THE CATHOLIC UNIVERSITY OF EASTERN AFRICA

CHD 125: MEDICAL MICROBIOLOGY AND PARASITOLOGY

CAT 1
TIME: 1 HOUR DATE: 22-10-2019

Instructions:
 Write your REGISTRATION NUMBER, COURSE, COURSE CODE and DATE.
 Answer all questions on the answer sheet provided.
 All questions are compulsory.
PART I: MULTIPLE CHOICE QUESTIONS (15 MARKS)
1. Which scientist is most responsible for finally laying the theory of spontaneous generation to
rest?
A. Joseph Lister
B. Francesco Redi
C. Robert Koch
D. Louis Pasteur
2. If you are asked to sterilize a heat sensitive item which of the following would be most
suitable?
A. Steam autoclave
B. Pasteurization
C. Ethyl Alcohol
D. Hot air oven
3. Bacteria that grow at 25-40°C are termed as ____
A. Psychrophiles
B. Mesophiles
C. Halophiles
D. Commensals
4. Superoxide dismutase is an enzyme that catalyzes the conversion of oxygen radicals to
peroxides. Which groups of organisms do not have this enzyme?
A. Aerobes
B. Facultative anaerobes
C. Strict anaerobes
D. Aerotolerant anaerobes
5. Which of the mentioned structure is not a part of gram-positive bacteria cell wall?
A. Lipopolysaccharide
B. Peptidoglycan
C. Teichoic acid
D. N-acetylmuramic acid
6. What is the primary characteristic used in laboratory diagnosis of tuberculosis? The
A. Gram stain in conjunction with the typical morphology
B. acid-fast stain in conjunction with typical morphology
C. morphology of tubercle bacilli
D. slow rate of growth

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7. Which of the following is a characteristic symptom of cholera?
A. Relapsing fever
B. Rice-water stools with the extensive loss of fluid
C. Extreme jaundice
D. Blood in respiratory tract secretions
8. The ability to obtain carbon for growth from organic compounds defines our microorganism
as a(n):
A. Phototroph
B. Heterotroph
C. Autotroph
D. Chemotroph
9. A child is diagnosed with Pertussis. How was this infection acquired?
A. Release of oral flora into the bloodstream by dental work.
B. Contact with livestock or animal products such as leather or wool.
C. Consumption of dairy products made from unpasteurized milk
D. Inhalation of respiratory droplets of another human being.
10. A 67-year-old man with chronic pulmonary disease develops pneumonia caused by
Streptococcus pneumoniae. What is the most important virulence factor of this bacterium? A
A. polysaccharide capsule
B. variety of secreted proteases
C. surface protein which inhibits complement activation
D. Protein fimbriae which attach bacteria tightly to lung epithelial cells
11. Traveler’s diarrhea is caused by ____
A. Enteropathogenic E. coli
B. Enteroinvasive E. coli
C. Enterotoxigenic E. coli
D. Enterohemorrhagic E. coli
12. Which of the following regarding BCG (Bacillus-Calmette-Guerin) vaccine, is false? It
A. contains a strain of avirulent Mycobacterium bovis
B. is administered intravenously
C. produces some protection against pulmonary tuberculosis
D. reduces the incidence of milliary and tuberculous meningitis in children
13. What is the colonization site of Corynebacterium diphtheriae?
A. Skin
B. Urethra
C. Eye
D. Throat
14. Virulence of microorganisms is not determined by ____
A. Ability to adhere and colonize
B. Host temperature and pH
C. Invasiveness
D. Ability to evade host defense mechanisms

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15. Virulence is a term means ____
A. Degree of pathogenity
B. Ability of microorganism to cause disease
C. Ability of an organism to debilitate n host
D. Ability to adhere to a host

PART II: ESSAY QUESTIONS (15 MARKS)

16. With the aid of a well labeled diagram, indicate 5 parts on the general structure of a bacteria
cell (5 Marks)
17. Explain the contribution of the following development of microbiology (5 Marks)
a) Edward Jenner
b) Louis Pasteur
c) Robert Koch
18. Describe the process of gram staining (5 Marks)