Thalassaemia International Federation and Hemanext® Inc.

Announce New
Strategic Alliance

Organizations create partnership to support the needs of people living with hemoglobin disorders.

Lexington, MA, June 11, 2020 --(PR.com)-- The Thalassaemia International Federation (TIF), a
worldwide organization dedicated to ensuring equal access to quality healthcare for every patient with
thalassaemia and other hemoglobin disorders across the world, and Hemanext Inc., a privately held
medical technology company dedicated to improving patients’ quality of life by delivering a better red
blood cell (RBC) replacement therapy, today announced a new strategic alliance on behalf of people
living with thalassaemia.

Hemanext and TIF are committed to helping elevate the standard of care for thalassaemia patients
worldwide through education and research and development initiatives that will lead to important clinical
advances. Through this new partnership, Hemanext will support TIF’s educational and advocacy
activities in support of patients, caregivers, healthcare providers and policymakers worldwide.

More than 600,000 people worldwide have one of many types of thalassaemia, all of which are inherited
blood disorders that are characterized by decreased production of hemoglobin, the protein found in RBCs
that carries oxygen to cells throughout the body. The disease causes the destruction of red blood cells
leading to anemia. As such, blood transfusions play a vital role in the treatment and management of
thalassaemia and other hemoglobin disorders.

Hemanext is seeking to maximize the therapeutic value of transfusions and reduce financial burdens to
health systems with its novel RBC replacement technology. Hemanext is developing a new hypoxic
storage method, which the company and many researchers and clinicians believe might improve the
quality of life for patients that require chronic and high-volume transfusions, including people with
thalassaemia and other hemoglobin disorders. Optimizing transfusions is critically important at this time,
as societies around the world attempt to preserve and expand the blood supply.

“Many efforts are being made to ensure the continuation of blood donations to avoid shortages, as very
sadly this pandemic is keeping people from donating blood,” said Dr. Androulla Eleftheriou, TIF’s
executive director. “We will be actively supporting the World Health Organization (WHO) World Blood
Donor Day on June 14th. And TIF’s theme for 2020 is The dawning of a new era for thalassaemia: Time
for a global effort to make novel therapies accessible and affordable to patients. TIF is pleased that
Hemanext shares our goal to develop new treatments for hemoglobin disorders. We welcome Hemanext
into our network of industry partners.”

“The fragility and inconsistency of the blood supply continues to be a concern. During this time,
transfusion medicine continues to encourage blood donations and is committed to using blood in the
safest and most efficacious way. However, new innovations are needed for the transfusion community,”
said Hemanext President and CEO Martin Cannon. “Working with researchers in the U.S. and Europe,
we are developing a technology that we think will deliver a higher-quality, more uniform red blood cell.

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We applaud TIF for its support of treatments in every country impacted by thalassaemia and other
hemoglobin disorders.”

In many countries, medical complications and financial burdens pose significant concerns to thalassaemia
patients, their families and national health systems. TIF is working with organizations around the world
that share the Foundation’s dedication to seeking solutions to these challenges.

“Transfusion physicians worldwide and patients with hemoglobinopathies they serve would benefit from
RBCs that are more durable than currently available cells,” said Dr. Michael Angastiniotis, a
paediatrician and former Head of the Cyprus Thalassaemia Centre, and currently TIF’s Medical Advisor.
“Based on preclinical data published by Hemanext and other researchers, hypoxic storage of RBCs may
help advance transfusion medicine by reducing the amount and frequency of RBC units need to achieve
desired therapeutic outcomes, thereby reducing patients’ risk of the dangerous condition of iron
overload.”

Alex Marichal, VP of Marketing for Hemanext, added, “During the COVID-19 crisis, patients with
thalassaemia and other hemoglobin disorders are even more vulnerable than they were before the
pandemic spread around the world. We want to do our part to help them, and we appreciate the
opportunity to work with TIF in support of the patients served by the Federation’s member
organizations.”

About Thalassaemia International Federation

The Thalassaemia International Federation (TIF) is a patient-orientated, non-profit, non-governmental

umbrella federation, established in 1986 with Headquarters in Nicosia, Cyprus. Its mission is to promote
access to optimal quality care for all patients with thalassaemia worldwide and it currently represents 224
members from 62 countries across the globe.

TIF works in official relations with the World Health Organization (WHO) since 1996 and enjoys active
consultative status with the United Nations Economic and Social Council (ECOSOC) since 2017. Most
remarkably, TIF has been awarded, in the context of the 68th World Health Assembly in May 2015, the
"Dr Lee Jong-wook Memorial Prize" for the Federation’s outstanding contribution to public health.

About Hemanext

Hemanext is a privately held medical technology company dedicated to improving the quality, safety,
efficacy and cost of transfusion therapy. The company’s research and development efforts center on the
study and future commercialization of hypoxically stored red blood cells (RBCs). HEMANEXT ONE®,
our initial product offering, is a RBC replacement therapy designed to potentially improve the quality of
life for chronic and high-volume transfusion patients while reducing costs. Visit Hemanext.com to learn
more.

Hemanext anticipates receiving CE Mark approval from the European Union for HEMANEXT ONE®

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within the next few months. Currently, the Hemanext RBC Processing System has not been cleared or
approved by any regulatory agency (including the FDA), or any notified body, and is not available for
sale.

TIF Media Contact:

Catherine Skari
Senior Communications Officer
thalassaemia-cs@thalassaemia.org.cy

Hemanext Media Contact:

Stacy Smith
Associate Director Marketing Communications
stacy.smith@hemanext.com

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Contact Information:
Hemanext
Stacy Smith
603-759-0458
Contact via Email
hemanext.com

Online Version of Press Release:

You can read the online version of this press release at: https://www.pr.com/press-release/814595

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