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RAJALAKSHMI ENGINEERING COLLEGE, CHENNAI 602 105.

DEPARTMENT OF BIOTECHNOLOGY

UNIT TEST II Date : 25.08.2010

Sub. Code : BT 1010 Max. Marks : 50
Sub. Name : Biopharmaceutical
Technology Duration : 90 minutes
Year : IV “A”

Answer All Questions

PART A – (5 x 2 = 10 Marks)

1. Define a Tablet
2. Name two preservatives used in oral solution, two preservative in parentrals.
3. Write notes on slugging
4. What are the differences between flocculated and deflocculated suspension?
5. Write short notes on disintegration of tablet

Answer All Questions

PART – B [16+16+8=40 Marks]

6 (a). Write about tablet manufacture according to the following heads

i) Granulation and excipients (8)
ii) Tablet compression (8)
OR
(b) Write briefly about Transdermal drug delivery system and pharmaceutical
emulsion (16)

7. (a). Discuss briefly about different mechanism of drug action (16)

OR
(b) i) Describe the steps involved in sugar coating
ii)Write briefly about enteric coated tablet (16)

8. What is flocculated suspension? What will be the degree of flocculation of a

suspension given the following data Total volume of suspension is 100 ml,
volume of flocculated suspension is 75 and in deflocculated suspension is 15 (8)
 Roll. NO
RAJALAKSHMI ENGINEERING COLLEGE, CHENNAI 602 105.
DEPARTMENT OF BIOTECHNOLOGY
UNIT TEST II Date : 25.08.2010
Sub. Code : BT 1010 Max. Marks : 50
Sub. Name : Biopharmaceutical
Technology Duration : 90 minutes
Year : IV “B”
Answer All Questions
PART A – (5 x 2 = 10 Marks)

1. What is a bulk drug? Give examples.

2. Define Clearance and total systemic clearance with expression.
3. What is a prodrug? Give examples.
4. Explain how radioactivity is used in pharmacokinetics.
5. Define Bioequivalence with examples and graphical representation.

Answer All Questions

PART – B [8+16+16=40 Marks]
6. (a). Describe the special requirements for manufacturing of bulk drugs. (16)
(OR)
(b). Discuss in detail about the processes and reactions involved in the
Manufacture of bulk drugs. (16)

7. a) Following a 650 mg i.v. bolus dose of a drug to a 65 Kg subject, the plasma drug concentration
was found to decline bioexponentially. The equation that best described the drug kinetics was :
C = 67 e-14t + 33 e-3t
Where t is in hours and C is in mcg/ml. Calculate the following.
a. The volume of the central compartment. (2)
b. The volume of the peripheral compartment. (2)
c. The apparent Vd at steady-state. (2)
d. Volume of distribution by area. (2)
e. Microconstants K12 and K21 (2)
f. The elimination rate constant for the disposal of drug from the central
compartment. (2)
g. The overall elimination half-life. (2)
h. The total systemic clearance of the drug. (2)

(OR)
b) Elaborate on the different mechanisms of drug action. (16)

8. (a). Define prodrug and its characteristics. What are the reasons for prodrug
Formulation? (8)

(OR)
(b). Give an account of renal excretion of drug metabolites. (8)