Case Outcomes (=1)

[MED1108] Case 4- Why am I tired doctor? (=9)

Describe the stages and role of the cell cycle in health and disease (=2)
• Describe defects of cell cycle control and how they may lead to malignancies [Taught]
- SBA, Cell biology,
• Describe the stages of the normal cell cycle and its role in cell proliferation [Taught]
- SBA, Cell biology,
Describe the carriage of oxygen and carbon dioxide in blood (=2)
• Describe and explain the carriage of carbon dioxide by the blood [Self Study]
- SBA, Physiology,
• Describe and explain the carriage of oxygen by haemoglobin and the molecular changes involved [Self Study]
- SBA, Physiology,
Describe the principles of cancer screening and surveillance (=4)
• Describe screening procedures used in medical practice, e.g. in cancer [Taught]
- SBA, Assignment, Public health,
• Describe the criteria that should be met before implementing a screening test [Taught]
- SAP, Public health,
• Describe the principles of cancer surveillance [Taught]
- SBA, Public health,
• Describe the relevance and importance of screening as a prerequisite to effective secondary prevention [Taught]
- SBA, Public health,
Describe the treatment options for anaemia (=1)
• Describe the drugs used in the treatment of anaemia, their indications and major side effects [Self Study]
- SBA, Assignment, Pharmacology,
Describe the pathophysiology relating to tumours (=11)
• Define dysplasia, neoplasia, tumour, papilloma, adenoma, carcinoma, sarcoma, carcinoma in situ, intraepithelial neoplasia, metastasis, invasion, grade
and stage of tumours [Taught]
- SBA, Pathology,
• Define transformation, clonality, carcinogen, initiator, promoter, oncogene, cellular oncogene, proto-oncogene, viral oncogene and tumour suppressor
gene [Taught]
- SBA, Pathology,
• Describe how neoplasms are classified and named [Taught]
- SBA, Pathology,
• Describe how the incidence of neoplasia can be influenced by geographical and environmental factors [Taught]
- SBA, Pathology,
• Describe the causes, pathology and clinical features of colonic carcinoma [Taught]
- SAP, Pathology,
• Describe the changes associated with cell transformation [Taught]
- SBA, Pathology,
• Describe the characteristic features of benign neoplasms and malignant neoplasms [Taught]
- SAP, Pathology,
• Describe the mechanisms by which neoplasms grow, become invasive and the pathways by which they spread [Taught]
- SBA, Pathology,
• Describe the molecular mechanisms by which radiation, viruses and chemicals may lead to carcinogenesis; including the role of oncogenes, tumour
suppressor genes and genes controlling apoptosis [Taught]
- SBA, Pathology,
• Describe the principles underlying the grading and staging of tumours [Taught]
- SBA, Pathology,
• Describe what is meant by the multistep hypothesis of carcinogenesis [Taught]
- SBA, Pathology,
Describe the causes, signs, symptoms and classification of anaemia (=9)
• Describe how chronic disease leads to anaemia [Taught]
- SBA, Physiology,
• Describe how deficiency in Vitamin B12 and folic acid result in anaemia [Taught]
- SBA, Nutrition, Physiology,
• Describe how drugs can cause anaemia [Taught]
- SBA, Pathology, Pharmacology,
• Describe how genetic defects in haemoglobin/ red blood cell function lead to anaemias [Taught]
- SBA, Physiology,
• Describe how iron deficiency results in anaemia [Taught]
- SBA, Assignment, Nutrition, Physiology,
• Describe sickle cell anaemia, thalassemia, spherocytosis [Taught]
- SBA, Assignment, Physiology,
• Describe the aetiology of anaemia [Taught]
- SBA, Assignment, Diagnostics, Physiology,
• Describe the classification of anaemias [Taught]
- SBA, Assignment, Diagnostics, Physiology,
• Describe the signs and symptoms of anaemia [Taught]
- SAP, Assignment, Diagnostics, Physiology,
Identify different classifications of anaemia from history and investigation data (=1)
• Apply the principles of clinical reasoning in formulating a differential diagnosis in a person with symptoms suggestive of anaemia [Taught]
- SAP, Diagnostics, Reasoning,
Explain the difference in presentation between different tumours (=1)
• Apply the principles of clinical reasoning in formulating a differential diagnosis for a patient presenting with symptoms suggestive of cancer [Taught]
- SAP, Diagnostics, Reasoning,
Describe normal and abnormal production and function of constituents of blood (=11)
• Describe and interpret the blood indices and other blood tests relevant to anaemia [Taught]
- SAP, Diagnostics, Physiology,
• Describe how the cellular elements of the blood are renewed from the pluripotential haemopoietic stem cell [Taught]
- SBA, Physiology,
• Describe the composition of blood and the primary function of the various constituents [Taught]
- SBA, Physiology,
• Describe the different blood groups, including the ABO and Rhesus systems [Taught]
- SBA, Diagnostics, Physiology,
• Describe the factors that affect the binding of oxygen by haemoglobin [Self Study]
- SBA, Physiology,
• Describe the haemopoietic differentiation of erythrocytes (erythropoiesis) and granulocytes (granulopoiesis) [Taught]
- SBA, Physiology,
• Describe the location of haematopoiesis throughout life [Taught]
- SBA, Physiology,
• Describe the regulation of erythropoiesis and granulopoiesis [Taught]
- SBA, Physiology,
• Describe the role of plasma proteins in capillary filtration and the oncotic pressure of plasma [Taught]
- SBA, Physiology,
• Describe the role of the reticuloendothelial system in health and disease [Taught]
- SBA, Physiology,
• Describe the structure and function of the spleen [Taught]
- SBA, Anatomy & histology, Physiology,