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INTRODUCTION:-
Immunization is the most effective way of protecting the human body from infectious diseases.
Immunization programmes are an integral and important part of the health activities of every
country in the world. Immunization is one of the most well – known and effective methods of
preventing childhood diseases. With the implementation of Universal Immunization
Programme, significant achievements have been made in preventing controlling the vaccine
preventable diseases. Immunization has to be sustained as a high priority to further reduce the
incidence of all VPDs, control measles, eliminate tetanus and eradicate poliomyelitis.
OBJECTIVES:-
Full immunization (i.e. received one dose of BCG, three doses of DPT, four doses of Hepatitis-B
and OPV each and one dose of measles before one year of age) gives a child for a healthy life.
Immunization is one of the safest and most cost effective health instruments available in the
world today.
Preventing diseases before it occurs saves, money energy and live.
Immunization is a key strategy to child survival.
By protecting infants from VPDs, immunization significantly lowers morbidity and mortality
rates in children.
Immunization is an indicator of a strong primary health care system.
1. BCG VACCINE:-
Tuberculosis which is caused by a bacterium (mycobacterium tubercle) affects the lungs,
intestine, bones and joints.
Indication:- to prevent tuberculosis.
Contraindication:- BCG should not given to patients suffering from generalized eczema,
infective dermatitis, with a history of deficient immunity6, patients under immunosuppressive
treatment .
Adverse reaction:-prolonged severe ulceration at the site of vaccination, supportive
lymphadenitis, osteomyelitis, disseminated BCG infection and death.
2. POLIO:-
Poliomyelitis is an acute viral infection caused by RNA virus. It is primarily an infection of
human alimentary tract but the virus may infect the central nervous system resulting in varying
degree of paralysis and possible death.
Indication:-both inactivated polio vaccine (IPV) and oral polio vaccine (OPV) is essential to give
all infants before 6 months of age to protect against polio.
Contraindication:- live vaccines are not usually given to immunocompromised individuals.
Patients suffering from leukemia and malignancy and those receiving corticosteroids may not be
given OPV. IPV is an alternative choice for immunization of children with HIV infection.
Adverse reaction: - OPV is remarkably free from complication. No serious adverse reaction to
IPV vaccines currently in use have been reported except minor local erythema, induration and
tenderness.
HEPATITIS-B: -
Hepatitis is a highly infectious viral disease and is the leading cause of jaundice, fulminant liver disease
cirrhosis and liver cancer.
ROTAVIRUS
Rotavirus is the leading cause of severe diarrhea among infants and young children.
Indications – For active immunization of infants from age of 6weeks for prevention of gastro-
enteritis due to rotavirus infection.
Contraindications – Should not be administered to subjects with hypersensitivity to any
components. Subjects with uncorrected congenital malformation of the GIT – Intussusception.
Adverse reactions – Diarrhea, vomiting, loss of appetite, fever, flatulence, abdominal pain.
HEPATITIS A:-
Hepatitis A (formerly known as "infectious" hepatitis or epidemic jaundice) is an acute
infectious disease caused by hepatitis A virus (HAV).
Therapeutic indications –
o Is indicated for active immunization against infections cause by hepatitis A virus.
o Recommended in subjects who are at increased risk.
o In areas of intermediate to high prevalence of hepatitis A.
Pregnancy and lactation – Should be used only when clearly needed.
Contra-indications – Should not be administered to subjects with known hypersensitivity to any
component of the vaccine
Adverse reactions –
Local – Injection site soreness, mild redness and swelling.
Systemic–headache, malaise, vomiting, fever, nausea and loss of appetite. Rarely allergic
reactions including convulsions and anaphylactic reactions reported.
MMR (LIVE)
The MMR vaccine is an immunization shot against measles, mumps, and rubella (also called German
measles).
Indications – Is indicated for active immunization in children 12months to 12 years of age
against measles, mumps and rubella infections simultaneously. Even in adults who missed the
dosage in childhood.
Contraindications – Pregnancy, Leukemia, other malignancy, severe febrile illness, history of
febrile convulsions, Patients on immune-suppressants. History of known hypersensitivity to egg
protein. Anaphylactic reactions to Neomycin.
Adverse reactions –
Mild, fever, slight enlargement of cervical and occipital lymph nodes.
Rarely parotid and other salivary gland enlargement is reported.
Varicella Vaccine, Live
Chickenpox or varicella is an acute, highly infectious disease caused by varicella-zoster
(V -Z) virus.
Indications –Is indicated for active immunization against varicella of healthy subjects and susceptible
healthy close contacts from age 12months onwards.
Susceptible healthy close contacts i.e., parents and siblings of high risk patients, medical,
paramedical personnel.
Contraindications –
Adverse reactions –
Local: Erythema, induration and tenderness.
Systemic: malaise, headache, vomiting, myalgia.
Rarely allergic type reaction
Meningococcal
Meningococcal meningitis or cerebro-spinal fever is an acute communicable disease caused
by N. meningitidiss.
Indications - Menactra is indicated for active immunization to prevent invasive meningococcal
disease caused by N meningitidissero groups A, C, Y and W-135. Menactra is approved for use
in individuals 9 months to 55 years of age.
Contraindications - Severe allergic reaction (e.g., anaphylaxis) after a previous dose of a
meningococcal capsular polysaccharide-, diphtheria toxoid- containing vaccine, or to any
component of Menactra vaccine.
Adverse reactions - Common (≥10%) solicited adverse events were injection site tenderness,
erythema, and swelling; irritability, abnormal crying, drowsiness, appetite loss, vomiting, fever,
headache, fatigue, malaise, and arthralgia.
Pneumococcal
Pneumonia caused by Streptococcus pneumoniae is a major cause of illness and death in
children.
Indications – Is indicated for vaccination against pneumococcal disease caused by those
pneumococcal types included in the vaccine in infants from 2months to 5 years of age.
Contraindications – Hypersensitivity to any component of the vaccine including Diphtheria
toxoid.
Adverse reactions –
Local reaction at injection site includes soreness, erythema, warmth, swelling and induration.
Systemic- Includes Fever ≤102°F, malaise, and headache.
Rabies Vaccine
Rabies also known as hydrophobia is an acute, highly fatal viral disease of central nervous
system caused by Lyssavirus type-1.
Indications – Active immunization against Rabies.
No contraindications.
Adverse reactions –
Adverse reactions –
The most common (≥10%) local and general adverse events were pain, redness and swelling at the
injection site, muscle aches, fatigue, and headache. irritability, loss of appetite, and drowsiness.
Japanese Encephalitis
Japanese encephalitis (JE) is mosquito-borne encephalitis caused by a group B arbovirus (Flavivirus)
and transmitted by culicine mosquitoes.
Indications – IXIARO is a vaccine indicated for the prevention of disease caused by Japanese
encephalitis virus (JEV) in persons.
Adverse reactions -
Yellow fever
Indications - YF-VAX vaccine is recommended for active immunization of persons 9 months of age
and older in the following categories:
Adverse reactions –
Local reactions including edema, hypersensitivity, pain or mass at the injection site have also
been reported
Immediate hypersensitivity reactions, characterized by rash, urticarial, and/or asthma, are
uncommon and occur principally among persons with histories of egg allergy.
Recommendation for IAP Immunization - updated 2014 Schedule
CONCLUSION:-
Immunization is the most effective way of protecting the human body from
infectious diseases. Immunization programmes are an integral and important part of the health activities
of every country in the world. Immunization is one of the most well – known and effective methods of
preventing childhood diseases disabilities.