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BIOCHEMISTRY GPAT EXAM QUESTION PAPER

2010

1. Cardiac glycosides have the following configuration in the aglycone part of


the steroid nucleus
(a) 5, 14 (b) 5, 14- (c) 5, 14 (d) 5, 14-
2. The chemical behaviour of morphine alkaloid is
(a) Acidic (b) Basic (c) Neutral (d) Amphoteric

3. At physiological pH the following compound would be MOSTLY in the

(a) Cationic form (b) Unionized form


(c) Zwitterionic form (d) Anionic form
4. For glyburide, all of the following metabolic reactions are logical EXCEPT
(a) O-demethylation (b) Aromatic oxidation
(c) Benzylic hydroxylation (d) Amide hydrolysis
5. Aminotransferases usually require the following for their activity
(a) Niacinamide (b) Vitamin B12
(c) Pyridoxal phosphate (d) Thiamine

6. In the TCA cycle, at which of the following enzyme-catalyzed steps,


incorporation ofelements of water into
an intermediate of the cycle takes place
(a) Citrate synthase (b) Aconitase
(c) Maleate dehydrogenase (d) Succinyl Co-A synthase

2011
1.Arrange the following fatty acids in decreasing order of their
unsaturation (highesttolowest)
[P] Stearic [Q]Oleicacid [R]Linolenicacid [S]Linoleicacid
(a) P>Q>R>S (b)S>R>P>Q
(c) R>S>Q>P (d)Q>P>R>S
2.Choose the correct statement for writing the sequence of amino acids in
a polypeptide?
(a)Amino terminal is to be written on the left hand side while the carboxyl
terminal is to be written on the right hand side
(b)Carboxyl terminal is to be written on the left hand side while the amino
terminal is to be written on the right hand side
(c)Any of the amino acid termina ls can be written on any sides but it is to
be mentioned by specifying the amino terminal and the carboxyl terminal
in abbreviations
(d)It varies from author to author how the sequence of amino acids in a
polypeptide is to be written

3. BETA- Carbo linering system is present in


(a) Emetine (b) Riboflavine (c) Deserpidine (d) d-Tubocurarine

4. Which one of the followings is NOT a bioisosteric pair?


(a) Divalentether(-0-)and amine(-NH)
(b) Hydroxyl(-OH)and thiol(-OH)
(c)Carboxylate(CO-)and sulfone(SO)
(d) Hydrogen(-H)and fluorine(-F)

134.The catalytic triadinacetyl cholinesterase is composed of which of the


following amino acid residues?
(a) Serine,HistidineandGlutamate
(b)Serine,ArginineandGlutamate
(c)Threonine,Histidine andAspartate
(d)Threonine,ArginineandGlutamate

2012

1. Identify the group of enzymes that utilizes NADP or NAD as coenzymes and
catalyzes biochemical reactions
by the transfer of electrons from one molecule to another.
(a) Isomerases (b) Oxidoreductases (c) Transferases (d) Ligases

2. Glucose is the only source of energy for one of the followings. Identify that.
(a) Cardiac cells (b) Nephrons (c) RBCs (d) Thrombocytes
3. Among the followings which one Is not only a non-reducing sugar but also
does not exhibit mutarotation?
(a) Glucose (b) Maltose
(c) Lactose (d) Sucrose
4. One of the following ring systems can be used as the bioisosteric replacement
for benzene ring in drug design:
[P]: Thiophene [Q]: Cyclohexa-l,3-diene
[R]: Pyrrolidine [S]: Imidazoline
Identify the correct answer. –
(a) P (b) Q (c) R (d) S
5. Which one of the following amino acids is the most effective contributor of
protein buffer?
(b) (a) Alanine (b) Glycine (c) Histidine (d) Arginine

2013
1. Vitamin K is constituted of ……………….ring
(a) Hdroquinone (b) Nathphaquinone
(c) Lonone (d) Denzimidazole
Match the following biochemical transformations with coenzymes involved
(i)  –Ketoglutarate to glutamic acid (a) Tetrahydrofalate
(ii) Uridine to thymidine (b) NADH
(iii) Pyruvid acid to acetyl coenzyme A (c) Thiamine pyrophosphate
(d) Pyridoxamine
(a) i-d, ii-a, iii-c (b) i-a, ii-b, iii-d
(c) i-b, ii-a, iii-c (d) i-d, ii-b, iii-c
2. An alternaive to glycolysis pathway is…………..
(a) Glyoxylate pathway (b) Pentose phosphate pathway
(c) Citric acid cycle (d) Gluconeogenesis
3. The chelate, EDTA4: can described as what type of chelating ligand
(a) Bidentate (b) Tetradentate (c) Hexadentate (d) Tridentafe

4. Living cells are negatively charged inside primarily because of………………


(a) ATP, organic acids, and other negative molecules that cannot escape
(b) Removal of sodium ions, which are positively charged, by the Na+/K pump
(c) Extrusion of Ca2+ ion, which is much more concentrated outside a cell than
inside
(d) Cell membranes that are more permeable to potassium than sodium
5. Osazone is formed by reaction of ………… moles of phenylthdrazine with
monosaccharide
(a) 1 (b) 2 (c) 3 (d) 4
6. If a sugar contains………… fuction, it is a reducing sugar
(a) Hemiacetal (b) Acetal (c) Aldehyde (d) Ketal

2014
1. Biological active form of Vit. D in man is:
(a) Cholecalciferol (b) Calcifediol
(c) Calciferol (d) Calcitriol
2. Choose the option with two reducing sugars
(a) Lactose and maltose (b) Trehalose and surcrose
(c) Maltose and tredhalose (d) Economic order quantity
3. Ferritin is:
(a) Coenzyme (b) The stored form of Iron
(c) Non-protein moiety (d) Isoenzyme

4. Which oil is solute is alcohol


(a) Arachis oil (b) Sesame oil
(c) Castor oil (d) Corn oil
5. One of the first step of the citric acid cycle is isomerization of citric acid to
isoctiric acid this step is necessary because
(a) Oxidation of secondary alcohols is very difficult
(b) Reduction of secondary alcohol is very impossible
(c) Reduction of tertiary alcohols would require a very powerful oxidizing agent
(d) Oxidation of tertiary alcohols would require oxidizing agents
6. Which of the following alkyl halides would undergo SN2 reaction most
rapidly
(a) CH3CH2-BR (b) CH3CH2-CL
(c) CH3CH2-I (d) CH3CH2-F
7. When glucose reacts with bromine water, the main product is
(a) Glucaric acid (b) Glucoronic acid (c) Sorbitols (d) Gluconic acid
8. Increase in melting temperature of DNA is due to high content of
(a) A+T (b) G+C (c) A+G (d) T+G
9. The Vitamin required for carboxylation of pyruvate to form oxaloacetate is
(a) Thiamine (b) Biotin (c) Pyridoxine (d) Niacin
2015
1. Cyclic AMP (cAMP) is an important second messenger in signal transduction
pathway(s)Which enzyme
catalyzes the generation/accumulation of cAMP after a receptor – ligand
interaction
(a) Protein kinase A (b) cAMP phosphodiesterase
(c) Guanylyl cyclase (d) Adenylate cyclase

2. Match the given condition with appropriate drug used for its treatment
(1) Pernicious anemia (P) Erythropetin
(2) Meagaloblastic anemia (Q) Oprelvekin
(3) Anemia associated with chronic renal failure (R) Ratenteral Vitamin B12
(4) Thrombocypeniadue to cancer chemotherapy (S) Folic acid
(a) 1-P, 2-Q, 3-R, 4-S (b) 1-R, 2-S, 3-P, 4-Q (c) 1-R, 2-Q, 3-S, 4-P (d) 1-R, 2-P,
3-S, 4-Q
3. In mammals, The major fat in adipose tissue is:
(a) Triglyceride (b) Cholesterol
(c) Sphingophospholipids (d) Phospholipids

4. Plarographic method of analysis to obtain individual amounts of Cu2+ and


Cd2+ in a given mixture of the two ions (Cu2+ and Cd2+) is achieved by
measuring their
(a) Half-wave potentials (b) Migration currents
(c) Decomposition potentials (d) Diffusion currents
5. Arrange the following esters as per decreasing order of rate of saponification
(I) Ethyl benzoate (II) Ethyl p- methoxybenzoate
(III) Ethyl p- chlorobenzoate (IV) Ethyl p-nitrobenzoate
(a) I>II>III>IV (b) IV>III>II>I (c) IV>III>I>II (d) II>IV>I>III
6. Grape fruit juice is P- glycoprotein and CYP40 enzyme inhibitor . if drug X
is degraded by proteolytic enzymes, administration of grapefruit juice with X
(a) Increase bioavailability of X
(b) Decrease Bioavailability of X
(c) Does not affect bioavailability of X
(d) Cause unexpected action of X

2016

1. Phenylalanine, a precursor of most of the phenolics is higher plants is a


product of which one of the following pathways
(a) Shikimic acid pathway (b) Malonic acid pathway
(c) Mevalonic acid pathway (d) Methylerhtritol pathway

2. Thiamine deficiency causes decreased energy production because


(a) It is required for the process of transamination
(b) It is a co-factor in oxidative reduction
(c) It is a co-enzyme for transketolase is pentose phosphate pathway
(d) It is a co-enzyme for pyruvate dehydrogenase & alpha ketoglutarate
dehydrogenase

3. What is the correct order for unsaturation in following fatty acids


(1) Palmitoleic Acid (2) Linolenic
(3) Linoleic acid (4) Arachidonic acid
(a) 1>2>3>4 (b) 3>4>2>1 (c) 4>3>2>1 (d) 4>2>3>1

4. The following drug metabolizing reaction in entirely non-microsomal:


(a) Glucuronide conjugation (b) Acetylation
(c) Oxidation (d) Reduction

2017
1. Reduction of imines to give amines in protic solvents can be carried out by
one of the following
reagents. Select the correct reagent
(a) Sodium hydride
(b) Sodium chloride and HCl
(c) Lithium aluminium chloride
(d) Sodium cyanoborohydride

2. Which of the following constituents is responsible for colour of shellac


(a) Shelloic acid (b) Laccaic acid (c) Aleurotic acid (d) All of the above
3. Which among the following statements related to Ceric sulphate as oxidizing
agent, as titrant are correct
(a) Ce (IV) during reaction exists as an anionic complex in media of sulphuric
acid
(b) Ionic equation is Ce3 Ce2  e
(c) Formal potential of Ce(III) Ce (II) couple is 1
(d) Ce (IV) does not permit use of HCl as reducing media
4. An intermediate 3- Chloroaniline 4, 6 - disulphonamide on heating with
formic acid yields a compound
(a) 6 chloro 2H -1,2,4benzothiadiazine 7 sulphonamide
(b) 3 chloro-2H 1,2,4- benzothiadiazine 7 sulphonamide
(c) Used in treatment of urinary tract infections
(d) Used as antibacterial
5. Acetyl Choline is hydrolyzed by enzyme
(a) Acetylase (b) Cholinase (c) Acetylcholinesterase (d) Transferase
6. The major component of liquid glucose is ……….and is prepared from
_______
(a) Maltose, Pectin (b) Dextrin, Starch (c) Dextrose, Starch (d) Glucose, Starch
7. The major differences between the prokaryotic and eukaryotic protein
synthesis mechanisms are in which part of the process
(a) The initiation of synthesis (b) The chain elongation process
(c) The chain termination process (d) None of the above

8. Glycosides are condensation products of


(a) Protein + aglycone (b) Sugar + Protein
(c) Sugar + aglycone (d) Fats + aglycone

9. Clavulanic acid is
(a) Inactivates bacterial - lactamase (b) Protien inhibitor of peptidoglycan
synthesis
(c) Specific for gram negative bacteria (d) Inhibitor of 50S ribosomal subunit
10. The method by which different constituents of a liquid mixture can be
separated without decomposition of the constituents is
(a) Distillation under reduced pressure (b) Molecular distillation
(c) Steam distillation (d) Fractional distillation
11. The number of glucopyranose units in the structure of alpha cyclodextrins
are
(a) 8 (b) 9 (c) 7 (d) 6
12. The compound 2 - (Diethylamino) ethyl [bicyclohexyl] - 1-carboxylate
hydrochloride is
(a) Dicycloverine (b) Diphenhydramine
(c) Both nicotinic and specific antispasmodic, (d) Diagonistic agent for
diagnosis of thyroid gland
13. A fatty acid not synthesized in human body and has to be supplied in diet is
(a) Stearic acid (b) Oleic acid (c) Palmitic acid (d) linolenic acid
14. The Michalis-Menten equation for standard for saturated active transport
system is-
(a) Vmax = kcat[E0] (b) Vmax = km (c) Vmax =km[S] (d) None
15. Which among the following describe the characteristic features of
Tetracyline
(a) Undergoes epimerization in solutions having intermediate pH range
(b) Forms Anhydroustetracycline in presence of acidic
(c) Forms Minocycline in basic medium
(d) Forms stable chelate complexes with potassium ions
16. In humans end product of purine catabolism is
(a) Uric acid (b) Urea (c) Purine oxide (d) Xanthine
2018

1. Match the following enzymes in Column I with their respective functions


under Column II

Column I Column II
i. DNA ligase (p) Synthe size a DNA copy of RNA
ii. Alkaline phosphatase (q) Forms a bond between 3’ –OH and 5’-
PO4
iii. Reverse transcriptase (r) Removes terminal PO4 from 3’ or 5’end of DNA
iv. Polynucleotide kinase (s) Adds phosphate to 5’ –OH end
(a) i-r, ii-s, iii-p, iv-q
(b) (b) i-p, ii-q, iii-r, iv-s
(c) (c) i-q, ii-r, iii-p, iv-s
(d) (d) i-s, ii-p, iii-q, iv-r

2. Which of the following replacement of amino acid in a protein may produce


greatest change in its
conformation?
(a) Ser Thr (b) Glu Val (c) Gln Tyr (d) Phe Ile

3. The hexose monophosphate pathway produces distinctively two useful


products. Identify these
products with the ratio in which they are produced.
(a) One NADPH to two ribose-6-phosphate
(b) Two NADPH to one ribose-5-phosphate
(c) Two NADPH to one ribulose-5-phosphate
(d) Two NADPH to one fructose-6-phosphate

4. The correct statement about Vitamin D is:-


(a) The oral administration of 1, 25-dihydoxycholecalciferol is required in
chronic renal failure
(b) 25-Hydroxycholecalciferol is the active form of the vitamin
(c) Vitamin D antagonizes the effects of parathyroid hormone
(d) A deficiency of vitamin D causes an increase in calcitonin secretion

5. All of the following enzymes are used in ELISA except:-


(a) Glucose oxidase (b) Alkaline phosphatase
(c) Coagulase (d) β-galactosidase
6. Which of the following equilibrium suggests noncompetitive inhibition of
enzyme E for conversion
of substrate S to product P with inhibitor I?

7. Which method is used for the Limit test for arsenic?


(a) Gutzeit method (b) Oswald method
(c) Arrhenius method (d) Karl-Fischer method

8. The agent used to prevent the dental carries is:-


(a) Sodium fluoride (b) Strontium chloride
(c) Zinc chloride (d) Dicalcium phosphate

9. Galactose and Glucose are:-


(a) Epimers (b) Anomers (c) Isomers (d) Ketose-Aldose isomers
10. Which among the following is a non-essential amino acid?
(a) Lysine (b) Threonine (c) Serine (d) Histidine

11. The role of glutathione in tissues includes all except:-


(a) Participate in decomposition of hydrogen peroxide
(b) Participate in activation of methionine
(c) Participate in detoxification reactions
(d) Biologically active in oxidized form

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