10 differences between neutrophils and macrophage.
Macrophages
Macrophages are antigen presenting
phagocytes with antigen presenting capacity
to T cells or can act as antigen presenting
cells (APC)
MHC Class II receptor is present as
Macrophages are antigen presenting cells
Macrophages plays an important role in both
innate (non-specific) and adaptive immune
response (specific) by recruiting lymphocytes
Morphology: Large mononuclear rounded
nucleus and are agranulocytes (absence of
granules in cytoplasm)
About 5-7% of circulating WBCs
Macrophages are found in all tissues.
Functions of Macrophages
Long life span (several months to years). After
phagocytosis and killing of pathogen it
migrates to the lymph nodes
Macrophages reaches during late stages of
infection. The primary role of macrophages is
in the removal of cellular debris, including
apoptotic neutrophils and phagocytosis of
large pathogens. 
Classically activated macrophages requires a
priming signal in the form of IFN-gamma via
the IFN-gamma R. Alternatively activated
macrophages does not require priming but
require IL 4 and IL 13
Macrophages are also able to engulf apoptotic
neutrophils and make use of the antimicrobial
molecules present in their granules.
Macrophages exist in different forms with
various names through out the body
Eg: Monocytes in bone marrow/blood
Kupffer cell in liver, Sinus histiocytes in lymph
nodes etc
Functions of macrophages
-once inside the body, the firsts cells that will deal with pathogens are macrophage.
These cells are just like soldiers that checks all cells continuosly in the body. Once an
intruder is identified, it will phagocytise and destroy the microbes. These are long
lived cells.
Neutrophils
Neutrophils are phagocytes without antigen
presenting capacity
Only MHC Class I is present
Neutrophils are primarily involved in innate (non-
specific) immune response with its phagocytic
capability
Smaller cells with multi-lobed nucleus and are
granulocytes
Most abundant white blood cells; accounts nearly
50-70% of circulating WBCs
Neutrophils are normally found in the blood
stream and is recruited to the site of infection or
injury
Short life span (few hours to less than 5 days).
After phagocytosis and killing of pathogen it
undergo apoptosis and taken up by macrophages
They are the first immune cells to reach site of
infection or injury
Generally activated upon bacterial or fungal
infection; by chemical signals such as IL-8 and
are the first immune cells to reach the site of
infection
Neutrophil die after phagocytosis of pathogen and
is immediately taken up by macrophages
No phenotypic variation or rare.
*IFN=interferon; IL=interleukin