EXCIPIENTS

EXCELLENCE IN
OLEOCHEMICAL EXCIPIENTS AND APIs

IOI Oleo GmbH

PHARMA
 Contents
EXCIPIENTS ................................................................................................ 5

Liquid lipids .................................................................................................... 6

Solid triglycerides ........................................................................................... 8

Partial glycerides ........................................................................................... 12

Emulsifiers .................................................................................................... 14

Specialties ...................................................................................................... 16

Register of chemical/monograph names ................................................. 18

Register of trademarks and product names ............................................. 20

Abbreviations:

CEP = Certificate of suitability to the monographs of the European Pharmacopoeia

CFR = Code of Federal Regulations

DAB = Deutsches Arzneibuch

DMF = Drug Master File

JPE = Japanese Pharmaceutical Excipients

Ph. Eur. = European Pharmacopoeia

USP-NF = United States Pharmacopeia-National Formulary

B.P. = British Pharmacopoeia

FCC = Food Chemicals Codex

HLB = Hydrophilic Lipophilic Balance

March 2019 GRAS = Generally Recognized As Safe

Contents | 3
 EXCIPIENTS
We have gathered our activities for the pharmaceutical industry under the umbrella of IOI OLEOCHEMICAL PHARMA,
with a strong commitment to quality and regulatory leadership in pharmaceutical oleochemicals.

Our pharmaceutical excipients for topical, oral, and rectal applications as well as our oleochemical-based active pharma­
ceutical ingredients for enteral and parenteral applications have been enjoying a good reputation for decades.

The WITEPSOL® product range with its different types is the worldwide leading market standard for suppository
bases (adeps solidus). Our MIGLYOL® brand comprises our MCT oil as well as related C8-C10 fatty acid esters. The
IMWITOR® product family provides functionalized lipids for drug delivery systems. With DYNASAN®, we offer mono­
acid triglycerides for various applications requiring precise physico-chemical characteristics.

Highest quality standards are continuously improved and controlled by the relevant German authority and US-FDA as well
as throughout regular customer audits by multinational companies. Our strict commitment to quality is confirmed by the
repeated granting of EU-GMP certification as well as repeated US-FDA approval.

Together with the first CEP ever granted for MCT, several type IV DMFs as well as one type II DMF submitted to the US
Food and Drug Administration, we demonstrate our self-conception as one of the leaders in quality and regulatory affairs
for oleochemical specialities in pharmaceutical applications.

Our expert team with decades of experience will be happy to provide you with individual solutions for your pharma­
ceutical formulations.

4 | Contents EXCIPIENTS | 5
1 Liquid lipids
Liquid lipids are fatty acid esters. They are neutral carriers for various pharmaceutical applications. Because of their polarity,
they exhibit superior solvent characteristics for some active drugs (compared to hydrocarbons).

Product Chemical description/monograph name Listed in Appearance Viscosity Properties and applications
mPa· s 20 ° C

C8 /C10 Triglycerides

MIGLYOL® 808 Tricaprylin — Oily liquid * ~ 23 Neutral, stable, penetration enhancer, drug carrier, dermal and oral use, solvent.

MIGLYOL® 810 N Triglycerides, Medium-Chain Ph. Eur., USP-NF, JPE, Oily liquid * ~ 28 Neutral, stable, penetration enhancer, drug carrier, solvent, oral use, dermal use.
US DMF Type IV, No. 800

MIGLYOL® 812 N Triglycerides, Medium-Chain Ph. Eur., USP-NF, JPE, CEP R0-CEP Oily liquid * ~ 30 Lipid component in parenteral nutrition. Neutral, stable, solubilizer and carrier
Drug Substance 2012-410-Rev 01, US DMF Type II, for oil-soluble actives.
No. 27975

MIGLYOL® 812 N Triglycerides, Medium-Chain Ph. Eur., USP-NF, JPE, Oily liquid * ~ 30 Neutral, stable, penetration enhancer, drug carrier as well as solvent for oral and dermal use.
Excipient US DMF Type IV, No. 800

MIGLYOL® 818 Caprylic/Capric/Linoleic Triglyceride — Oily liquid * ~ 31 Neutral, stable, drug carrier, oral and dermal use. The oil is stabilized with an antioxidant.

MIGLYOL® 829 Caprylic/Capric/Succinic Triglyceride — Light yellowish ~ 260 Neutral, stable oil of high viscosity and with a density of ~ 1.01, based on MCT and
oily liquid succinic acid. Superfatting agent and emulsion stabilizer.

C8 /C10 Esters

MIGLYOL® 840 Propylene Glycol Dicaprylocaprate Ph. Eur., USP-NF Oily liquid * ~ 11 Oil component, high spreading emollient with low viscosity.

Other Esters

DYNACET® 285 Acetylated Monoglycerides GRAS acc. to 21 CFR sect. 172.828 Oily liquid * ~ 30 Food grade softener, plasticizer and solvent. Stable hydrophilic oil.

MIGLYOL 128® NON-GMP Cocoyl Caprylocaprate Ph. Eur. Slightly yellowish ~ 11 Fast spreading emollient, refatting agent.
oily liquid

SOFTISAN® 645 Bis-Diglyceryl Polyacyladipate-1 — Yellowish ~ 6.000 Liquid lanolin substitute, adhesive to skin and wet mucous membranes, suitable for
liquid syrup wound dressing systems and irritated skin, non-occlusive.

* Almost colorless and odorless.

6 | Liquid lipids Liquid lipids | 7

 Solid triglycerides
2 Apart from suppository manufacturing, solid triglycerides (hard fats) are used as carriers in capsule fillings, implants, oint-
ments, creams, and in dental products. They also act as surface treatment and binder in tablets.
precise properties regarding melting point, hydrophilicity (hydroxyl value) and consistency.
All suppository hard fats have a low content of medium-chain fatty acids (C8/C10) except the
Solid triglycerides are manufactured through direct esterification of glycerol with defined fatty acid blends and have there­fore softer adjusted WITEPSOL® H 35.

Product Chemical description/monograph name Listed in Melting Point Hydroxyl value Properties and applications
°C mg KOH/g

Hard fat suppository bases

WITEPSOL® H 5 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 34.0–36.0 max. 5 WITEPSOL® H grades (except H 19) are hard fats with a low hydroxyl value of max. 15.
They comprise mainly of triglycerides with portions of max. 15% of diglycerides and max.
WITEPSOL® H 12 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 32.0–33.5 5–15 1% of monoglycerides.
WITEPSOL® H 19 is a hard fat containing certain amounts of Glyceryl Ricinoleate* (stabilized)
WITEPSOL H 15
®
Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 33.5–35.5 5–15
which lead to a slightly higher hydroxyl value compared to the other H grades.
WITEPSOL H 19
®
Hard Fat + Glyceryl Ricinoleate* (stabilized) — 33.5–35.5 20–30 They are characterized by a small gap between melting and solidification temperatures, show-
ing a low tendency towards posthardening (polymorphism).
WITEPSOL® H 32 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 31.0–33.0 max. 3 Shock cooling should be avoided because of their brittleness.

WITEPSOL® H 35 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 33.5–35.5 max. 3

WITEPSOL H 37
®
Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 36.0–38.0 max. 3

WITEPSOL® W

WITEPSOL® W 25 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 33.5–35.5 20–30 WITEPSOL® W grades are hard fats with hydroxyl values between 20 and 50. They comprise
a mixture of 65–80% of triglycerides, 10–35% of diglycerides and 1–5% of monoglycerides.
WITEPSOL® W 32 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 32.0–33.5 40–50 Correspondingly, they have a wider gap between melting and solidification temperatures
and are therefore more insensitive (elastic) to shock cooling. They solidify more slowly. The
WITEPSOL® W 35 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 33.5–35.5 40–50
amount of partial glycerides delays the sedimentation of solid active ingredients and pro­
WITEPSOL W 45
®
Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 33.5–35.5 40–50 motes wetting of mucous membranes.

WITEPSOL® S

WITEPSOL® S 51 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether US DMF No. 420 30.0–32.0 55–70 WITEPSOL® S grades contain special additives. They are suitable for manufacturing vaginal
+ Glyceryl Ricinoleate* (stabilized) and rectal preparations, requiring a more intensive wetting of mucosae, a greater dispersability,
or an enhanced absorption. They all contain an ethoxylated emulsifier which makes them
WITEPSOL® S 55 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether US DMF No. 420 ~ 35** 50–65 suitable for use in aqueous or ethanolic/aqueous active ingredients (emulsion suppositories).
+ Beeswax

WITEPSOL® S 58 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether US DMF No. 420 31.5–33.0 60–70
+ Glyceryl Ricinoleate* (stabilized)

* Compound contains unsaturated components; interactions with oxygen must be considered. ** Due to additive beeswax, determination of solidification point is recommended.

8 | Solid triglycerides Solid triglycerides | 9

 Solid triglycerides (continued)
2 Important selection criteria are melting point and hydroxyl value. During formulation development, the tendency to the
posthardening (polymorphism) effect should be considered. Our technical application department in Witten will be glad
to advise you.

Product Chemical description/monograph name Listed in Melting Point Hydroxyl value Properties and applications
°C mg KOH/g

Hard fat suppository bases

WITEPSOL® E 75 Hard Fat + Beeswax US DMF No. 420 ~ 38* * max. 15 WITEPSOL® E grades are hard fats with a melting range above body temperature. They can
be used to raise the melting point if active ingredients are processed which will decrease the
WITEPSOL® E 76 Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 37–39 30–40 melting point.
WITEPSOL E 85 ®
Hard Fat, Adeps solidus Ph. Eur., USP-NF, JPE, US DMF No. 420 42–44 5–15

SOFTISAN® 378 Hard Fat, Adeps solidus Ph. Eur., USP-NF ~ 38 7–17 Hard fat with softer consistency, similar to natural lard, but stable, odorless, emollient in
creams, capsule filling mass.

Triglycerides with higher melting point

DYNASAN® 110* Tricaprin — 29–31 max. 10 In powders as fast-melting component and to prevent clumping.

DYNASAN 112 *®
Trilaurin — 43–46 max. 10 In ointments and creams as body-imparting and structure-forming component.

DYNASAN 114 ®
Trimyristin — 55–58 max. 10 A high melting point lipid for use in modified/sustained release in oral solid dosage matrices.
Effective lubricant for tablets/capsules.

DYNASAN® 116 Tripalmitin — 63–68 max. 10 A high melting point lipid for use in modified/sustained release in oral solid dosage matrices.
Effective lubricant for tablets/capsules. Hot melt extrusion, hot melt coating, solid lipid
DYNASAN® 118 Glyceryl Tristearate USP-NF, GRAS acc. to CFR 21 sect. 172.811 69–73 max. 5 nanoparticles.

DYNASAN® P 60 (F) NON-GMP Hydrogenated Palm Oil USP-NF 58–62 max. 10 Palmitic/stearic triglycerides, suitable for hot melt coating, USP type I.

SOFTISAN® 154 Hydrogenated Palm Oil — 53–58 max. 10 Suitable for hot melt coating, similar to hydrogenated vegetable oil.

* Available on demand only, but can be offered in sample volumes. ** Due to additive beeswax, determination of solidification point is recommended.

10 | Solid triglycerides (continued) Solid triglycerides (continued) | 11

 Partial glycerides
3 Partial glycerides are esters of glycerol with fatty acids, whereby only part of the existing hydroxyl groups is esterified. Some
hydroxyl groups within the glycerol ester are free, contributing to the hydrophilic properties of the material. Short-chain partial
glycerides are more hydrophilic and have excellent solvent properties for many poorly soluble drugs.

Product Chemical description/monograph name Listed in Appearance Melting Point Content of Properties and applications
°C monoglycerides

Glyceryl Monostearates (GMS)

IMWITOR® 491 Glyceryl Monostearate USP-NF Off-white powder 66–77 > 90.0% Lipophilic matrix for oral solid dosage forms (granulation, hot
melt technique). Tablet lubricant, emulsion stabilizer, dispers­
ing agent for pigments. More than 90.0% of monoglycerides,
stabilizer, stiffening and dispersing agent.

IMWITOR® 900 (F) P Glycerol Monostearate 40–55%, Type I Ph. Eur., USP-NF* Off-white powder 54–64 40–55% Lipophilic matrix for oral solid dosage forms (granulation, hot
melt technique). 40 to 55% of monoglycerides, used as tablet
lubricant, emulsion stabilizer, dispersing agent for pigments
IMWITOR® 900 K Glycerol Monostearate 40–55%, Type II Ph. Eur., USP-NF* Off-white powder 54–64 40–55%
and for sustained release.

IMWITOR® 960 K Glyceryl Monostearate, self-emulsifying B. P. Flakes 56–61 > 30% Self-emulsifying GMS for dermal use.

Medium-Chain Partial Glycerides

IMWITOR® 308 NON-GMP Glycerol Monocaprylate, Type II Ph. Eur., USP-NF Crystalline solid 27–33 > 80.0% Emulsifier, co-surfactant, excellent antibacterial properties.

IMWITOR® 742 Glycerol Monocaprylocaprate, Type I Ph. Eur., USP-NF Liquid to pasty/solid ~ 25 45.0–75.0% Penetration enhancer, solvent, defoaming agent in
effervescent tablets.

IMWITOR® 928 Glyceryl Cocoate — White, similar to hard fat 33–36 40–55% Dispersing agent for solids and oils, solubilizer in suppositories.

IMWITOR 988 ®
Glycerol Monocaprylate, Type I Ph. Eur., USP-NF Clear, oily liquid ~ 23 45.0–75.0% Penetration enhancer, solvent.

Unsaturated Partial Glycerides

IMWITOR® 948 Glycerol Mono-Oleate Ph. Eur., USP-NF Yellowish, liquid to pasty liquid 32.0–52.0% O/W stabilizer, forms gels in excess water. Contains an antioxidant.

SOFTIGEN® 701 Glyceryl Ricinoleate** (stabilized) — Yellowish, liquid to pasty ~ 25 > 40% Stabilized skin-protective agent, waterdispersible
W/O co-emulsifier.

* USP-NF: “Mono- and Diglycerides”

** Compound contains unsaturated components; interactions with oxygen must be considered.

12 | Partial glycerides Partial glycerides | 13

4 Emulsifiers

Product Chemical description/monograph name Listed in Appearance HLB value Properties and applications

W/O Emulsifiers (see also partial glycerides)

IMWITOR® 600 NON-GMP Polyglyceryl-3 Polyricinoleate — Yellow to ~4 FCC-compliant W/O emulsifier for systems of low viscosity.
brownish liquid

O/W Emulsifiers

IMWITOR® 491 Glyceryl Monostearate USP-NF Off-white powder ~4 Lipophilic matrix for oral solid dosage forms (granulation, hot melt technique). Tablet lubricant,
emulsion stabilizer, dispersing agent for pigments. More than 90.0% of monoglycerides, stabilizer,
stiffening and dispersing agent.

IMWITOR® 900 (F) P Glycerol Monostearate 40–55%, Type I Ph. Eur., USP-NF Off-white powder ~3 Lipophilic matrix for oral solid dosage forms (granulation, hot melt technique). 40 to 55% of
monoglycerides, used as tablet lubricant, emulsion stabilizer, dispersing agent for pigments and
IMWITOR® 900 K Glycerol Monostearate 40–55%, Type II Ph. Eur., USP-NF Off-white powder ~3 for sustained release.

IMWITOR® 960 K Glyceryl Monostearate, self-emulsifying B. P. Flakes 9–12 Self-emulsifying GMS, for dermal use.

IMWITOR® 372 P Glyceryl Stearate Citrate — Light brownish 10–12 Partly ionic, still oil-soluble emulsifier, similar to lecithin for stable emulsions
flakes at pH range 4 to 7.

IMWITOR® 375 Glyceryl Citrate/Lactate/Linoleate/Oleate — Yellow to brown­ ~ 11 Suitable for use in the preparation of SMEDDS. Partly ionic, still oil-soluble emulsifiers, similar
ish sticky liquid to lecithin for stable emulsions at pH range 4 to 7.

14 | Emulsifiers Emulsifiers | 15
5 Specialties
Fatty acid esters, further modified or compounded, help creating specific pharmaceutical formulations.

Product Chemical description/monograph name Listed in Appearance Melting point Properties and applications
°C

Special Esters

MIGLYOL® Gel B Triglycerides, Medium-Chain — Oleogel, brownish softpaste —

(and) Stearalkonium Hectorite
(and) Propylene Carbonate

MIGLYOL® Gel 840 B Propylene Glycol Dicaprylocaprate — Oleogel, brownish softpaste — Heat-stable oleogel, maintains viscosity between 0 °C and 100 °C, e.g. for
Dicaprate (and) Stearalkonium water and temperature-resistant formulations. Soft lamellar structure for easy
Hectorite (and) Propylene Carbonate distribution on skin. Consistency and viscosity stabilizer in emulsions.

MIGLYOL® Gel T Triglycerides, Medium-Chain — Oleogel, greenish softpaste —

(and) Stearalkonium Bentonite
(and) Propylene Carbonate

DYNACET® 285 Acetylated Monoglycerides GRAS acc. to 21 CFR sect. 172.828 Oily liquid — Food grade softener, plasticizer, and solvent. Stable hydrophilic oil.

SOFTISAN® 601 Glycerides, C12-C18 mono- and di-, Glyceryl Stearate, — Off-white soft pastilles 40–45 Water-free self-emulsifying system, ready-to-use O/W cream base, suitable to
PEG-4, Polyoxyethylene (25) Cetyl Stearyl Ether, process a variety of pharmaceutical active ingredients.
PEG-32, PEG-6, Medium-Chain Triglycerides,
Glyceryl Ricinoleate* (stabilized)

SOFTISAN® 645 Bis-Diglyceryl Polyacyladipate-1 — Yellowish liquid syrup — Liquid lanolin substitute, adhesive to skin and wet mucous membranes, suit­
able for wound dressing systems and irritated skin, non-occlusive.

SOFTISAN® 649 Bis-Diglyceryl Polyacyladipate-2 — Off-white opaque mass ~ 35 Semi-solid lanolin substitute, adhesive to skin and wet mucous membranes,
suitable for wound dressing systems and irritated skin, non occlusive.

SOFTIGEN® 701 Glyceryl Ricinoleate* (stabilized) — Yellowish, liquid to pasty ~ 25 Stabilized skin-protective agent, water-dispersible W/O co-emulsifier.

SOFTIGEN® 767 Macrogol-6 Glycerol Caprylocaprate Ph. Eur. Clear liquid ~ 14 Suitable for use in the preparation of SEDDS. Solubilizer for drugs, wetting
and refatting agent. Soluble in water and hydrophilic oils (e.g. MCT oil).

* Compound contains unsaturated components; interactions with oxygen must be considered.

16 | Specialties Specialties | 17
6 Register
of chemical/monograph names

Chemical/monograph name Product Page Chemical/monograph name Product Page

A Acetylated Monoglycerides DYNACET® 285 6, 16 H Hard Fat, Adeps solidus WITEPSOL® H 5, H 12, H 15, H 32, H 35, H37 8, 10
WITEPSOL® W 25, W 32, W 35, W 45
WITEPSOL® E 76, E 85
B Bis-Diglyceryl Polyacyladipate-1 SOFTISAN® 645 6, 16
SOFTISAN® 378
Hard Fat + Beeswax WITEPSOL® E 75 10
Bis-Diglyceryl Polyacyladipate-2 SOFTISAN 649®
16
Hard Fat + Polyoxyethylene (25) WITEPSOL® S 55 8
Cetyl Stearyl Ether + Beeswax
C Caprylic/Capric/Linoleic Triglyceride MIGLYOL® 818 6
Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether WITEPSOL® S 58, S 51 8
Caprylic/Capric/Succinic Triglyceride MIGLYOL 829®
6 + Glyceryl Ricinoleate* (stabilized)

Cocoyl Caprylocaprate NON-GMP MIGLYOL® 128 6 Hard Fat + Glyceryl Ricinoleate* (stabilized) WITEPSOL® H 19 8

Hydrogenated Palm Oil NON-GMP DYNASAN P 60 (F)

®
10

G Glycerides, C12-C18 mono- and di-, Glyceryl Stearate, SOFTISAN® 601 16 Hydrogenated Palm Oil SOFTISAN® 154 10
PEG-4, Polyoxyethylene (25) Cetyl Stearyl Ether,
PEG-32, PEG-6, Medium-Chain Triglycerides,
Glyceryl Ricinoleate* (stabilized) M Macrogol-6 Glycerol Caprylocaprate SOFTIGEN® 767 16

Glycerol Monocaprylate, Type I IMWITOR 988®

12 Medium-Chain Triglyceride MIGLYOL® 810 N, 812 N Drug Substance, 812 N Excipient 6

Glycerol Monocaprylate, Type II NON-GMP IMWITOR® 308 12 Medium-Chain, Triglyceride MIGLYOL® GEL T 16
(and) Stearalkonium Bentonite
Glycerol Monocaprylocaprate, Type I IMWITOR® 742 12
(and) Propylene Carbonate
Glycerol Mono-Oleate IMWITOR 948®
12
Medium-Chain, Triglyceride MIGLYOL® GEL B 16
Glycerol Monostearate 40–55%, Type I NON-GMP IMWITOR 900 (F) P
®
12, 14 (and) Stearalkonium Hectorite
(and) Propylene Carbonate
Glycerol Monostearate 40–55%, Type II IMWITOR® 900 K 12, 14

Glyceryl Citrate/Lactate/Linoleate/Oleate IMWITOR® 375 14

Glyceryl Cocoate IMWITOR 928®

12
P Polyglyceryl-3 Polyricinoleate NON-GMP IMWITOR® 600 14

Propylene Glycol Dicaprylocaprate MIGLYOL® Gel 840 B 16

Glyceryl Monostearate IMWITOR® 491 12, 14
Dicaprate (and) Stearalkonium
Glyceryl Monostearate, self-emulsifying IMWITOR® 960 K 12, 14 Hectorite (and) Propylene Carbonate

Glyceryl Ricinoleate* (stabilized) SOFTIGEN® 701 12, 16 Propylene Glycol Dicaprylocaprate MIGLYOL® 840 6

Glyceryl Stearate Citrate IMWITOR 372 P

®
14

Glyceryl Tristearate DYNASAN 118 ®

10 T Tricaprin ** DYNASAN® 110 10

Tricaprylin MIGLYOL® 808 6

* Compound contains unsaturated components; interactions with oxygen must be considered. Trilaurin ** DYNASAN® 112 10

Trimyristin DYNASAN 114®

10

Tripalmitin DYNASAN 116®

10

** Available on demand only, but can be offered in sample volumes.

18 | Register of chemical/monograph names Register of chemical/monograph names | 19
7 Register
of trademarks and product names

Product Chemical/monograph name Page Product Chemical/monograph name Page

D DYNACET® 285 Acetylated Monoglycerides 6, 16 M MIGLYOL® 128 NON-GMP Cocoyl Caprylocaprate 6

DYNASAN® 110* Tricaprin 10 MIGLYOL® 808 Tricaprylin 6

DYNASAN® 112* Trilaurin 10 MIGLYOL® 810 N Medium-Chain Triglyceride 6

DYNASAN 114 ®
Trimyristin 10 MIGLYOL 812 N Drug Substance
®
Medium-Chain Triglyceride 6

DYNASAN 116 ®
Tripalmitin 10 MIGLYOL 812 N Excipient
®
Medium-Chain Triglyceride 6

DYNASAN® 118 Glyceryl Tristearate 10 MIGLYOL® 818 Caprylic/Capric/Linoleic Triglyceride 6

DYNASAN® P 60 (F) NON-GMP Hydrogenated Palm Oil 10 MIGLYOL® 829 Caprylic/Capric/Succinic Triglyceride 6

MIGLYOL 840 ®
Propylene Glycol Dicaprylocaprate 6

I IMWITOR 308 ®
NON-GMP Glycerol Monocaprylate, Type II 12 MIGLYOL® Gel 840 B Propylene Glycol Dicaprylocaprate 16
Dicaprate (and) Stearalkonium
IMWITOR® 372 P Glyceryl Stearate Citrate 14 Hectorite (and) Propylene Carbonate
IMWITOR® 375 Glyceryl Citrate/Lactate/Linoleate/Oleate 14
MIGLYOL® Gel B Medium-Chain, Triglyceride 16
IMWITOR 491 ®
Glyceryl Monostearate 12, 14 (and) Stearalkonium Hectorite
(and) Propylene Carbonate
IMWITOR® 600 NON-GMP Polyglyceryl-3 Polyricinoleate 14
MIGLYOL® Gel T Medium-Chain, Triglyceride 16
IMWITOR® 742 Glycerol Monocaprylocaprate, Type I 12
(and) Stearalkonium Bentonite
IMWITOR® 900 (F) P Glycerol Monostearate 40-55, Type I 12, 14 (and) Propylene Carbonate

IMWITOR 900 K
®
Glycerol Monostearate 40-55, Type II 12, 14

IMWITOR® 928 Glyceryl Cocoate 12 S SOFTIGEN® 701 Glyceryl Ricinoleate 12, 16

IMWITOR® 948 Glycerol Mono-Oleate 12 SOFTIGEN® 767 Macrogol-6 Glycerol Caprylocaprate 16

IMWITOR® 960 K Glyceryl Monostearate, self-emulsifying 12, 14 SOFTISAN® 154 Hydrogenated Palm Oil 10

IMWITOR 988 ®
Glycerol Monocaprylate, Type I 12 SOFTISAN 378 ®
Hard Fat, Adeps solidus 10

SOFTISAN® 601 Glycerides, C12-C18 mono- and di-, Glyceryl 16

Stearate, PEG-4, Polyoxyethylene (25) Cetyl
* Available on demand only, but can be offered in sample volumes. Stearyl Ether, PEG-32, PEG-6, Medium-Chain
Triglycerides, Glyceryl Ricinoleate** (stabilized)

SOFTISAN® 645 Bis-Diglyceryl Polyacyladipate-1 6, 16

SOFTISAN® 649 Bis-Diglyceryl Polyacyladipate-2 16

** Compounds contain unsaturated components; interactions with oxygen must be considered.

20 | Register of trademarks and product names Register of trademarks and product names | 21
7 Register
of trademarks and product names

Product Chemical/monograph name Page

W WITEPSOL® E 75 Hard Fat + Beeswax 10

WITEPSOL® E 76 Hard Fat, Adeps solidus 10

WITEPSOL® E 85 Hard Fat, Adeps solidus 10

WITEPSOL H 5 ®
Hard Fat, Adeps solidus 8

WITEPSOL H 12®
Hard Fat, Adeps solidus 8

WITEPSOL® H 15 Hard Fat, Adeps solidus 8

WITEPSOL® H 19 Hard Fat + Glyceryl Ricinoleate* (stabilized) 8

WITEPSOL H 32®
Hard Fat, Adeps solidus 8

WITEPSOL H 35®
Hard Fat, Adeps solidus 8

WITEPSOL® H 37 Hard Fat, Adeps solidus 8

WITEPSOL® S 51 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether 8

+ Glyceryl Ricinoleate* (stabilized)

WITEPSOL® S 55 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether 8

+ Beeswax

WITEPSOL® S 58 Hard Fat + Polyoxyethylene (25) Cetyl Stearyl Ether 8

+ Glyceryl Ricinoleate* (stabilized)

WITEPSOL® W 25 Hard Fat, Adeps solidus 8

WITEPSOL W 32®
Hard Fat, Adeps solidus 8

WITEPSOL® W 35 Hard Fat, Adeps solidus 8

WITEPSOL® W 45 Hard Fat, Adeps solidus 8

* Compound contains unsaturated components; interactions with oxygen must be considered.

All registered trademarks displayed in this brochure are the property of the IOI Oleochemicals Group. Users of this brochure
are not permitted to use these trademarks without the prior written consent of their proprietor. All rights are reserved. All
rights not expressly granted are reserved.

We reserve the right to make any changes as a result of technological progress or developments. No guarantee or warranty
is implied or intended as to any particular properties of our products. The customer is not exempted from the obligation
to conduct careful inspection and testing of incoming goods. Reference to trademarks used by other companies is neither
a recommendation, nor should it give the impression that products of other companies cannot be used. All IOI Oleochemicals
business transactions are exclusively governed by our General Business Terms and Conditions – please see www.ioioleo.de
(Terms and Conditions)

22 | Register of trademarks and product names Register of trademarks and product names | 23
 Contact
IOI Oleo GmbH
Hamburg, Germany | +49 40 28 00 31-0 | pharma@ioioleo.de | www.ioioleo.de