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The Nature of ATP | How to Make ATP | Learning Objectives | Terms | Links
Figure 1. A 2-D stick view of the structure of ATP. The above drawing of ATP is from EcoCyc
at http://hapuna.ai.sri.com:1555/new-image?type=COMPOUND-IN-PATHWAY&object=ATP
Figure 2. A cartoon and space-filling view of ATP. Image from Purves et al., Life: The Science
of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman
(www.whfreeman.com), used with permission.
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Energy is stored in the covalent bonds between phosphates, with the greatest amount of energy
(approximately 7 kcal/mole) in the bond between the second and third phosphate groups. This
covalent bond is known as a pyrophosphate bond.
We can write the chemical reaction for the formation of ATP as:
The chemical formula for the expenditure/release of ATP energy can be written as:
An analogy between ATP and rechargeable batteries is appropriate. The batteries are used,
giving up their potential energy until it has all been converted into kinetic energy and
heat/unusable energy. Recharged batteries (into which energy has been put) can be used only
after the input of additional energy. Thus, ATP is the higher energy form (the recharged battery)
while ADP is the lower energy form (the used battery). When the terminal (third) phosphate is
cut loose, ATP becomes ADP (Adenosine diphosphate; di= two), and the stored energy is
released for some biological process to utilize. The input of additional energy (plus a phosphate
group) "recharges" ADP into ATP (as in my analogy the spent batteries are recharged by the
input of additional energy).
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Figure 3. Enzymes and the formation of NADH and ATP. Images from Purves et al., Life: The
Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman
(www.whfreeman.com), used with permission.
Chemiosmosis, shown in Figure 4, involves more than the single enzyme of substrate-level
phosphorylation. Enzymes in chemiosmotic synthesis are arranged in an electron transport chain
that is embedded in a membrane. In eukaryotes this membrane is in either the chloroplast or
mitochondrion. According to the chemiosmosis hypothesis proposed by Peter Mitchell in 1961,
a special ATP-synthesizing enzyme is also located in the membranes. Mitchell would later win
the Nobel Prize for his work.
Figure 4. A typical representation of an electron transport chain. Images from Purves et al.,
Life: The Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH
Freeman (www.whfreeman.com), used with permission.
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Figure 5. A generalized view of an electron transport system. Image from Purves et al., Life: The
Science of Biology, 4th Edition, by Sinauer Associates (www.sinauer.com) and WH Freeman
(www.whfreeman.com), used with permission.
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Usually the terminal phosphate is not simply removed, but instead is attached to another
molecule. This process is known as phosphorylation.
Glucose can be converted into Glucose-6-phosphate by the addition of the phosphate group
from ATP.
ATP serves as the biological energy company, releasing energy for both anabolic and catabolic
processes and being recharged by energy generated from other catabolic reactions.
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electron
covalent
chloroplast cytoplasm transport endergonic enzyme
bonds
chain
oxidation- second law of
mitochondrion phosphorylation ribose
reduction thermodynamics
Energy View an online slideshow (102 slides) by Susan Blanchard that covers thermodynamics, ATP
and all that stuff.
The Nobel Prize in Chemistry 1997 Three scientists were awarded the Nobel Prize in 1997 for their
work studying enzymes involved with the formation and use of ATP. The press release is of particular
note.
The Nobel Prize in Chemistry 1978 Press Release Peter D. Mitchell proposed a wild idea about how
ATP was made...and he was subsequently validated by other researchers. Read the Nobel Foundation
Press release announcing the prize.
Small Molecules for Modern Biology This site requires the Chime Plugin (available from that site) for
your browser. You can view images of a variety of small molecules, including ATP.
Mitochondrial Mysteries Demystified This site uses the Shockwave Plugin to provide a multimedia tour
of the mitochondrion and its role in cellular metabolism.
Text ©1992, 1994, 1997, 1998, 1999, 2000, 2001, 2002, 2007 by M.J. Farabee, all rights reserved.
Email: mj.farabee@emcmail.maricopa.edu
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