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Antimicrobials in a nutshell

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Dr. Nikita Nanwani Nathani


MBBS,MD,DNB (Radiodiagnosis)
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All drugs inhibiting protein synthesis are
bacteriostatic except aminoglycosides
and streptogramins.

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A 19-year-old man presents to the emergency room with a
severe headache, photophobla, and a stiff neck. After a
lumbar puncture, the patient is diagnosed with bacterial
meningitis. Which of the following cephalosporins is most
appropriate for empiric treatment?

IAI Cefazolin

(Bl Cefepine

(Cl Ceftriaxone

(DI Cefuroxime

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A 35-year-old woman with a history of type 2 diabetes
presents to her primary care physician with fever and dysuria.
She is started on a medication that has the potential to cause
tendon rupture. What is the mechanism of action for the drug
that was started?
Inhibition of bacterial cell wall synthesis

(B) Inhibition ofDNA gyrase

(C) Inhibition of RNA synthesis

(D) Inhibition of the 30s ribosome

(E) Inhibition of the 50s ribosome

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A 45-year-old man presented to the hospital 3 days ago with
severe cellulitis and a large abscess on his left leg. Incision and
drainage were performed on the abscess, and cultures revealed
methicillin-resistant Staphylococcus aureus. Which is the most
appropriate treatment option for once-daily outpatient
intravenous therapy in this patient?
Ertapenem

B. Ceftaroline

C. Daptomycin

D. Piperacillinltazobactam

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A 72-year-old man is admitted to the hospital from a nursing home
with severe pneumonia. He was discharged from the hospital 1
week ago after open heart surgery. The patient has no known
allergies. Which of the following regimens is most appropriate for
empiric coverage of methicillin-resistant Staphylococcus au reus
and Pseudomonas aeruginosa in this patient?
A. Vancomycin + cefepime + ciprofloxacin

B. Vancomycin + cefazolin + ciprofloxacin

C. Telavancin + cefepime + ciprofloxacin

D. Daptomycin + cefepime + ciprofloxacin

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Anti tubercular drug which acts by inhibiting DNA dependent RNA
polymerase

a) Rifampicin
b) INH
c) Prazinamide
d) Ethambutol

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Which of the following cephalosporins has activity against gram-negative
anaerobic pathogens like Bacteroides fragilis?

Cefoxitin

B. Cefepime

C. Ceftriaxone

D. Cefazolin

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