Pharma info

GPAT DEMO PAPER 1

1 Calculate the no. of NMR peaks in 2, 2, 3 trimethyl butane?

A) 1
B) 2
C) 3
D) 4

2 Which is the most stable conformation?

A) Anti
B) gauche
C) Both are equally stable
D) Eclipsed

3 Which of the following is not the extracting media in systemic injection test for
plastics, IP 2007-
A) PEG 400
B) PEG 4000
C) Arachis Oil
D) Ethanol 5% v/v

4 Tautomerism involves….
A) movement of only proton
B) movement of proton and the shifting of bonding electrons
C) movement of only bonding electrons
D) movement of a proton and electron

5 Select the false statement for plant tissue culture (PTC)….

A) Often to produce clones of a plant
B) Production of multiples of plants in the absence of seeds
C) Propagate plants under only sterile conditions
D) Generate a new plant without any culture media

6 Form no. 21 is specified for…

A) Licence to sell drug specified in schedule C & C1
B) Licence to manufacture drug specified in schedule C & C1
C) Licence to sell drug specified in schedule G

For registration Contact: 1

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
D) Licence for retail pharmacy

7 In SN-2 reactions the rate is dependent on.

A) Both the Reactants
B) Only Base
C) Presence of Hologen Group
D) Presence Of alcohol IP

8 Calculate the NMR peaks of 2, methyl-2-pentene.

A) 4
B) 5
C) 6
D) 7

9 Which of the following can be used as suspending agent in parenteral suspensions:

A) Lecithin
B) Lactic acid
C) PEG 4000
D) Procaine HCl

10 In above question the drug ‘A’ acts by one of the following mechanism:
A) Metal is complexed with SH (Sulphydryl) group
B) Metal is complexed with OH group
C) Metal is complexed with -NH2 (Amino group) group
D) None of the above
11 Which of the following is NOT correct pair in terms of heavy metal poisoning and the
treatment:
A) Copper- Penicillamine
B) Iron - Desferrioxamine
C) Lead- Dimercaprol
D) Arsenic-BAL

12 Fermi resonance in IR is due to…

A) Interaction between Fundamental & Overtone Frequency
B) Interaction between Fundamental & Combination frequency
C) Both a & b
D) None of these

13 Attachment of amino group to above compound in above qus no. 5 will results in…
A) 6 peaks, downfield & deshielding

For registration Contact: 2

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
B) 7 peaks, downfield & deshielding
C) 5 peaks, upfield & shielding
D) None of these

14 Select the best suited analytical technique for 20%w/v & 0.2%w/v suspension of
Aspirin.
A) Nephlometry & Turbidimetry respectively
B) Turbidimetry & Nephlometry respectively
C) Any method from Nephlometry & Turbidimetry
D) Nephlometry & Turbidimetry are not suitable for suspensions

15 Arsenic poisoning is treated primarily with one of the following drug ‘A’:
A) Dimercaprol
B) EDTA (Ethylene Diamine Tetra Acetate)
C) Desferrioxamine Mesylate
D) Trientine
16 In Carbanions the order of Stability is.
A) Tert >Sec> Pri
B) Pri> Sec > Tert
C) Pri >Tert >Sec
D) Sec>Tert > Pri

17 Which of the following class room is used to carry out Aseptic Transfer operations:
A) Class 10,000
B) Class 1000
C) Class 1
D) Class 100

18 The acid used for titrating the alkalinity of the glass in accordance with IP 2007 is
A) 0.1 M HCl
B) 0.01 M HCl
C) 0.02 N Sulphuric acid
D) 0.2 M Sulphuric acid

19 Bioassay is to be performed for which of the following drug?

A) Paracetamol
B) Gatifloxacin
C) Naproxen
D) d-tubocurarine

For registration Contact: 3

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
20 Which of the following acts protective colloid in parenteral suspensions:
A) Sodium CMC
B) Gelatin
C) Acacia
D) All of the above
21 In E, Z system of nomenclature cis-cis 2, 4 hexadiene will be known as
A) E, E Hexadiene
B) Z, Z Hexadiene
C) E, Z Hexadiene
D) Z, E Hexadiene

22 Select the suitable set about NMR spectra of neopentane.

A) 2 peaks, doublet (1:1) and singlet
B) 4 Peaks, all are quintet (1:4:4:6:4:4:1)
C) It is not a NMR sample
D) None of these

23 Official Test to ensure pyrogen free parenteral and irrigating solutions in IP is-
A) Antiinflammatory response in rats
B) Fever response in rabbits
C) Antihypertensive activity in Dogs
D) Fever response in Dogs

24 Bioassay is a procedure for determining the

A) Quantitative relationship between the dose (or concentration) of a drug and
magnitude of response
B) Qualitative relationship between the dose (or concentration) of a drug and magnitude
of response
C) Qualitative relationship between the dose (or concentration) of a drug and duration of
response
D) Quantitative relationship between the dose (or concentration) of a drug and duration
of response

25 Which of the following is NOT used in parenterals

A) PMN (1 %)
B) glycerin
C) Sorbitol (2 %)
D) Polysorbate 80 (0.04-4.0%)
26 In above question no. 58, the number of spitted hydrogen are?
A) Zero
B) 1
C) 2

For registration Contact: 4

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
D) 4

27 The drug , in above question 11, is bioassayed by following method

A) hypoglycemic convulsions in mice
B) blood pressure raising effect in dogs or cat
C) Rabbit head drop method
D) Contraction of the frogs rectus abdominis muscle

28 Lead poisoning is primarily treated with:

A) Dimercaprol
B) Calcium Di sodium edetate
C) Sodium thiosulphate
D) BAL

29 1-bromo-1, 2-dichloro ethene has the confirmation?

A) (E)-1-bromo-1, 2 dichloro-ethene
B) (Z)-1-bromo-1, 2 dichloro-ethene
C) (E, Z)-1-bromo-1, 2 dichloro-ethene
D) (Z, E)-1-bromo-1, 2 dichloro-ethane

30 Which of the following Biological indicators are used for Dry heat sterilization
A) Bacillus atrophaeus
B) Bacillus stearothermophilus
C) Bacillus pumilus
D) Bacillus subtilis
31 The method of expressing magnetic field strength is…
A) Cycles/sec
B) Gauss
C) Debye units
D) Hertz

32 Toxicity of plastic materials may be evaluated by

A) Fever response in rabbit
B) Elute injection in mice intramuscularly
C) Implanting small plastic material in rabbits
D) All of the above

33 Which of the following is not used as antioxidant in sterile products:

A) Sodium bisulfite
B) Mannitol
C) Sodium formaldehyde sulfoxylate

For registration Contact: 5

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
D) Both B and C

34 Seeds that have very low chances of germinating and growing are….
A) Orchids
B) Nepenthes
C) Both a & b
D) None of these

35 In Diastereomers
A) Physical Properties are same
B) Physical Properties are Different
C) Chem. Properties are same
D) Both (b) & (C)
36 Choose the couple of the compounds give 1 signals in the NMR spectroscopy.

1.CH3OCH3 2. CH3CH2CH2OH

3. CH3CH2NH2 4. CH3CH2CH2Cl
A) 2, 3
B) Only 1
C) 1, 3
D) 1, 2

37 Molecular ion peakof Marsh gas will come in mass spectrum at…
A) 15 & 16
B) 16 & 15
C) Only 16
D) None of these

38 Eye irritation test for packages intended for ophthalmic preparation is performed on
which of the following animal in accordance to IP 2007:
A) Guinea Pig
B) Rat
C) Dog
D) None of the above

39 Best suited explant for plan tissue culture is….

A) Undifferentiated cells
B) Differentiated cells
C) Both a & b
D) Any type of cell of a plant

For registration Contact: 6

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
40 Select the suitable electric field strength for methane to analyze under 2 unit radius
mass spectrometer with 10 unit magnetic field. (All units are same)?
A) 12.5e- unit
B) 1.25e- unit
C) 0.125e- unit
D) None of these
41 Select the true statement for FLOURIMETRY….
A) Measurements are based upon Transmitted light
B) Scattered light is of lower wavelength than incident light
C) Wavelength of incident light is greater than scattered light
D) All of these

42 In E-2 Reaction How Many Reaction steps are invoked.

A) Two
B) One
C) Three
D) Four

43 In Cis -Trans isomerism what is the essential requirement?

A) Presence of double bond
B) Presence of a halogen group
C) An electron donating group
D) none

44 Characteristic IR region for in formation about type of bonds/vibrations present in IR

sample.
A) 400-1000 units
B) 1250-4000 units
C) 1250-400 units
D) 400-4000 units

45 Inversion of Stereochemistry is seen in which type of reaction mechanism. .

A) SN-1
B) SN-2
C) Both a & b
D) None
46 Which of the following is NOT true about heavy metals:
A) They binds with SH, -OH, and -NH2 groups and interfere with cell
functioning
B) Their toxicity is treated with Chelating agents
C) The anidote used in heavy metal poisoning is also designated with heavy
metal Antagonists

For registration Contact: 7

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
D) A single chelating agent like DIMERCAPROL is effective in all type of
heavy metal poisonings

47 In SN-1 reaction how many steps are involved?

A) Two
B) One
C) Three
D) Four

48 Wilson’s disease is caused by one of the following heavy metal:

A) Copper
B) Lead
C) Iron
D) Antimony

49 Which of the following is used in treatment Wilson’s disease

A) BAL
B) Penicillamine
C) EDTA
D) Desferrioxamine

50 As per IP 2007 the reference condition for steam sterilization for aqueous preparations
are heating at a minimum of
A) 121 degree Celsius for 15 minutes
B) 160 degree Celsius for 2 hours
C) 121 degree Celsius for 30 minutes
D) Both B and C
51 The reaction mechanism of Keto-enol isomerism forms an intermediate, which is
known as….
A) Enolate Cation
B) Enolate Anion
C) Both a & b
D) None of these

52 Which of the following drug can be bioassayed by Radioimmunoassay method?

A) Paracetamol
B) Adrinamycin
C) Naproxen
D) Nimusalide

53 The Depot type of preparation in parenterals are intended for:

A) Delivering large volume of fluids to the body

For registration Contact: 8

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
B) Longer duration of action of drug
C) Storage of large volume parenterals for longer period of time
D) Both A and C

54 Name the Intermediate ,which is Generated as a Results of Homolytic Fission.

A) Free Radicals
B) Carbanions
C) Carbocations
D) Carbanions & Carbonations both

55 Syrup coating under sugar coating involves….

A) Polishing of tablet
B) Colour application
C) Sealing of tablet
D) None of these
56 Which of the following is used for terminal sterilization
A) Alpha rays
B) Beta rays
C) X-Rays
D) Gama Rays

57 Sodium Chloride intravenous infusion, IP contains which of the following

preservative:
A) Phenyl Mercuric nitrate
B) Benzyl alcohol
C) Methyl or propyl paraben
D) None of the above

58 The drug ‘A’ in above questions may also be used in following heavy metal
poisoning:
A) Iron
B) Mercury
C) Copper
D) All of the above

59 Under Plant tissue culture (PTC) profound effects on the morphology of the tissues
that grow from the initial explant is very much deppends upon.
A) Whole culture media content
B) Sterliting agent
C) Nitrogen source
D) None of these

For registration Contact: 9

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info
60 Choose the couple of the compounds give 3 signals in the NMR spectroscopy.

1.CH3COOH 2. CH3CH2NH2

3. CH3OH 4. CH3CH2CH2Cl
A) 1, 2, 3
B) 2, 4
C) 1, 3
D) 1, 2, 3 & 4

For registration Contact: 10

pharmainfo.gpat@yahoo.in Patelashit58@gmail.com, Pharma info