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Q.2: Define drug adulteration and drug evaluation. Enlist methods of drug evaluation.
Answer:
Adulteration –
The term adulteration is defined as substituting original crude drug partially or wholly with other
similar looking substances. The substance, which is mixed, is free from or inferior in chemical and
therapeutic property.
Drug Evaluation –
Evaluation of crude drug means confirmation of identity, determination of purity and quality and
detection of nature of adulterant.
b. pseudo alkaloids
Diterpene -Aconitine
c. proto alkaloids
Alkylamine- Ephedrine, Colchicine
Q.2 : Define drug evaluation with different methods of drug evaluation in detail with
examples.
Answer: Evaluation of drug means confirmation of its identity and determination of its quality and
purity and detection of nature of adulteration.
The evaluation of crude drug is necessary because of three reason:
1. Biochemical variation in the drug
2. Deterioration due to treatment and storage
3. Substitution and adulteration, as a result of carelessness, ignorance or fraud
Methods of drug evaluation: The different techniques involved in standardization of crude
drugs are as follows:
· Organoleptic evaluation
· Microscopic evaluation
· Physical evaluation
· Chemical evaluation
· Biological evalution
1. Organoleptic Evaluation: In this method the morphological characters are studied
like size, shape, color, odor, taste
For eg – Quills of cinnamon, Conical shape of aconite, Ribbon shape of tragacanth
2. Microscopic Evaluation: In this method microscopic characters were studied like cell
content in crude drugs like lignin, starch grains, calcium oxalate crystals, aleurone grains.
Also studied about the stomata, trichomes etc.
For eg – Lignified trichomes of Nux Vomica, Covering trichomes of senna, Wavy walls of
medullary rays in cascara bark.
3. Physical Evaluation: There are various physical parameters by which the drug can be
evaluated.
o Moisture content – The percentage of active constituent in crude drug is
mentioned on air dried basis, so moisture content should be determined and
controlled.
For eg: Moisture content of Digitalis is NMT 10%
Moisture content of Aloe is NMT 05%
o Viscosity – It is an important diagnostic character in physical evaluation of liquid
chemical constituent.
For eg: Liquid Paraffin – NLT 64 centistokes
o Melting Point – Used to determine the purity of crude drug.
For eg : Kokum Butter – 39-420C
Bees wax – 62 - 650C
o Solubility
o Refractive Index
o Optical rotation
o Ash value
o Extractive value
4. Chemical evaluation: This method of evaluation is mainly related to chemical
constituent of crude drug This method consist of 3 methods
1. Chemical test Method – Qualitative test and Quantitative Test
2. Chemical assay Method
3. Physical Chemical assay Method
5. Biological evaluation: When the potency of crude drug is carried out on living organisms
like bacteria, fungal growth, animal tissue or entire animal. This is known as Bioassay. There
are three methods in this method.
1. Toxic Method
2. Symptomatic Method
3. Tissue Method
UNIT – II
Chapter Outline
Study of Laxative drugs, Cardiotonic drugs, Carminative drugs, Astringent drugs, drugs act
on Nervous system, Antihypertensive drug, Antitussive drugs
Review questions /comprehensive questions
Multiple Choice Questions
Note: All questions carry 01 mark each.
Q.1 : “Foeniculumvulagare” is the biological source of which drug.
a) Coriander
b) Fennel
c) Ajwain
d) Cinnamon
Q.2 : Which drug acts as laxative.
a) Ajwain
b) Fennel
c) Isapgol
d) Digitalis
Q.3 : Cinnamon Belongs to which family
a) Lauraceae
b) Umbellifarae
c) Scrophularaceae
d) Liliaceae
Q.4 : Aloe belongs to which family
a) Lauraceae
b) Umbellifarae
c) Scrophularaceae
d) Liliaceae
Q.5 : The important chemical constituents of rauwolfia is
a) Reserprine
b) Resercinnamine
c) Ajmalicine
d) Desperidine
Q.6 : Biological source of Nux vomica
a) Styrchnousnux vomica
b) StrychnousPotatorum
c) Strychnousnuxblanda
d) Strychnouswallichiana
Q.7 : Which drug is used as antitussive
a) Tulsi
b) Vasaka
c) Both a & b
d) None
Q.8 : Anethole and Fenchone are present in volatile oil obtained from
a) Fennel
b) Cardamom
c) Cinnamon
d) Caraway
Q.9 : Biological source of Isapgol
a) Plantagoovata
b) Aeglemarmelous
c) Gelidiumamansii
d) Carumcarvi
Q.10 : “Food of the god” is synonym of which drug
a) Caraway
b) Nutmeg
c) Asafoetida
d) Fennel
ANSWERS
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Chemical Constituent – Fennel contains volatile oil. The Volatile oil contains anethole,
fenchone and also contains fixed oil and proteins.
2. Isapgol:
Common Name: Isapghula, Psyllium
Biological Source: It consists of dried seeds and husk of “Plantagoovata”.
Family: Plantaginaceae
Geographical Source:It is cultivated in Gujarat, Punjab and Rajasthan.
Macroscopic Characters:
o Color – Pinkish grey- brown
o Odor - Odorless
o Taste – Characteristics
Chemical Constituent – It contains arabinose, uronic acid, xylose, Ribose, Galactose
3. Digitalis:
Common Name: Foxglove leaves
Biological Source: It consists of dried leaves of “Digitalis Purpurea”.
Family: Scrophularaceae
Geographical Source:It is cultivated in India, North America, England, Holland
Macroscopic Characters:
o Color – dark greyish green
o Odor - Slight
o Taste – Bitter
o Size - 10-14 cm.* 4-15 cm.
Uses – Used in the treatment of congestive heart failure, also used in atrial fibrillation,
supraventricular tachycardia, diuretic effect also.
Q.2 : Write biological source, family, macroscopic character, chemical constituent and
uses of any two drugs:
a. Belladonna
b. Vasaka
c. Ephedra
Answer: 1. Belladonna:
Common Name: Deadly night shade leaf, belladonna leaf
Biological Source: It consists of dried or fresh leaves, flowering and fruiting tops of “Atropa
belladonna”.
Family: Solanaceae
Geographical Source:It is cultivated in India, South Europe, Germany, England.
Macroscopic Characters:
o Color – Green to brownish green
o Odor - Characteristics
o Taste – Bitter and acrid
o Size - 5-25* 2.5-12 cm.
Uses – Used as sympathomimetic in asthma, used in hay fever, bronchitis and hay fever.
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Q.2 : Write down the chemical constituent and uses of ipecac and ergot .
Answer: 1. Ipecac:
Chemical Constituents – It contains isoquinoline type of alkaloids like Cepahaline,
Psycotrine, Psycotrine methyl ester and emetine. It also conatinsipecacuanhic acid,
glycoside, starch, phytosterol, citric acid, fat and calcium oxalate.
Uses – Used as expectorant in small doses and emetic in higher doses. It also used in the
treatment of dysentery. It is also used as antitumour.
2. Ergot:
Chemical Constituents – It contains ergometrine, ergometrinine, ergotamine, ergosine,
ergotoxine, ergocryptine, ergocristine.
Uses –Ergometrine has oxytocic action. They are used in labour to assist delivery and to
reduce postpartum hemorhhage. Ergotamine is used in migraine.
Q.4 : Write biological source, family, chemical constituent and uses of guggul.
Answer:Guggul
Biological source: It is an oleo gum resin obtained by incision obtained by incision from
the bark of “Commiphoramukul”.
Family: Burseraceae
Chemical Constituent: It contain resin contains steroids Guggulosteron I,II,III,
Guggulosterons Z & E. It also contains pentosan, pentose and furfural.
Uses: 1. Used in essence sticks.
2. Used as anti-inflammatory, diuretic, antihypertensive, srtomachic, hypolipidemic and
antifertility activity.
3. Used in treatment of osteoarthrirtis, frozen shoulders, sciatica and dental infections.
4. Used in neurological disorders, antispasmodic, hay fever, anemia, syphilis, thyroid
disorders.
Long Answer Questions
Note: All questions carry 10 marks each.
Q.1 : Write a detail account on antimalarial drugs.
Answer:Malaria is a widespread infectious disease. The causative organism of malaria are species
of Plasmodium. Four species of Plasmodium namely P.ovale, P. vivax, P.falcipuram, P.
malaria.
Cinchona:
Synonym: Peruvian bark, Jesuits bark
Biological Source: It is dried bark of “Cinchona calisaya, Cinchona officinalis, Cinchona
succirubra, Cinchona ledgiriana”
Family:Rubiaceae
Geographical source: It is cultivated in java, peru, India, Nilgiri, Darjeling.
Macroscopic Characters:
o Colour: Brown
o Odour: Slight
o Taste: Astringent and Bitter
Chemical Constituents: It contains quinoline alkaloids like quinine, quinidine, cinchonine,
cinchonidine, cinchonicine, hydroquinine.
Uses:1. Quinine is used as antimalarial, bitter stomachic, Antipyretic.
2. Quinidine is antiarrythmic, in treatment of atrial fibrillation.
Q.2 : Write biological source, family, macroscopic character, chemical constituent and
uses of any two drugs:
a. Neem
b. Colchicum
c. Myrrh
Answer:1. Neem:
Common Name: Indian lilac, Neem tree
Biological Source: It consists of aerial parts of “Azadiractaindica”.
Family: Meliaceae
Geographical Source:It is cultivated in India, tropical and subtropical countries of the world.
Macroscopic Characters:
o Color – Greenish
o Odor - Characteristics
o Taste – Bitter
o Size - 20-38* 0.5-15 cm.
corm
o Color – Yellowish - Yellowish brown
o Odor - None
o Taste – Bitter
o Size - 2-5 cm.
Chemical Constituent – It contains Volatile oil like eugenol, phenol, cuminic aldehyde,
Contain resins like resinic acid, cammoniphoric acid.
ANSWERS
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Q.2 : Write down the chemical constituent and uses of papaya and Guargum.
Answer: 1. Papaya:
Chemical Constituents – It contains papain, chymopapain, the proteolytic enzyme which
hydrolysed polypeptides, amides and esters.
Uses – 1. Used for removal of protein deposits from surface of soft contact lenses.
2. Used as meat tenderizer and clarification of bevarages.
3. Used as protein digestant.
2. Guar gum:
Chemical Constituents – It contains water soluble and water insoluble parts. Water soluble
part is known as guaran which iis high molecular weight polysaccharide. Guaran on
hydrolysis gives galactose and mannose which is combined through glycosidic linkage.
Uses –1.Used as thickening, binding and disintegrating agent.
2. Used as bulk laxative, appetite depressant and in peptic ulcer therapy.
3. Used as good emulsifying agent.
Q.3 : Explain any two drugs which come under pharmaceutical aids in detail.
Answer: 1.Honey:
Common Name: Madhu, shahad
Biological Source: it is sugar secretion deposited in honeycomb by the bees “Apismellifera”
Family: Apidae
Geographical Source:It is cultivated in India, Australia, Africa, Newzealand.
Macroscopic Characters:
o Color – Yellowish Brown
o Odor - Characteristics
o Taste – Sweetish
Chemical Constituent – It contains carbohydrates, invert sugar, Enzymes, Vitamins.
Uses – 1.Used as Pharmaceutical aid.
2. Used as nutrient and demulcent.
3. Used as laxative.
2.Guar gum:
Common Name: Jagaur gum, Guar flour
Biological Source: Guar gum is the powder of the endosperm of the seeds of
“Cyamopsistetragonolobus”
Family: Leguminosae
Geographical Source:It is cultivated in India, Pakistan, USA.
Macroscopic Characters:
o Color – Colorless or pale yellow white
o Odor - Characteristics
o Taste – Gummy
Chemical Constituent – It contains water soluble and water insoluble parts. Water soluble
part is known as guaran which iis high molecular weight polysaccharide. Guaran on
hydrolysis gives galactose and mannose which is combined through glycosidic linkage.
Uses – 1.Used as thickening, binding and disintegrating agent.
2. Used as bulk laxative, appetite depressant and in peptic ulcer therapy.
3. Used as good emulsifying agent.
Q.4 : Write biological source, family, chemical constituent and uses of Liquorice.
Answer: Liquorice:
Common Name: Glycrrhiza, Mulethi.
Biological Source: It consists of dried peeled or unpeeled root and stolon of
“Glycrrhizaglabra”.
Family: Leguminosae
Geographical Source:It is cultivated in spain, sicily, England, Russia, Iran, Iraq and India.
Macroscopic Characters:
o Color – Yellowish - Brown
o Odor – Characteristics
o Taste – Sweet
Chemical Constituent – It contains Glycyrrhizin, Glycyrrhinic acid, Isoliquertin and liquertin.
Answer: 1. Amla:
Common Name: Indian Goose Berry, Embelica
Biological Source: It consists of fresh or dried fruits of “Emblicaofficinalis”.
Family: Euphorbiaceae
Geographical Source:It is cultivated in India, Srilanka and Burma.
Macroscopic Characters:
o Color – Green to light yellow.
o Odor - None
o Taste – Sour and Astringent
o Size - 1.5 – 2.5 cm.
Chemical Constituent – It contains Vit.C, Phyllanthin, Phyllantidine, gallic acid, elagic acid
and emblicol.
2. Garlic:
Common Name: Lehsun, Allium
Biological Source: It consists of ripe bulbs of “Allium sativum”.
Family: Liliaceae
Geographical Source:It is cultivated in India, Russia, Italy, USA and Europe.
Macroscopic Characters:
o Color – White to Pinkish
o Odor - Aromatic
o Taste – Aromatic and Pungent
o Size - 1.5 – 2.5 cm.
Chemical Constituent – It contains allyl propyl disulphide, diallylsulphide, allicin.
Q.2 : Write biological source, family, macroscopic character, chemical constituent and
uses of any two drugs:
a. Sandalwood oil
b. Shatavari
c. Honey
Answer: 1. Sandalwood Oil:
Common Name: Chandan oil, Yellow sandalwood
Biological Source: It consists of dried heartwoof of “Santalum album”.
Family: Santalaceae
Geographical Source:It is cultivated in India, Malaya, Archipelago.
Macroscopic Characters:
o Color – Yellowish or pale reddish.
o Odor – Strong fragrant
o Taste – Slightly Bitter
Chemical Constituent – It contains Volatile oil α and β- santalene, α and β- santalol,
isovaleraldehyde, santalone, santanone, santalic acid.
Uses – Used for healing wounds, for blisters caused by small pox vaccination, and treatment
of dysuria, gonorrhea, cough.
2. Shatavari:
Common Name: Shatmuli, Shatavar
Biological Source: It consists of dried roots and leaves of “Asparagudracemosus”.
Family: Liliaceae
Geographical Source:It is cultivated in India, Australia, Africa, Asia.
Macroscopic Characters:
o Color – White to Buff
o Odor - Characteristics
o Taste – Sweetish
Chemical Constituent – It contains steroidal saponins: Shatavarin I – IV, Quercetin, β-
Sitosterol, rutin.
Uses – 1. Used as galactogogue, tonic and diuretics.
2. It has antioxytocic property
3. Used in treatment of rheumatism and nervine disorders.
3. Honey:
Common Name: Madhu, shahad
Biological Source: it is sugar secretion deposited in honeycomb by the bees “Apismellifera”
Family: Apidae
Geographical Source:It is cultivated in India, Australia, Africa, Newzealand.
Macroscopic Characters:
o Color – Yellowish Brown
o Odor - Characteristics
o Taste – Sweetish
Chemical Constituent – It contains carbohydrates, invert sugar, Enzymes, Vitamins.
Uses – 1.Used as Pharmaceutical aid.
2. Used as nutrient and demulcent.
3. Used as laxative.
UNIT-V
Multiple Choice Questions
Note: All questions carry 01 mark each.
Q.1 : Which fibre is used for manufacturing of crepe bandages.
e) Cotton
f) Silk
g) Wool
h) Flax
Q.2 : Cork and Cortex is absent in which drug
a) Cinchona
b) Fennel
c) Cinnamon
d) Nux vomica
Q.3 : Which combination is correct.
e) Gossypiumherbaceum - Tiliaceae
f) Corchorusolitorius Linn. - Malvaceae
g) Gossypiumherbaceum - Malvaceae
h) Linumusitatissimum - Tiliaceae
Q.4 : Aerenchyma is present in which drug
a) Cinnamon
b) Clove
c) Cinchona
d) None
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Short Answer Questions
Note: All questions carry 05 marks each.
Q.1 : Define and classify fibres.
Answer: Fibres: The term fibre is used with restriction to describe certain specific characters of
plant and animals. Fibres are used in pharmacy as filtering media and also used for making,
dressings and sutures.
Classification of Fibres:
Q.2 : Write chemical constituent and uses of absorbent cotton and silk.
Answer: 1. Absorbent Cotton:
Chemical Constituents – It contains pure form of cellulose. Cellulose material is made of
glucose residue united by 1,4 β- glucosidic linkage.
Uses – 1.Used as surgical dressings.
2. It gives mechanical support to absorb blood, mucus, pus.
3. Used as filtering media, absorbent guaze and colloidon.
2. Silk:
Chemical Constituents – It contains protein known as fibroin which on hydrolysis gives
amino acids like glycine and alanine.
Uses –1.Used in preparation of ligatures and sieves.
Q.2 : Discuss in detail about methods of cultivation, collection, processing and drying.
Answer: Cultivation:
Cultivation of medicinal plants requires intensive care and management. The conditions
and duration of cultivation required vary depending on the quality of medicinal plant
materials required.
Methods of Cultivation:
Vegetative propagation (Asexual Method):
Vegetative propagation can be defined as regeneration or formation of a new individual
from any vegetative part of the plant body. The method of vegetative propagation involves
separation of a part of plant body, which develops into a new plant.
Importance of asexual propagation:
1. It is a cheaper, easier and rapid method of multiplication.
2. Plants like roses and chrysanthemum, etc do not form viable seeds. Thus, vegetative
propagation is the only method of propagation
3. All the plants developed by these methods will be generally similar to the parent plant.
4. Micro propagation is useful in raising disease free plants, homozygous diploids, and
those without viable seeds.
Seed Propagation (Sexual Method):
In this method the plants are raised from seeds. Such plants are known as seedlings. The
seeds must be of good quality, capable of high germination rate and free from disease.
The process of sexual propagation:
(i) Microsporogenesis:Microspores are formed from microspore mother cells inside the
anther.
(ii) Pollination: This is the transfer of pollen grains from the anther to the stigma.
(iii) Microgametogenesis: This involves the formation of male gametes from microspore.
(iv) Megasporogenesis: This process leads to the formation of megaspores from
megaspore mother cell, inside the ovule.
(v) Megagametogenesis: The events involving the formation of embryo sac from
megaspore are included in this process.
(vi) Fertilization: Fusion of male and female gametes takes place, resulting in the formation
of zygote.
(vii) Embryogeny: The process involves development of embryo from zygote.
Collection of drugs:
Medicinal plant materials should be collected during the appropriate season or time period
to ensure the best possible quality of both source materials and finished products.The
collected medicinal plant materials should be protected from insects, rodents, birds and
other pests. If more than one medicinal plant part is to be collected, the different plant
species or plant materials should be gathered separately and transported in separate
containers. Cross-contamination should be avoided at all times.
Time of collection:
The period of growth or development at which medicinal activity is highest has been
carefully determined for many plants. The proportion, of alkaloid in the leaves of
Hyocyamus Niger and of belladonna is largest at the beginning of flowering, whilst with
Stromonium the peak coincides with full bloom.
Primary processing:
Collected raw medicinal plant materials should be promptly unloaded and unpacked upon
arrival at the processing facility. Prior to processing, the medicinal plant materials should
be protected from rain, moisture and any other conditions that might cause deterioration.
Medicinal plant materials should be exposed to direct sunlight only where there is a
specific need for this mode of drying.
The materials may be stored under refrigeration, in jars, in sandboxes, or using enzymatic
and other appropriate conservation measures immediately following harvest/collection
and during transit to the end-user.
For example, dried medicinal plant materials should be inspected, sieved or winnowed to
remove discoloured, mouldy or damaged materials, as well as soil, stones and other
foreign matter. Mechanical devices such as sieves should be regularly cleaned and
maintained.
All processed medicinal plant materials should be protected from contamination and
decomposition as well as from insects, rodents, birds and other pests, and from livestock
and domestic animals.
Drying:
When medicinal plant materials are prepared for use in dry form, the moisture content of
the material should be kept as low as possible in order to reduce damage from mould and
other microbial infestation.
Medicinal plants can be dried in a number of ways:
1. In the open air (shaded from direct sunlight);
2. Placed in thin layers on drying frames, wire-screened rooms or buildings.
3. By direct sunlight, if appropriate.
4. In drying ovens/rooms and solar dryers.
5. By indirect fire; baking; lyophilization; microwave; or infrared devices.
6. Vacuum drying
7. Spray dryer: Examples: Papaya latex and pectin’s, etc.