Neurovascular Intervention Devices Global Market

–Forecast to 2027

Neurovascular Intervention Devices Global Market estimated to be worth $4.2

billion by 2027

IQ4I Research & Consultancy published a new report on “Neurovascular Intervention

Devices Global Market – Forecast To 2027” This report analyzes and studies the overall
market, major Drivers & Opportunities, Restraints & Threats in North America, Europe, Asia-
Pacific and Rest of the World.

IQ4I’s Report Contains 102 market data tables and 89 figures spread through 426
pages and an exhaustive TOC on “Neurovascular Intervention Devices Global
Market”, [Products {Artificial Embolization Devices (Coils [Bare metal coils and
Coated coils], Liquid Embolics, Flow diverter, Flow disruptor, and Others), Stents
(Intracranial stents [Stenosis stent, Aneurysm coil stent], and Carotid stents),
Thrombectomy devices (Stent Retrievers and Aspiration devices) and Support
devices}; Applications {Intracranial aneurysm, Ischemic stroke, Arteriovenous
malformation and others}; Region (North America, Europe, Asia-Pacific and Rest of
the World)]

Neurovascular Intervention is a specialized field of neuroscience, which involves the

treatment of neurological disorders like intracranial aneurysm, ischemic stroke,
arteriovenous malformation and carotid stenosis and others by performing minimally invasive
procedures. Cerebral aneurysm also called as intracranial aneurysm is a disorder wherein a
weak or thin spot on a blood vessel in the brain bulges out and fills with blood which then
exerts pressure on the nerves or surrounding brain tissues and may lead to leak or rupture.
Ischemic stroke a disorder of blockage or occlusion of cerebral arteries due to blood clots or
fatty deposits in the case of atherosclerosis and thereby interrupts the blood flow to the
brain. The arteriovenous malformation (AVM), a disorder characterized by an abnormal
tangle of vessels in the brain in which one or more arteries are directly connected to one or
more veins. The carotid stenosis is caused due to plaque (abnormal thickening of the artery
wall) deposits in the carotid arteries present on both the left and right side of the neck and
intracranial stenosis is caused due to abnormal plaque deposition within the brain arteries.
According to the Center for Disease Control and Prevention (CDC), about 140,000
Americans die due to stroke (the fifth leading cause of death in the U.S.) i.e. 1 out of every
20 deaths. The annual incidence of AVM in the United States is 1.34 per 100,000 people
and about 12% of the AVM are estimated to be clinically symptomatic. The worldwide
prevalence of cerebral aneurysm is estimated to be 3.2% with a mean age of 50 with a
gender ratio of 1:1. Globally, in 2020, approximately 58 million people are leaving with
carotid stenosis aged between 30 – 79 years. Some of the causes for carotid stenosis are
age (65-75 years), high blood pressure and hypertension.

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In modern medicine, minimally invasive interventions are considered as the cornerstone and
in this regard over the past decade, there is a gradual shift from complex open surgery to
minimally invasive image-guided interventions having lesser complications, better outcomes
and lower cost. Such interventions are also being implemented in treating neurovascular
diseases. The minimally invasive procedures for neurovascular interventions include artificial
embolization, stenting and mechanical thrombectomy. Artificial Embolization devices like
coils, liquid embolics, flow diverters and flow disruptors are used to treat intracranial
aneurysm and arteriovenous malformations. Stenting procedure is done to treat carotid
stenosis, intracranial aneurysm and intracranial stenosis with products like carotid stents and
intracranial stents which are implanted into the artery. Neurovascular thrombectomy is a
mechanical endovascular treatment done to remove blood clots present in the brain which
leads to stroke. Thrombectomy devices are stent retrievers and aspiration devices. Some of
the support devices used during coil embolization, stenting and thrombectomy devices are
microcatheters, balloon catheters, guidewires, and neurovascular sheath.

According to IQ4I Analysis, Neurovascular Intervention devices global market is expected to

reach $4,167.4 million by 2027 growing at a high single digit CAGR from 2020 to 2027.
Some of the factors driving the market are increase in incidence and prevalence of
neurovascular diseases like cerebral aneurysm, stroke, arteriovenous malformations, and
increase in the aging population, technological advancement, acquisitions and favourable
reimbursements. Rise in the number of product recalls, lack of skilled professionals, adverse
effects of product implant are restraining the growth of the market. The stringent regulatory
process and alternative treatments that include surgical clipping, pharmaceutical drugs and
stem cell therapies are some of the threats to the market.

Neurovascular Intervention Devices global market is classified based on products,

applications and geography. The products segment is further categorized into four sub-
segments i.e., Artificial embolization devices (coils, liquid embolics, flow diverter, flow
disruptor and others such as embolic spheres and vascular plugs), stents (intracranial and
carotid stents), thrombectomy device (stent retriever and aspiration device) and support
devices (microcatheter, and others such as guidewires, balloon catheters and sheaths).
Artificial embolization device segment holds the largest share in 2020 and is projected to
grow at a low single digit CAGR from 2020 to 2027. Among artificial embolization devices,
coils segment accounts for the largest revenue in 2020 and it is expected to grow at a low
single digit from 2020 to 2027. The Flow Diverter segment is the fastest-growing segment

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and is projected to grow at a high single digit CAGR from 2020 to 2027 due to increased
safety, less recurrence, less radiation exposure, lower cost and shorter recovery time.

Further, based on the type of coil, the bare metal coil segment accounted for the largest
revenue in 2020 and coated coils are expected to grow at a low single digit CAGR from 2020
to 2027. The thrombectomy device segment is the fastest-growing segment and is projected
to grow at a high single digit CAGR from 2020 to 2027 due to increase in ischemic stroke
procedures, technological advancements in stent retrievers and aspiration devices. Under
the thrombectomy devices, stent retriever segment contributed to the largest revenue in
2020 and is expected to grow at a high single digit CAGR from 2020 to 2027.

Based on the application, the Neurovascular Intervention Devices global market is

segmented into intracranial aneurysm, ischemic stroke, arteriovenous malformation and
others. Among application, the intracranial aneurysm segment accounted for the largest
share in 2020 and is projected to grow at a low single digit CAGR from 2020 to 2027, due to
the increase in incidence and prevalence of intracranial aneurysm and increase in aging
population. The Ischemic stroke segment is the fastest-growing segment and is projected to
grow at a high single digit CAGR from 2020 to 2027 due to increase in product regulatory
approvals for stent retrievers, increase in ischemic stroke patients and procedures,
technological advancement in stent retriever and aspiration devices.

The neurovascular intervention market by region is segmented as North America, Europe,

Asia-Pacific and the Rest of the world. North America accounts for the largest revenue in
2020 and it is expected to grow at a low single digit CAGR from 2020 to 2027 due to
adoption of the technological advancements, increasing incidences of neurovascular
diseases, increasing demand for minimally invasive procedures, favorable reimbursements,
product launches, skilled personnel and strong product pipeline. The Asia-Pacific region is
the fastest-growing region with a high single digit CAGR from 2020 to 2027 due to increasing
healthcare awareness, rapid economic growth, large patient pool, reduced cost of
neurovascular intervention devices and increase in aging population are creating demand for
neurovascular intervention devices in this geography.

Considering the attractiveness of the neurovascular intervention market, several venture

capitalists are aggressively investing. Globally, funding is more concentrated on product
developments, approvals and also execution of go-to-market strategies. For instance, in
August 2020, Wallaby Medical (China) which has its R&D centre in the U.S. has raised more
than $20.0 million and the funding will be used for the development of its innovative stroke
solution portfolio and regulatory approvals. In addition to external investments, several

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companies are investing in their R&D activities to develop innovative products. For instance,
Silk Road Medical Inc (U.S.) has invested ~19.2% of the total revenue during 2020 (Q2) in
R&D, and Balt Extrusion (France) every year is investing ~10.0% of its total revenue in R&D.

According to IQ4I analysis, the average number of coils used per embolization procedure is
estimated to be xx units (ASP - $xx). The average number of stent retrievers and aspiration
devices used per ischemic stroke procedure is estimated to be xx (ASP - $xx) and xx ($xx)
respectively. Globally, the total number of aspiration devices used is estimated to be xx in
2020 and is expected to grow at a low double digit CAGR from 2020 to 2027.

Neurovascular intervention market has a huge opportunity for existing players and new
entrants. According to IQ4I analysis, it is estimated that in the U.S. 6.5 million people have
unruptured brain aneurysm and the incidence of ruptured aneurysm is about 10 in every
100,000 people per year. Currently, xx intracranial aneurysm procedures are performed in
the U.S. annually indicating a penetration rate of xx% with an opportunity of xx% in the
market. Globally, ~xx intracranial aneurysm procedures are performed per year and the
numbers of procedures are increasing due to the advantage of endovascular coiling over
surgical clipping. Similarly, in the U.S. there are about 700,000 people who are living with
stroke and about 87% of all strokes are ischemic strokes. Approximately, xx procedures are
performed by using stent retrievers and xx procedures are performed by using aspiration
devices every year in the U.S. indicating penetration of xx% with an opportunity of xx%.

Some of the companies are coming up with technological advancements to maintain their
leadership status in the neurovascular intervention market. For instance, a U.K. based
company called Anaconda Biomed has developed a thrombectomy system consisting of a
delivery catheter, a funnel-shaped aspiration catheter, and a stent retriever and when used
the funnel self-expands and confirms it’s direct to the artery up to 5 mm. The device is also
designed to locally arrest flow and thrombus extraction without fragmentation.

The neurovascular intervention companies mainly focus on expansion, new product

launches, and acquisitions to be competent and gain access to new technologies both in
existing and new market areas. For instance, the currently marketed clot retrievers have an
issue with respect to exerting pressure on the vessel which lead to further complications like
vessel damage. In this regard, Rapid Medical (Israel) received CE mark approval for its
Tigertriever XL stentrievers in July 2020, which is a fully visible clot retriever, and a self-
adjustable device used for the treatment of ischemic stroke and the device can retrieve large
clots. The Tigertriever XL features a length of 53 mm and an adjustable diameter that can

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conform to any vessel diameter up to 9 mm. It is delivered via a standard microcatheter with
an internal diameter of 0.021 inches. Another added advantage is the presence of mesh
which is radiopaque for better visibility inside the vessels and eliminates the need for long-
term antiplatelet therapy as required in the case of stent implantation.

Stryker Corporation launched its flow diverter Surpass Evolve Flow Diverter in August 2020
in the U.S. following FDA approval and the device is made up of cobalt-chromium and
platinum tungsten braided which is self-expandable and is used for the treatment of wide-
neck and fusiform intracranial aneurysms. The same device was launched in Europe in
2019. It is the 64-wire cobalt-chromium flow diverter and the device has the ability to
excellent flow diversion and highly flexible implant enhanced vessel wall contact as
compared to traditional 48-wire flow diverters.

The Neurovascular Intervention Devices market is consolidated with the top 7 players
occupying major share of the market. Some of the major players in the market include
Stryker Corporation (U.S.), Medtronic Plc (Ireland), Penumbra, Inc. (U.S.), Terumo
Corporation (Micro Vention, Japan), Johnson & Johnson (U.S.), Balt Extrusion (France),
Abbott Laboratories (U.S.), Boston Scientific Corporation (U.S.), Silk Road Medical Inc.
(U.S.), Microport Scientific Corporation (China), and Acandis GmbH (Germany).

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Reasons for buying this report:

 Neurovascular Intervention devices global market is expected to reach $4,167.4
million by 2027 growing at a high single digit CAGR.
 Identification and analysis of the Neurovascular Intervention devices market by
identifying various segments by products, application and geography.
 Revenue forecast for Neurovascular Intervention devices global market and strategic
analysis of each sub-segment with respect to segmental growth trends.
 Identification of major market trends, Porter's model and factors driving and
restraining Neurovascular Intervention devices market growth.
 Analysis of the opportunities for stakeholders by identifying the high-growth
segments of the market.
 Market penetration of intracranial aneurysm and ischemic stroke, Number of units
and average selling price (coils liquid embolics, stent retrievers, aspiration devices,
intracranial stents and carotid stents), Procedural volume and product matrix.
 Market share analysis of Neurovascular Intervention devices global market and
individual market share analysis for Coils, Stent, Flow diverter, Intracranial stent,
Carotid stent and Stent retriever global market.
 Analyzing patent filing trends to assess innovation activities.
 Identification of key technology developments and innovations driving the market.
 Profiles of major players in Neurovascular Intervention devices market and analysis
of their product offerings, financial revenue, business strategies and SWOTs.
 Revenue forecast of the Neurovascular Intervention devices market with respect to
North America (U.S. and Others), Europe (Germany, U.K. France and others), Asia-
Pacific (Japan, China, India and others) and Rest of the World (RoW) (Brazil, Rest of
Latin America and Middle-East & Others) regions.

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FIGURE 1

NEUROVASCULAR INTERVENTION DEVICES GLOBAL MARKET

SEGMENTATION

NEUROVASCULAR INTERVENTION DEVICES GLOBAL MARKET

Products Type Application

Intracranial
Artificial Thrombectomy Support Aneurysm
Stents
Embolization Devices Devices
Ischemic Stroke
Intracranial Stent Retriever Microcatheters
Coils
Stents
Arteriovenous
Bare Metal Aspiration Malformation
Stenosis Stents Others
coils Devices
Others
Aneurysm Coil
Coated coils
Stents

Liquid Embolics Carotid Stents

Flow Diverters

Flow Disruptors

Others

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