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The anatomy of the head and neck is an anatomy in ways that can help visualize anatomy,
important set of knowledge for the oral maxillo- disease, and provide insight into surgical ap-
facial surgeon. Current imaging techniques and proaches [1]. Intravenous iodinated contrast en-
the exquisite detail that they provide are fre- hancement is generally used to help identify
quently the first glimpse at disease and important vascular structures and potentially contrast en-
to surgical planning. CT and MRI are the primary hancing pathology.
modes of neck imaging and are complimentary in Although contrast-enhanced CT provides ex-
the information that they provide. This article cellent detail of the vasculature of the neck, allow-
reviews the current methods of anatomic imaging ing one to evaluate both the venous and arterial
and the current methods of analysis of the region systems, CT angiography is performed to provide
by radiologists. additional resolution and detail to the vascula-
ture. Multidetector CT scanners allow for rapid
high-resolution acquisition of data timed to cor-
Imaging
respond to the contrast bolus passing through the
CT arterial system of the neck. This method has
developed to a point where CT angiography chal-
Although CT has long been one of the primary lenges catheter angiography as the initial method
methods of imaging the head and neck, current to evaluate the vasculature of the neck [2,3].
scanners have several advantages over the pre-
vious generations of scanners. Multidetector spi-
ral (helical) scanners now are composed of an MRI
array of detector elements mounted in a gantry MRI examinations of the neck are generally
that can continually rotate while the table and customized for the anatomic area of interest and
patient move through the scanner. This has the clinical history. Different techniques, coils,
largely replaced the ‘‘step-and-shoot’’ process of and sequences can be used for areas adjacent
earlier CT scanners. This configuration allows to the skull base versus the infrahyoid region.
extremely rapid acquisition of a volume data set. Because of the large number of variables that can
The practical advantage is less motion artifact be manipulated during scanning, customization
from the rapid scan and a data set that allows for and careful attention to scan quality are vital to
multiplanar manipulation after data acquisition. obtain information that is clinically useful.
Postprocessing in the coronal or sagittal planes Although there is no clear superiority of MRI
(and into any other nonstandard plane) and into or CT, MRI does have the advantage in the area
three-dimensional volume-rendered images and of soft tissue contrast. Depiction of normal soft
various slice thicknesses allows depiction of the tissue anatomy and pathologic process is excellent
with MRI. The relative lack of dental artifact on
MRI gives it the advantage when evaluating the
* Corresponding author. oral cavity and to some extent the oral pharynx and
E-mail address: andejame@ohsu.edu adjacent regions. CT data can be markedly de-
(J.C. Anderson) graded by the streak artifacts from dental
1042-3699/08/$ - see front matter Ó 2008 Elsevier Inc. All rights reserved.
doi:10.1016/j.coms.2008.02.001 oralmaxsurgery.theclinics.com
312 ANDERSON & HOMAN
Neck anatomy
The complexity of neck anatomy has led to
Fig. 1. Normal upper aerodigestive tract. This sagittal
various means of organizing the structures for upper aerodigestive tract illustrates its major subdivi-
analysis. One of the more entrenched methods is sions: the nasopharynx (N), oropharynx (OP), oral cav-
based on the location of and spread of squamous ity (OC), hypopharynx (HP), and larynx (L). Only the
cell cancer of the mucosa in the head and neck. most cephalad aspect of the larynx and hypopharynx
This uses the terms ‘‘nasopharynx,’’ ‘‘oral phar- is above the hyoid bone (arrow). This traditional method
ynx,’’ ‘‘hypopharynx,’’ and ‘‘larynx’’ to divide the of subdivision for the upper aerodigestive tract follows
neck into locations of the primary disease. This along the lines of the primary sites in the extracranial
method of division defines the areas by the head and neck where squamous cell carcinoma is found.
This traditional terminology remains central to the stag-
directly visualized mucosa and anatomic struc-
ing issued in squamous cell carcinoma of the upper aero-
tures. Radiographically, these areas can be de-
digestive tract.
fined and the extent of deep tissue invasion of
squamous cell cancer can be evaluated [6].
The nasopharynx is defined anteriorly by the
nasal choana and posteriorly by the prevertebral cell carcinoma, they do little to help with the
musculature, upper cervical spine, and inferior remainder of the anatomy deep to the mucosal
clivus. The lateral borders are the mucosal sur- surfaces when imaged in the traditional transverse
faces including the fossa of Rosenmüller and the plane of the cross-sectional imaging of CT and
eustachian tube. The inferior extent is the soft MRI.
palate and the imaginary line extending posteri-
orly from the hard and soft palate [6].
The oral pharynx is defined superiorly by the
Spaces
soft palate, and anteriorly by the ring of structures
composed of the posterior tongue (circumvallate Because of the transverse plane in which CT
papilla), the anterior tonsil pillars, and the soft imaging has long been viewed, radiologists have
palate. The inferior extent is the epiglottis and used various methods to describe the region in
glossoepiglottic fold and the phyngoepiglottic a manner that allows accurate communication of
fold. Posteriorly, the superior and middle con- both the anatomy and the disease processes of the
strictor muscles are the border [6]. head and neck. Unfortunately, there have been
The hypopharynx or laryngopharyx is the area debates about the terminology and definition of
inferior to the inferior margin of the oral pharynx, the fascia of the neck; it is difficult to define
and posterior to the larynx. It extends inferiorly to a single agreed on method for separating the
the lower border of the cricoid cartilage (Fig. 1) regions of the neck [6–10].
[6,7]. The method described next is primarily based
Although these definitions and divisions are on a system refined by Harnsberger. Although
useful in the staging and evaluation of squamous this may only be one of many methods, it has
RADIOGRAPHIC CORRELATION WITH NECK ANATOMY 313
somewhat simplified the analysis of the neck when spaces. Each of these spaces contains a definable
imaged in the transverse plane. In this method the set of structures and is easily identified on cross-
fascial planes of the head and neck are used to sectional imaging and facilitates communication
divide the region into definable areas and as a between radiologists and clinicians [7].
means of systematically analyzing the complex
anatomy to help communicate the imaging find-
ings between colleagues. This spatial method of
Suprahyoid spaces
analysis has both an anatomic basis and is a
relatively systematic way to evaluate the neck in The sublingual space is located in the floor of
the transverse plane on CT and MRI. This the mouth with the mandible defining the antero-
method divides the neck into the suprahyoid and lateral border, the mylohyoid the inferiorly, hyoid
infrahyoid neck and then further divides regions posteriorly, and oral mucosa superiorly. The sub-
by the anatomic fascial planes. In this algorithm, lingual glands, deep lobes and ducts of the sub-
the facial structures are divided into the sinonasal mandibular glands, lingual arteries, nerves and
region, the orbit, and the oral cavity (Fig. 2). The veins, V3 branches from the trigeminal nerve,
remainder of the structures of the face and neck genioglossus, geniohyoid, styloglossus, palato-
are divided into spaces using the fascia as defining glossus, hyoglossus, and fat are contained within
structures. The spaces of the suprahyoid neck the sublingual space. Of pathologic importance,
are pharyngeal mucosal space, parapharyngeal the posterior margin of the sublingual space freely
space, masticator space, parotid space, carotid communicates with the submandibular and para-
space, retropharyngeal space, danger space, and pharyngeal spaces. A common description of the
perivertebral space. Additionally, there are the an- sublingual space is the ‘‘horizontal horseshoe.’’
atomic locations associated with the oral cavity The submandibular space lies superior to the
including the sublingual and submandibular hyoid and inferiolateral to the mylohyoid muscle
and freely communicates with the sublingual
space. This space contains the superficial lobes
of the submandibular glands, anterior bellies of
the diagastric muscles, and level 1A and 1B lymph
nodes. This space is also referred to as the
‘‘vertical horseshoe’’ [11].
The pharyngeal mucosal space is defined by the
mucosal surfaces of the nasopharynx, orophar-
ynx, and suprahyoid hypopharynx. The mucosal
surfaces of the oral cavity can be included, but
more commonly, the oral cavity is considered its
own space. The immediate submucosa is also
included; this space contains mucosa, lymphoid
tissue, minor salivary glands, and some muscular
tissue. MRI is considered the imaging modality of
choice for this space to evaluate for lesions that
cannot be directly visualized or for invasion deep
to the submucosa (Fig. 3) [12].
The parapharyngeal space is a primarily fat-
filled space extending from skull base to hyoid
bone. This space is defined in various ways by
Fig. 2. The ‘‘head and neck man.’’ In teaching and writ- various authors. Some authors divide this space
ing about the extracranial head and neck area the discus- into the prestyloid and poststyloid compartments;
sion is usually divided by the major anatomic regions others include portions of the deep parotid and
shown in this drawing. The suprahyoid neck (SHN) rep-
muscular tissue of the masticator. The primary
resents the deep core tissues posterior to the sinonasal
(S/N) and oral cavity (OC) areas. Below the level of area of debate on this space in the literature is
the hyoid bone (arrow) the infrahyoid neck (IHN) can whether the carotid sheath and its fascial layers
be seen. A distinct area within the infrahyoid neck is are the posterior border. For the purposes of this
the larynx (L). BOS, base of skull; CN, cranial nerves; article, however, the definition of this space is the
O, orbit; TB, temporal bone. one used by Harnsberger, which limits the
314 ANDERSON & HOMAN
Fig. 3. T1-wieghted transverse MRI at the level of the Fig. 4. Transverse CT image through the nasopharynx.
nasopharynx in the suprahyoid head and neck. The pha- Outlined in black is the parapharyngeal space as defined
ryngeal mucosa is well seen (arrows) as distinct from the by Harnsberger. This fat-filled structure is centrally lo-
fat and musculature deep to the mucosal surface. cated between the other spaces of the neck and is helpful
in determining location of origin of masses.
Fig. 5. Transverse CT image through the nasopharynx. Fig. 7. Transverse CT image through the nasopharynx.
Outlined in white is the masticator space, which on this The carotid space is outlined in black and indicated by
image consists of the masseter muscle (M), mandibular the black arrowheads. The styloid process (white arrow)
ramus (R), and pterygoid muscules (Pt). Adjacent struc- lies anterior to the internal jugular vein (J). Masseter
tures include the parotid (P), styloid process (white ar- muscle (M) and parotid (P) are indicated.
row), internal carotid artery (C), internal jugular vein
(J), and vertebral artery (V). between the prevertebral layer of the deep cervical
fascia and the buccopharyngeal fascia. It is limited
skull base to the mediastinum and is in both the by the carotid sheaths lateral and also extends from
suprahyoid and infrahyoid neck (Fig. 7) [7,17]. skull base to mediastinum. It is primarily a potential
The retropharyngeal space and danger space space filled with loose connective tissue; however,
can be discussed together because they are situated in the suprahyoid portion there are lymph nodes
present, most notably the lateral retropharyngeal
nodes or nodes of Rouvière [18,19].
The perivertebral space is the area defined by
the prevertebral fascia, which encloses the bony
vertebra and surrounding muscles. This space is
divided into an anterior and posterior portion by
fascia that attaches to the transverse processes of
the vertebral bodies. This space extends both
suprahyoid and infrahyoid [20].
Infrahyoid
The infrahyoid neck can also be defined by
the anatomic facial planes and correlated with
the usual surgical approaches to these areas. The
traditional approach to these areas is the surgical
and gross dissection triangles. These triangles are
less easily defined and visualized using cross-
sectional imaging viewed in the transverse plane.
Fig. 6. Transverse CT image through the nasopharynx. Confusion often ensues when transverse images
The partotid spaces are outlined in white bilaterally. are viewed and attempted to be interpreted using
This space consists of the parotid gland, vessels, facial the anterior and posterior triangles as anatomic
nerve, and intraparotid lymph nodes. areas. An alternate method of analysis that is
316 ANDERSON & HOMAN
based on the cross-sectional images and fascially The visceral space is enclosed by the pretra-
defined spaces and can then be translated into the cheal layer of the deep cervical fascia, or to avoid
triangle vernacular has been devised. This con- confusion the visceral layer, because it surrounds
tinues the terminology and method developed for the tracheal, esophagus, and thyroid (Fig. 9). This
the suprahyoid neck [21]. extends from the hyoid into the thorax. Posteriorly
The anterior triangle is defined by the sternoclei- the visceral layer blends with the buccopharyngeal
domastoid muscle as the posterior and lateral fascia and laterally with the carotid sheath [21].
border, the midline is the medial border, and the The posterior cervical space is essentially the
inferior border is the clavicle. The triangle is further primarily fat-filled space, with some lymph nodes
divided by the hyoid bone into a suprahyoid and and the spinal accessory nerve, which lies between
infrahyoid components. The suprahyoid compo- the perivertebral space posteromedially, the ca-
nents of the submental and sublingual triangles are rotid space anteromedially, and the investing layer
not discussed here. The infrahyoid components are of the deep cervical fascia surrounding the ster-
further divided by the superior belly of the omo- nocleidomastoid muscle laterally. This space is
hyoid muscle into the muscular and carotid triangles. predominantly infrahyoid in location, although
The posterior triangle is defined anterorme- a small portion does extend superior to the hyoid.
dially by the sternocleidomastoid muscle, posteri- This space is essentially equivalent to the posterior
orly by the trapezius muscle, and inferiorly by the triangle [19,21].
clavicle. It is further divided by the inferior belly
of the omohyoid into the occipital and supra-
clavicular triangles [19].
Lymphatic system
The spatial analysis of the infrahyoid neck uses
the anatomic fascial planes to define five spaces, The use of imaging in the evaluation of the
two of which are unique to the infrahyoid anatomy cervical lymphadenopathy for neoplastic, inflam-
and the other three are continuations from the matory, and infectious processes is frequently
suprahyoid neck. These spaces are the visceral encountered in current medical practice. It is
space, carotid space, retropharyngeal space, peri- critical for the interpreting radiologist and con-
vertebral space, and posterior cervical space. The sulting surgeon to have a comprehensive knowl-
carotid, retropharyngeal, and perivertebral spaces edge base and understanding of the normal
have been discussed previously (Fig. 8). cervical lymphatic anatomy.
Fig. 8. (A) Transverse CT image through the infrahyoid neck. The investing fascia is highlighted and demonstrates it
splitting around the sternocleidomastoid muscule (SCM) and the trapezius muscle (T). (B) Transverse image through
the infrahyoid neck. The prevertebral fascia is highlighted. This fascia defines the perivertebral space, which is both
suprahyoid and infrahyoid in location, extending from skull base into the thoracic region.
RADIOGRAPHIC CORRELATION WITH NECK ANATOMY 317
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