the ligand was lost upon coor-
we reported for the preparation of (2-hydroxyphe- dination. The two downfield signals of the protic hydro-
nyl)bis(3-methylimidazolium-1-yl)methane diiodide, gens in the precursor 2 disappeared, suggesting that the
and, in fact, provides an easy method to access to a coordination has taken place. The signal due to the pyr-
new type of tripodal biscarbene ligands. idine hypso-hydrogen appears at d = 9.2, suggesting that
Compounds 1 and 2 were fully characterized by the pyridine remains unbound. The two methyl groups
NMR and elemental analysis, and the molecular struc- of the imidazolium fragments appear as two different
ture of a hexafluorophosphate salt of 2 was confirmed signals at 4.09 and 4.03 ppm. The 13C NMR spectrum
by means of X-ray crystallography. Fig. 1 shows the shows two doublets at 159.18 and 151.09 ppm (1JC–Rh =
molecular structure of 2. As expected, the molecule con- 42.9 and 44.1 Hz, respectively) in the region where
sists of two methylimidazolium fragments and a pyridyl Rh(III)–NHC compounds appear, thus confirming that
ring bound to a CH central group. The distances and the metallation has occurred. The pattern of the signals
angles of this carbene precursor lie in the expected due to the imidazolylidene and pyridine rings, as well as
range. the two different methyl groups observed, confirm the
In the presence of a weak base as NEt3, 2 reacted with lost of the binary symmetry of the ligand in the complex.
[Rh(COD)2](BF4) yielding a pale brown highly insoluble In order to confirm that the pyridine is not bound to the
species that we could hardly analyse. The product Rh atom, we performed a 1H–15N correlation of the me-
showed very little solubility in most organic solvents tal complex, observing that the signal due to the nitro-
(CH2Cl2, THF, acetone, acetonitrile, methanol) and gen atom of the pyridine appears in the region typical
H2O, which we attributed to a polymeric nature of the for unbound pyridine fragments. (d = 110) and we
compound (3 in Scheme 2). The exchange of the BF4 did not observe any 105Rh–15N coupling (Fig. 2). The
counter-anion by PF6 or BPh4 did not improve the sol- signals due to the nitrogen atoms of the imidazolylidene
rings appear between 64 and 70 ppm. A 1H–13C cor-
relation was also performed in order to assign all the sig-
O nals of the 1H and 13C NMR spectra (see ESI).
C
N The mass spectroscopy analysis for a solution of
N
N N CoCl .6H O N N the complex in CH3CN, showed peaks (m/z) at 693.6
+ 2 2 MeI
OHC
N N N N (I)2 [(PYBIMMe)I2Rh(CH3CN)2]+, 650.9 [(PYBIMMe)-
N N 1 N N N I2Rh(CH3CN)]+, and 609.9 [(PYBIMMe)I2Rh]+,
2
whereas a solution of the complex in DMSO showed
Scheme 1. peaks at 687.2 [(PYBIMMe)I2Rh(DMSO)]+ and 609.9
5578 E. Mas-Marzá et al. / Journal of Organometallic Chemistry 690 (2005) 5576–5580
[Rh(COD)2](BF4) H
N N N
+ NEt3
CH3CN, 45˚C N
N
I Rh N
N (I)2 I (BF4)n
N
N N n
H3CCN
3
2
DMSO-d6
H
N N N
DMSO N
I Rh N
I
(BF4)
DMSO
Scheme 2.
[(PYBIMMe)I2Rh]+. According to these results, we have As observed for the coordination of other imidazo-
tentatively assigned a polymeric structure such as that lium-based biscarbene ligands [14,17,27], the Rh(I) start-
shown in Scheme 2 (compound 3), for the polymeric ing compound [Rh(COD)2](BF4) oxidized to Rh(III)
compound obtained from the reaction of 2 and [Rh- upon coordination of the ligand. We recently proposed
(COD)2](BF4). In DMSO, the pyridine is displaced by a that an oxidative addition of the C2–H bond of the imi-
molecule of solvent forming 4, thus facilitating the dazolium precursor may help to explain this observation
solution of the complex. The same effect is observed [17], and further experimental evidences to support this
in CH3CN forming compound [(PYBIMMe)I2Rh- proposal will be published soon.
(CH3CN)2](BF4) (5), although the lower coordination We believe that the failure of the ligand [PYBIMMe]
capability of this solvent may be responsible for the lower to coordinate in a tripodal form is mainly due to topo-
solubility of the compound, which could only be detected logic restrictions of the ligand. Iodide removal from
by Mass Spectroscopy analysis, and no NMR spectrum in the coordination sphere of 3 and 4 with AgBF4 always
CD3CN could be recorded. resulted in decomposition of the product, and changing
E. Mas-Marzá et al. / Journal of Organometallic Chemistry 690 (2005) 5576–5580 5579
the conditions of the reaction only resulted in a reduc- with ether, precipitated with CH3OH/ether and dry un-
tion of the reaction yield. In fact, the g2-coordination der vacuum, giving a brown solid. Yield: 0.90 g (80%).
1
of the bis-NHC rings may be pushing the pyridine ring H NMR (DMSO-d6, 500 MHz): 9.44 (s, 2H, NCHN),
out of the coordination sphere of the complex, thus 8.76 (d, 3JH–H = 4.5 Hz, 1H, pyridine-H), 8.55 (s, 1H,
releasing the steric constrain about the CH linker. In C-H), 8.10 (t, 3JH–H = 7.0 Hz, 1H, pyridine-H), 8.03
any case, we are carrying out further experiments with (s, 2H, imidazole-H), 7.90 (s, 2H, imidazole-H), 7.78
other metals such as Cu(I) and Fe(III) for which we (d, 3JH–H = 7.5 Hz, 1H, pyridine-H), 7.67 (m, 1H, pyri-
believe that the tripodal coordination of the ligand dine-H), 3.91 (s, 6H, CH3–N). 13C{1H} NMR (DMSO-
may be possible, and may provide interesting catalytic d6, 500 MHz): 150.98 (C–H, pyridine), 149.42 (C,
performances. pyridine), 139.39 (C–H, pyridine), 138.27 (2C, NCHN),
126.87 (C–H, pyridine), 125.23 (2C, imidazole-C),
122.26 (2C, imidazole-C), 71.37(C-H), 37.24 (2C,
3. Experimental CH3–N). Anal. Calc. for C14H17I2N5 (509.13): C,
33.03; H, 3.37; N, 13.76. Found: C, 33.45; H, 3.29; N,
NMR spectra were recorded on a Varian Innova 300 13.98%.
and 500 MHz instruments, using CDCl3 and DMSO-d6.
Elemental analyses were carried out in an EA 1108 3.3. X-ray diffraction studies of compound 2
CHNS-O Carlo Erba Analyser. Electrospray mass spec-
tra (ESI–MS) were recorded on a Micromass Quatro LC A single crystal of a hexafluorophosphate salt of 2
instrument, nitrogen was employed as drying and nebu- was mounted on a glass fiber in a random orientation.
lizing gas. The [Rh(COD)2]BF4 precursor was obtained Data collection was performed at room temperature
according to the literature methods [28]. All the other re- on a Siemens Smart CCD diffractometer using graphite
agents are commercially available and were used as monochromated Mo Ka radiation (k = 0.71073 Å). The
received. diffraction frames were integrated using the SAINT
package.
Space group assignment was based on systematic ab-
3.1. Synthesis of (2-pyridine)bis(imidazolyl)methane (1) sences, E statistics and successful refinement of the
structures. The structure was solved by direct methods
A mixture of 1,1-carbonyldiimidazole (4.40 g, 27.14 with the aid of successive difference Fourier maps and
mmol), 2-pyridinecarboxaldehyde (2.58 mL, 27.14 mmol) were refined using the SHELXTL 6.1 software package.
and CoCl2 Æ 6H2O (31 mg, 0.13 mmol) was stirred at All non-hydrogen atoms were refined anisotropically
80 °C for 12 h. The mixture was allowed to cool to room and hydrogen atoms were assigned to ideal positions
temperature, dissolved in 30 mL of CH2Cl2 and ex- and refined using a riding model.
tracted with water. Then the organic layer was dry under
Na2SO4. The product was purified by column chroma- 3.4. Syntheses of complexes 3 and 4
tography; elution with CH2Cl2/CH3OH (9:1) afforded
the desired compound 1 as a brown oil. Yield: 5.19 g A mixture of [Rh(COD)2](BF4) (200 mg, 0.49 mmol),
(85%). 1H NMR (CDCl3, 500 MHz): 8.68 (d, 3JH–H = 2 (251 mg, 0.49 mmol), and NEt3 (250 lL, 1.8 mmol)
4.0 Hz, 1H, pyridine-H), 7.78 (t, 3JH–H = 7.5 Hz, 1H, was heated at 45 °C in CH3CN overnight. During this
pyridine-H), 7.56 (s, 1H C–H), 7.38 (m, 1H, pyridine- time, a pale brown solid appeared. The solid containing
H), 7.36 (s, 2H, NCH N), 7.14 (d, 3JH–H = 8.0 Hz, 1H, 3 was filtered and washed with CH2Cl2. Yield: 190 mg
pyridine-H), 7.10 (s, 2H, imidazole-H), 7.00 (s, 2H, (52%). Compound 4 was obtained dissolving 3 in
imidazole-H). 13C{1H} NMR (CDCl3, 500 MHz): DMSO-d6. 1H NMR for complex 4 (DMSO-d6,
151.59 (C, pyridine), 150.60 (C–H, pyridine), 138.06 500 MHz): 9.20 (d, 3JH–H = 3.5 Hz, 1H, pyridine-H),
(C–H, pyridine), 136.79 (2C, NCHN), 130.48 (2C, imid- 8.36 (s, 1H, C–H), 8.23 (t, 3JH–H = 7.5 Hz, 1H, pyri-
azole-C), 125.08 (C–H, pyridine), 122.27 (C-H, pyri- dine-H), 8.03 (d, 3JH–H = 7.5 Hz, 1H, pyridine-H), 7.93
dine), 118.36 (2C, imidazole-C), 71.08 (C–H). Anal. (d, 3JH–H = 1.5 Hz, 1H, imidazole-H), 7.92 (d, 3JH–H =
Calc. for C12H11N5 (225.10): C, 63.99; H, 4.92; N, 1.5 Hz, 1H, imidazole-H), 7.70 (t, 3JH–H = 6.5 Hz, 1H,
31.09. Found: C, 64.25; H, 5.00; N, 29.99%. pyridine-H), 7.52 (d, 3JH–H = 1.5 Hz, 1H, imidazole-
H), 7.51 (d, 3JH–H = 1.5 Hz, 1H, imidazole-H), 4.09 (s,
3.2. Synthesis of (2-pyridine)bis(3-methylimidazolium-1- 3H, CH3–N), 4.03 (s, 3H, CH3–N). 13C{1H} NMR of
yl)methane diiodide (2) complex 4 (DMSO-d6, 500 MHz): 159.18 (d, 1JC–Rh =
42.9 Hz, C–Rh), 156.96 (pyridine-C), 151.15 (pyri-
A mixture of 1 (0.5 g, 2.2 mmol) and iodomethane dine-C), 151.09 (d, 1JC–Rh = 44.1 Hz, C–Rh), 141.73
(3 mL, 48.2 mmol) was refluxed in CH3OH overnight. (pyridine-C), 127.54 (pyridine-C), 126.05 (2C, imidaz-
The solvent was evaporated and the product was washed ole-C), 125.00 (pyridine-C), 122.76 (imidazole-C),
5580 E. Mas-Marzá et al. / Journal of Organometallic Chemistry 690 (2005) 5576–5580
121.75 (imidazole-C), 71.96 (C–H), 43.67 (CH3–N), [12] W.A. Herrmann, C.P. Reisinger, M. Spiegler, J. Organomet.
39.90 (CH3–N). Anal. Calc. for C16H18BF4N6I2Rh Chem. 557 (1998) 93;
A.M. Magill, D.S. McGuinness, K.J. Cavell, G.J.P. Britovsek,
(complex 3) (737.87): C, 26,04; H, 2,46; N, 11,39. V.C. Gibson, A.J.P. White, D.J. Williams, A.H. White, B.W.
Found: C, 26.48; H, 2.47; N, 10.80%. Electrospray Skelton, J. Organomet. Chem. 617 (2001) 546;
MS. Cone 30V. m/z (fragments) for 3 in DMSO (com- D.S. McGuinness, K.J. Cavell, Organometallics 19 (2000)
plex 4): 687.2 [(PYBIMMe)I2Rh(DMSO)]+ and 609.9 741;
[(PYBIMMe)I2Rh]+. Electrospray MS. Cone 30V. m/z A.A.D. Tulloch, A.A. Danopoulos, G.J. Tizzard, S.J. Coles,
M.B. Hursthouse, R.S. Hay-Motherwell, W.B. Motherwell,
(fragments) for 3 in CH3CN (complex 5): 693.9 Chem. Commun. (2001) 1270;
[(PYBIMMe)I2Rh(CH3CN)2]+ 650.9 [(PYBIMMe)I2Rh- E. Peris, J.A. Loch, J. Mata, R.H. Crabtree, Chem.
(CH3CN)]+ and 609.9 [(PYBIMMe)I2Rh]+. Commun. (2001) 201;
W.A. Herrmann, J. Schwarz, M.G. Gardiner, Organometal-
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Acknowledgements S. Grundemann, M. Albrecht, J.A. Loch, J.W. Faller, R.H.
Crabtree, Organometallics 20 (2001) 5485;
We gratefully acknowledge financial support from J.A. Loch, M. Albrecht, E. Peris, J. Mata, J.W. Faller,
R.H. Crabtree, Organometallics 21 (2002) 700;
CICYT(MAT2002-04421-C02-01). We thank the Span- R.S. Simons, P. Custer, C.A. Tessier, W.J. Youngs,
ish MEC for a fellowship to E.M.-M. We thank Dr. Organometallics 22 (2003) 1979;
Cristian Vicent (SCIC) for his helpful comments on A.A.D. Tulloch, S. Winston, A.A. Danopoulos, G. Eastham,
the 1H–15N NMR interpretations. M.B. Hursthouse, Dalton Trans. (2003) 699;
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