DEPARTMENT OF CHEMICAL PATHOLOGY 2019-2020

AIM:
1. To produce doctors that will apply knowledge attained in Phase 1 (Physiology and Biochemistry) to investigate pathologies of body
functions and systems to support diagnosis and treatment monitoring for the management of patients.
2. To produce doctors who will be able to utilize Biochemical tests in diagnosis, prognosis, monitoring and screening in modern
medicine.

COURSE CONTENT.
SN TITLE COURSE CONTENT TIME STATUS FACULTY
(hrs)**
1 Introduction to Clinical Investigations-, Discretionary tests, profile & 3 COMPLETED Dr I Wurie
concept of screening tests, Establishing diagnosis, the
Chemical management of illness, Specimen Management,
Pathology Constraints in the interpretation of laboratory test normal
values.

2 Disturbances of Investigations in disordered K+ metabolism, Fluid and 6 COMPLETED

water and electrolyte balance in surgical patients, Acid-base
Electrolyte balance and oxygen transport; Renal mechanisms for
balance and HCO3- re-absorption and H+ excretion; Respiratory
Acid base insufficiency
Balance
3 Disorders of Calcium homeostasis; Hyper / Hypo-calcaemia; 6 COMPLETED

1
 calcium, Metabolic bone disease; Phosphate metabolism;
phosphate and Magnesium metabolism.
magnesium
metabolism

4 Chemical Anterior pituitary disease and its investigation; Posterior 6 ONGOING

Pathology of pituitary hormones; Thyroid hormone synthesis action
the Endocrine and metabolism; Abnormalities of thyroid function;
Disorders of the adrenal cortex and medulla;
Investigation of gonadal function infertility; menstrual
irregularities and hirsutism; Inherited adrenocortical
enzyme defects.

5 PAEDIATRIC Apoptosis; Inherited metabolic disease; Age related 3 Dr I Wurie

AND ELDERLY investigations and effect/impact

6 Central CSF composition and examination, Differential diagnosis 6 COMPLETED

nervous and interpretation, Referral for non-chemical pathology,
systems and Monitoring.
cerebrospinal
fluids:

7 Chemical Impaired renal function, Biochemical tests of renal 6 COMPLETED Dr I Wurie

Pathology of function, Impaired Glomerulus and Tubular functions,
the kidney Plasma creatinine and urea levels, Renal disorders-
Diseases: acute and chronic renal failures- biochemical profile,

2
 Management of chronic renal failure, Syndromes
reflecting predominant tubular damage, Renal calculi
and Proteinuria.
8 Carbohydrate Diabetic Mellitus and Hypoglycaemia, Glucose 6 COMPLETED Dr I Wurie
metabolism homeostasis, Lactic acidosis and ketosis, Measurement
disorders: of blood glucose, Hyperglycaemia and diabetes mellitus
types, Metabolic features of diabetes mellitus, diagnosis,
Acute metabolic complications of diabetes, Hypo
glycaemia, cause and diagnosis.

9 Cardio Diagnosis of MI, Thromboembolic disease, Plasma and 6

Vascular cardiac enzymes, cardiovascular risk factors, Plasma
Disorder: lipids and lipoproteins abnormalities, Disorders of
plasma lipids and lipoproteins, Laboratory practical on
plasma lipids and lipoproteins.

10 Liver functions Impaired liver function, bilirubin metabolism, disorders 6 COMPLETED

and diseases of bile pigment metabolism, jaundice and its
classification, scope of tests used in liver disease,
biochemical changes in individual liver disease,
congenital hyperbilirubinaemia, metabolic liver disease,
bile acids and gall stones.

11 Gastrointestina Stomach, Pancreas, Small intestine and colon, Mal- 6 COMPLETED

l tract disease: absorption and diarrhoea.

3
12 Nutrition in Dietary constituent, Assessment of nutritional status, 3
Chemical Major nutrition abnormality, abnormal derivatives of
pathology and hemoglobin (INTEGRATION)
Disorder of iron
and
Prophyrins:
13 Impaired Purine Uric Acid Nitrogenous compounds, Purine metabolism 6 COMPLETED
metabolism: and uric acid, Non-protein nitrogen constituents of the
blood and urine, Nitrogen balance ( hypo/ hyper
uricaemia), Disorders of uric acid metabolism- gout and
pseudo-gout - investigations and diagnosis.

14 Toxicology: Therapeutic drugs monitoring (TDM), Poisoning effect 6

and investigations, Occupational and industrial Hazards

PRACTICAL/CASE STUDIES SESSIONS:

AIM: To provide knowledge and skills required to enable students perform basic Clinical Chemistry
and interpretation of related Pathologies

OUTCOMES
1. Perform disease specific investigations
2. Identify biomarkers to support differential diagnosis
3. Interpret test result and link with clinical signs

Chemical Pathology of the kidney Diseases - Biochemical tests of renal 3hr 1400 - 1730
function eGFR

4
 Metabolic bone disease - – Calcium load extimation and interpretation 3hr 1400 - 1730

Carbohydrate metabolism disorders - Measurement of blood glucose and 2hr 1400 - 1730
glucose tolerance test, Urine glucose chemistry

Cardio Vascular Disorder - 3hr 1400 - 1730

Liver functions and diseases - Impaired liver function (determination of 3hr 1400 - 1730
Proteins; Bilirubin, liver enzymes)

Gastrointestinal tract disease – 6hr 1400 - 1730

Disorders of uric acid metabolism - gout - investigations and diagnosis

NOTES TO FACULTY:

1. To review department power-point presentation format forwarded by Acting HOD

2. Submit lecture power point presentation in format for review and compilation to be copied for students
3. To submit 50 MSQs and 25 SAQs for each topic at the start of the course for compilation in the question pool.
4. Submit practical sessions guidelines
5. To attend schedule department review meeting. ( scheduled to be agreed upon by all.)