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Abstract
Objective:
The aim of this study was to evaluate the clinical and histopathological effects of two
different dosages of alcohol extract of Tarantula cubensis (Theranekron) on open wounds.
Method:
A total of 24 Sprague-Dawley rats were randomly divided into Tarantula cubensis extract
(TCE1, n=8) 1/10 diluted, TCE (TCE2, n=8), and (3) vehicle-control (0.2 ml of 96 %
ethanol, n=8) groups. Experimental full-thickness 1 x 1cm wounds were created on dorsum
skin. TCE or vehicle were given systemically by subcutaneous injections on postoperative
days 1 and 4. Wound planimetry and procurement of biopsies was performed on days 4, 8,
12 and 16.
Results:
The mean non-epithelialised wound area in the vehicle-control group was significantly
larger than in the TCE1 group on days 4, 8, 12 and 16, and in the TCE2 group on days 8, 12
and 16 (p<0.05). The mean percentage of wound contraction was significantly higher in the
TCE1 and TCE2 groups than in the vehicle control group on days 8, 12 and 16 (p<0.05).
Histopathologically, wound healing was characterised by a significant decrease in the
neutrophil counts and a significant increase in neovascularisation; neither were effected by
TCE.
Conclusion:
Our results suggest that alcohol extract of Tarantula cubensis accelerates epithelialisation
and, thus, has beneficial effects on open wound healing in rats.
https://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2017.26.2.66
PMID: 26143454
DOI: 10.1016/j.homp.2015.02.005
Abstract
Introduction: Aflatoxins are toxic fungal metabolites that have adverse effects on
humans and animals. Tarantula cubensis D6 is used as a homeopathic medicine for
different purposes. The present study investigates the effects of Tarantula cubensis
D6 on the oxidant-antioxidant balance and some biochemical parameters against
exposure to aflatoxin.
Copyright © 2015 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights
reserved.
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MeSH terms
Aflatoxins / antagonists & inhibitors*
o
o
o
Aflatoxins / toxicity
o
o
o
Animals
o
o
o
Antioxidants / pharmacology
o
o
o
Antioxidants / therapeutic use*
o
o
o
Female
o
o
o
Oxidative Stress / drug effects*
o
o
o
Rats
o
o
o
Rats, Sprague-Dawley
o
o
o
Spider Venoms / pharmacology
o
o
o
Spider Venoms / therapeutic use*
o
o
o
Substances
Aflatoxins
Antioxidants
Spider Venoms
https://pubmed.ncbi.nlm.nih.gov/26143454/