A.

Medicamente indicate in
infectii virale respiratorii
A.I. Inhibitori ai decapsidarii virale si penetrarii virale in celula umana

A.I.1. Derivati de adamantan:

Amantadina.
Amantadine hydrochloride (DCI)
Rimantadina
Rimantadine hydrochloride (DCI)
 Spectru antiviral

 Indicatii terapeutice:
Reactii adverse:

Interactiuni:

Contraindicatii:
Amantadina: AMANTADINA , VIREGYT –K – capsule 100 mg
A-PARKIN , SYMMETREL - compr filmate 100 mg
PARITREL – drajeuri 100 mg

 Rimantadina: FLUMADINE – compr. 100 mg; sirop 50 mg /5 ml

A.I.2. Pleconaril
Spectru antiviral:
IT:

Fcin:

R adv:

PICOVIR – compr. 50 mg
A. II. Inhibitori ai neuraminidazelor virusurilor gripale A si B:
Analogi ai acidului sialic : Zanamivir ,
Oseltamivir
 Zanamivir Oseltamivir

Farmaco-cinetica

Posologie

R adv.

Cind
Prec

PF RELENZA ROTADISK TAMIFLU – capsule

pulbere pt aerosoli 5 mg (Diskhaler) suspensie orala
 A.III. Inhibitori ai biosintezei DNA/RNA viral:

RIBAVIRIN

Spectrul antiviral:
IT
 RIBAVIRIN

R. adv
Cind:

Interactiuni medicam:

REBETOL – caps 200 mg; solutie orala 40 mg/ml

RIBAVIRIN - comp film. 200 mg;
solutie aerosoli;
COPEGUS – compr 200 mg + peginterferon 2a
B. Antivirale indicate in infectii cauzate de Herpesvirusuri
Spectru antiviral:

B.I. Inhibitori ai biosintezei materialului genetic viral:

B.I.1. Analogi nucleotidici ai bazelor azotate
DCI Spectru antiviral Posologie Reactii adverse
Indicatii Produse farm. Contraindicatii
terapeutice

IDOXURIDINA HSV-1, HSV-2, VZV DENDRID –sol oftalmica - Fotofobie,

(IDU) Keratita si 0,1% edem
IDOXURIDINE keratoconjunctivita HERPLEX – colir 0,1%; palpebral,
(DCI) cauzate de HSV-1 unguent oftalmic prurit, durere;
Herpes 0,5% -Sensibilitate la
labial/genital si STOXIL- ung. oftalmic IDU
herpes zoster 0,5%
DCI Spectru antiviral Posologie Reactii advers
Indicatii terapeutice Produse farm. Contraindicatii

TRIFLURIDINA Exclusiv local Discomfort la

TRIFLURIDINE Keratoconjunctivite TRIHERPINE -ung ; sol instilare, edem
(DCI) si keratite recurente oftalmica 1% palpebral,
(HSV-1 si HSV-2) VIROPTIC – sol cresterea PIO,
oftalmica 1% r alergice,
keratopatii
epiteliale
DCI Spectru antiviral Posologie Reactii adverse
Indicatii terapeutice Produse farm. Contraindicatii

EPERVUDIN Infectii herpetice Exclusiv local – ung. Iritatie locala

cutanate si genitale; HEVIZOS – unguent 0,8%
Adjuvant in herpes zoster

BRIVUDIN HSV-1 si varicelo- Keratita herpetica si Bine tolerat

zosterian; herpes labial: (Greata, varsaturi,
Keratita herpetica unguent 5% cefalee)
 Zona zoster Sol oftalmica 0,1%
HELPIN – compr 125 mg
ZOSTEX – compr 125 mg
DCI Spectru antiviral Posologie Reactii adverse
Indicatii terapeutice Produse farm. Contraindicatii

VIDARABINA Forma farm: Lacrimare,

HSV-1, HSV-2 si
VIDARABINE Ung. oftalmic 3% senzatie corp
v. varicelo-zosterian;
(DCI) strain, arsura,
Keratoconjuctivita
VIRA-A - ung. oftalmic iritatie
acuta, keratita
3% conjunctivala,
epiteliala recurenta
fotofobie;
Cind:
+corticosteroizi

CICLARADIN HSV-1, HSV-2 si

v. varicelo-zosterian;
 B. Antivirale indicate in infectii cauzate de Herpesvirusuri
B.I. 2. Aciclo-nucleozide

Structura chimica/ relatii structura –activitate

Spectru antiviral

Rezistenta tulpinilor virale la aciclo-nucleozide

 Aciclovir Valaciclovir

Farmaco-
cinetica

IT, posologie

R adverse

Prec

Cind

PF ACICLOVIR –compr 200 mg, 400 mg VALTREX – compr 500 mg, 1 g

unguent 5%
ZOVIRAX - compr 200 mg, 400, 800 mg
Sol uz intern
Ung si crema 5%
Ung oftalmic 3%
Flac pulb injectabila i.v.
(solub in ser fiziol)
 Penciclovir * Famciclovir

Farmaco- Prodrug: deriv diacetilat al penciclovirului;

cinetica Biodisponib orala crescuta

Spectru Similare Aciclovir

antiviral,
IT, R adv

Mod de Exclusiv local, -Herpes genital ac:

admin. unguent -Herpes zoster:

PF DENAVIR – crema 1% FAMVIR – compr 125 mg, 250 mg, 500 mg

VECTAVIR - crema 1%
 Ganciclovir Valganciclovir

IT

R adv

Cind

PF CYMEVENE – flac pulb liofilizata VALCYTE -compr 450 mg

compr 250 mg, 500 mg
 B. Antivirale indicate in infectii cauzate de Herpesvirusuri
B.I. Inhibitori ai biosintezei DNA viral: Aciclo-nucleozide

Cidofovir

Spectru antiviral:

IT:

R adv: -

Cind:

PF: VYSTIDE – flac uz parenteral (perfuzie)

B.I. Inhibitori ai biosintezei DNA viral: Analogi non-nucleozidici

 FOSCARNET

Spectru antiviral

Ind terap:
Mod admin:
R adv:

Cind:

PF: FOSCAVIR - sol inj

 MARIBAVIR  Profilaxia si terapia infectiilor cu citomegalovirus

(tulpini rezistente la ganciclovir si foscarnet)

la pacienti sero-pozitivi si cu transplant de maduva
Admin:p.o., doze= 300-1200 mg/zi
Bine tolerat (modif gustului, cefalee, diaree)

 MOROXIDINA Blocarea formarii capsidei virale: HSV-1, HSV-2, VZV

(profilactic si curativ)  herpes labial, varicela, herpes zoster
HERPESTOP – unguent (+lidocaina)
MOROXIDIN – compr 100 mg
 C. Antivirale indicate in terapia hepatitelor b si C.
C.I. inhibitori ai biosintezei Adn/arn viral
Clasa chimica:
 ENTECAVIR

 LAMIVUDINA
LAMIVUDINE (DCI)

Spectru antiviral:

Mec act: activare

Rezistenta:

F-cin:
 LAMIVUDINA

IT:

R adv:

Interactiuni:

PF: EPIVIR – compr 150 mg; sol pediatrica 10 mg/ml

EPIVIR HBV , ZEFIX - compr 100 mg; sol pediatrica 5 mg/ml
COMBIVIR – compr (lamivudina 150 mg + zidovudina 300 mg)
 EMTRICITABINA

IT:

PF: EMTRIVA – caps 200 mg

TRUVADA – compr (emtricitabina 200 mg + tenofovir 300 mg)

 ADEFOVIR DIPIVOXIL

IT:

R adv:

PF: HEPSERA – compr 10 mg

 TENOFOVIR DISOPROXIL

IT:

R adv:

PF: VIREAD – compr 300 mg

TRUVADA – compr (emtricitabina 200 mg + tenofovir 300 mg)

 D. Anti-retrovirale
D.I. Inhibitori nucleozidici RT

Zidovudina , Stavudina Lamivudina, Zalcitabina

 ZIDOVUDINA Zidovudinum (DCI) Sin: Azidotimidina, AZT

IT:

Posologie:

Reactii adverse:

Novo AZT – capsule 100 mg

RETROVIR – capsule 100 mg; sol injectabila; sirop
 STAVUDINA STAVUDINE (DCI)

IT:
R adv:

ZERIT – capsule (15 mg, 20 mg, 30 mg, 40 mg); pulbere suspensie orala

 ZALCITABINA ZALCITABINE (DCI) Sin: ddC (didezoxicitidina)

R adv:

HIVID – comprim. 0,375 mg, 0,750 mg

 DIDANOSINA Didanosine (DCI) ddI (didezoxi-inozina)

R adv.:

VIDEX – compr masticabile 25mg, 50 mg, 100 mg, 150 mg

 ABACAVIR

ZIAGEN – compr; sol interna

TRIZIVIR – compr (+ Lamivudina + Zidovudina)
D.II. Inhibitori non-nucleozidici ai RT
 NEVIRAPIN NEVIRAPINE (DCI)

VIRAMUNE – compr 200 mg; suspensie uz intern

 EFAVIRENZ
STOCRIN – capsule 50 mg, 100 mg, 200 mg

 DELAVIRDIN Delavirdine (DCI)

RESCRIPTOR - compr 100 mg, 200 mg
 D.III. Inhibitori ai proteazei HIV

Reprezentanti terapeutici: Saquinavir, Indinavir, Ritonavir, Nelfinavir,

Amprenavir, Lopinavir, Fosamprenavir, Atazanavir, Tipranavir
ritonavir

amprenavir
 RITONAVIR
NORVIR – capsule 100 mg, sol injectabila

 NELFINAVIR
IT:

R adv:
VIRACEPT – comprim. 250 mg; suspensie orala
 Saquinavir
INVIRASE – capsule gelatinoase 200 mg

 INDINAVIR
CRIXIVAN – capsule 100, 200, 300, 400 mg
 AMPRENAVIR
AGENERASE – capsule 50 mg

 LOPINAVIR
KALETRA – capsule (133,3 mg lopinavir + 33,3 mg ritonavir)
FOSAMPRENAVIR
TELZIR – compr film. 700 mg;
- suspensie orala 50mg/ml

ATAZANAVIR
REYATAZ – capsule 100 mg, 150 mg, 200 mg, 300 mg
-pulb pt solutie orala 50 mg/ 1.5 g

TIPRANAVIR

APTIVUS – capsule moi 250mg

 D.IV. Inhibitori de fuziune

 ENFUVIRTIDE
IT: + alti agenti anti-retrovirali

Posologie:

R adv.: - durere, discomfort, induratie, prurit, echimoze – la locul inj.

-↑ riscul pneumoniilor bacteriene (prec adm); tulb neurologice, g-i, limfadenopatie

FUZEON – pulb liofilizata