SYLLABUS OF B.E. Bio-Medical Engg.

7th & 8th Semester MAHARSHI DAYANAND UNIVERSITY, ROHTAK

Maharshi Dayanand University

Rohtak

Syllabus and Courses of

Reading for
B.E Bio-Medical Engg. 7th & 8th Semester
Examination

Session 2008-2009

Available from:
Incharge (Publication) Price :
Maharshi Dayanand University At the Counter : Rs. 50/-
Rohtak-124 001 (Haryana) By Regd. Parcel : Rs. 75/-
By Ordinary Post : Rs. 60/-
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 1 2 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
SCHEME OF STUDIES & EXAMINATION List of Open Electives
B.E IN BIOMEDICAL ENGINEERING 1 HUM-451-E Languages 8 CSE-303 Computer
SEMESTER - VII Graphics
2 HUM-453-E HumanResource 9 CSE-451-E Artificial
Modified ‘E’ Scheme effective from (2008-09)
Management Intelligence
& Expert
Course Subject Teaching Schedule Marks Examination Total Dura- System
No. of Class Theory Practical Marks tion of 3 HUM-455-E Enterpreneurship 10 IC-403-E Embedded
L T P Total Work Exam Systems
(in hrs.) 4 HUM-457-E Business 11 IC-455-E Intelligent
Communication Instrumen
EE - Control 3 1 - 4 50 100 - 150 3 tation for
304 E System Engineers
Engine
ering 5 PHY-451-E NanoTechnology 12 CH-451-E Pollution &
BME- Practical - - - - 50 - - 50 3 Control
409 E Training 6 PHY-453-E LaserTechnology 13 IT-204-E Multimedia
Technologies
BME- Advance 3 1 - 4 50 100 - 150 3 7 ME-451-E Mechatronics 14 IT-204-E Management
411E Bio- Information
Medi-
cal Systems
Engg.
Note :
BME Principleof 3 1 - 4 50 100 - 150 3
Medical 1. Students will be allowed to use single memory, non-
413E Imaging-II
programmable scientific calculator during exam.
BME- Principle
Medical
of - - 2 2 25 - 25 50 3 2. All the scheme has been given the code “ E” which shows
415-E Imaging-II
Lab. the current for all the branches to avoid any confusion in
BME- Nuclear 3 1 - 4 50 100 - 150 3 various schemes.
417-E Medicare 3. There has been no previous syllabus for Bio- Medical
Radaiation
& Safety Engineering and Bio- technology Engineering. The 1st schme
Open 4 - - 4 50 100 - 150 3
for these courses start from” E”code.
Elective 4. The subject Hospital Mangement (BME-403-E) and Speech
BME- Project/ - - 4 4 100 - - 100 3 Processing(BME-405-E) have been replaced by Nuclear
421-E Indutrial Medicaine Radition & Safety (BME-417-E) and Advanced
Project Bio-medical Engineering (BME-411-E) respectively w.e.f..
2008-09.
Total 16 4 6 26 425 500 25 950 5. The subject Biological Control system (BME-401-E)has
been replaced by Control system Engineering (EE-304-E)
w.e.f. 2008-09.
6. The subject A1 and Expert Systems (CSE-451-E) has
been replaced by principle of Medical Imaging Lab. II ( BME-
415- E) and Project/ Industrial Project (BME-419-E) w.e.f.
2008-09.
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 3 4 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
The Code of Practical Training II(BME- 409 -E) has been
changed to Practical Training II (BME-421-E) SCHEME OF STUDIES & EXAMINATION
8. Elective- I has been replaced by Open elective w.e.f. 2008- B.E IN BIOMEDICAL ENGINEERING
09.Students will be permitted to opt. for any elective run by SEMESTER - VIII
the other departments. However, the departments will offer Modified ‘E’ Scheme effective from 2008-09
only those electives for which they have expertise. The
choice of the students to any elective shall not be a binding Course Subject TeachingSchedule Marks of Examination Total Duration
for the department to offer, if the department does not have No. Class Theory Practical Marks of Exam
L T P Total Work (in hrs.)
expertise.
10.Assessement of Practical Training-II, carried out at the end BME B io -M e d i c a l 3 1 - 4 50 100 - 150 3
of VI semester, will be based on seminar, viva-voce and 402-E Ethics & device
regulation
project report of the student from the industry. According to Dept. Elective-I 4 - - 4 50 100 - 150 3
performance, letter Grades A, B, C, F are to be awarded. A Dept. Elective-II 4 - - 4 50 100 - 150 3
BME Independent - - 4 4 50 - - 50 3
student who is awarded ‘F’ grade is required to repeat 404-E study Seminar
Practical Training. BME Biological 3 1 - 4 50 100 - 150 3
11.Project load will be treated as 2 hrs. per week for Project co- 406-E Control Systems
ordinator and 1 hr. for each participating teacher. Project will BME Project in - - 6 6 100 - 150 250 3
408-E In du s tria l /
committee in VIIt semester where the students will identify Research
Lab./ Hospital
the Project problem, complete the design/ procure the GP General - - - - 50 - 100 150 3
maternal/ start the fabrication/ complete the survey etc., BME- Fitness for
depending upon the nature of the problem. Project will continue 402-E the Profession
in VIII the semester. Total 14 2 10 26 400 400 200 1050

Dept. Elective -I
BME-451-E Medical Physics
BME-453-E Fiber Optics and Lasers in medicine
BME-455-E Principles of Bioengineering
BME-457-E Tissue Engineering
BME-459-E Bionanotechnology
Dept. Elective -II
BME-452-E Rehabilitation Engineering
BME-456-E Bio-Electromagnetism
BME-462-E Operation Management
BME-451-E AI and Expert System
BME-462-E OOPS and C ++
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester
5 6
Note :
1. Students are allowed to u se sing le memory, non-
programmable scientific calculator during exam. Sharing of
calculator wil not be permitted in the examination.
2. All the scheme has been given the code “ E” which shows
the current for all the branches to avoid any confusion in
various schemes.
3. There has been no previous syllabus for Bio- Medical
Engineering and Bio- technology Engineering. The 1st scheme
for these courses start from” E”code.
4. Te new subject Biological control system (BME 406-E) has
been introduced w.e.f. 2008-09.
5. Project Load will be treated as 2 hrs. per week for the project
coordinator and 1 hour for each participating teacher. project
involving design, fabrication, testing computer simulation,
case studies etc. which has been commenced by students
in VII semster, will be completed in VIII semester.
6. For subject BME-404-E(Independent Study Seminar), a
student will select a opic from emerging areas of Bio-Medical
Engineering and study it thoroughly and independently. Later
he will give a seminar alk on the topic.
7. A team consisting of Principal/ Director, HOD of concerned
department and external examiner appointed by University
shall carry out the evaluation of the student for his/her General
Fitness for the Profession.
8. The subject GFBME-410-E (General Fitness for the
Profession) code has been changed to GFBME-402-E and
will be effective from 2008-09.
MAHARSHI DAYANAND UNIVERSITY, ROHTAK
SEMESTER - VII
EE - 304 E CONTROL SYSTEM ENGINEERING
L T P Class Work : 50
3 1 - Exam : 100
Total : 100
Duration of Exam. : 3 hrs.
UNIT - I INTRODUCTORY CONCEPTS :
System/ Plant model, types of models, llustrative examples
o f p l a n t s a n d t h e i r i n p u ts a n d o u t p u ts , c o n t r o l l e r,
servomechanism, regulating system, linear time - invariant
(LTI) system, time- varying system, casual system, open loop
control system, closed loop control system, illustrative
examples of open-loo p and feedback control systems,
continous time and sampled data control systems. Effects
of feedback on sensitivity (to parameter variations), stability,
external disturbance (noise), ovearall gain etc. Introductory
remarks about non-linear control systems.
UNIT - II MATHEMATICAL MODELLING
Concept of transfer function, relationship between transfer
function and impluse response, order of a system, block
diagram algebra, signal flow graphs : Mason’s gain formula &
its application, characteristics equation, derivation of transfer
functions of electrical and electromechanical systems. Transfer
functions of cascaded and non-loading cascaded elements.
Introduction to state variable analysis and design.
UNIT - III TIME DOMAIN ANALYSIS
Typical test signals, time response of first order systems to
various standard input, time response of 2nd order system
to step input, relationship between location of rots of
char acte rist ics equa tion, w and wn, t ime do ma in
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 7 8 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
specifications of a general and an under damped 2nd order 4. Modern Control Engg : R.C. Dorl & Bishop : Addison -
system, steady state error and error constants, dominant Wesley.
c l o s e d l o o p p o l e s , c o n c e p t s o f s t a b l i t y, p o l e z e r o Note : Eight questions are to set - at least one from each
confi guration and stability, ne cessary a nd suffcicient unit. Students have to attempt five questions.
conditions for stability, Hurwitz stability criterion, Routh Prcatical Training - II (6 Weeks )
stability criterion and relative stability.
BME - 409 E
UNIT IV ROOT LOCUS TECHNIQUE :
L T P Class Work : 25 Marks
Root locus concept, development of root loci for various - - - P/VV : 25 Marks
systems, stability considerations. Total : 50 Marks
UNIT V FREQUENCY DOMAIN ANALYSIS : At the end of sixth semester each student would undergo six
w ee ks p ra ct ic al t ra in in g in an i nd us tr y/ P ro f e ss io na l
Relationship between frequency resonse and time- response
organization/ research laboratory/ Hospital with the prior
for 2nd order system, polar, Nyquist, Bode plots, stability,
approval of the Director Principal/ Principal of the concerned
Gain margin and Phase Margin, relative stability, frequency
college and submit a written typed report along with a
response specifications.
certificate from the organization. The record will be evaluated
UNIT VI COMPENSATION : by examiner(s) to be appointed by the Director principal/
Ne ce ss ity o f co mpe ns at ion , co mp ens at io n n et wo rk s, Principal of the concerned college.
application of lag and lead compensation, basic modes of ADVANCED BIOMEDICAL ENGINEERING
f eedback control, proportional, integral and derivative BME - 411 E
controllers, illustrative examples.
L T P Class Work : 50 Marks
UNIT VII CONTROL COMPONENTS : 31 - Theory : 100 Marks
Synchros, AC and DC teco- generators, servomotors, Total : 150 Marks
stepper motors & their applications, magnetic amplifier. Duration of Exam. : 3 Hrs.

TEXT BOOK : CONT ENTS

1. Control System Engineering : I.J. Nagrath & M. Gopal; New Age 1. Introduction to Artificial Organs : substitutive medicine,
biomaterial outlook f or organ transplant, design
REFERENCE BOOKS :
considerations.
1. Automatic Control Systems : B.C. Kuo, PHI.
2. Modern Control Engg : K. Ogata : PHI 2. Artificial Heart and Circulatory assist devices, Artificial Kidney
3. Control Systems : Principles & Design : Madan Gopal : : Structure and function of the Kidney, Kidney disease, renal
Tata Mc Graw Hill. failure, treatment of renal failure, renal transplantation.
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester
9 10
3. Artificial Blood : Modern history of transfusion and
blood substitutes, oxygen carrying artifical blood, Hb-
based artificial blood.
4. N a n o t e c h n o l o g y - Tr e n d s i n B i o m e d i c a l
Nanotechnology; Drug Delivery Systems and Drug
Synthesis; Nanotechnology in diagnostics; nano-
enabled components for biodefense; implants and
prosthetics, Toxicity in nanomaterials
5. Bioinformatics - Introduction to Molecular biology &
biological Chemistry, Data structure and pair wise
alignments, substitution pattern, Distance based and
Character based methods of phylogenetics, Genomics
& gen e re cognit ion, Prote in & RNA stru cture
prediction, Proteomics.
6. Tissue Engineering - Basic principles of Tissue
Engineering, Gene Therapy and Tissue Engineering,
Biomaterials : Protein - Surface Interactions.
7. B i o me m s : Int r o d uction to BioMEMS ; Historical
background - Smart Materials and structures, Microsystems and
their advantages. Materials used - Technology involved in MEMS.
General Aplication in Healthcare.
TEXT BOOK :
1. Biomedical Engineering Handbook edited by Bronzino
D Joseph, CRC Press (New York) 1995.
REFERENCE BOOKS :
1. Biomedical Engineering Principles Volume 1 by Cooney
Devid Marcel Decker 1976.
2. Hand book of Biomedical Engineering. Kline Jacob,
Academic Press (New York) 1988.
MAHARSHI DAYANAND UNIVERSITY, ROHTAK
3. Fundamental concepts of bioinformatics by Dane E
Karne & Michael C Raymer (Pearsons Education) 2006.
Note : Examiner will set eight questions in all, Students
will be required to attempt any five questions.
PRINCIPLES OF MEDICAL IMAGING - II
BME - 413 E
L T P Class Work : 50 Marks
31 - Theory : 100 Marks
Total : 150 Marks
Duration of Exam. : 3 Hrs.
CONT ENTS
1. Fundamentals of Acoustic Propagation, characteristic
impedance, intensity, radiation force, reflection and
refraction, attenuation, absorption, scattering.
2. Generation and detection of ultrasound : piezsoelectric
ef f ect, ultrason ic tra nsduc ers (mech an ica l and
electrical matching), transducer beam characteristics,
axial and lateral resolution, focusing arrays.
3. Ultrasonic diagnostic methods : pulse-echo systems
(A or amplitude mode, B or brightness mode, M or
motion mode and C- mode), Doppler Effect and
Doppler methods, color Doppler.
4. Biological effects of ultrasound : Acoustic phenomena
at high intensity levels, ultrasound bioeffects.
5. Funda mentals of Nuclear magnet ic Resonance :
a n g u l a r m o m e n t u m, m a g n e t i c d i p o le m o me n t ,
magnetization, Larmor frequency, rotating frame of
reference and the RF magnetic field.
6. Generation and Detection of NMR Signals : The
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 11 12 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
m ag ne t (s u pe rc on d uc ti ng m a gn et s, p e rm an en t PRINCIPLES OF MEDICAL IMAGING - II LAB
magnets), magnetic field gradients, the NMR coil/ BME - 415 E
probe, data acquistion. L T P Class Work : 25 Marks
7. Im a g in g Me t h o d s : S lic e s e le c tio n , f re q u e n c y - - 2 P/w : 25 Marks
e n c o d i n g , p h a s e e n c o d in g , s p in e c h o im a g i n g , Total : 50 Marks
gradient- echo imaging, blood flow imaging. Duration of Exam. : 3 Hrs.

8. Biological effects of magnetic fields : Static magnetic CONT ENTS

fields, radio frequency fields, gradient magnetic fields. 1. G e ne r a t ion a n d d e t ec t io n o f u lt ra s ou n d u si n g
9. Radiotherapy equipment : High Voltage X-ray machines, ultrasound equipment.
Cobalt-60 machines, Medical Linear X-ray machines. 2. Study various Ultrasound modes - A mode, B mode,
TEXT BOOK : AB mode, C mode and M mode.

1. K. Kirk Shung, Michael B Smith, Bejamin Tsui, 3. Generation and Detection of NMR Signal using MRI
Principles of Medical Imaging, academic Pre, inc., machine.
London, 1992. 4. Image formation using High Voltage X-ray machines.
2. Handbook of Biomedical Instrumentation : R.S. 5. Study different types of magnets used in Imaging with
Khandpur. their properties
REFERENCE BOOKS : 6. With help of magnets study the fundametals of Nuclear
1. Avinash C. Kak, Malcolm Slaneyavailble in pdf format magnetic Resonance.
at www.slan ey. org /pct/in dex.ht ml, Principles of 7. Study of different ultrasound probes
Computerized Tomographic Imaging, IEEE Press, New
8. Study of Radiotherapy effects of electromagnetic radiation.
York, 1988.
9. Study of Biological effects of elecltromagnetic radiation.
2. B.H. Brown, R H smallwood, D C Barbere et al, medical
10. Study of different images taken by MRI.
Physics and Biomedical engineering, Institute of physics.
Note : Ten experiments are to be performed selecting any
Note : Examiner will set eight questions in all, Students
seven experiments from the above list Remaining
will be required to attempt any five questions.
three experiments may either be performed from the
above list, or designed and set by the concerned
institution as per the scope of the syllabus.
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 13 14 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
NUCLEAR MEDICINE : RADIATION AND SAFETY Note : Examiner will set eight questions in all, Students
BME - 417 E will be required to attempt any five questions.
L T P Class Work : 50 Marks
31 - Theory : 100 Marks PROJECT / INDUSTRIAL PROJECT
Total : 150 Marks BME - 421 E
Duration of Exam. : 3 Hrs.
L T P Class Work : 100 Marks
CONT ENTS - - 4 Total : 100 Marks
Introduction : Properties and effects of radio active emissions Duration of Exam. : 4 Hrs.
and their applications in nuclear medicine. Project involving design/ f abrication/ testing/ computer
Radiation detectors : Types and applications in nuclear simulation/ case studies etc. will be evaluated through a
medicine. panel of examiners consisting of HOD of the concerned
Radio Isotope Imaging : The gamma camera, Construction department, project coordinator and one external examiner
an d wo rkin g, P erf o rman ce Characte rist ics, SPE CT to be appointed by the University.
Construction and Working, Position Emission Tomography.
The student will be required to submit three copies of his/
The computer in NM : applications, Image Construction, her project report to the office of the concerned depratment
Frame Modes.
f or record (one copy each f or the departmen t off ice,
Units of exposure and dose. participating teacher and college library).
Radiation protection and safety, Safety of non : ionizing
Project coordinator will be assigned the project load of 3 hrs.
radiation, Stocastic and non-Stocastic effects, Risk Factors,
per week while the participating teachers will be assigned 2
Safety limits.
hr. load for the same.
Principls of radiation dosimetry : Internal and External
SEMESTER - VIII
dosimetry.
BIOMEDICAL ETHICS AND DEVICE REGULATIONS
TEXT BOOK :
BME - 402 E
1. The physics of radiology By H.E. Johns and J.R.
L T P Class Work : 50 Marks
Gunningham.
31 - Theory : 100 Marks
2. Physics and Radiobiology in Nuclear Medicine By Total : 150 Marks
Saha G (Springer verlag N. Y.) Duration of Exam. : 3 hrs.
3. Quality control of Nuclear Medicine instrumentation CONT ENTS
By R. F. Mould (IPSM. York )
Part 1 - Sources of Medical Law and Ethics.
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 15 16 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
. Nature and sources of medical ethics 2. Ethics of Health Care : An Introductory Textbook by
Sources of medical laws Benedict M. Ashley, Kevin D. O’ Rourke, Georgetown
University Press, 3rd edition, 2002.
Part 2 - Consent, Confidentially and Clinical Negligence
INDEPENDENT STUDY SEMINAR
. Consent to Treatment BME - 404 E
Confidentiality
L T P Class Work : 50 Marks
Clinical Negligence - - 4 Total : 50 Marks
Part 3 - Medical Health The student will select a topic in e merging areas of
Biomedical Engineering and study independently. He will give
. Mental Health
a seminar talk on the same before the committee constituted
Adults with Incapacity
by the head of the dept. The committe should comprise of at
Part 4 - Issues least three faculty members.
. The law in relationship to abortion BIOLOGICAL CONTROL SYSTEMS
The ethics of abortion BME - 406 E
Reproductive technology and surrogacy L T P Class Work : 50 Marks
The law in relationship to end of life issues 31 - Theory : 100 Marks
Total : 150 Marks
The ethics of end of life issues.
Duration of Exam. : 3 hrs.
Research
CONT ENTS
Part 5 - Maintaining professional standards
1. Introduction to state variable analysis of control
Maintaining standards and regulation systems :- Introduction to state variable concept,
Presenting evidence and reports definition of state variables, matrix representation of
The Coroner’s court state equation, state transition equation, properties of
The General Medical Council transition matrix, relationship between state equations
and higher order diffrential equations, state eqaution
Part 6 - Doctor’s rights
and transfer function, characteristics equation, Eigen
Employment and other rights of doctors values & Eigen vectors.
TEXT BOOK : 2. Transformation to phase variables canonical forms of
1. Ronald Munson’s Intervention and Reflection : Basic s t at e va r i ab l e s, c o nt ro ll a b il it y c a n on i cal f or m ,
Issues in Medical Ethics 5th Ed. observability canonical form Jordan canonical form,
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester MAHARSHI DAYANAND UNIVERSITY, ROHTAK
17 18
controllability of linear system, observability of linear TEXT BOOK :
s y st e m r e l a t io n s h i p a m o n g c o n t ro l l a b i l it y, 1. Automatic control systems : By Bejamin C Kuo.
observability and transfer function.
2. Control system Engineering : By I.J. Nagarath & M.
3. Introduction to biological control system : Introduction, Gopal.
Dynamic systems and their control, modelling and
3. Bio-Medical Engineering Principles By : David. 0.
block diagrams, the pupil control systems, general
Cooney, Michel Deckker INC
s t ruc t u re o f c o n tro l s y st e ms , t h e d y na mi c
r e s p o n s e ch a r a c t e r i s t i c s o f t h e p u p i l c o n t ro l 4. Biological control systems : John H Milsom Mc Graw
system, open & close loop systems, instability, Hill 1966.
automatic aperture con trol. 5. The Application of Control Theory of A Physiological
4. Mathematical modeling of the system : Thermo System by Howard T Milhorn Sounders Publication.
regulation, Thermoregulation of cold bloodedness & REFERENCE :
warm bloodedness, the anatomy of thermo regulation, 1. Modern Control Engineering : By K. Ogata
lumping & partial differential equations, heat transfer
examples mathematical model of the controlled
PROJECT IN INDUSTRY / RESEARCH LAB./ HOSPITAL
process of the body.
BME - 408 E
5. Modelling the body as compartments, behaviour in
simple compartmental system, pharmacy kinetic L T P Class Work : 100 Marks
model, urea distribution model, multi compartmental - - 6 Practical : 150 Marks
system. Dissolution of drugs in solid form, distribution Total : 250
a n d a c ce s s ib i l i ty o f b o d y w a t e r & ti ss u e Duration of Exam. : 3 hrs.
compartments, basis for zero order & first order Project involving design/ fabrication/ testing/ computer
chemical kinetic behaviour in the biological system simulation/ case studies etc. will be evaluated through a
6. B i o l o g i c a l re c e p t o r s : I n t r o d u c t i o n , r e c e p t o r panel of examiners consisting of HOD of the concerned
characteristics, transfer function models of receptors, department, project coordinator and one external examiner
receptors and perceived intensity. to be appointed by the University.

7. Respiratory model & systems, cardio vascular control The student will be required to submit three copies of his/
system, skeletal muscle servo mechanism. her project report to the office of the concerned depratment
f or record (one copy each f or the department off ice,
participating teacher and college library).
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester MAHARSHI DAYANAND UNIVERSITY, ROHTAK
19 20
Project coordinator will be assigned the project load of 3 hrs. I. Academic Performance (15 Marks) :
Performance in University Examination
per week while the participating teachers will be assigned 2
hr. load for the same. --------------------------------------------------------------------------
Scale Result %age of Number of
GENERAL FITNESS FOR THE PROFESSION
Marks obtained attempt in
BME - 402 E which the
Sem. exam.
L T P Class Work : 50 has been
Practical : 100 cleared
------------------------------------------------------------------------------------
Total : 150
I
Duration of Exam. : 3 hrs. II
At the end of the year studnts wil beevaluated on the basis III
o f t h e ir pe r f o rm a nc e in v ar i ou s f ie l ds i n B i om ed i ca l IV
V
Engineering. the evaluation will be made by the panel of three
VI
experts/ examiner/ teachers to be appointed by the Principal/ VII
Director of the College, A specimen perform indicating the ------------------------------------------------------------------------------------
weightage to each component/ activity is given below :- II. Extra Curricular Activities (10 Marks) :
Item Level of Participation Remarks
Name : _________________________ College Roll No. (Position Obtained)
_________________________________ Indoor Games __________________ __________________
(Specify the __________________ __________________
Uni. Roll No., ____________________ Games __________________ __________________
Branch__________________________ Year of Admission OutdoorGames __________________ __________________
(Specify the __________________ __________________
_________________________________
Games __________________ __________________
Essay __________________ __________________
Competition __________________ __________________

Scientific __________________ __________________

Technical __________________ __________________
Exhibitions __________________ __________________
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester
Debate __________________
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Drama __________________
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Dance __________________
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Music __________________
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Fine Arts __________________
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Painting __________________
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Hobby Club __________________
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N.S.S. __________________
__________________
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Hostel __________________
Management __________________
__________________
Any other __________________
activity (Please __________________
Specify) __________________
21 22
__________________ III.
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1.
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1.
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6.
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MAHARSHI DAYANAND UNIVERSITY, ROHTAK
Educational tours/ visits/ Membership of Professional
Socterties (10 Marks)
__________________________________________________
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__________________________________________________
__________________________________________________
__________________________________________________
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Contribution in NSS Social Welfare Floor Relief/
draught relief/ Adult Literacy mission/ Lieterecy
Mi s s i o n / B l o o d D o n a t io n / ANy o t h e r S o c i a l
Service. (5 Marks)
__________________________________________________
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Briefly evaluate your academic & other perfromance &
achievements in the Institution (5 Marks)
__________________________________________________
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__________________________________________________
__________________________________________________
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 23 24 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
VI. Performance in Viva voce before the committee (10 Marks) MEDICAL PHYSICS

__________________________________________________ BME - 451 E

L T P Class Work : 50
__________________________________________________
3 1 - Theory : 100
__________________________________________________ Total : 150
__________________________________________________ Duration of Exam. : 3 hrs.
CONT ENTS
__________________________________________________
1. Heat and cold in medicine : Physical basis of heat
* Marks obtained I.( )+II( )+III( )+IV( )+V( )+VI( )=
and temperature. Thermography and temperature
scales, mapping of body’s teperatures. Heat therapy,
use of cold in medicine, Cryosurgery and safety
** Total Marks : aspects.
2. Energy, work, Power and pressure : Conservation of
energy in the body. Energy changes in the body work,
power heat losses of body. Measurement of pressure
Member Member Member in the body, pressure inside skull, Eye, Digestive
system, Skeleton, Urinary bladder etc. Hyperbaric
oxygen therapy.
3. Physics of the lung & breathing : The airways, blood
& lung interaction, measurement of lung volumes
Pressure flow- volume relationship of the lungs.
Physics of the alveoli Breathing mechanism, airway
resistance. W ork of breathing. Physics of some
common lung diseases.
4. P h y si cs o f t h e Ca r d i o va s cu l ar s ys te m : Ma j o r
components of the Cardiovascular system. Oxygen
and Carbon dioxide exchange in the capilary system.
Work done- by the heat. B.P. and its measurements
Transmural pressure. Bemoulli’s principle applied to
Cardiovascular system. Laminar and turbulent blood
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester
f l o w. H e a r t s o u n d s . T h e p h y si cs o f
cardiovascular diseases.
5. Electricity within the body : nervous system and
neurnus. Electrical potentials of nerves.
electromyogram. ECG, EEG, Electroretinogram and
Electrooculogram, Mageneto cardiogram and Magneto
encephalogram. Electric shock. High frequency & low
frequency electricity in medicine and magnetism in
medicine.
6. Sound in Medicine : General properties of sound. The
body as a drum. The stethoscope, Ultrasound picture
o f t h e b o d y. U l t r a s o u n d t o m e a s u r e m o t i o n ,
Physiological effects of Ultrasound in Therapy. The
production of speech.
7. Physics of Ear & hearing : The outer ear, The middle
Ear, The inner ear, Sensitivity to the ears. Testing your
hearing, Deafness and Hearing Aids.
8. Light in medicine : Measurement of light & its unit.,
Applications of Visual light in medicine, Applications
of UV & IR in me dic ine , LA S ERS in me di cin e,
Applications of microscopes in medicine.
9. Physics of Eyes and Vision : Focusing elements of
the eye. The retina, diffraction effects of the eye,
optical illusion, defective vision and correction, color
vision and chromatic aberration. Instrument used in
ophthalmology.
TEXT BOOK :
1. Medical physics, J R Cameron & J G Skofronick, 1978.
25 26 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
so me FIBER OPTICS AND LASERS IN MEDICINE
BME - 453 E
L T P Class Work : 50 Marks
31 - Theory : 100 Marks
Total : 150 Marks
Duration of Exam. : 3 hrs.
CONT ENTS
1. In t r o d u c t io n t o f i b e r o p t ic s : B a s i c f i b e r l i n k ,
applications, principles of light : Introduction, EM
spectrum, internal & external reflections, Snell’s law,
optical fiber numerical aperture, Fresnel reflection.
2. Optic fiber & its properties : Introduction, basic fiber
construction, propagation of light, modes of operation,
refrective index profile, types of fibers, dispersion,
data rate and bandwidth, attenuation, losses.
3. Connectors, Splices & Couplers : Introduction, splices
: mechanical fusion, protection of splice, connectors :
SMA, STC bionic etc., coupling : passive, Stan, TEE
type s. Opt ical so urce s & Photo Det ecto rs :
Introduction : creation of photons, LED, ILD, photo
detectors : introduction, PIN photodiode, avalanche
photodiode, photodiode parameters, detector noise,
speed of response, SNR.
4. Modulation scheme for fiber optics transmission :
Introduction, digital modulation, analog modulation
schemes, multiplexing.
5. Laser Systems : Introduction, types of lasers : Solid
state lasers, Gas lasers, Dye lasers, Lasers used in
medical practice : Ruby laser, CO 2 laser, Nd-Y AG
laser and related solid state laser.
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 27 28 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
6. Laser - Tissue Interaction : terminology : special band CONT ENTS
designations, energy & power irradiant & radiant * Human Physiological Fluid Mechanics.
exposure, fluence, thermal diffiusion fibers & contact
* Physiological of the Human Circulatory System,
tips, Types of laser-tissue interactions.
Hemodynamics in the Arterial System.
7. Laser Applications in Medical Therapy : Introduction,
a p p l i c a t i o n i n g e n e r a l s u r g e r y, d e r m a t o l o g y, * Blood Flow in the Microcirculation, and other Body
ophthalmology, cardiovascular & chest surgery, Fluid Systems
dentistry, neuro surgery, otolaryngology & head and * Pulse and Wave Propagation in Blood Vessels
neck surgery, tumor surgery, gynecologic laser. * Mechanical Forces on Blood Vessels : Pressure,
TEXT BOOK : Stretss and Shear Force
1. Therapeutic Lasers - Therapy and practice by G. david * Viscoelasticity and Mechanical properties of the
Baxter, Churchill livingstone publications. Vessel
2. Medical Lasers and their safe use by David H Shiney, * Vascular Remodeling and Tissue-Engineered Vascular
Stephen and L. Trokel , Springer= verlag publications. Grafts ;- Mechanical forces
3. Elements of fiber optics by S.L. Wymer, Regents- * Biomaterials Associated with Coronary Stents.
Prentice Hall publications. * Membrane Potentials & Cable Model.
4. Biomedical Electronics & Instrumentation by S.K. * Hodgkin Huxley Model
Venkata Ram. Galgotia publications. * Dielectric Properties of Cells & Biopolymers
REFERENCES: * Quantitative Physiology of Brain Blood Flow.
1. Laser and optical fibers in medicine by Katzer and * Imaging Brain Blood Flow with Magnetic Resonance
Abraham, Academic Press Publications. Imaging
2. An Introduction to optical fibers by A.M. Cherin, Mc * Visual System Physiology - The interpretation of noisy
Graw Hill Publications. nerve messages : a signal analysis problem.
PRINCIPLES OF BIOENGINEERING
* Visual System Psychophysical Bioengineering :
BME - 455 E
matching warming signals to the properties of the eye
L T P Class Work : 50 Marks and the visual nervous system.
31 - Theory : 100 Marks
* Visual Science Clinical Aspects
Total : 150 Marks
Duration of Exam. : 3 hrs. * Geometrical Optics
* Physical Optics and Microscopes
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 29 30 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
* Optical Imaging. CONT ENTS
* Multi- dimensional Signal Processing. Introduction : Basic definition of tissue engineering,
* Basic Electronics for Bioengineers Structural and organization of tissue Epithlial, connective;
* Capacitors, Inductors and Semiconductors. vascularity and angiogenesis, basic wound healing, cell
migrat ion, curre nt scop e of de velo pme nt a nd use in
* Bio Nanotechnology
therapeutic and in-vitro testing.
* Wireless Bioengineering
Cell Culture : Different types of cell, progenitor cells and
* Imaging as an Inverse Problem cell diff e rentiations, dif f erent kind of matrix, cell-cell
* Computed Tomography interaction, Aspect of Cell Culture, Cell expansion, cell
* Human Molecular Imaging t r a n s f e r, c e l l s t o r a g e a n d c e l l c h a r a c t e r i z a t i o n ,
* DNA Arrays Immunomodulation and Immunoisolation , Bioreactors.

* Bios tatistics : A pplica tions o f DNA arrays to Molecular biology aspects : Cell signaling molecules,growth
schizophrenia disease genetics factors, hormone and growth factor signaling, growth factor
* Bioreactor Arrays delivery in tissue engineering, cell attachement : differential
cell adhesion, cell migrat ion, cell- cell commun icatio n,
* Bioheat Transfer Applications to Cryosurgery
receptor- ligand binding, and Cell surface markers.
* Stem cell Research.
* Bioastronautics Scaffold and transplant : Engineering biomaterials for tissue
engineering, Degradable materials (collagen, silk and
* Biological Molecular Structure and function
p o l yl a ct i c a c id ) , p o r o s it y, m e ch a n i ca l s t re n g t h , 3 - D
* Computational Modelling of Protein Structure and
Function architecture and cell incorporation. Engineering tissues for
replacing bone, cartilage, tendons, ligaments, skin and liver.
* Molecular Structure/ Function of Neurodegeneration
Basic transplant immunology, stems cells : introduction
TEXT BOOK : hepatopoiesis.
1. S. Berger Introduction to Bioengineering
Case study and regulatory issues : Mechanical properties
TISSUE ENGINEERING of Biological tissues, Transport properties of biological
BME - 457 E tissues, Cell transplantation f or liver, musculokeletal,
L T P Class Work : 50 Marks cardiovascular, neural, visceral tissue engineering. Ethical
31 - Theory : 100 Marks FDA and regulatory issues of tissue engineering.
Total : 150 Marks TEXT BOOK :
Duration of Exam. : 3 hrs.
1. Principles of tissue engineering, Robert. P. Lanza,
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 31 32 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
Robert Langer & W illiam L. Chick, Academic Press. needles, Microelectrodes, Prosthesis and catheter and
se ns or s.
2. The Biomedical Engineering - Handbook, Joseph D.
Bronzino, CRC Press. Biomedical Nanotechnology
Trends in Biomedical Nanotechnology ; Drug Delivery
3. Introduction to Biomedical Engg., Endarle, Blanchard
S y s t e m s a n d D ru g S y n t h e s i s ; N a n o t e c h n o l o g y i n
& Bronzino, Academic Press.
diagnostics; nano-enabled components for biodefen se;
4. Frontiers of Tissue Engineering - Patrick. Mikos, implants and prosthetics, Toxicity in nanomaterials
Maclntire, Pergamon Press. Text / References BOOK :
5. Tissue Engineering, B. Palsson, J.A. Hubbell, R. 1. The MEMS Handbook, Second Edition - 3 Volume Set
Plonsey & J.D. Bronzino, CRC - Taylor & Francis. (Mechanical Engineering) : Mohamed Gad-el-Hak;
CRC; 2 edition (2005)
BIONANOTECHNOLOGY
2. Fundamentals of Micro fabrication : The Science of
BME - 459 E
Miniaturization, Second Edition : Mare J. madou; CRC;
L T P Class Work :50 Marks 2 edition (2002)
31 - Theory : 100 Marks 3. Fundamentals of Bio MEMS and Medical Microdevices
Total : 150 Marks (SPIE Press Monograph Vol. PM 153); Steven S.
Duration of Exam. : 3 hrs. Saliterman; SPIE-- the International Society for Optical
Introduction to MEMS : Introduction to Bio MEMS; Historical Engineering (2006)
background - Smart Materials and structures Microsystems
4. MEMS and Microsystems : Design and Manufacture ;
and their advantages. Materials used - Technology involved Tai- Ram Hsu; Mc Graw Hill; 1 Editionm (2001)
in MEMS. General Application in Healthcare.
5. Biomedical Nanotechnology; Neelina H Malsch; CRC
Micromachining Technology : Soft Lithography, Etching,
(2005)
Ion implantation, water bonding, Integrated processing, Wet
& Dry Bulk micro machining surface micromachining, coating REHABILITATION ENGINEERING
technology and CVD -LIGA process BME - 452 E
Pri nc iples of Mic rosyste ms : G enera l principles - L T P Class Work : 50 Marks
Microsystems - Pressure system ; Actuators, Electrostatic 31 - Theory : 100 Marks
forces Piezoelectric Crystals. Total : 150 Marks
BIOMEMS Duration of Exam. : 3 hrs.
Special feat ures, Requirements for medical applications, Introduction to Rehabilitation Engineering
ME MS f o r He a l th ca r e , D ru g d e l i v e ry s y s t e m s ,
Principles involved in the study of Rehabilitation Engineering.
Application in Blood pressure sensors, B iochip, Micro
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 33 34 MAHARSHI DAYANAND UNIVERSITY, ROHTAK
Rehabilitation Engineering-Science and Technology PART IV Theoretical Methods in Bioelectromagnetism
Conce pts in Mot or rehabilita tion an d Communicati on PART V Electric and Magnetic Measurement of the
disorders Electric Activity of the Neural Tissue.
Prosthetics and Orthotics in Rehabilitation Engineering PART VI Electric and Magnetic Measurements of the
Electric Activity of the Heart.
Fundamentals. Applications and summary
PART VII Electric and Magnetic Stimulation of Neural
Sensory Augmentation and Substitution, Visual Systems,
Tissue.
a u d i t o r y sy st e m , Ta c t u a l S yst e m R e h a b i li ta t io n
PART VIII Electric and Magnetic Stimulation of the Heart
Engineering technologies; Principles and Application
T he Conce ptual framework - Education and Quality PART IX Measurement of the Intrinsic Electric
Properties of Biological Tissues
assuarance, Future development
PART X Other Bioelectromagnetic Phenomena
Text / References BOOK :
Text :
1. The Biomedical Engineering Handbook ; Joseph D
Bronzino; 3 rd Ed.; CRC Press (2006) 1. Malmivuo, J and Plonsey, R, Bioelectromagnetism ;
Principles and Applications of Bioelelctric and Biomagnetic
2. Handbook of B io med i ca l Engineering Fields, Oxford University Press, New York, 1995.
( H a n d b o o k s i n S c i e n c e a n d Te c h n o l o g y ) :
Jacob Kline; Academic Press (1988)
OPERATIONS MANAGEMENT
BIOELECTROMAGNETISM
HUM - 462 E
BME - 456 E
L T P Class Work : 50 Marks
L T P Class Work : 50 Marks 31 - Theory : 100 Marks
31 - Theory : 100 Marks Total : 150 Marks
Total : 150 Marks Duration of Exam. : 3 hrs.
Duration of Exam. : 3 hrs.
CONT ENTS
CONT ENTS
1. Operations Analysis : This initial module covers basic
PART I The Concept of Bioelectromagnetism; Subdivisions
of Bioelectromanetism -Theoretical and Anatomical tools used to analyze manufacturing and service
basis; Importance and History of Bioelectromagnetism. operations. W e will introduce diff erent types of
PART II Anatomical and Physiological basis of processes and the strategies behind their selection.
Bioelectromagnetism 2. Coordination and Planning - Operations management
PART III Bioelectric Sources and Conductors and their consists largely of coordination and planning tasks -
Modelling
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 35 36 MAHARSHI DAYANAND UNIVERSITY, ROHTAK

inventory, production and service provision must be AI AND EXPERT SYSTEMS

managed to meet the needs of the customer. In this CSE - 451 E
module, we will introduce tools and techniques L T P Class Work : 50 Marks
employed by organizations to perform these tasks. 31 - Theory : 100 Marks
3. Q u a l i t y Ma n a g e m e n t - Q u a l i t y h a s r e c e i v e d Total : 150 Marks
considerable attention during the last two decades and Duration of Exam. : 3 hrs.
is an integ ral co mpo nen t of man y o f t he too ls CONT ENTS
introduced in the preceding module. This two section
mini module provides a brief overview of the most 1. Introduction to Artificial intelligence : Scope, history
important quality concepts. & applications. AI as representation and search the
predicate calculus inf erence rules. Logic based
4. Project Management - Effective project management
financial advisor, structures and strategies for state
is crucial for the sucess of many companies. In this
space search grapg theory strategies for space using
3-class module, we introduce tools to succefully
manage large projects and discuss examples from state space to represent reasoning with the predicate
aerospace and entertainment industries. caculus.

5. Logistics and supply Chain Management. the final 2. Heuristics Search : An algorithm for heuristic search,
module introduces proble ms of the entire su pply a d m i ss i b i l it y mo n o t o n i ci t y a n d i n f o r m e d n e s s
chain from vendor to customer and the methods used heuristics in games, complexity issues, control and
to manage these supply chains. Strategic issues, global implementation of state space search recursion based
implications and product and process development receive search, pattern directed search. Production systems,
particular attention in this module. predicate calculus and planning the black board
TEXT BOOK : architecture for problems solving.
1. N a h mi a s, St e v e n P ro d u c t io n a n d O p e a r t io n s 3. LISP and PRO LO G, Kn owled ge re pre senta tion
Analysis. 4th ed. Mc Graw Hill, 2001. languages issues in knowledge representations
2. Hopp, W. J., and M. L. Spearman. Factory Physics, n e t w o r k re p r e s e n t a t i o n l a n g u a g e , st r u c t u r e d
representations, introduction to LISP. Search in LISP : a
2nd ed. M c Graw Hill, 2000
functional approach to the farmer, Wolf, Goat and
3. Goldraft, E.M. and J. Cox. The Goal : A Process of cabbage problem, higher order functions & procedural
Onagoing Improvement. 2nd Revised ed. North River abstraction, search strategies in LIPS.
Press, 1992.
4. Expert systems : Introduction, History basic concepts,
structure of expert systems, the human element in
ES, how ES works, problem areas addressed by ES,
SYLLABUS OF B.E. Bio-Medical Engg. 7th & 8th Semester 37 38
ES sucess factors, types of expert systems, ES and
the internet interacts web, knowledge engineering , CSE - 462 E
scop e o f kno wle dge , dif f iculties, in knowled ge
L T P
a c q u is it io n me t h o d s o f k n o wl e d g e a c q u is it io n
31 -
machine learning, intelligent agents, selecting an
appropriate knowledge acquisition method, knowledge
acquisition f orm multiple experts validation and
CONT ENTS
verification of the knowledge base, analyzing coding,
documenting & diagramming 1.
5. Expert systems - II, societal impacts reasoning in
artificial intelligence, inference with rules, with frames
: model based reasoning, case based reaszoning, 2.
e x p la n a t io n & m e t a kn o w led g e in f e re n c e w it h
uncertainty representing uncertainty probabilities and
related approaches theory of certainty (certainty
factors) Qualitative reasoning, the development life
cycle phases I, II, III, IV, V, VI the future of expert
system development process societal impacts.
TEXT BOOK :
3.
1. Efrain Turban and Jay E Aranson : Decision support
systems & intelligent systems (5th Edn.) Prentice
Hall, 1988.
4.
2. Donald A Waterman : A Guide to expert Systems,
Addison - Wesley 1995.
5.
3. G.F. Luger & WA Stubble Field Artificial intelligence
structures and strategies for complex problem solving,
3rd Edn. Addision W esley 1988. 6.
4. E. Rich and Knight Artificial Intelligence, Second Edn,
Tata Mc Graw Hill Publishing, 1981.
MAHARSHI DAYANAND UNIVERSITY, ROHTAK
OOPS and C++
Class Work : 50 Marks
Theory : 100 Marks
Total : 150 Marks
Duration of Exam. : 3 hrs.
In t r o d u c t i o n O b j e c t o r i e n t e d p r o g r a m m i n g ,
characteristics of object oriented languages classes,
C++ and C
C++ programming language : Program statements -
Declaration statements and variables, assignment
systems, C in and C out statements, function call
statement variables and constants, integer and
character types, arithmatic ope ration, loops a nd
decisions for while and do loops, if else, else if, Switch
statements, logical AND, OR, NOT operators, break,
continue and go statements.
Functions : defining a function, function arguments
and passing by value, array and pointers, functions
and strings, function and structure.
Classes and objections, class constructors and
destructures operator overloading.
Class inheritance - derived class and base class
virtual functions multiple inheritance
Input output and files, Streams buffers and the I/O
stream oh file, redirection output with C out and input
with C in, file input and output
 39

TEXT BOOK :
1. The wait group object orieted programming in Turbo
C++ by Robert Lafore- Galgatia.
2. The wait Groups C++ Primer Plus - Stephen Partia -
Galgatia
REFERENCES :
1. C++ Programming Languages - Bjarne Strusstrup
Addison Wesley 3rd Edn.