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Ki

dneyandur
inar
ytr
actdi
seases:
Gl
omer
ulonephr
it
is:
-
Gl
omerul
onephri
ti
sorbr
ightdi
seaseisthet
erm usedf
ori
nsuf
fi
cientf
unct
ioni
ngr
enal
glomer
uli
t
ypi
cal
l
yfoll
owingstr
ept
ococcali
nfecti
on.

Si
gnandsy
mpt
om:
-
 Smokyorcof
feecol
our
edur
ineduet
ohemat
uri
a.

 Decr
easedur
inat
ionorol
i
gur
eaduet
odecr
easedGFR.

 Dy
spneaduet
opul
monar
yEdema.

 Per
ior
bit
alEdema.

 Pr
otei
nur
ia.

Et
iopat
hogenesi
s:-
I
nfect
iongr
oupA,
B hemol
yti
cst
rept
ococcus.

Hepat
it
isBmal
i
gnantt
umorandgoodpost
uresy
ndr
ome.

St
imul
ati
onandf
ormat
ionofant
ibodi
es.

Ci
rcul
ati
ngAg.
-Ab.compl
exesbecomel
odgedi
nthegl
omer
uli
capi
l
lar
y.

Rel
easeofi
mmunol
ogi
csubst
ancest
hel
ysi
scel
landi
ncr
easedmembr
aneper
meabi
l
ity
.
Act
ivat
ionofbi
ochemi
cal
medi
atorofi
nfl
ammat
ionandl
ysosomal
enzy
me.

Damaget
ogl
omer
ularcel
lwal
l
.

Leadst
opl
atel
etsaggr
egat
ionandpassageofpr
otei
nandRBCi
ntot
heur
ine.

Pr
otei
nur
iaandhemat
uri
a.

Decr
easedr
enal
bloodf
lowandGFR.

Nasecr
eti
on,
hyper
tensi
onandEdema.

Pat
hol
ogi
cal
changes:
-
 Gr
ossyt
heki
dney
sar
easy
mmet
ri
cal
l
yenl
arge,
wei
ght
ed.

 Cutsect
ionshowsf
leebi
tenki
dney
.

 Gl
omerul
iar
eenl
argedandhy
percel
l
ularduet
oinf
il
tr
ati
onofl
eukocy
tes,
pol
ymor
phand
monocyt
es.

 Swel
l
ingi
nthet
ubul
es.

 Somedegr
eeofi
ntest
inal
Edemai
spr
esent
.

Di
agnost
icmet
hods:
-
 Ur
ineanal
ysi
s.

 Bl
oodanal
ysi
s.
 Thr
oatcul
tur
eforgr
oupA,
Bhemol
yti
cst
rept
ococcus.

 X-
rayofki
dney
.

 Renal
biopsy
.

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