Dissolution Methods

Drug Name
Abacavir Sulfate
Abacavir Sulfate/Dolutegravir Sodium/Lamivudine
Abacavir Sulfate/Lamivudine
Abacavir Sulfate/Lamivudine/Zidovudine
Abemaciclib
Abiraterone Acetate
Acalabrutinib
Acamprosate Calcium
Acarbose
Acetaminophen
Acetaminophen
Acetaminophen/Aspirin/Caffeine
Acetaminophen/Butalbital
Acetaminophen/Butalbital/Caffeine
Acetaminophen/Butalbital/Caffeine/Codeine Phosphate
Acetaminophen/Caffeine/Dihydrocodeine Bitartrate
Acetaminophen/Caffeine/Dihydrocodeine Bitartrate
Acetaminophen/Hydrocodone Bitartrate
Acetaminophen/Oxycodone
Acetaminophen/Oxycodone HCl
Acetaminophen/Pentazocine HCl
Acetaminophen/Propoxyphene HCl
Acetaminophen/Propoxyphene Napsylate
Acetaminophen/Tramadol HCl
Acetazolamide
Acetazolamide
Acetazolomide
Acetylcysteine
Acitretin
Acrivastine/Pseudoephedrine HCl
Acyclovir
Acyclovir
Acyclovir
Acyclovir
Adefovir Dipivoxil
Afatinib Dimaleate
Albendazole
Albendazole
Albuterol Sulfate
Albuterol Sulfate
Alectinib HCl
Alendronate Sodium
Alendronate Sodium/Cholecalciferol
Alfuzosin HCl
Aliskiren Hemifumarate
Aliskiren Hemifumarate
Aliskiren Hemifumarate/Amlodipine Besylate
Aliskiren Hemifumarate/Amlodipine Besylate/Hydrochlorothiazide
Aliskiren Hemifumarate/Hydrochlorothiazide
Aliskiren Hemifumarate/Valsartan
Allopurinol
Almotriptan Malate
Alogliptin Benzoate
Alogliptin Benzoate/ Metformin HCl
Alosetron HCl
Alprazolam
Alprazolam
Alprazolam
Altretamine
Alvimopan
Amantadine HCl
Amantadine HCl
Ambrisentan
Amiloride HCl
Amiloride HCl/Hydrochlorothiazide
Aminocaproic Acid
Aminosalicylic
Amiodarone HCl (Test 1)
Amiodarone HCl (Test 2)
Amitriptyline HCl
Amlodipine Besylate
Amlodipine Besylate
Amlodipine Besylate/Atorvastatin Calcium
Amlodipine Besylate/Benazepril HCl
Amlodipine Besylate/Hydrochlorothiazide/Olmesartan Medoxomil
Amlodipine Besylate/Hydrochlorothiazide/Valsartan
Amlodipine Besylate/Olmesartan Medoxomil
Amlodipine besylate/Perindopril Arginine
Amlodipine Besylate/Telmisartan
Amlodipine Besylate/Valsartan
Amoxicillin
Amoxicillin
Amoxicillin
Amoxicillin
Amoxicillin/Clarithromycin/Lansoprazole
Amoxicillin/Clarithromycin/Omeprazole
Amoxicillin/Clavulanate Potassium
Amphetamine
Amphetamine
Amphetamine Aspartate/Amphetamine Sulfate/Dextroamphetamine Saccha
Amphetamine Aspartate/Amphetamine Sulfate/Dextroamphetamine Saccha
Amphetamine Aspartate/Amphetamine Sulfate/Dextroamphetamine Saccharat
Amphetamine ER
Amphotericin B
Ampicillin/Ampicillin Trihydrate
Amprenavir
Anagrelide HCl
Anastrozole
Apixaban
Apremilast
Aprepitant
Aprepitant
Aripiprazole
Aripiprazole
Aripiprazole
Armodafinil
Asenapine Maleate
Aspirin
Aspirin
Aspirin/ Omeprazole
Aspirin/Butalbital/Caffeine
Aspirin/Butalbital/Caffeine
Aspirin/Butalbital/Caffeine/Codeine Phosphate
Aspirin/Caffeine/Orphenadrine Citrate
Aspirin/Dipyridamole
Aspirin/Hydrocodone Bitartrate
Aspirin/Meprobamate
Aspirin/Methocarbamol
Aspirin/Oxycodone HCl
Atazanavir Sulfate
Atazanavir Sulfate/ Cobicistat
Atenolol
Atenolol/Chlorthalidone
Atomoxetine HCl
Atorvastatin Calcium
Atorvastatin Calcium/Ezetimibe
Atovaquone
Atovaquone
Atovaquone/Proguanil HCl
Atropine Sulfate/ Diphenoxylate HCl
Auranofin
Avanafil
Axitinib
Azacitidine
Azathioprine
Azilsartan Kamedoxomil
Azilsartan Kamedoxomil/Chlorthalidone
Azithromycin
Azithromycin
Azithromycin
Azithromycin
Baclofen
Baclofen
Balsalazide Disodium
Balsalazide Disodium
Bedaquiline Fumarate
Benazepril HCl
Benazepril HCl/Hydrochlorothiazide
Bendroflumethiazide/Nadolol
Benzonatate
Benzphetamine HCl
Bepridil HCl
Betamethasone Acetate/Betamethasone Sodium Phosphate
Bethanechol Chloride
Betrixaban
Bexarotene
Bicalutamide
Bisacodyl/Polyethylene glycol 3350/ Potassium Chloride/Sodium Bicarbonat
Bismuth Subcitrate Potassium/Metronidazole/Tetracycline HCl
Bisoprolol Fumarate
Bisoprolol Fumarate/Hydrochlorothiazide
Boceprevir
Bosentan
Bosentan
Bosutinib Monohydrate
Brexpiprazole
Brigatinib
Brimonidine Tartrate/Brinzolamide
Brinzolamide
Brivaracetam
Bromocriptine Mesylate
Budesonide
Budesonide
Bumetanide
Buprenorphine
Buprenorphine HCl
Buprenorphine HCl
Buprenorphine HCl
Buprenorphine HCl/Naloxone HCl
Buprenorphine HCl/Naloxone HCl
Bupropion HCl
Bupropion HCl
Bupropion Hydrobromide
Buspirone Hydrochloride
Busulfan
Cabergoline
Cabozantinib S-Malate
Cabozantinib S-Malate
Calcifediol
Calcitriol
Calcium Acetate
Calcium Acetate
Canagliflozin
Canagliflozin (Can)/ Metformin HCl (Met)
Canagliflozin/Metformin HCl
Candesartan Cilexetil (16 mg, 8 mg and 4 mg)
Candesartan Cilexetil (32 mg)
Candesartan Cilexetil/Hydrochlorothiazide (16/12.5 mg)
Candesartan Cilexetil/Hydrochlorothiazide (32/12.5 mg and 32/25 mg)
Capecitabine
Captopril
Carbamazepine
Carbamazepine
Carbamazepine
Carbamazepine
Carbamazepine
Carbidopa
Carbidopa/Entacapone/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbinoxamine Maleate
Carglumic Acid
Cariprazine HCl
Carisoprodol
Carvedilol
Carvedilol
Carvedilol Phosphate
Carvedilol Phosphate
Cefaclor
Cefaclor
Cefaclor
Cefadroxil
Cefadroxil
Cefadroxil
Cefdinir
Cefdinir
Cefditoren Pivoxil
Cefixime
Cefixime
Cefixime
Cefixime
Cefpodoxime Proxetil
Cefpodoxime Proxetil
Cefprozil
Cefprozil
Cefprozil
Cefprozil Monohydrate
Ceftibuten Dihydrate
Cefuroxime Axetil
Celecoxib
Cephalexin
Cephalexin
Ceritinib
Cetirizine
Cetirizine HCl
Cetirizine HCl
Cetirizine HCl/Pseudoephedrine HCl
Cevimeline HCL
Chlorambucil
Chlordiazepoxide HCl/ Clidinium Bromide
Chlorothiazide
Chlorpheniramine Maleate
Chlorpheniramine Maleate/Codeine Phosphate
Chlorpheniramine Maleate/Ibuprofen/Phenylephrine HCl
Chlorpheniramine Maleate/Ibuprofen/Pseudoephedrine HCl
Chlorpheniramine Polistirex/ Codeine polistirex
Chlorpheniramine Polistirex/Hydrocodone Polistirex
Chlorpheniramine Polistirex/Hydrocodone Polistirex
Chlorpromazine HCl
Chlorthalidone
Chlorzoxazone
Cholic Acid
Choline Fenofibrate
Ciclopirox
Cilostazol
Cinacalcet HCl
Ciprofloxacin
Ciprofloxacin
Ciprofloxacin HCl
Ciprofloxacin HCl
Ciprofloxacin HCl/Hydrocortisone
Ciprofloxacin/Ciprofloxacin HCl (AB)
Ciprofloxacin/Dexamethasone
Citalopram HBr
Citalopram Hydrobromide
Clarithromycin
Clarithromycin
Clarithromycin
Clindamycin HCl
Clobazam
Clobazam
Clomiphene Citrate
Clomipramine HCl
Clonazepam
Clonazepam
Clonidine
Clonidine ( 0.1 mg)
Clonidine ( EQ. 0.17 mg and EQ. 0.26 mg)
Clonidine HCl
Clonidine HCl (0.1 mg & 0.2 mg)
Clopidogrel Bisulfate
Clorazepate Dipotassium
Clotrimazole
Clotrimazole
Clozapine
Clozapine
Clozapine
Cobicistat
Cobicistat (Cobi)/ Darunavir Ethanolate (Drv)
Cobicistat/Elvitegravir/ Emtricitabine/Tenofovir Alafenamide Fumarate
Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate
Cobimetinib Fumarate
Codeine Sulfate
Colchicine
Colchicine
Colesevelam HCl
Crizotinib
Crofelemer
Cyclobenzaprine
Cyclobenzaprine HCl
Cyclophosphamide
Cycloserine
Cyclosporine
Cyclosporine (100 mg) (AB1)
Cyproheptadine HCl
Cysteamine Bitartrate
Cysteamine Bitartrate
Dabigatran Etexilate Mesylate
Dabrafenib Mesylate
Daclatasvir Dihydrochloride
Dalfampridine
Danazol
Dantrolene Sodium
Dantrolene Sodium
Dapagliflozin Propanediol
Dapagliflozin Propanediol/ Metformin HCl
Dapsone
Dapsone
Darifenacin Hydrobromide
Darolutamide
Darunavir Ethanolate
Darunavir Ethanolate
Dasabuvir Na/ Ombitasvir/Paritaprevir/Ritonavir
Dasatinib
Deferasirox
Deferasirox
Deferasirox
Deferiprone
Delafloxacin Meglumine
Delavirdine Mesylate
Demeclocycline HCl
Demeclocycline HCl
Desipramine HCl
Desloratadine
Desloratadine
Desloratadine/Pseudoephedrine Sulfate (2.5 mg/120 mg)
Desloratadine/Pseudoephedrine Sulfate (5 mg/240 mg)
Desmopressin Acetate
Desogestrel/Ethinyl Estradiol
Desvenlafaxine Succinate
Deutetrabenazine
Dexamethasone
Dexamethasone
Dexamethasone/Neomycin Sulfate/ Polymyxin B Sulfate
Dexamethasone/Tobramycin
Dexbrompheniramine Maleate/Pseudoephedrine Sulfate
Dexlansoprazole
Dexlansoprazole
Dexmethylphenidate HCl
Dexmethylphenidate HCl
Dextroamphetamine Sulfate
Dextroamphetamine Sulfate
Dextromethophan HBr/Guaifenesin
Dextromethorphan Hydrobromide/Quinidine Sulfate
Dextromethorphan Polistirex
Diazepam
Diazepam
Diazoxide
Diclofenac
Diclofenac Epolamine
Diclofenac Potassium
Diclofenac Sodium
Diclofenac Sodium
Diclofenac Sodium/Misoprostol Enteric Coated
Dicloxacillin Sodium
Didanosine
Didanosine
Dienogest/Estradiol Valerate
Diethylpropion HCl
Diflunisal
Digoxin
Diltiazem HCl
Diltiazem HCl (AB2)
Diltiazem HCl (AB3)
Diltiazem HCl (AB4)
Dimethyl Fumarate
Dinoprostone
Dinoprostone
Diphenhydramine Citrate/Ibuprofen
Diphenhydramine HCl/Ibuprofen
Dipyridamole
Disopyramide Phosphate
Disopyramide Phosphate
Disulfiram
Divalproex Sodium
Divalproex Sodium
Divalproex Sodium
Dofetilide
Dolasetron Mesylate
Dolutegravir Na/Rilpivirine HCl
Dolutegravir Sodium (10 mg)
Donepezil HCl/Memantine HCl
Donepezil HCl
Donepezil HCl
Donepezil HCl (23 mg)
Doxazosin Mesylate
Doxazosin Mesylate
Doxepin HCl
Doxepin HCl
Doxercalciferol
Doxorubicin HCl
Doxycycline
Doxycycline
Doxycycline Calcium
Doxycycline Hyclate
Doxycycline Hyclate
Doxycycline Hyclate ( 120 mg and 60 mg)
Doxycycline Hyclate ( 150 mg and 75 mg)
Doxycycline Hyclate ( 200 mg, 150 mg, 100 mg, 80 mg and 75 mg)
Doxycycline Hyclate ( 50 mg)
Doxylamine Succinate/Pyridoxine HCl
Dronabinol
Dronedarone HCl
Drospirenone/Estradiol
Drospirenone/Ethinyl Estradiol
Drospirenone/Ethinyl Estradiol/Levomefolate Calcium
Droxidopa
Duloxetine HCl
Dutasteride
Dutasteride/Tamsulosin HCl
Efavirenz
Efavirenz
Efavirenz 600 mg; Emtricitabine 200 mg; Tenofovir Disoproxil Fumarate 300
Elbasvir/Grazoprevir
Eletriptan Hydrobromide
Eliglustat Tartrate
Eltrombopag Olamine
Eltrombopag Olamine
Eluxadoline
Elvitegravir
Empagliflozin
Empagliflozin/ Metformin HCl
Empagliflozin/Linagliptin
Empagliflozin/Metformin HCl
Empagliflozin/Metformin Hydrochloride
Emtricitabine
Emtricitabine/Rilpivirine HCl/Tenofovir Alafenamide Fumarate
Emtricitabine/Rilpivirine HCl/Tenofovir Disoproxil Fumarate
Emtricitabine/Tenofovir Alafenamide Fumarate
Emtricitabine/Tenofovir Disoproxil Fumarate
Enalapril Maleate
Entacapone
Entecavir
Enzalutamide
Eplerenone
Eprosartan Mesylate
Eprosartan Mesylate/Hydrochlorothiazide
Ergocalciferol
Erlotinib HCl
Erythromycin
Erythromycin
Erythromycin Ethylsuccinate
Erythromycin Ethylsuccinate
Erythromycin Ethylsuccinate/Sulfisoxazole Acetyl
Escitalopram Oxalate
Escitalopram Oxalate
Eslicarbazepine Acetate
Esomeprazole Magnesium
Estazolam
Esterified Estrogens
Estradiol
Estradiol
Estradiol (0.014 mg/24 hr)
Estradiol (0.025 mg/24 hr, 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.06 mg/24 hr,
Estradiol (Test 1) (0.025 mg/24 hr, 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.075
Estradiol (Test 2) (0.05 mg/24 hr and 0.1 mg/24 hr)
Estradiol (Test 3) 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1
Estradiol/Norethindrone Acetate
Estradiol/Norgestimate (1mg/0.09mg)
Estradiol/Progesterone
Estramustine Phosphate Sodium
Estrogens Conjugated Synthetic A
Estrogens, Conjugated (EC)/Medroxyprogesterone Acetate (MPA)
Estrogens, Conjugated Synthetic B
Eszopiclone
Ethacrynic Acid
Ethambutol HCl
Ethinyl Estradiol
Ethinyl Estradiol/Ethynodiol Diacetate
Ethinyl Estradiol/Etonogestrel
Ethinyl Estradiol/Levonorgestrel
Ethinyl Estradiol/Levonorgestrel (AB)
Ethinyl Estradiol/Levonorgestrel (AB2)
Ethinyl Estradiol/Norethindrone
Ethinyl Estradiol/Norethindrone
Ethinyl Estradiol/Norethindrone Acetate
Ethinyl Estradiol/Norethindrone Acetate
Ethinyl Estradiol/Norethindrone Acetate [0.01mg,0.01 mg;1 mg]
Ethinyl Estradiol/Norethindrone Acetate [0.02mg;1mg]
Ethinyl Estradiol/Norgestimate
Ethinyl Estradiol/Norgestimate (AB)
Ethinyl Estradiol/Norgestrel
Ethinyl Estradiol; Norelgestromin
Ethionamide
Ethosuximide
Etidronate Disodium
Etodolac
Etodolac
Etoposide
Etravirine (200 mg)
Etravirine (25 and 100 mg)
Everolimus
Exemestane
Ezetimibe
Ezetimibe/Simvastatin
Ezogabine
Famciclovir
Famotidine
Famotidine
Famotidine
Famotidine
Famotidine/Calcium Carbonate/Magnesium Hydroxide
Famotidine/Ibuprofen
Febuxostat
Felbamate
Felbamate
Felodipine
Fenofibrate
Fenofibrate
Fenofibrate (40 mg and 120 mg)
Fenofibric Acid
Fenoprofen Calcium
Fentanyl
Fentanyl Citrate
Fentanyl Citrate
Fentanyl Citrate (0.1 mg and 0.4 mg)
Fentanyl Citrate (0.2 mg, 0.3 mg, 0.6 mg and 0.8 mg)
Fentanyl Citrate (0.2 mg, 0.4 mg, 0.6 mg and 0.8 mg)
Fentanyl Citrate (1.2 mg)
Ferric Citrate
Ferric Maltol
Ferrous Fumarate
Fesoterodine Fumarate
Fexofenadine HCl
Fexofenadine HCl
Fexofenadine HCl
Fexofenadine HCl
Fexofenadine HCl/Pseudoephedrine HCl
Fidaxomicin
Finafloxacin
Finasteride
Fingolimod
Flavoxate HCl
Flecainide Acetate
Flibanserin
Fluconazole
Fluconazole (200 mg/5 mL)
Fluconazole (50 mg/5 mL)
Flucytosine
Fludarabine Phosphate
Fludrocortisone Acetate
Fluoxetine
Fluoxetine HCl
Fluoxetine HCl
Fluoxetine/Olanzapine
Fluphenazine HCl
Flutamide
Fluvastatin Sodium
Fluvastatin Sodium
Fluvoxamine Maleate
Fluvoxamine Maleate
Fosamprenavir Calcium
Fosamprenavir Calcium
Fosfomycin Tromethamine
Fosinopril Sodium
Fosinopril Sodium/Hydrochlorothiazide
Frovatriptan succinate
Furosemide
Gabapentin
Gabapentin
Gabapentin Enacarbil
Galantamine HBr
Galantamine HBr
Ganciclovir
Gefitinib
Gemfibrozil
Gemifloxacin Mesylate
Glimepiride
Glimepiride/Pioglitazone HCl
Glimepiride/Rosiglitazone Maleate
Glipizide
Glipizide
Glipizide/Metformin HCL
Glyburide (Micronized)
Glyburide (Non-micronized)
Glyburide/Metformin HCl
Glycopyrrolate
Goserelin Acetate
Granisetron
Granisetron
Granisetron HCl
Griseofulvin
Griseofulvin (Microcrystalline)
Griseofulvin (Microcrystalline)
Griseofulvin (Ultramicrocrystalline)
Guaifenesin
Guaifenesin/Pseudoephedrine Hydrochloride
Guanfacine
Haloperidol
Homatropine Methylbromide/Hydrocodone Bitartrate
Hydralazine HCl
Hydrochlorothiazide
Hydrochlorothiazide
Hydrochlorothiazide/Irbesartan
Hydrochlorothiazide/Lisinopril
Hydrochlorothiazide/Losartan Potassium
Hydrochlorothiazide/Metoprolol Succinate
Hydrochlorothiazide/Metoprolol Tartrate
Hydrochlorothiazide/Moexipril HCl
Hydrochlorothiazide/Olmesartan Medoxomil
Hydrochlorothiazide/Quinapril HCl
Hydrochlorothiazide/Spironolactone
Hydrochlorothiazide/Telmisartan
Hydrochlorothiazide/Triamterene
Hydrochlorothiazide/Valsartan
Hydrochlorothizide/Triamterene
Hydrocodone Bitartrate
Hydrocodone Bitartrate
Hydrocodone Bitartrate/Ibuprofen
Hydrocortisone
Hydromorphone HCl
Hydromorphone HCl
Hydroxyurea
Hydroxyzine HCl
Hydroxyzine Pamoate
Hydroxyzine Pamoate
Ibandronate Sodium
Ibrutinib
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen Potassium
Ibuprofen Sodium
Ibuprofen/Diphenhydramine
Ibuprofen/Oxycodone HCl
Ibuprofen/Phenylephrine HCl
Ibuprofen/Pseudoephedrine HCl
Ibuprofen/Pseudoephedrine HCl
Icosapent Ethyl
Idelalisib
Iloperidone
Imatinib Mesylate
Imipramine HCl
Imipramine Pamoate
Indapamide
Indinavir Sulfate
Indomethacin
Indomethacin (40 mg and 20 mg)
Indomethacin (50 and 25 mg)
Irbesartan
Isavuconazonium Sulfate
Isocarboxazid
Isoniazid
Isosorbide Dinitrate
Isosorbide Dinitrate/Hydralazine HCl
Isosorbide Mononitrate
Isosorbide Mononitrate
Isotretinoin
Isradipine
Isradipine (10 mg)
Isradipine (5 mg)
Itraconazole
Itraconazole
Ivabradine HCl
Ivacaftor
Ivacaftor/lumacaftor
Ivacaftor/Tezacaftor [FDC: IVA+ TEZ]; Ivacaftor [IVA]
Ivermectin
Ixazomib Citrate
Ketoconazole
Ketoprofen
Ketoprofen
Ketorolac Tromethamine
Labetalol HCl
Lacosamide
Lamivudine
Lamivudine 150 mg/Zidovudine 300mg Tablets and Abacavir Sulfate 300 mg
Lamivudine/Raltegravir Ka
Lamivudine/Stavudine/Nevirapine
Lamivudine/Zidovudine
Lamivudine/Zidovudine + Efavirenz
Lamivudine/Zidovudine + Nevirapine
Lamivudine/Zidovudine/ Nevirapine
Lamotrigine
Lamotrigine
Lamotrigine
Lansoprazole
Lansoprazole
Lanthanum Carbonate
Lapatinib Ditosylate
Ledipasvir/Sofosbuvir
Leflunomide
Leflunomide (100 mg)
Lenalidomide
Lenvatinib Mesylate
Lesinurad
Letermovir
Letrozole
Letrozole (LET); Ribociclib Succinate (RIB)
Leucovorin Calcium
Leuprolide Acetate
Levetiracetam
Levetiracetam
Levetiracetam
Levocarnitine
Levocetirizine Dihydrochloride
Levofloxacin
Levomilnacipran HCl
Levonorgestrel
Levonorgestrel
Levothyroxine Sodium
Lidocaine
Linaclotide
Linagliptin
Linagliptin/Metformin HCl
Linagliptin/Metformin HCl
Linezolid
Linezolid
Liothyronine Sodium
Lisdexamfetamine Dimesylate
Lisinopril
Lithium Carbonate
Lithium Carbonate
Lithium Carbonate
Lomefloxacin HCl
Lomitapide Mesylate
Lomustine
Loperamide HCl
Loperamide HCl
Loperamide HCl
Loperamide HCl
Loperamide HCl/Simethicone
Lopinavir/Ritonavir
Lopinavir/Ritonavir
Loratadine
Loratadine
Loratadine
Loratadine/Pseudoephedrine Sulfate (10 mg /240 mg)
Loratadine/Pseudoephedrine Sulfate (5 mg /120 mg)
Lorazepam
Lorcaserin HCl
Lorcaserin HCl
Losartan Potassium
Losartan Potassium
Loteprednol Etabonate
Loteprednol Etabonate/Tobramycin
Lovastatin
Lovastatin/Niacin
Lubiprostone
Lurasidone HCl
Macitentan
Magnesium Hydroxide/Omeprazole/Sodium Bicarbonate
Magnesium Hydroxide/Omeprazole/Sodium Bicarbonate
Maraviroc
Mebendazole
Mebendazole ( 500 mg)
Mecamylamine HCl
Meclizine HCl
Meclizine HCl
Medroxyprogesterone Acetate
Medroxyprogesterone Acetate
Medroxyprogesterone Acetate (104mg/0.65ml)
Mefenamic Acid
Mefloquine HCl
Megestrol Acetate
Meloxicam
Meloxicam
Meloxicam
Melphalan
Memantine HCl
Memantine HCl
Menthol/Methyl Salicylate
Meprobamate
Mercaptopurine
Mercaptopurine
Mesalamine
Mesalamine
Mesalamine (1.2 gram)
Mesalamine (250 mg and 500 mg)
Mesalamine (375 mg)
Mesalamine (400 mg and 800 mg)
Mesalamine Enema
Mesna
Mestranol/Norethindrone
Metaxalone
Metformin HCl
Metformin HCl
Metformin HCl
Metformin HCl/Pioglitazone HCl
Metformin HCl/Saxagliptin
Metformin HCl/Sitagliptin Phosphate
Metformin/Repaglinide
Methadone HCl
Methazolamide
Methenamine Hippurate
Methimazole
Methocarbamol
Methotrexate Sodium
Methoxsalen
Methscopolamine Bromide
Methylergonovine Maleate
Methylnaltrexone Bromide
Methylphenidate
Methylphenidate
Methylphenidate
Methylphenidate
Methylphenidate (BX)
Methylphenidate HCl
Methylphenidate HCl
Methylphenidate HCl
Methylphenidate HCl
Methylphenidate HCl
Methylprednisolone
Methylprednisolone Acetate
Methyltestosterone
Methyltestosterone
Metoclopramide HCl
Metoclopramide HCl
Metolazone
Metoprolol Succinate
Metoprolol Tartrate
Metronidazole
Metronidazole
Metronidazole
Metyrosine
Mexiletine HCl
Miconazole
Miconazole Nitrate
Midodrine HCl
Midostaurin
Mifepristone
Mifepristone [300 mg]
Miglitol
Miglustat
Milnacipran HCl
Miltefosine
Minocycline HCl
Minocycline HCl
Minocycline HCl
Minocycline HCl
Minocycline HCl (135 mg and 105 mg)
Minoxidil
Mirabegron
Mirtazapine
Mirtazapine
Misoprostol
Mitotane
Modafinil
Moexipril HCl
Molindone HCl
Montelukast
Montelukast Sodium
Montelukast Sodium
Morphine Sulfate
Morphine Sulfate
Morphine Sulfate
Morphine Sulfate (AB)
Morphine Sulfate (AB2)
Morphine Sulfate (BC)
Morphine Sulfate/Naltrexone HCl
Moxifloxacin
Mycophenolate Mofetil
Mycophenolic acid
Nabilone
Nabumetone
Nadolol
Naldemedine
Naloxegol Oxalate
Naltrexone
Naltrexone HCl
Naltrexone HCl / Oxycodone HCl
Naltrexone HCl/Bupropion HCl
Naproxen
Naproxen
Naproxen
Naproxen Sodium
Naproxen Sodium
Naproxen Sodium
Naproxen Sodium/Diphenhydramine HCl
Naproxen Sodium/Diphenhydramine HCl
Naproxen Sodium/Sumatriptan Succinate
Naproxen/Esomeprazole Magnesium
Naratriptan HCl
Nateglinide
Nebivolol HCl
Nebivolol/Valsartan
Nefazodone HCl
Nelfinavir Mesylate
Nelfinavir Mesylate
Neomycin Sulfate
Nepafenac
Netupitant/Palonosetron HCl
Nevirapine
Nevirapine
Nevirapine
Niacin
Niacin/Simvastatin
Nicardipine HCl
Nicardipine HCl
Nicotine
Nicotine Polacrilex
Nicotine Polacrilex
Nicotine Polacrilex
Nifedipine
Nifedipine
Nilotinib Hydrochloride Monohydrate
Nilutamide
Nimodipine
Nintedanib Esylate
Niraparib
Nisoldipine
Nitazoxanide
Nitazoxanide
Nitisinone
Nitisinone
Nitisinone
Nitrofurantoin
Nitrofurantoin
Nitroglycerin
Nitroglycerin
Nizatidine
Norethindrone
Norethindrone Acetate
Nortriptyline HCl
Nystatin
Nystatin
Obeticholic Acid
Octreotide Injection
Ofloxacin
Olanzapine
Olanzapine
Olanzapine Pamoate
Olaparib
Olmesartan Medoxomil
Olsalazine Sodium
Ombitasvir/ Paritaprevir/ Ritonavir and Dasabuvir Sodium
Ombitasvir/Paritaprevir/Ritonavir
Omega-3-Acid Ethyl Esters
Omeprazole
Omeprazole
Omeprazole (Orally Disintegrating)
Omeprazole Magnesium
Omeprazole Magnesium
Omeprazole Sodium Bicarbonate
Omeprazole Sodium Bicarbonate
Ondansetron
Ondansetron
Ondansetron HCl
Orlistat
Orphenadrine Citrate
Oseltamivir Phosphate
Oseltamivir Phosphate
Osimertinib Mesylate
Ospemifene
Oxaprozin
Oxcarbazepine
Oxcarbazepine
Oxcarbazepine (150 mg)
Oxybutynin
Oxybutynin Chloride
Oxycodone
Oxycodone HCl
Oxycodone HCl
Oxycodone HCl
Oxycodone HCl/ Naloxone HCl
Oxymorphone HCl
Oxymorphone HCl
Palbociclib
Paliperidone
Paliperidone Palmitate
Paliperidone Palmitate [3-month injection]
Palonosetron HCl
Pancrelipase
Pancrelipase
Panobinostat Lactate
Pantoprazole Sodium
Pantoprazole Sodium
Paricalcitol
Paromomycin Sulfate
Paroxetine
Paroxetine HCl
Paroxetine HCl
Paroxetine Mesylate
Paroxetine Mesylate
Pazopanib HCl
Pemoline
Penbutolol Sulfate
Penicillamine
Penicillin V
Penicillin V Potassium
Pentosan Polysulfate Sodium
Pentoxifylline
Perampanel
Perampanel
Pergolide Mesylate
Perindopril Erbumine
Perphenazine
Phendimetrazine Tartrate
Phenelzine Sulfate
Phenoxybenzamine HCl
Phentermine HCl
Phentermine HCl
Phentermine HCl
Phentermine HCl
Phentermine HCl/Topiramate
Phenytoin
Phenytoin
Phenytoin Sodium
Phytonadione
Pilocarpine HCl
Pimavanserin Tartrate
Pimozide
Pindolol
Pioglitazone HCl
Pirfenidone
Pirfenidone
Piroxicam
Pitavastatin Calcium
Pomalidomide
Ponatinib HCl
Posaconazole
Posaconazole
Potassium Chloride
Potassium Chloride
Potassium Citrate
Pramipexole Dihydrochloride
Pramipexole Dihydrochloride
Prasugrel HCl
Pravastatin Sodium
Praziquantel
Prednisolone
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisone
Prednisone
Pregabalin
Pregabalin
Primaquine Phosphate
Primidone
Procarbazine HCl
Prochlorperazine
Progesterone
Progesterone
Promethazine HCl
Promethazine HCl
Propafenone HCl
Propafenone HCl
Propranolol HCl
Propranolol HCl
Propylthiouracil
Protriptyline HCl
Prucalopride Succinate
Pseudoephedrine HCl
Pseudoephedrine HCl/Triprolidine HCl
Pyrazinamide
Pyridostigmine Bromide
Pyridostigmine Bromide
Pyrimethamine
Quetiapine Fumarate
Quetiapine Fumarate
Quinapril HCl
Quinine Sulfate
Rabeprazole Sodium
Rabeprazole Sodium
Raloxifene HCl
Raltegravir Potassium
Raltegravir Potassium
Ramelteon
Ramipril
Ramipril
Ranitidine HCl
Ranitidine HCl
Ranitidine HCl
Ranolazine
Rasagiline Mesylate
Regorafenib
Repaglinide
Ribavirin
Ribavirin
Ribociclib
Rifabutin
Rifampin
Rifapentine
Rifaximin (200 mg)
Rifaximin (550 mg)
Rilpivirine HCl
Riluzole
Rimantadine HCl
Rimexolone
Riociguat
Risedronate Sodium
Risedronate Sodium
Risedronate Sodium/Calcium Carbonate
Risperidone
Risperidone
Risperidone
Ritonavir
Ritonavir
Ritonavir
Rivaroxaban (10 mg)
Rivaroxaban (15 and 20 mg)
Rivaroxaban (2.5 mg)
Rivastigmine
Rivastigmine Tartrate
Rizatriptan Benzoate
Rizatriptan Benzoate
Roflumilast
Rolapitant HCl
Ropinirole HCl
Ropinirole HCl
Rosiglitazone Maleate
Rosuvastatin Calcium
Rotigotine
Rucaparib
Rufinamide
Rufinamide
Ruxolitinib Phosphate
Sacubitril/Valsartan
Safinamide Mesylate
Sapropterin Dihydrochloride
Sapropterin Dihydrochloride
Saquinavir Mesylate
Saquinavir Mesylate
Saxagliptin HCl
Scopolamine
Secnidazole
Selegiline HCl
Selegiline (20 mg/20 cm2 and 30 mg/30 cm2)
Selegiline (40 mg/40 cm2)
Selegiline HCl
Selexipag
Sertraline HCl
Sevelamer Carbonate
Sevelamer HCl
Sevelamer HCl
Sibutramine HCl
Sildenafil Citrate
Sildenafil Citrate
Silodosin
Simeprevir Sodium
Simvastatin
Simvastatin
Simvastatin
Sirolimus
Sitagliptin Phosphate
Sitagliptin Phosphate/Simvastatin
Sodium Iodide I-123
Sodium Phenylbutyrate
Sodium Phosphate Dibasic Anhydrous/Sodium Phosphate Monobasic Mono
Sofosbuvir
Sofosbuvir/Velpatasvir
Solifenacin Succinate
Sonidegib Phosphate
Sorafenib Tosylate
Spironolactone
Stavudine
Succimer
Sucralfate
Sucralfate
Sucroferric Oxyhydroxide
Sulfadiazine
Sulfamethoxazole/Trimethoprim
Sulfamethoxazole/Trimethoprim
Sulfasalazine
Sulfasalazine
Sulfisoxazole Acetyl
Sumatriptan Succinate
Sunitinib Malate
Suvorexant
Tacrolimus
Tacrolimus
Tadalafil
Tamoxifen Citrate
Tamsulosin HCl
Tapentadol HCl
Tapentadol HCl
Tasimelteon
Tedizolid Phosphate
Telaprevir
Telbivudine
Telithromycin
Telmisartan
Temazepam
Temozolomide
Tenofovir Alafenamide Fumarate
Tenofovir Disoproxil Fumarate
Tenofovir Disoproxil Fumarate
Terazosin HCl
Terazosin HCl
Terbinafine HCl
Terconazole
Teriflunomide
Testosterone
Testosterone
Testosterone
Tetrabenazine
Tetracycline HCl
Tetracycline HCl
Thalidomide
Theophylline
Theophylline (100 mg and 200 mg)
Thioguanine
Tiagabine HCl
Ticagrelor
Ticlopidine HCl
Timolol Maleate
Tinidazole
Tiopronin
Tipiracil HCl/Trifluridine
Tipranavir
Tizanidine HCl
Tizanidine HCl
Tofacitinib Citrate
Tofacitinib Citrate
Tolcapone
Tolterodine Tartrate
Tolterodine Tartrate
Tolvaptan
Topiramate
Topiramate
Topiramate
Topiramate
Topotecan HCl
Toremifene Citrate
Torsemide
Tramadol
Tramadol HCl
Tramadol HCl
Trametinib Dimethyl Sulfoxide
Trandolapril
Trandolapril/Verapamil HCl
Tranexamic Acid
Tranylcypromine Sulfate
Trazodone HCl
Trazodone HCl
Treprostinil Diolamine
Tretinoin
Triamcinolone Acetonide
Triamcinolone Acetonide
Triamterene
Trientine HCl
Trimethoprim
Trimipramine Maleate
Triptorelin Pamoate
Triptorelin Pamoate
Trospium Chloride
Trospium Chloride
Ulipristal Acetate
Ursodiol
Ursodiol
Valacyclovir Hydrochloride
Valbenazine
Valganciclovir HCl
Valproic Acid
Valsartan
Valsartan
Vancomycin hydrochloride
Vandetanib
Vardenafil HCl
Vardenafil HCl
Varenicline Tartrate
Vemurafenib
Venetoclax
Venlafaxine HCl
Venlafaxine HCl
Venlafaxine HCl
Verapamil HCl
Verapamil HCl
Verapamil HCl
Verteporfin
Vigabatrin
Vilazodone HCl
Vismodegib
Vorapaxar Sulfate
Voriconazole
Voriconazole
Vorinostat
Vortioxetine HBr
Warfarin Sodium
Zafirlukast
Zalcitabine
Zaleplon
Zidovudine
Zidovudine
Zileuton
Zileuton
Zinc Acetate
Ziprasidone HCl
Zolmitriptan
Zolmitriptan
Zolpidem Tartrate
Zolpidem Tartrate
Zolpidem Tartrate (1.75 and 3.5 mg)
Zolpidem Tartrate (5 and 10 mg)
Zonisamide
Dosage Form
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet (Delayed Release)
Tablet
Suppository
Tablet (Extended Release)
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule (Extended Release)
Tablet
Tablet (Effervescent)
Capsule
Capsule
Suspension
Capsule
Tablet
Tablet (Buccal)
Tablet
Tablet
Tablet
Tablet (Chewable)
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule (pellet)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet (Orally Disintegrating)
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Granule (Delayed Release)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
For Oral Suspension
Capsule
Tablet
Capsule/Tablet/Capsule (Copackage)
Capsule/Tablet/Capsule (Copackage)
Tablet (Chewable)
Tablet
Suspension
Tablet (Extended Release, Orally Disintegrating)
Suspension (Extended Release)
Tablet
Capsule
Injectable (Liposomal)
for Oral Suspension
Capsule
Capsule
Tablet
Tablet
Tablet
For Oral Suspension
Capsule
Tablet
For Intramuscular Suspension (Extended Release)
Tablet
Tablet (Sublingual)
Capsule
Capsule
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Oral Suspension
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Injectable Suspension
Tablet
Tablet
Tablet
Oral Suspension
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet (Delayed Release), For Solution,
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet (For Suspension)
Tablet
Tablet
Tablet
Ophthalmic Suspension
Tablet
Tablet
Capsule
Tablet
Film, Transdermal (Extended Release)
Implant
Film (Buccal)
Tablet (Sublingual)
Tablet (Sublingual)
Film (Sublingual)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Suspension
Tablet
Tablet (Chewable)
Tablet
Tablet
Tablet
Suspension (Enteral)
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet (Chewable)
Capsule
Tablet
Capsule
Suspension
Capsule
Suspension
Tablet
Suspension
Tablet
Tablet (Chewable)
Capsule
Suspension
Tablet
Tablet
Tablet
For Oral Suspension
Suspension
Suspension
Tablet
Capsule
Suspension
Capsule
Capsule
Capsule (Soft-Gelatin)
Tablet (Regular & Chewable)
Capsule
Tablet
Capsule
Suspension
Tablet
Tablet
Extended Release Oral Suspension
Tablet
Tablet
Tablet
Capsule
Capsule (Delayed Release)
Topical Suspension
Tablet
Tablet
Oral Suspension
Injectable Suspension [Otic]
Tablet
Otic Suspension
Otic Suspension
Tablet
Capsule
Suspension
Tablet
Capsule
Tablet
Oral Suspension
Tablet
Capsule
Tablet
Transdermal
Tablet
Tablet
Tablet
Tablet (Vaginal)
Lozenge
Tablet
Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Capsule
Capsule
Capsule (Liquid filled)
Tablet
Capsule
Capsule
Capsule
Tablet
Capsule
For suspension (Intravenous )
Capsule
Tablet
Gel (Topical)
Tablet
Tablet
Oral Suspension
Tablet
Tablet
Tablet (for Oral Suspension)
Granule
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Implant (Intravitreal)
Tablet (Delayed Release, Orally Disintegrating)
Tablet
Tablet
Capsule
Tablet
Gel (Rectal)
Oral suspension
Capsule
Topical patch
Powder for Oral Solution
Capsule
Tablet
Capsule
Tablet (Chewable)
Capsule (Delayed Release Pellets)
Tablet
Tablet
Tablet
Vaginal Suppository
Vaginal Insert (Extended Release)
Tablet
Capsule
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet (Orally Disintegrating (ODT))
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Injectable (Liposomal)
Suspension
Suspension
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Oral granule
Suspension
Granules for Oral Suspension
Tablet
Capsule
Tablet
Capsule (Delayed Release Pellets)
For Oral Suspension (Delayed Release)
Tablet
Tablet
Vaginal Ring
Vaginal Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Vaginal Ring
Tablet
Tablet
Tablet
Tablet (Chewable)
Tablet
Tablet
Capsule
Tablet (Chewable)
Tablet (Chewable)
Tablet
Tablet
Tablet
Film, Transdermal
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Suspension
Tablet (Chewable)
Tablet
Tablet (Chewable)
Tablet
Tablet
Tablet
Suspension
Capsule
Capsule (Micronized)
Tablet
Tablet
Tablet
Tablet
Capsule
Transdermal
Tablet (Sublingual)
Lozenges
Tablet (Buccal)
Tablet (Buccal)
Film (Buccal)
Film (Buccal)
Tablet
Capsule
Tablet
Suspension
Tablet
Capsule
Tablet
Otic Suspension
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Suspension
Suspension
Capsule
Tablet
Tablet
Capsules (Delayed Release)
Capsule
Tablet
Capsule
Tablet
Capsule
Capsule
Tablet
Tablet
Oral Suspension
For Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Implant
Injectable (Extended Release)
Tablet
Oral Suspension
Oral Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Suspension
Tablet
Capsule
Tablet (Chewable)
Suspension
Suspension/Drop
Tablet
Capsule (Soft-Gelatin/Liquid Fill)
Capsule (Soft-Gelatin/Liquid Fill)
Capsule
Capsule
Tablet
Tablet
Capsule
Suspension
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet/Tablet (Copackage)
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet (Copackage)
Tablet (Copackage)
Tablet
Tablet (Regular)
Tablet (Chewable dispersible)
Tablet (Delayed Release, Orally Disintegrating)
Chewable Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet/Tablet (Copackage)
Tablet
Tablet, for Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Intrauterine Device
Tablet
Topical Patch
Capsule
Tablet
Tablet
Tablet
Suspension
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Capsule
Capsule
Capsule
Tablet
Oral Suspension
Tablet (Chewable)
Tablet
Tablet (Combination)
Tablet (Chewable)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet (Chewable)
Tablet (Chewable)
Tablet
Tablet (Chewable)
Tablet (Chewable)
Tablet
Tablet (Chewable)
Tablet
Tablet
Capsule
Tablet
Oral Suspension
Suspension
Tablet
Capsule
Tablet
Tablet
Topical Patch
Tablet
Oral Suspension
Tablet
Suppository
Rectal Enema
Tablet
Tablet
Tablet
For Suspension (Extended Release)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Transdermal Patch
Tablet (Extended Release, Orally Disintegrating )
Tablet
Tablet (Chewable)
Powder for Suspension (Extended Release)
Tablet (Extended Release, Chewable)
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule
Capsule
Tablet (Buccal)
Suppository (Vaginal)
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
ER Tablets
Capsule
Tablet
Tablet
Tablet
Tablet (Orally Disintegrating (ODT))
Tablet
Tablet
Tablet
Tablet
Tablet
Granule
Tablet
Tablet (Chewable)
Tablet
Tablet
Suspension
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Suspension
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Powder for Suspension
Tablet
Capsule
Suspension
Tablet
Capsule
Lozenge
Chewing Gum
Lozenge (Mini)
Capsule
Capsule
Tablet
Capsule
Capsule
Capsule
Oral Suspension
Tablet
Capsule
Suspension
Tablet
Capsule
Suspension
Tablet (Sublingual)
Capsule
Tablet
Tablet
Capsule
Oral Suspension
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Capsule
OTC Tablet (Delayed Release)
For suspension (Delayed Release)
Powder for suspension (Immediate Release)
Capsule
Film (Oral)
Tablet
Capsule
Oral Suspension
Capsule
Tablet
Tablet
Tablet
Suspension
Tablet
Tablet
Tablet
Trans-dermal
Capsule
Tablet
Tablets
Capsule
Intramuscular Suspension (Extended Release)
Intramuscular Suspension (Extended Release)
Capsule
Tablet
Capsule
Delayed Release Granules for Oral Suspension
Capsule
Capsule
Suspension
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Suspension
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Capsule
Suspension
Tablet (Chewable)
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule
Tablet
Oral Suspension
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Capsules
Rectal Suppository
Vaginal Insert
Capsule
Tablet
Rectal Suppository
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet (Chewable)
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet (Effervescent)
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet (Copackaged)
Tablet
Injectable
Powder
Tablet
Capsule
Tablet
Tablet
Tablet
Film, Transdermal
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Transdermal
Tablet
Suspension
Tablet
Tablet
Tablet
Tablet
Powder for Oral Solution
Tablet
Tablet
Capsule
Tablet
Transdermal
Granule
Capsule
Transdermal
Transdermal
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Suspension
Capsule
Capsule
Suspension
Tablet
Tablet
Tablet
Tablet
Capsule
Powder for Oral
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Capsule
Capsule
Suspension
Tablet
Tablet (Chewable)
Tablet
Tablet
Suspension
Tablet
Oral Suspension (Pediatric)
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Powder for Oral
Tablet
Tablet
Capsule
Tablet
Suppository (Vaginal)
Tablet
Pellet Implant
Buccal Tablet (Extended Release)
Tablet
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule (Sprinkle)
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Intra-Articular, For Suspension (Extended Release)
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Capsules
Tablet
Tablet
Capsule
Tablet
Capsule
Capsule
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Injectable
Tablet
Tablet
Capsule
Tablet
Tablet
Suspension
Capsule
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Capsule
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet (Sublingual)
Tablet (Sublingual)
Capsule
USP Apparatus
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle) with sinker
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)

I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Teflon coated paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

I (Basket)
I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle), with option to use a sinker for 20/10 mg strength
II (Paddle)
II (Paddle) with PEAK vessels
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
IV (Flow through cell)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
VI (Cylinder) with adapter, if needed

II (Paddle
I (Basket) 100 mL round bottom vessel
I (Basket)
I (Basket)
V (Paddle over Disk) with 56 mm, 40 mesh stainless steel disk.
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
II (Paddle)
Met: I (Basket, 40 mesh): Can: I (Basket, 10 mesh [with option of tablet holder])
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle) with option to use a sinker
II (Paddle)
III (Reciprocating Cylinder)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
IV (Flow through cell-closed loop) / 22 mm
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
Cobi: II (Paddle): Drv: II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
I (Basket)
I (Basket) for 75 strength: I (Basket with modified diameter of 24.5 mm) for 150 mg strength:
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket- 20 mesh)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
III (Reciprocating Cylinder [40 mesh (for bottom and top of the inner tube)]
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle) over a disk (62 mm with 16 mesh)
VII (with reciprocating 50 mesh baskets)

I (Basket)
I (Basket -100 mesh)
I (Basket)
I (Basket)
I (Basket)
I ( Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
V (Paddle over Disk) with a watchdish (a diameter of 6 cm)
II (Paddle
II (Paddle
II (Paddle)
II (Paddle) (diclo) II (Paddle) (miso)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
Dutasteride: II (Paddle) with sinker. Tamsulosin: II (Paddle)
II (Paddle) A sinker may be used with justification if necessary.
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
II (Paddle)
Incubator shaker
I (Basket)
VI (Cylinder) attach the patch to a disk at the bottom of the cylinder

V (Paddle over Disk) with a stainless steel disk
VI (Cylinder) attach the patch to the cylinder with double-sided tape
II (Paddle)
III (Reciprocating Cylinder) [40 mesh for bottom and top of the inner tube]
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Modified USP Type V (Paddle-over-disk)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle
II (Paddle
II (Paddle)
VII (Reciprocating holder)- cylinder.

II (Paddle)
II (Paddle)
II (Paddle) small volume dissolution apparatus
II (Paddle) small volume dissolution apparatus
I (Basket) 100 mL dissolution vessel
I (Basket) 100 mL dissolution vessel
II (Paddle)
II (Paddle with sinker)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Prior to sampling, the jar is removed from incubation and mechanically swirled with digital orbital s
VI (Cylinder)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
I (Basket-10 mesh)
II (Paddle)
VII (Reciprocating holder) (Sample holder-Cage)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)

II (Paddle)
I (Basket)
II (Paddle)
I (Basket, with 20 mesh)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

Lumacaftor: II (Paddle); Ivacaftor: II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Reciprocating Cylinder (Apparatus 3 modified)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Paddle over Disk (Apparatus 5)

I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
Test 1: IV (Flow through cell), 22.6 mm cell, 13 g of 1 mm beads; Test 2: II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
VI (Cylinder)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
VI (Cylinder)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
IV (Flow-Through Cell-Open system)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket- 10 mesh)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket) (100 mesh)

II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle) with sinkers
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
Niacin: I (40 mesh rotating Basket); Simvastain: I (10 mesh rotating Basket)
II (Paddle)
II (Paddle)
I (Basket)
Chewing Machine as desribed in European Pharmacopoeia (2.9.25)
I (Basket)
II (Paddle)
II (Paddle
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Modified USP Type V (Paddle-over-disk)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
IV (Flow through cell), 22.6 mm cell

II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
V (Paddle over Disk) with a stainless steel disk (120 mesh screens)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle) with wire sinker
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)

II (Paddle)
II (Paddle)
I (Suppository, dissolution baskets, palmieri type)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket, with 20 mesh)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket -100 mesh)
II (Paddle)
II (Paddle)
II (Paddle)
Modified USP Type VI (cylinder)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Reciprocating disk (Apparatus 7)
I (Basket)

Rotating Cylinder (Apparatus 6)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Basket (20 mesh)

I (Basket)
II (Paddle) with stainless steel stationary quadrangular hanging basket
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (with Palmieri type basket)
II (Paddle)
V (Paddle over disk). Paddle 25 mm above the film on the disk.
II (Paddle, may use sinker)

II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
I (Basket)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle
II (Paddle)
I (Basket)
I (Basket)
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
I (Basket)
II (Paddle)
III (Reciprocating Cylinder) [Bottom Screen: 200 mesh stainless steel]
II (Paddle)
I (Basket)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
II (Paddle)
Speed (RPMs)
75
85
75
75
75
50
50
180
75
50
50
50
50
100
100
100
50
75
50
50
60
50
75
50
50
100
For Alendronate: 50; For Cholecalciferol: 75

100
100
100
100
100
100
100
50
50
50
50 (for 1 mg) & 75 (for 0.5 mg)
100
50
50
50
75
100
100
50
75
50
75
100
50
50
75
75
50
100
75
75
50
100
50
50
25
50
100
50
75
60
50
100
50
75
50
50
100
100
75
100
75
100
50
50
75
50
75
75
50
50
50
50
75
50
50
50
50
25
100
50
150
50
100
50
100
Flow @ 8 mL/min
75
50
50
100
75
75
50
50
75
50
50
70
50
100
75
50
50
100
100
100
100
75
50
50
75
75
75
50
75
Met: 100: Can:100
Canagliflozin: 75; Metformin: 50
50
50
50
50
50
75
75
50
Carbidopa and Levodopa: 50; Entacapone: 125
50
25
75
50
50
100
100
50
100
100
25
50
50
75
50
25
100
50
25
25
50
50 mg, 100 mg and 200 mg: 50 rpm; 400 mg: 75 rpm

25
60
50
50
100
50
75
27 dpm
50
50
50
50
50
50
100
50
75
75
100
Flow @ 6 mL/min
100
50
50
50
75
75
50
50
50
50
50
50
50 RPM (12.5 mg, 25 mg and 100 mg); 75 RPM (150 mg and 200 mg)
75
Cobi: 75; Drv:75
100
100
50
75
100
75
100
75
75
75
100
65
75
50
50
100
60
100
100
75
75
75
25 dpm
60
50
75
75
50
60
50
50
50
50
50
75
100
75
30 cycles per min
12 dpm
100
100
100
100
100
100
50
100
50
50
100
50
75
50
50
100 (diclo) 50 (miso)
75
100
50
100
100
100
50
50
100
100
100
75
50
50
50
100
50
50
50
75
50
25
75
100
75
100
100
100 and 150
75
50
50
100
50
Dutasteride: 75 Tamsulosin: 50
50
50
100
100
100
75
50
50
100
75
75
100
50
50
50
50
75
75
75
50
50
50
50
50
75
75
100
75
75
75
50
100
100
100
50
50
130
40
50
50
50
50
100
50
50
50
50
75
75
100
75
75
75
75
75
50
75
70
50
50
100
50
50
75
50
25 and 50
50
50
50
75
50
75
75
75
50
50
75
30 cycles per minute. amplitude of about 2m.

50
175
100
100
100
100
100
75
75
50
50
50
50
75
100
100
50
50
50
50
50
50
50
50
50
75
25
50
50
50
50
60
50
50
75
75
75
50
50
75
Swirl orbit of 50 mm at 205 rpm for 6 seconds
50
50
25 and 50
25 and 50
75
50
75
100
50
50
100
Hydrochlorothiazide: 100; Metoprolol succinate: 75
50
50
100
100
100
50
30 cycles per min

50
75
50
50
150
150
150
100
100
50
150
50
75
50
50
100
50
100
75
50
100
50
100
50
50
50
100
75
65
Lumacaftor:65; Ivacaftor: 65
FDC: IVA: 65/TEZ:75; IVA: 65
50
100
100
50
50
50
75
75
75
Lamivudine and Zidovudine: 75 Efavirenz: 50

50
50
50
50
75
10 dpm (dip rate per minute)
55
75
100
100
50
50
75
75
RIB: 50; LET: 75
100
50
50
50
75
75
50
50
50
50
100
50
50
50
50
50
25
50
75
50
50
75
50
75
50
100
50
50
50
100
50
50
75
150
150
100
75
75
100
100
Test 1: 17 mL/min; Test 2: 50 rpm
100
25
75
100
100
100
50
50
50
75 (for 500 mg) & 125 (for 1000 mg)
Phase 1 & 2: 100 rpm; Phase 3: 50 rpm
100
100
50
50
100
50
100
75
50
100
50
50
50
75
75
100
100
75
75
50
50
75
100
60
100
50
50
75
50
75
100
50
50
100
100
100
100
50
50
50
50
50
50
50
50
100
50
50
50
100
50
50
40
40
50
50
50
50
50
50
50
75
75
75
75
Naproxen::50 rpm Esomeprazole::75 rpm
50
50
100
50
50
50
50
Netupitant:100; Palonosetron: 75
75
25
100
100
50
50
100
60 cycles (chews) per minute
20 dpm
100
50
100
50
50
100
75
50
50
50
50
100
50
25, 50 and 75
75
75
100
Flow @ 3 mL/min
100
100
75
75
100
100
100
100
50
75
50
50
75
25
50
50
50
75
75
60
60
60
50
100
50
50
50
50
50
50
50
50
75
50
100
100
100
50
100
60
75
75
75
50
50
50
50
50
50
50
50
50
100
50
100
75
50
50
35
50
50
75
25
100
50
75
50
50
100
50
50
50
100
50
50
50
50
200
Acid Stage: 75 rpm; Buffer Stage: 60 rpm

100
50
50
100
50
50
50
50
50
75
50
100
50
50
75
75
75
50
50
75
75
50
50
100
75
75
75
50
50
50
50
50
50
100
50
50
50
75
50
75
75
100
50
50
50
50
Stroke depth: 2-3 cm; 30-60 cycles per minute
50
50
50
50
50
75
50
100
50
50
75
50
75
120
100
100
100
75
100
75
75
50
75
75
50
75
75
50
50
30
30
50
75
100
50
50
100
75
100
50
60
50
50
50
100
75
100
50
50
50
50
100
50
50
60
50
100
50
50
100
50
75
50
100
100
50
50
50
100
50
100
50
100
50
50
50
100
50
50
50
50
100
100
75
60
50
50
50
50
100
100
75
100
200
75
50
50
50
50
50
50
50
50
50
100
75
20 dpm
50
100
50
50
60
75
50
50
50
100
50
50
75
50
75
50
75
50
50
50
50
75
50
Medium
0.1 N HCl
0.01 M Phosphate Buffer with 0.5% sodium dodecyl sulfate (SDS), pH 6.8
0.1 N HCl
0.1 N HCl
0.01 N HCl
0.25% SLS in 56.5 mM phosphate buffer, pH 4.5
0.1 M HCl
Acid Stage: 0.1 N HCl Buffer Stage: "Citrate-sodium hydroxide" buffer pH 6.8 (150 ml of 2N NaOH, 21.014 gm of
Water (deaerated)
Phosphate buffer, pH 5
Refer to USP
Refer to USP
Water (deaerated)
Refer to USP
Water (deaerated)
Water
Water
Refer to USP (provide individual unit data).
Refer to USP
0.1 N HCl
Water (deaerated)
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
Acetate Buffer, pH 4.5 with 2.2% Tween 20
Refer to USP
Develop a dissolution method
Refer to USP
0.01 N HCl
0.1 N HCl
Refer to USP
Refer to USP
Phosphate Buffer, pH 6.0
0.01 N HCl
McIlvaine Buffer pH 4.0
Refer to USP
0.1 N HCl
Refer to USP
0.1 N HCl
pH 1.2, Simulated Gastric Fluid without pepsin, containing 4 % Triton X-100 [polyoxyethylene[10]octylphenyl ethe
Refer to USP
For Alendronate: Deaerated Water; For Cholecalciferol: 0.3% SDS in USP Water
0.01 N HCl
0.01 N HCl
0.01 M HCl (degas)
0.01 N HCl, pH 2.0
0.01 N HCl
0.1 N HCl
Refer to USP
0.1 N HCl
0.01 N HCl
0.01 N HCl
Water (deaerated)
1% Phosphate Buffer, pH 6.0
Refer to USP
70 mM Potassium Phosphate Buffer, pH 6.0
Refer to USP
0.1 N HCl
Water (deaerated)
Refer to USP
0.05 M Acetate Buffer, pH 5.0
Refer to USP
Refer to USP
Refer to USP
Acid Stage: 0.1 N HCl; Buffer Stage 2: pH 7.5 Phosphate Buffer
1% SLS in water
Acetate Buffer, pH 4.0, with 1% Tween 80
Refer to USP
0.01 N HCl
0.01 N HCl
0.01 N HCl
Refer to USP
0.01 N HCL
Telmisartan: Phosphate Buffer, pH 7.5; Amlodipine: 0.01N HCl, pH 2
Refer to USP
Water (degassed)
Refer to USP
Refer to USP
3 Stage dissolution: 50 mM potassium phosphate monobasic buffer at pH 4.0 (0-2 hours), 6.0 (2-4 hours) and 6.8
Refer to USP for monographs of Amoxicillin Capsules, Clarithromycin Tablets and Lansoprazole Delayed-Release Capsules
Refer to USP for monographs of Amoxicillin Capsules, Clarithromycin Tablets and Omeprazole Delayed-Release Capsules
Refer to USP
Refer to USP
Water (deaerated)
Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8
Dilute HCl, pH 1.1 for first 2 hrs, then add 200 mL of 200 mM Phosphate Buffer and adjust to pH 6.0 for the rema
Deionized Water
Media 1: pH 1.1±0.1, Dilute HCl 2 hours; Media 2: pH 6.0±0.1, Phosphate Buffer 3rd hour, Media 3: pH 7.5±0.1, P
750 ml of dilute HCl, pH 1.1 for the first 2 hours, then add 200 ml of 200 mM phosphate buffer, and adjust to pH
Develop a method to characterize in vitro release
Water (deaerated)
0.1 N HCl
0.1 N HCl
Water
0.05 M Sodium Phosphate Buffer with 0.05% SLS, pH 6.8
0.15% SLS in 25 mM Sodium Phosphate Buffer, pH 6.8
Water (with 1.2% Tween 80)
2.2% sodium dodecyl sulfate in distilled water
Refer to USP
0.25% Sodium Dodecyl Sulfate (SDS) Solution
Acetate Buffer, pH 4.0
0.1 N HCl
Refer to USP
0.05M Potassium Phosphate Buffer (pH 7.4) with trypsin (.001%w/v) and sodium azide (.025% w/v)
Acid Stage: 0.1 N HCl (degassed); Buffer Stage: Phosphate Buffer, pH 6.8 (degassed)
Refer to USP
Refer to USP
Refer to USP
Water (deaerated)
0.01 N HCl for first hour, 0.1 M Phosphate Buffer, pH 5.5, thereafter
Water (deaerated)
Water (deaerated)
Refer to USP
0.025 N HCl
0.05 M Citrate Buffer (pH 2.8)
Refer to USP
Refer to USP
0.1 N HCl
0.05 M Phosphate buffer, pH 6.8
Phosphate buffer, pH 6.8 with 0.2% w/v Tween 80
40% isopropanol buffered to pH 8.0 with potassium dihydrogen phosphate
40% isopropranol buffered to pH 8.0 with potassium dihydrogen phosphate
Develop dissolution method(s) to characterize the dissolution of both components
Water (deaerated)
Simulated gastric fluid without pepsin.
0.01 N HCl
Refer to USP
Phosphate Buffer, pH 7.8 (deaerated)
Phosphate Buffer, pH 6.8 containing 1.0% Tween 80,
Phosphate buffer, pH 6.0
Refer to USP
Refer to USP
50 mM Acetate Buffer, pH 4.5
Refer to USP
Water (degassed)
pH 6.8 buffer
0.01 N HCl
Water (deaerated)
0.1 N HCl
Refer to USP
Refer to USP
Water
0.1 N HCl
0.05% SLS, pH 3.0 or Develop an in vitro release method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Pad
Refer to USP
0.01 N HCl, (with addition of pepsin if gelatin crosslinking is observed)
Tier 1 Medium: 0.5% HDTMA in 0.05 M phosphate buffer, pH 7.5 Tier 2 Medium: 0.5% HDTMA in 0
1% SLS in water
Acid stage: 0.1 N HCl: Buffer stage: 0.05 M Phosphate buffer, pH 6.8, with 0.15% sodium lauryl sulfate (SLS) [only
Tetracycline and Metronidazole: 0.1 N HCl; Bismuth Subcitrate Potassium: Water
Refer to USP
0.1 N HCl
50 mM phosphate buffer, pH 6.8 with 0.1% sodium dodecyl sulfate
1% SLS in water
0.1 N HCl with 0.5% sodium dodecyl sulfate (SDS), pH 1.1
0.1 N HCl
0.05 M Acetate buffer, pH 4.3
50 mM Potassium Phosphate Buffer, pH 7.2
Refer to USP
Acid Stage: 0.1 M HCl containing 0.5% Macrogol Cetostearyl Ether; Buffer Stage: pH 7.2 phosphate buffer contain
Acid stage: 0.1 N HCl; Buffer stage: Phosphate Buffer, pH 7.5
Refer to USP
0.9% Sodium Chloride at 32°C
Water
0.05M NaH2PO4.H2O Phosphate Buffer, pH 4.5
Water
Water
Acetate Buffer, pH 4.0 (12.5mM Sodium acetate trihydrate and 60mM glacial acetic acid. Adjust the pH with glacial acetic acid
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
Water (Deaerated)
0.1 N HCl
0.01 N HCl with 0.375% Triton X-100 (degassed)
0.01 N HCl with 0.5% Triton X-100 (degassed)
0.5% SDS in 5 mM Sodium Dihydrogenphosphate Monohydrate, pH 6.8
Develop a quantitative rupture test
Refer to USP
Water
0.75 % sodium lauryl sulfate (SLS) in water
Met: Simulated Gastric Fluid [SGF] without enzyme, pH 1.2; Can: 0.1% (w/v) polysorbate 20 in 0.05 M sodium ph
Canagliflozin (50 mg): 0.025 % Polysorbate 20; Canagliflozin (150 mg):0.075 % Polysorbate 20; Metformin: Phosph
0.35% Polysorbate 20 in 0.05 M Phosphate Buffer, pH 6.5
0.70% Polysorbate 20 in 0.05 M Phosphate Buffer, pH 6.5
0.35% Polysorbate 20 in phosphate buffer pH 6.5
0.70% Polysorbate 20 in phosphate buffer pH 6.5
Refer to USP
Refer to USP
Refer to USP
Water (deaerated)
First 4 hours: Dilute Acid, pH 1.1. After 4 hours: Phosphate Buffer, pH 7.5 with 0.1% sodium lauryl sulfate (SLS).
Refer to USP
1% SLS in Water
0.1 N HCl
For both Carbidopa and Levodopa: 0.1 N HCl, For Entacapone: Phosphate buffer pH 5.5
0.1 N HCl
Refer to USP
0.05 M Sodium Acetate Buffer, pH 4.5
Acid stage: Simulated Gastric Fluid [SGF] without enzyme; Buffer stage: pH 7.0, 50 mM Phosphate Buffer
0.1 N HCl
0.4 M Phosphate Buffer
0.05M Phosphate Buffer, pH 6.8
Sodium Acetate Buffer, pH 5.0 (degas)
Refer to USP
Refer to USP
SGF without enzyme
0.1 N HCl
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Water
Simulated Gastric Fluid without enzyme
Refer to USP
0.05 M Phosphate Buffer, pH 7.2
Glycine Buffer (0.04 M) pH 3.0
Refer to USP
Refer to USP
Refer to USP
Water
Water (deaerated)
Refer to USP
Tier 1 Medium: 0.04 M tribasic sodium phosphate (pH 12) with 1% SLS. Tier 2 Initial Medium: 750 mL of simulated g
Water
Refer to USP
0.01 M HCl (degassed)
25 mM pH 6.8 phosphate buffer
Water (deaerated)
Refer to USP
0.1 N HCl
0.1 N HCl
0.1 N HCl
Row 1: Test Fluid 1 (0.1N HCl) for 1st hour. Row 2: Test fluid 2 (Phosphate Buffer, pH 7.5) for 5th hour
Simulated gastric fluid (SGF) without enzyme (pH 1.2)
50 mM Potassium Phosphate Buffer, pH 6.5 (degassed)
Acid Stage: 0.1 N HCl; Buffer Stage: pH 6.8 Phosphate Buffer [500 mL 0.1 N HCl for 1 hour, followed by addition
Simulated Intestinal Fluid without enzyme
Simulated Gastric Fluid (SGF) at 37ºC ± 0.5ºC
Refer to USP
Refer to USP
Refer to USP
Acid Stage: 0.05M Sodium Phosphate, pH 3.5 ± 0.05; Buffer Stage: 0.05 M Sodium Phosphate, pH 6.8 ± 0.05
0.3% SLS in water
0.05 N HCl
0.05 M Acetate Buffer with 0.025% Brij35 (polyoxyethylene lauryl ether), pH 4.5
50 mM Acetate Buffer, pH 4.5 @37°C ± 0.5 [use glass beads; sample volume: 100 μl]
0.1 N HCl
Refer to USP
0.1 N HCl
Refer to USP
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl (degassed)
0.1 N HCl (degassed)
Refer to USP
Refer to USP
Refer to USP
Water
Refer to USP
500 mL 0.1N HCl for the 1st hour, then add 400 mL 0.27M Sodium Phosphate (Dibasic) buffer solution
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
Refer to USP
Acetate Buffer (pH 4.0)
pH 4.5 Acetate Buffer
50 mM Sodium Acetate Buffer, pH 4.5
Cobi: 0.05 M Citrate Phosphate Buffer, pH 4.2; Drv: 0.05 M Sodium Phosphate Buffer, pH 3.0, 2% Tween 20
0.05 M sodium citrate buffer pH 5.5 containing 2.0% w/v polysorbate 80
0.01 N HCl with 2% w/w Polysorbate 80
50 mM Acetate Buffer, pH 4.5
Refer to USP
Refer to USP
Deionized Water with 2% Sodium Lauryl Sulfate (SLS)
Disintegration Testing as per USP <701> in various media such as deionized water, simulated gastric fluid and simulated intes
0.1N HCl (degassed)
Acid stage: 0.1 N HCl; Buffer stage: Sodium phosphate buffer, pH 6.8
Refer to USP
Refer to USP
Water (deaerated)
Refer to USP
Refer to USP
0.1 N HCl containing 4 mg of N,N-dimethydodecylamine-N-oxide per mL
Refer to USP
0.1 N HCl
Acid stage: 0.1N HCl; Buffer stage: 0.05 M Sodium Phosphate buffer, pH 6.8
0.01 N HCl (pH 2.0)
0.2% Cetyl trimethylammonium bromide (CTAB) in 0.1N HCl
Phosphate Buffer, pH 6.8 with 0.75% Brij 35
Refer to USP
0.5% Benzalkonium Chloride in water
0.5% Hyamine 10X in water, adjust to pH 6.8 with 0.1 N KOH or 0.1 N HCl
Refer to USP
0.01N HCl Comparative dissolution data should also be provided in 900 ml pH 4.5 buffer, pH 6.8 buffer, and wate
1% sodium lauryl sulfate (SLS) in 0.01N HCl
0.05% Polysorbate 20 in 0.05M Phosphate Buffer, pH 6.8
2% Tween-20 in 0.05 M Sodium Phosphate Buffer, pH 3.0
15 mM hexadecyltrimethylammonium bromide (CTAB) in 0.03M Sodium Phosphate Buffer, pH 6.8
pH 4.0 Acetate buffer containing 1% Triton X-100
Phosphate buffer pH 6.8 with 0.5% Tween 20
Phosphate Buffer, pH 6.8 with 0.5% Tween 20
0.5% Tween 20 in Phosphate Buffer, pH 6.8
0.1 N HCl
0.05 M Phosphate Buffer, pH 7.4 (degassed)
0.05 M Phosphate Buffer, pH 6.0 containing 0.6% w/v SDS
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
0.1 N HCl
First hour: 0.1 N HCl; After 1 hour: 0.1M Potassium Phosphate Buffer pH 7.5
First hour: 0.1 N HCl; After 1 hour: 0.1M Potassium Phosphate Buffer pH 7.5
Water (deaerated)
Refer to USP
0.9% NaCl in water
pH 3.0 Acid Phthalate Buffer
Refer to USP
Phosphate Buffered Saline containing 0.05 g/L sodium dodecyl sulfate at 45 ± 0.5°C
0.02N HCl (2 hours) followed by 0.05M Phosphate Buffer pH 7.5
Acid Stage: 0.1 N HCl, Buffer Stage: pH 7.0 Phosphate Buffer with 5 mM SLS
Acid Stage: 0.1 N HCl; Buffer Stage: pH 7.2 Phosphate Buffer with 5 mM Sodium lauryl sulfate
Water
First 2 hours: 0.01 N HCl, Hours 2-10: Phosphate Buffer, pH 6.8
Water
0.1 N HCl
0.01 N HCl
pH 1.2, Simulated Gastric Fluid without enzyme
0.1 N HCl
Refer to USP
10 mM Citrate Buffer pH 5.5 with 0.05% Sodium Dodecyl Sulfate (SDS)
pH 6.8 phosphate buffer at 32 ± 0.5°C
0.05M phosphate buffer (TriSodium Phosphate Dodecahydrate in 0.1 N HCl and pH adjusted to 6.8)
50 mM Phosphate buffer pH 6.8
SIF without enzyme
Refer to USP
Refer to USP
Diclofenac: Acid Stage: 0.1 N HCl Buffer Stage: 750ml 0.1N HCL+250ml 0.2M phos.buffer, pH 6.8 (Method A) Mis
Refer to USP
Water (deaerated)
Acid stage: 0.1 N HCl; Buffer stage: 0.1 N HCl:0.2M Tribasic Sodium Phosphate (3:1), pH 6.8
0.4% SLS in water
Water (deaerated)
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Acid stage: 0.1 N HCl; Buffer stage: pH 6.8 Phosphate Buffer
Deionized Water
50 mM Phosphate Buffer, pH 6.5
Refer to USP
Refer to USP
Refer to USP
2% SDS
Refer to USP
Refer to USP
Refer to USP
0.001 M HCL
Refer to USP
1.0 % Tween 20 in 0.01 M HCl, pH 2.0
0.01M pH 6.8 phosphate buffer
0.01M pH 6.8 phosphate buffer containing 0.15% w/v sodium dodecyl sulfate (SDS)
0.01M pH 6.8 phosphate buffer containing 0.25% w/v sodium dodecyl sulfate (SDS)
pH 1.2 NaCl/HCl buffer
0.1 N HCl
Refer to USP
0.01 N HCl
SGF without enzyme
Simulated Gastric Fluid w/o enzyme (pH 1.1-1.3)
Refer to USP
Develop a method to characterize in vitro release, starting at pH 6.00 ± 0.05 and at 47ºC ± 0.5ºC. Replicate for 12 dosage vials
0.01 N HCl
Dilute HCl, pH 1.1 for 2 hours and then add 200 mL of 0.1 N NaOH in 200 mM Phosphate Buffer. Adjust pH to 6.
Refer to USP
Refer to USP
Acid stage: 0.06 N HCl; Buffer stage: Neutralized Phthalate Buffer, pH 5.5
Water
Refer to USP
Acid stage: 0.06 N HCl; Buffer stage: Neutralized Phthalate Buffer, pH 5.5
Acid stage: 0.1 N HCl: Buffer stage: 0.2M sodium phosphate buffer pH 6.8
10% Labrasol in Water; (In addition, the USP capsule rupture test should also be conducted)
pH 4.5 Phosphate buffer
Water
Refer to USP
Phosphate buffer pH 6.8, saline with 0.03 % ascorbic acid
0.1N HCl
Refer to USP
Tier I: Dissolution Medium: 0.1 N HCI with 2% (w/v) sodium dodecyl sulfate (SDS) (900 mL) Tier II: Dissolution Med
Dutasteride::Tier I: Dissolution Medium: 1%w/v cetyltrimethylammonium bromide (CTAB) in 0.1 N HCl. Tier II: Di
1% Sodium Lauryl Sulfate in water
2% SLS in water
2% SLS in water
Phosphate Buffer, pH 6.8 with 0.45% (w/v) Polysorbate 80
0.1 N HCl
0.1 N HCl
50 mM potassium phosphate in water, pH 6.8 with 0.2% polysorbate 80
0.5% Polysorbate 80 in Phosphate Buffer, pH 6.8
0.05M Phosphate Buffer, pH 4.5
2.0% w/v Polysorbate 80 in 0.01 N HCl (pH 2.0) at 37 ºC
pH 6.8 Phosphate Buffer
Phosphate Buffer, pH 6.8 (degas)
Phosphate Buffer, pH 6.8 (deaerated)
Tier 1: 0.1 N HCl Tier 2: 0.1 N HCl containing Pepsin 750,000 USP units/L. Tier 2 is used after failure of Tier 1 testi
Rilpivirine (RPV): 0.5% Polysorbate 20 in 0.01 N HCl; Emtricitabine (ETC) and Tenofovir alafenamide (TAF): 50 mM
0.5%(w/w) polysorbate 20 in 0.01N HCl (pH 2.0)
50 mM Sodium Citrate buffer, pH 5.5
0.01 N HCl
Refer to USP
Phosphate buffer pH 6.8 (50mM)
Tier 1 Medium: 0.3% cetyl trimethyl ammonium bromide (CTAB) in 0.1 N HCl;Tier 2 Medium: 0.3% CTAB in 0.1 N H
0.1 N HCl
0.5 N NaOH with 10% Triton-X-100
0.02% Tween 80 in 0.01 N HCl
Refer to USP
Refer to USP
Monobasic Sodium Phosphate, pH 6.8 Buffer with 1% SLS Buffer w/ 1% SLS
0.1 N HCl
0.1 N HCl
Refer to USP
Acid stage: 0.1 N HCl; Buffer stage: Sodium Phosphate Buffer, pH 6.8
Water (deaerated)
Water
0.9% Saline
Phosphate Buffer, pH 4.75 ± 0.05
Water at 32 ± 0.5°C
Refer to USP
0.3% SLS in water
3% sodium lauryl sulfate (SLS) in 0.1N HCl
Water
Water
EC: 0.02 M Na Acetate Buffer (pH 4.5); MPA: 0.54% Sodium Lauryl Sulfate [SLS] in water
Water
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
0.25% Sodium Lauryl Sulfate (SLS) in Water
Refer to USP
Refer to USP
Refer to USP
0.09% Sodium Lauryl Sulfate in 0.1 N HCl
Refer to USP
Refer to USP
Phosphate Buffer, pH 6.8, containing 0.07% w/v Triton X 100
0.025 M Na Acetate Buffer with 0.15% Sodium Lauryl Sulfate [SLS] (pH 5.0) [degassed]
0.025 M Sodium Acetate Buffer with 0.15% SLS, pH 5.0
0.05% Tween 20 in water
0.05% Tween 20 in water
Water with 5 ppm of Tween 80
0.1% Hydroxypropyl-beta-cyclodextrin at 32º C
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
1.0 % Sodium lauryl sulfate (SLS) in 0.01 M HCl in two phases: Phase 1: 1000 mL of degassed 0.01 M HCl for 10 mi
1.0 % Sodium lauryl sulfate (SLS) in 0.01 M HCl in two phases: Phase 1: 500 mL of degassed 0.01 M HCl for 10 min
Water with 0.4% sodium dodecylsulfate
0.5%(w/v) SLS Solution
0.45% SLS in 0.05 M Acetate Buffer, pH 4.5
0.01 M Sodium Phosphate, pH 7.0/0.5% SDS
0.01 N HCl
0.1 N HCl
Refer to USP
Refer to USP
Water (deaerated)
Refer to USP
Phosphate Buffer w/ 2% Tween 80 and 0.1% pancreatin, pH 6.8
0.025 M SLS in water
0.75% Sodium lauryl sulfate in water
25 mM Sodium lauryl sulfate in water
0.05 M Sodium lauryl sulfate in water
Refer to USP
Equimolar mixture of 0.005 M phosphoric acid solution, and 0.005 M sodium phosphate, monobasic monohydrate (pH
Phosphate Buffered Saline solution, pH 7.0
Phosphate Buffered Saline solution, pH 7.0
25-mM Phosphate Buffer, pH 6.4
25-mM Phosphate Buffer, pH 6.4
EDTA media ( 2.0 grams of EDTA Na2 2H2O to 1000 mL of purified water)
Tier 1: KCl/HCl Buffer, pH 1.2; Tier 2: KCl/HCl Buffer pH 1.2, with pepsin
Refer to USP
0.001 N HCl
0.001 N HCl
Water (deaerated)
0.001 N HCl
Refer to USP
Water with 2% Tween 80
Refer to USP
0.1 N HCl with 0.2% SDS (sodium dodecyl sulfate)
0.1 N HCl
Refer to USP
Mcilvaine Buffer (Citric Acid/Phosphate Buffer), pH 4.0
Water (deaerated)
Water (deaerated)
Water (deaerated)
Refer to USP
Water
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
Refer to USP
Water (deaerated)
Refer to USP
Water (deaerated)
250 mM Sodium Acetate/Acetic acid buffer pH 3.5
10 mM HCl
Water (deaerated)
Refer to USP
Phosphate Buffer pH 5.5
Refer to USP
Refer to USP
Refer to USP
10 mM Phosphate buffer at pH 7.4 with 1.0 % SLS
Refer to USP
50 mM potassium dihydrogen phosphate buffer pH 6.5 Comparative dissolution data should also be provided in 900
Water (deaerated)
Tween 80 (5% v/v) in water
Refer to USP
0.01 N HCl
For Pioglitazone: pH 2.0, HCl Buffer. For Glimepiride: pH 6.8, Sodium Phosphate Buffe
0.01 M HCl with 0.5% Sodium Dodecyl Sulfate
Simulated Intestinal Fluid without pancreatin, pH 7.5
Refer to USP
Refer to USP
0.05 M Borate Buffer, pH 9.5
Refer to USP
Refer to USP
Each implant should be incubated in 50 mL of phosphate buffered saline, pH 7.4, at 39°C (warmed overnight befo
80 microL /L phosphoric acid (85%) at 32 ± 0.5°C
Refer to USP
Refer to USP
0.1 N HCl
0.01 N HCl
HCl Buffer, pH 2.2
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
0.1 N HCl
0.1 N HCl
Water (deaerated)
Hydrochlorothiazide: 0.1N HCl; Metoprolol succinate: Phosphate Buffer, pH 6.8
Refer to USP
0.1 N HCl
Water (deaerated)
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Simulated gastric fluid (SGF) without enzyme (pH 1.2)
Refer to USP
Refer to USP
Water
Refer to USP
Refer to USP
Refer to USP
Water
3.0% w/v Polysorbate 20 in 50 mM Phosphate Buffer, pH 6.8
Refer to USP
Refer to USP
50mM Phosphate Buffer, pH 7.2
Phosphate Buffer (200 mM), pH7.2
50 mM Potassium Phosphate Buffer, pH 6.5, (degassed)
Tier 1: 0.05 M phosphate buffer, pH 7.2 Tier 2: 0.05 M phosphate buffer, pH 7.2 with NMT 1750 USP protease unit
Develop an in vitro release method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Paddle) or any other app
0.01 N HCl
0.1 N HCl
0.1 N HCl
Refer to USP
0.1 N HCl without pepsin and with 0.3% pepsin (addition of pepsin is recommended only when significant slow dis
Refer to USP
0.1 M Citrate Buffer, pH 3.8
Refer to USP
10 mM citric acid buffer, pH 5.75
Refer to USP
Refer to USP
Diluted McIlvaine Buffer [12.5 mM disodium hydrogen phosphate solution +6.25 mM citric acid solution ] + 0.5 %
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.05 N HCl
Water (deaerated)
Refer to USP
0.05 M Potassium Phosphate Buffer, dibasic, pH 7.8, containing 0.5% solid LDAO
0.1% Lauryl Dimethylamine Oxide (LDAO) in water
SGF without Enzyme
0.1 N HCl
50 mM Sodium Phosphate Buffer with 0.7% Sodium Dodecyl Sulfate (SDS), pH 6.8
Lumacaftor: 0.5% (w/v) CTAB in 50 mM Sodium Acetate Trihydrate buffer (pH 4.5); Ivacaftor: 0.4% (w/v) SLS in
FDC: IVA: 50 mM Sodium Phosphate Buffer with 0.4% Sodium Dodecyl Sulfate (SDS), pH 6.8/TEZ: 0.2 SDS% in 0.1
0.5% SDS in 0.01 M Monobasic Sodium Phosphate, pH 7.0
0.1 N HCl
Simulated gastric fluid w/o pepsin
SIF Buffer without enzyme, pH 7.4
0.05 M Phosphate Buffer pH 7.4
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
0.1 N HCl
Water
0.1 N HCl
Refer to USP
Lamivudine and Zidovudine: 0.1 N HCl Efavirenz: 2% SLS in water
Lamivudine and Zidovudine: water Nevirapine: 0.06 M HCl (pH 1.2)
0.01 N HCl
Refer to USP
0.1 N HCl
0.1 N HCl
Refer to USP
Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8 with 5 mM Sodium Dodecyl Sulfate
0.25 N HCl
2% Polysorbate 80 in 0.1 N HCl
1.5% Polysorbate 80 in 10 mM Potassium Phosphate Buffer with 0.0075 mg/mL Butylated Hydroxytoluene (BHT),
Water (deaerated)
Water (deaerated) + 0.6% Polyoxyethylene Lauryl Ether
0.01 N HCl
0.1 N HCl
pH 4.5 sodium acetate buffer with 1% SLS
25 mM Na Acetate Buffer, pH 4.5 with 0.6% Tween-80
Refer to USP
RIB: 0.01 N HCl; LET: 0.1 N HCl
Refer to USP
Develop a dissolution method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Paddle) or any other appropr
Phosphate Buffer, pH 6.8 (degas)
Water (deaerated)
Refer to USP
Water
Refer to USP
Water (deaerated)
0.1 N HCl with 0.1% SLS
Refer to USP
Acetic acid/sodium acetate buffer, pH 4.0 at 32ºC
0.1 N HCl
0.1 N HCl
Simulated Gastric Fluid (SGF) without enzyme (pH 1.2) (degassed)
Refer to USP
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.01 N HCl
0.001 N HCl with 0.1% Polysorbate 80
Refer to USP
0.01 N HCl
0.1N HCl
Tier 1: 0.05 M Polyoxyethylene 10 Lauryl Ether with 10 mM Sodium Phosphate monobasic (pH 6.8); Tier II: same
Refer to USP
SGF without enzyme
Tier I: 0.1N HCl with 0.1% Tween 20. Tier II: 0.1N HCl with 0.1% Tween 20 with addition of pepsin (as per USP).
0.1 N HCl
900 mL 0.1 N HCl for one hour, then replace the medium with 900 mL 0.05 M phosphate buffer at pH6.8 containin
900 mL 0.1 N HCl for one hour, then replace with 900 mL 0.05 M phosphate buffer at pH 8.2 containing 0.01% sod
Refer to USP
0.1 N HCl (deaerated)
0.1 N HCl (deaerated)
Water (deaerated)
Refer to USP
0.5% sodium lauryl sulfate (SLS) / sodium phosphate buffer (0.01M), pH 6.5
For Niacin: Water; for Lovastatin: 0.05 M phosphate buffer, pH 7.0 with 0.5% sodium dodecyl sulfate
0.1 N HCl/1% HCO-40 (Polyoxyl 40 hydrogenated castor oil)
McIlvaine buffer, pH 3.8 [(0.025 M Citric acid Solution + 0.05M Na2HPO4 solution (3:2)] Measure the pH and adjust to 3.8, if n
Phosphate Buffer, pH 6.8 with 0.1% of Cetrimonium bromide (CTAB)
0.029 M sodium phosphate buffer w/ 0.5% SDS, pH 7.4
pH 7.4 Phosphate Buffer with 0.5% SDS
0.01 N HCl
0.1 N HCl containing 1% Sodium Lauryl Sulfate
1% Sodium Lauryl Sulfate (SLS) in 0.01 N HCl
Refer to USP
0.01 N HCl
0.01 N HCl
Test 1: 0.5 % SDS in water ; Test 2: 0.35 % SDS in water (provide data with both tests)
Refer to USP
Refer to USP
SGF without enzyme
Refer to USP
Phosphate buffer at pH 7.5
Phosphate Buffer, pH 6.1 with 0.1% Sodium Lauryl Sulfate (SLS)
Refer to USP
pH 1.2 NaCl/HCl Buffer (degas)
0.1 N HCl with NaCl (12 g NaCl in 6 L water adjust pH to 1.2 with HCl)
Neutralized phthalate buffered solution (0.2 M potassium biphthalate) with pH of 5.0 at 32 ± 0.5°C
Refer to USP
0.1N HCl
0.1 N HCl
For 500 mg strength: 0.2 M Phosphate buffer, pH 7.5 at 37 deg. C For 1000 mg strength: 0.2 M Phosphate buffer,
Phase 1: 0.1N HCl (degas); Phase 2: pH 6.0 Buffer (degas); Phase 3: pH 7.2 Buffer
Acid stage (A): 100 mM HCl Buffer stage (B): Phosphate Buffer, pH 6.4
Refer to USP
Acid Stage: 0.1N HCl Buffer stage: Phosphate Buffer, pH 6.8
Refer to USP
0.06 N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
pH 2.5 McIlvaine buffer (0.1 M Citric acid adjusted to pH 2.5 with 0.2 M Na2HPO4)
0.025 M NaCl
Citric acid/phosphate buffer, pH 5.0
Refer to USP
pH 4.5 Acetate Buffer
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
Water
0.01 N HCl at 32ºC
Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8
Refer to USP
0-2 hrs:0.01 N HCl. 2-10 hrs: Phosphate Buffer, pH 6.8.
Water
Acid Stage:(First 2 hours) 0.01 N HCl; Buffer Stage (2-10 hours): Phosphate Buffer, pH 6.0
0.4M KH2PO4 solution (degas)
Refer to USP
0.55 % SDS
Refer to USP
Water
Water
Refer to USP
2% SLS in 0.05 M Sodium Phosphate Buffer, pH 7.5
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
0.5% SDS (Sodium dodecylsulfate) in water-pH adjusted to 6.5 ± 0.5
0.45% SLS in water
0.1 N HCl
Tier 1:Deionized water with 0.5% Polysorbate 20; Tier 2: Deionized water with 0.5% Polysorbate 20 containing pe
0.01 N HCl
pH 1.8 KCl Buffer
Water
0.1 N HCl
0.1 N HCl
0.1 N HCl
0.1 N HCl
0.1 N HCl
Refer to USP
Refer to USP
pH 2.1 Buffer (Degassed)
Refer to USP
0.1 N HCl
0.1 N HCl
Water (deaerated)
Refer to USP
0.1 N HCl
Water (deaerated)
Refer to USP
0.5% w/v SDS in Water
0.5% SDS in water
0.5% SDS in water
Simulated Gastric Fluid [SGF] without enzyme
Deionized Water
Refer to USP
Water (deaerated)
Water
Acid stage: 0.1 N HCl; Buffer stage: 0.05 Phosphate Buffer, pH 7.5
0.1 N HCl
0.1 N HCl
0.1 N HCl
0.1 N HCl
Acid Stage: 0.1 N HCl; Buffer Stage: Buffer Solution, pH 6.8 (After initial 120 mins., 250 mL of 0.2 M sodium pho
0.1% Tween 80 solution
Refer to USP
Refer to USP
Mixture of pH 6.8 phosphate buffer [25 mM disodium hydrogen phosphate] solution and water (1:1)
0.1 N HCl
Phosphate buffered saline with 0.02% Tween 20 and 0.02% Sodium azide, pH 7.4 (final osmolality should be 270 ± 20 mOsm),
Refer to USP
Water (degassed)
Refer to USP
Refer to USP
Refer to USP
Sodium Phosphate Buffer, pH 7.4 ± 0.05
0.1M Sodium Phosphate buffer, pH 7.4 (deaerated)
0.1M Sodium Phosphate Buffer, pH 7.4
Naproxen:: Acid Stage: 0.1M HCl; Buffer Stage: 0.05M Phosphate buffer, pH 6.8. Sampling for Acid stage: Transfe
Refer to USP
0.01 N HCl with 0.5% (w/v) SLS
0.01 N HCl
67 mM Phosphate Buffer pH 6.8 with 0.5% SDS
0.1 N HCl
0.1 N HCl
0.1 N HCl
Netupitant: 0.07M Phosphate buffer pH 6.8 containing 1% sodium SDS ; Palonosetron: 0.01 N HCl
0.04 M Sodium phosphate buffer pH 6.8 containing 2% sodium lauryl sulfate
0.1 N HCl
Refer to USP
Water
Niacin: Water; Simvastatin: 0.5 % SDS in 0.01 M Sodium Phosphate, pH 7.0
0.1 N HCl
0.033 M Citric Acid Buffer, pH 4.5
Refer to USP
Phosphate Buffer, pH 7.4 or or any other appropriate buffer and conditions
Phosphate buffer pH 7.4
Refer to USP
Refer to USP
0.1 N HCl
0.5% SDS in water
0.1 N HCl
Tier 1: 0.08M Sodium Acetate Buffer, pH 4.0; Tier 2: 0.08M Sodium Acetate Buffer, pH 4.0 containing pepsin (750,
HCl with SLS (32.5 ± 0.1 g Sodium Lauryl Sulfate in 6489 mL of purified water containing 17.0 mL HCl, pH adjusted
Phosphate buffer at pH 7.5 with 6% hexadecyltrimethyl ammonium bromide, bath temperature at 25ºC
Phosphate buffer at pH 7.5 with 6% hexadecyltrimethyl ammonium bromide, bath temperature at 25ºC
pH 1.2 HCl Buffer (degassed)
Refer to USP
Deionized Water at 32º C
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.1 % and 0.2% SLS in water
Water with 0.1% SLS
0.08% polysorbate 80 in 50mM sodium phosphate dibasic buffer, pH 6.8
0.1 N HCl
Refer to USP
Refer to USP
1% SLS in pH 6.8 Phosphate Buffer
1% Polysorbate 80 in Water
Refer to USP
Ombitasvir, paritaprevir, ritonavir: 0.05 M sodium phosphate buffer, pH 6.8 with 0.3% polyoxyethylene 10 lau
0.05M Sodium Phosphate Buffer, pH 6.8 with 0.3% (w/v) Polyoxyethylene 10 Lauryl Ether (POE10LE)
Develop an in vitro release method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Paddle) or any other app
Refer to USP
Tablets are pre-exposed to 750 ml of 0.1M HCL for 2 hrs and then 250 ml of 0.2M Na3PO4 is added to the medium
Tablets are pre-exposed to 500 ml of 0.1M HCL for 2 hrs and then 400 ml of 0.235M Na2HP04 is added to the medi
Pre-exposed to 300 mL of 0.1M HCl for 2 hrs and then 700 mL of 0.086 M Na2HPO4 is added to the medium to gi
Tablets are pre-exposed to 300 mL of 0.1M HCL for 2 hrs and then 700 mL of 0.086 M Na2HPO4 is added to the m
0.25 mM Sodium Phosphate Buffer, pH 7.4
Refer to USP
0.1 N HCl
Water (deaerated)
3% SLS in 0.5% Sodium Chloride, pH 6.0
Refer to USP
0.1 N HCl
0.1 N HCl
0.2 % NaCl solution in water [adjust to pH 1.3]
2% Sodium Dodecyl Sulfate (SDS) in Water
Refer to USP
1.0% SDS in Deionized Water (degassed)
1% SDS in water
0.3% SDS in water
0.6% SDS in water
1% SDS in water
Phosphate Buffer, pH 4.5 @ 32oC
Refer to USP
22 mM Sodium Acetate buffer, pH 4.5 with 0.03% Tween 20
0.1 N HCl
Refer to USP
Refer to USP
Simulated Gastric Fluid [SGF, pH 1.2] without enzyme
0.1 N HCl
0.1 N HCl
Modified SGF, pH 1.0 [NaCl (0.2% w/w) in 0.0825N HCl]
0.489% (w/v) Polysorbate 20 in 0.001 N HCl @25.0 °C.
0.489% (w/v) Polysorbate 20 in 0.001 N HCl @25.0 °C.
0.1 N HCl
Refer to USP
0.01 N HCl
Acid Stage: 0.1 N Hydrochloric Acid; Buffer Stage: 0.05 M Tribasic Sodium Phosphate (Add 250 mL of 0.2 mM Trib
Refer to USP
4 mg/mL (0.4%) Lauryldimethylamine N-oxide (LDAO)
Refer to USP
SGF without enzyme
Refer to USP
Simulated Gastric Fluid (SGF) without enzymes
Simulated Gastric Fluid without enzyme , pH 1.2+0.05
50 mM Sodium Acetate buffer, pH 4.5, containing 0.75% SDS
Water (deaerated)
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Water
Refer to USP
0.1 N HCl
0.1 N HCl
Simulated gastric fluid TS with cysteine without enzymes
0.1 N HCl
Refer to USP
Refer to USP
Refer to USP
1 hour - SGF w/o Enzymes; after 1 hour - SIF w/o Enzymes
Simulated Gastric Fluid without enzymes, pH 1.2
Refer to USP
Water
Refer to USP
Water
Water (deionized and degassed)
Refer to USP
Refer to USP
Refer to USP
0.1 N HCl
0.1 N HCl
Refer to USP
HCl-0.3 M KCl Buffer, pH 2.0
Water
Water (Deionized)
Refer to USP
0.1 N HCl
pH 2.1, KCl/HCl buffer (degassed)
Acid Stage: 0.01 N HCl: Buffer Stage: 50 mM phosphate buffer, pH 6.8 with 0.37 % Polysorbate 80 (after 120 minu
0.3% SLS
Refer to USP
Refer to USP
Refer to USP
0.05 M phosphate buffer, pH 6.8
0.023 M Citrate/0.155 M Phosphate Buffer, pH 6.8
Citrate-Phosphate buffer (0.023M Citric acid+0.026M Sodium Phosphate, Dibasic), pH 4.0
Water (deaerated)
Refer to USP
Refer to USP
Develop an in vitro release method
22 mM Sodium Acetate Buffer, pH 4.5
Refer to USP
Water
0.06 N HCl
0.06 M HCl
Refer to USP
Refer to USP
Water
0.1 N HCl at 38° C
0.25% sodium dodecyl sulfate (SDS) in DI water
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Refer to USP
0.1N HCl
Refer to USP
Refer to USP
Refer to USP
Refer to USP
Water
Refer to USP
Water (deaerated)
0.05M citric acid and 0.09 N NaOH (pH 4.8) [solution A]. At 5 hrs, pH adjusted to 6.6 by addition of 100 mL of
Refer to USP
Refer to USP
Acid Stage:0.1 N HCl; Buffer Stage: 0.05 M Phosphate Buffer, pH 6.8 (After Acid Stage, add 250 mL of 0.2 mol/L t
700 mL 0.1 N HCl (Acid stage), after two hours add 300 mL of 0.6 M Tris buffer; adjust to pH 8.0 (Buffer stage) wi
0.1% Polysorbate 80 in water
Water(deareated)
Water (Deaerated)
Water
0.1 N HCl
0.1 N HCl
Water (deaerated)
Refer to USP
0.1 N HCl
Acetate Buffer pH 4.5 with 0.1% Sodium Dodecyl Sulfate (SDS)
Refer to USP
Water (deaerated)
Water (deaerated)
0.01N HCl (Degassed)
Refer to USP
Refer to USP
0.8% SLS in Phosphate Buffer, pH 7.0
0.1M sodium phosphate buffer pH 7.4 containing 0.45% Sodium Lauryl Sulfate
0.1M sodium phosphate buffer pH 7.4 containing 0.8% Sodium Lauryl Sulfate
0.5% Polysorbate 20 in 0.01N HCl (pH=2.0)
0.1 N HCl
Water
pH 6.8 Phosphate Buffer with 0.1% Sodium Lauryl Sulfate [SLS]
Acid stage: 0.1 N HCl; Buffer stage: Phosphate buffer, pH 6.8
Refer to USP
For Risedronate Tablets: Refer to USP; For Calcium Carbonate Tablets: Refer to USP.
0.1 N HCl
0.1 N HCl
0.1 N HCl
Refer to USP
Refer to USP
Acetate Buffer pH 4.5, 0.2% sodium dodecyl sulfate (SDS)
Acetate Buffer pH 4.5, 0.4% SDS
Acetate Buffer pH 4.5
0. 9 % NaCl at 32º C
Water (deaerated)
Water (deaerated)
Water (deaerated)
1.0% SDS (sodium dodecyl sulfate) in Phosphate Buffer, pH 6.8
0.05 M Sodium Acetate buffer, pH 4.0
Refer to USP
pH 4.0 Citrate-THAM Buffer
0.01M Acetate Buffer, pH 4.0
0.05 M Sodium Citrate Buffer pH 6.6 ± 0.05
Phosphate Buffer, pH 4.5 at 32°C
0.01 N HCl
2.0% SDS (sodium dodecyl sulfate) in water
Refer to USP
0.1 N HCI
Phosphate Buffer, pH 6.8[degassed]
0.1 N HCL with Sodium Chloride [2% (wt/vol) solution], pH 1.2
0.1 N HCl
0.1 N HCl
Citrate Buffer (pH 3.0)
Refer to USP
0.1 N HCl
Distilled Water
Refer to USP
0.1 M Phosphate buffer, monobasic, pH 5 at 32°C
0.1 M Phosphate buffer, monobasic, pH 5 at 32°C
Water
0.05 M Sodium Acetate Buffer, pH 4.5
Disintegration Testing in 0.1 N HCl as per USP <701>
0.01 N HCl
McIlvaine Buffer, pH 5.0
0.1 N HCl
0.05 M Phosphate Buffer, pH 6.8 with 1.0% polysorbate 20
Phosphate Buffer, pH 7.0, with 0.14% sodium dodecyl sulfate (SDS)
0.15% SDS Buffer, pH 6.8
Refer to USP
0.4% SLS in water
Water
10 mM Sodium phosphate buffer containing 1% Tween 80 with 50 μg/mL Butylated hydroxyanisole
Water (deaerated)
Simulated Intestinal Fluid
Water (deionized)
50 mM sodium acetate buffer,pH 5.0, with 0.5% w/v Cetyltrimethyl ammonium bromide (CTAB)
Water
Tier 1: 0.1 M HCl with 1.0% SDS; Tier II: Stage 1: 850 mL of 0.1 N HCl solution with pepsin [250’000 units/L]. St
0.1 M HCl with 1% SDS
Refer to USP
Refer to USP
0.01 N Phosphoric Acid
0.1N HCl/0.067 M KCl, pH 1.0
0.1 N HCl/0.067 M KCl, pH 1.0
0.1 N HCl
Refer to USP
Refer to USP
1 mL of 0.2 N HCl in water
Refer to USP
Refer to USP
1% SLS in 0.1N HCl
0.01 N HCl
0.1 N HCl
0.4% Sodium Lauryl Sulfate in Water
0.005% HPC in Water with 0.50% SLS adjusted to pH 4.5
Hydroxypropyl Cellulose Solution (1 in 20,000). Adjust to pH 4.5 by Phosphoric Acid
0.5% Sodium Lauryl Sulfate
Refer to USP
0-2 hours: 0.003% polysorbate 80, pH 1.2 2-8 hours: phosphate buffer, pH 7.2
0.1 N HCl
0.05 M Phosphate Buffer of pH 6.8, Simulated intestinal fluid (without enzyme)
0.1 N HCl
0.05 M phosphate buffer pH 6.8
1% SLS in Water
0.1 N HCl
0.1 N HCl
Refer to USP
Refer to USP
Water
50 mM Sodium Acetate buffer pH 4.5
0.2% polysorbate 80 in 0.01 M HCl
0.1 N HCl
Water (deaerated)
Water (deaerated)
Citrate Buffer, pH 3.0 adjusted with HCl
0.12 N HCl with 1% SLS
0.1 M sodium chloride containing 2.5% (v/v) of Tween 40 at 32 ± 0.5°C. Delivery surface faces upwards towards t
1% sodium dodecyl sulfate in double distilled water
0.1 N HCl
Refer to USP
Refer to USP
1.5% (w/v) SLS (pH 3.0, adj w/ HCl)
Refer to USP
SGF without Enzyme, pH 1.2 during 1st hour. Phosphate Buffer at pH 7.5 from end of hour 1 through the duration
SGF without Enzyme, pH 1.2 during 1st hour. Phosphate Buffer at pH 7.5 from end of hour 1 through the duration
SGF without enzyme, pH 1.2 during 1st hour. SIF without enzyme from end of hour 1 through the duration of the
Refer to USP
Water
0.2% w/v Polysorbate 80 in water
Water (deaerated)
Refer to USP
Water (Deaerated)
0. 08N HCl containing 0.2% w/v NaCl
0.1 N HCl
0.05 M phosphate buffer pH 6.8
0.01 N HCl
0.1 N HCl
0.1N HCl
Refer to USP
SGF without enzymes, pH 1.2
Phosphate buffer (pH 6.8)
Water (deaerated)
50 mM Tris buffer, pH 7.2
Water (deaerated)
Acetate Buffer with 0.15% SDS, pH 4.5
0.02 N HCl
0.1 N HCl
Water (Deaerated )
0.1 N HCl
0.1 N HCl
pH 4.5, 50 mM Sodium Acetate with 0.75% Sodium Lauryl Sulfate [SLS]
Water (deaerated)
For Trandolapril: Water; For Verapamil: 0-1 hour Gastric Fluid w/o Pepsin pH=1.2, 1-8 hour Intestinal Fluid w/o P
Water
Refer to USP
Refer to USP
Water
0.05 M Phosphate Buffer, pH 6.8 (deaerated)
0.5% solid Lauryldimethylamine-oxide (LDAO) in 0.05M Phosphate Buffer, pH 7.8
0.3% SDS in 10 mM phosphate buffer, pH 7.2 + 0.02% sodium azide @35°C
Refer to USP
Refer to USP
Refer to USP
Water (deaerated)
Water-Methanol (95:5); Reconstitute vial in 2 mL Water for Injection, add to 500 mL medium at 37°C
50 mL of methanol to 950 mL of water
0.1 N HCl, pH 1.1 for 2 hrs and then add 200 mL of 0.1 N NaOH in 200 mM Phosphate Buffer. Adjust pH to 7.5 us
0.1 N HCl
0.1 N HCl
Refer to USP
Refer to USP
0.1 N HCl
Tier 1: 0.1N HCl; Tier 2: 0.1N HCl containing pepsin (750,000 units per 1000 mL)
Refer to USP
Refer to USP
Refer to USP
Refer to USP
pH 1.2 Buffer [0.05 M KCl in water, adjust the pH with HCl or NaOH]
0.1 N HCl
0.1 N HCl
0.01 N HCl
1% hexadecyltrimethylammonium bromide (HTAB) in 0.05 M Phosphate Buffer, pH 6.8
Phosphate Buffer, pH 6.8 with 0.4% sodium dodecyl sulfate (SDS) [3 small drops of antifoaming agent may be us
Water (deaerated)
Water
Water (deaerated)
Refer to USP
Refer to USP
Refer to USP
Develop a method to characterize in vitro release.
Water
0.1% v/v Glacial acetic acid solution (pH 3.1)
0.01 N HCl with 1.0% sodium lauryl sulfate (SLS)
41 mM Na2HPO4, 1.5% Citric Acid, pH 3.0 ± 0.5
0.1 N HCl
0.1 N HCl
2% Tween 80 in Water
0.1 N HCl
Refer to USP
1% w/v Aqueous Sodium Dodecyl Sulfate
Refer to USP
Deionized Water
Refer to USP
Refer to USP
0.05 M SLS in water
0.1 M SDS (sodium dodecyl sulfate) in water
0.1 N HCl
Tier I: 0.05 M Na phosphate buffer, pH 7.5 + 2% SDS (w/w) Tier II: 0.05 M Na phosphate buffer, pH 7.5 (700ml) +
0.1 N HCl
0.1 N HCl
Refer to USP
0.01 N HCl, pH 2.0
Simulated intestinal fluid (without enzyme), pH 6.8, (deaerated)
Water (deaerated)
Volume (mL)
900
900
900
Acid Stage: 900 mL; Buffer Stage: 1000 mL
900
900
900
Media 1: 750 mL pH 1.1±0.1; Media 2: 950 mL pH 6.0±0.1; Media
900
900
900
1000
900
900
900
900
900
900
900
900
1000
600
900
900
900
900
For Alendronate: 900; For Cholecalciferol: 500

900
500
500
500
900
900
1000
900
900
900
500
500
500
900
500
900
1000
1000
900
500
500
900
500
900
900
1000
Telmisartan: 900; Amlodipine: 500
900
900
ed-Release Capsules
d-Release Capsules
As appropriate
900
0-2 hrs: 750 mL. After 2 hrs: 950 mL

500
Media 1: 750 mL; Media 2: 950 mL; Media 3: 1000 mL
750 ml of dilute HCl, 200 ml of phosphate buffer
900
900
900
900
900
900
900
900
900
1000
900
500
900
Acid Stage: 900; Buffer Stage: 900
900
0-1 hrs: 900 mL. 900 mL thereafter
900
900
900
1000
1000
1000
900
900
900
900
900
900
900
900
900
900
900
500 mL (10 mg) or 1000 mL (20mg)
1000
900
900
500
500
900
900
plicable, Apparatus II (Paddle) or any other appropriate method, for comparati
900
900
1000
Acid stage: 900 mL; Buffer stage: 900 mL
900
900
900
900
900
900
900
900
2.5 and 5 mg tablets: 500 mL; 10, 25, 50, 75 and 100 mg tablets:
Acid Stage: 500 mL ; Buffer Stage: 1000 mL

Acid stage: 1000; Buffer stage: 1000
600
900
60
500
500
900
900
500
500
900
900
500
900
600
Met: 900: Can: 900
Canagliflozin (50 mg): 900; Canagliflozin (150 mg): 900 ; Metformi
900
900
900
900
900
First 4 h: 900. After 4 h: 900
900
750
Carbidopa and Levodopa: 750 ml. Entacapone: 900 ml
900
500
Acid stage: 500 mL [for 23.75/95 mg strength], 900 mL [other stre
750
900 [ 895 mL 0.4 M Buffer +5 mL Suspension]
750
500
900
900
900
900
900
900
900
900
900
900
900
900
900
1000
Tier 1: 1000 mL Tier 2: 750 mL (initial) 1000 mL (final)

900
900
900
900
500
900
900
Row 1: 250 mL. Row 2: 250 mL

900
900
900
500
495
500 mL for 50 mg capsule; 900 mL for 250 mg capsule

900
900
900
480
900
900
900
900
900
900
900

900
900
900
900
Cobi: 900 mL; Drv: 900 mL
1000
1000
900
500
fluid and simulated intestinal fluid.
900
900
1000
900
900
900
1000
900
900
900
1000
1000
900
1000
900
900
250
1000
900
900
900
1000
900
900
500
900
1000
1000
500
900
500
30
250
Acid Stage: 500; Buffer stage: 900
900
Acid: 500, Buffer: 500
500
500
900
900
500
500
900
500
400
900
900
Diclo: Acid: 750 Buffer:1000 Miso: 500
900
1000
900
900
900
500
900
900
900
900
900
900
900
900
900
900
900
900
900
900
plicate for 12 dosage vials.

900

900
900
500
1000
900
900
900
900
Dutasteride: 900. Tamsulosin: Acid stage: 750; Buffer stage:
900
1000
1000
900
900
900
750
900
900
700 mL for 85 mg tablets; 1000 mL for 150 mg tablets 1000 mL for
900
900
900
900
900
900
RPV: 1000 mL; ETC and TAF: 500 mL
1000
500
900
900
1000
900
1000
1000
1000
500
1000
900
900
900
1000

900
900
250
500
0.025 mg/24 hr and 0.0375 mg/24 hr: 500 mL; 0.05 mg/24 hr, 0.0
900
0.0375 mg/24 hr: 500 mL; 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1
500
250
900
900
900
900
500
600
500
900
500
600
600
600
500
900
900
1000 (phase 1): 1800 (phase 2)

500 (phase 1): 900 (phase 2)
500
900
500
900
1000
900
900
900
900
900
900
900
900
1000
900
1000
1000
900
250 mL for the 75 and 100 mcg/hr, 200 mL for the 50 mcg/hr and
500
500
100
200
60
100
900
1000
900
900
900
900
500
900
500
900
900
900 (For 150, 200, 300 & 400 mg tabs) 500 (For 50 & 100 mg tabs)
900
500
900
900
1000
900
900
900
900
900
900
500 (for 300 mg); 900 (for 600 mg)
900
900
1000
900
900
900
900
900
900
500
50
1000
500
1000
1000
900
900
900
900
1000
900
900
Hydrochlorothiazide: 500; Metoprolol succinate: 500
900
900
900
500
900
900
50
500
900
900
900
900
900
900
900
500
900
900
900
(Paddle) or any other appropriate pharmacopoeial apparatus, for comparative evaluation by the Agency.
750
500
1000
900
900
750
900
900
900
900
900
500
1000
500
900
900
900
Lumacaftor: 900; Ivacaftor: 900
FDC: IVA: 900/ TEZ: 900; IVA: 900
900
500
800
900
1000
900
900
900
900
Lamivudine and Zidovudine: 1000 Efavirenz: 900

900
900
900
900
500 (Acid), 900 (Buffer)

900 (modified from the standard apparatus 3 vessel to achieve sin
900
900
1000
1000
900
900
900
900
RIB: 900; LET: 900
le) or any other appropriate method, for comparative evaluation by the Agency
900
900
900
900
900
1000
1000
500
500
900
900
900
900
900
900
900
500 mL (5 mg strength); 1000 mL (10 and 20 mg strength)
900
500
500
900
900
900
500
900
900
900
900
900
900
900
900
900
900
900
900
900
900
900
900
900
Test 1:use Open Mode: Test 2: 900 mL
900
900
900
500 mL (for 5 mg); 1000 mL (for 10 mg)
900
900
900
900
900
900
Phase 1: 500; Phase 2: 900; Phase 3: 900
Acid stage (A): 750 mL; Buffer stage (B): 950 mL; Buffer stage (C)
900
500
1000
900
1000
900
900
900
1000
500
900
0-2 hrs: 500. 2-10 hrs:500
900
Acid: 500 mL; Buffer: 500 mL
900
900
900
900
900
900
1000
900
900
900
900
900
900
1000
900
750
900
900
900
900
900
900
500
900
900
900
900
900
900
900
900
900
500
900
900
900
900
750 (Acid), 1000 (Buffer)
1000
500
500
ould be 270 ± 20 mOsm), or any other appropriate medium, at 37°C. Develop an in vitro release method using USP IV (Flow-Through Cell),
900
900
900
900
900
900
Naproxen::Acid Stage: 1000; Buffer Stage: 1000; Esomeprazole::90
1000
900
900
900
900
900
900
Netupitant: 900; Palonosetron: 500

900
900
900
900
1000
900
900
20
250
1000
900
900
900
900
900
900
1000
1000
2 mg tablets: 500 mL; 5 mg and 10 mg tablets: 900 mL
900
900
500
900
900
900
900
use Open Mode

1000
900
900
900
(Paddle) or any other appropriate pharmacopoeial apparatus, for comparative evaluation by the Agency.

300 ml for the acid stage; 1000 ml for the buffer stage
900
900
900
500
900
900
900
900
900
900
900
900
900
900
900
900
500
900
900
900
900
500
900
900
500
900
900
500
900
900
900
900
900
900
900
900
900 [890 mL 0.1 N HCl + 10 mL perampanel suspension]
500
900
900
900
900
500 mL (15 mg) or 900 mL (30 mg and 37.5 mg)

750
500
900
900
1000
1000
900
900
900
Acid Stage: 750 mL; Buffer Stage 1000 mL
900
500
500
900
900
500
500
900
900
900
900
900
900
900
900
900 [solution A]. 1000 [final]
Acid Stage: 750; Buffer Stage:1000

1000
900
900
900
500
500
900
500
900
900
900
900
900
1000
1000
900
900
900
900
500
500
900
900
900
900
500
500
900
900
1000
900
500
900
900
900
900
900
900
900
900
900
900
900
900
25 × 150 mm test-tubes containing 20 mL
900
500
1000
500
900
900
500
900
500
900
900
900
900
500
900
900
500
900
900
900
900
900
Tier 1: 900; Tier 2: Stage 1: 850 mL, Stage 2: 900 mL
900
900
900
900
900
900
900
900
900
900
900
900
1000
500
900
900
500
900
900
900
900
500 (for 5 mg); 900 ml (for other strengths)

500
900
900
900
900
500
900
1000
900
1000
900
900
900
900
900
900
900
900
900
900
900
900
900
500
500
900
900
900
900
900
750
900
900
900
500
1000
900
900
900
900
500
500
For Trandolapril: 500; For Verapamil: 900
900
900
500
900
1000
1000
500
950
0-2 hrs: 750 ml, After 2 hrs: 950 ml.
1000
900
900
900
1000
1000
900
900
500
900
250
900
900
900
900
1000
900
900
900
900
900
900
1000
900
900
900
900
900
900
500
500
900
500
900
900
Recommended Sampling Times (minutes)
5, 10, 15, and 30

Abacavir and lamivudine: 10, 15, 20, 30 and 45; Dolutegravir: 5,15, 25, 35 and 45.
10, 20, 30, and 45
5, 10, 15, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
5, 10, 15, 20, 30 and 45
120 (Acid) 30, 60, 90, 120, and 180 (buffer)
10, 15, 20, 30 and 45
15, 30, 45, 60 and 90
15, 30, 45, 60 and 90
10, 20, 30, 45 and 60

10, 15, 30, 45 and 60
10, 20, 30, 45 and 60
0.25, 0.5, 1, 2, 4, 6 and 8 hours

10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
1, 2, 5, 7, 9, 12 and 14 hours
5, 10, 15 and 30
10, 20, 30, 45 and 60
1, 2, 3, 5, 7, 9 and 12 hours
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
1, 2, 4, 6, 9 and 12 hours
10, 20, 30, 45, 60, 75 and 90
10, 15, 20, 30 and 45

1, 2, 12, 20 hours
10, 20, 30 and 45
5, 10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
5, 10, 15, and 30

5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 20, 30 and 45
1, 4, 8, 12 and 16 hours
2, 5, 10, 15 and 20
5, 10, 15, 20, 30 and 45

10, 20, 30, 45 and 60
5, 10, 15, 30, and 45
Acid Stage: 2 hours; Buffer Stage: 1, 2, 3 and 4 hours

10, 20, 30, 45, 60 and 90
10, 20, 30, 45, 60 and 90
10, 20, 30, 45 and 60

5, 10, 15 and 20
5, 10, 15 and 30
10, 20 , 30, 45, and 60
5, 10, 15, 20, 30 and 45
10, 20, 30 and 45

5, 10, 15, 20 and 30
Telmisartan: 10, 15, 20, 30 and 45; Amlodipine: 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
0.25, 0.5, 1, 2, 2.25, 2.5, 3, 4, 4.25, 4.5, 5 and 6 hours
0, 0.5, 1, 2, 3, 4 and 5 hours

5, 10, 15 and 30
Acid Stage: 10, 15, 30, 45, 60, 90, 120; Buffer Stage: 5, 10, 15, 30 and 45
0.5, 1, 2, 3, and 4 hours

10, 20, 30 and 45
0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours
1, 2, 3, 4, and 6 hours
5, 10, 15, 20
10, 15, 30, and 45
5, 10, 15, 30 and 45
5, 10, 15, and 30 and 45
5, 10, 20, 30 and 45
10, 15, 20, 30, and 45
5, 10, 15 and 20
10, 15, 20, 30 and 45
10, 15, 30, 60, 120, 180, 240, 300, 360, 420 and 480
10, 20, 30 and 45
10, 20, 30 and 45
1, 2, 3, 4 and 5
1, 2, 3, 6, 9, 12, 16, 22 and 30 hours

Acid Stage:120; Buffer Stage:10, 20, 30, 45, 60 and 75
10, 20, 30, 45 and 60

Acid: 10, 20, 30, 45 and 60 min; Buffer:1, 2, 5, and 7 hours
10, 20, 30, 45, 60 and 90
10, 20, 30, 45, 60 and 90
10, 20, 30, 45, 60 and 90
10, 20, 30 and 45

Atazanavir: 10, 15, 20, 30 and 45; Cobicistat: 5, 10, 15, 20 and 30
10, 20, 30 and 45

5, 10, 15 and 30
5, 10, 15, 20, 30 and 45
10, 20, 30, 45, 60 and 90

15, 30, 45 and 60
10, 20, 30, and 45

5, 10, 15, 20 and 30
5, 15, 30, 45 and 60
5, 10, 15, 20, 30 and 45

5, 10, 15, 20, 30 and 45
10, 20, 30, and 45
15, 30, 45, 60, 120 and 180
5, 10, 15 and 30
10, 20, 30, 45, 60, 75, 90 and 120

10, 20, 30, and 45
10, 15, 20, 30 and 45
10, 20, 30 and 45
10, 20, 30 and 45
10, 20 , 30, and 45

10, 20, 30, 45 and 60
5, 10, 15, 30, 45, 60, 90, 120, 180, 240, 300, and 360
5, 10, 15, 20 and 30

15, 30, 45 and 60
10, 20, 30, 45 and 60
Acid stage: 60; Buffer stage: 10, 20, 30, 45 and 60
5, 15, 20, 30 and 45
5, 10, 20, 30 and 45

10, 20, 30, 45, 60 and 75
15, 30, 45 and 60
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
Acid Stage: 2 hours; Buffer Stage: 1, 2, 4, 6, 8 and 10 hours

Acid stage: 2 hours; Buffer stage: 0.25, 0.5, 1, 2, 4, 6 and 8 hours
0.5,1, 2, 4, 6, 8,12, 16 and 24 hours

1, 4, 12, 24, 36, 48, 72, 96, 120, 144 and 168 hours
10, 15, 20, 30, 45 and 60
2, 5, 8, 10, 15, and until at least 80% of the labeled content is dissolved
1, 3, 5, 7.5, 10, 15 and 20
1, 2, 3, 5, 7 and 10
1, 2, 4, 6, 8 and 10 hours
5, 10, 15 and 30
5, 10, 15 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
1, 2, 4, 6, 8, 10 and 12 hours
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
Met: 1, 2, 4, 6, 8 10 and 12 hours: Can: 10, 15, 20, 30, 45 and 60 minutes;
Canagliflozin: 10, 15, 20, 30 and 45; Metformin: 5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
10, 20, 30, 45 and 60
10, 20, 30, 45 and 60
15, 20, 30, 45 and 60
10, 20, 30, 45 and 60

1, 2, 4, 6, 8, 10 and 12 hours
15, 30, 45, 60 and 90

10, 15, 20, 30 and 45
10, 20, 30, 45 and 60
0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours
5, 10, 15, 20, 30, 40 and 60

Acid stage: 30, 60 and 120 minutes; Buffer stage: 15, 30, 60, 90, 120, 180 and 240 minutes
5, 10, 15, 30, and 45
0.5, 1, 2, 3, 4, 6, 8 and 12 hours
5, 10, 15, 20 and 30
5, 10, 15, 20, 30 and 45
10, 20, 30 and 45

1, 2, 4, 6, 8, 12, 18 and 24 hours
1, 4, 8, 12, 18 and 24 hours
5, 10, 15, 30 and 45

5, 10, 15, 30 and 45
10, 20, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 15, 20, 30, and 45

10, 20, 30, 45 and 60
10, 20, 30 and 45
5, 10, 15, 20 and 30

5, 10, 15 and 30
10, 20, 30 and 45
10, 20, 30, 45 and 60

5, 10, 20, and 30
5, 10, 15, 20, 30 and 45
10, 20, 30 and 45
0.17, 0.25, 0.5, 1, 2, 6 and 8 hours

5, 10, 15, and 30
10, 20, 30, and 45
1 hour for test fluid 1, and 4 hours for test fluid 2

0.5, 1, 2, 4, 6, 8 and 12 hours
5, 10, 15, 20 and 30
10, 20, 30 and 45
Acid Stage: 1 hour; Buffer Stage: 1, 2, 4, 6, 8 and 12 hours
1, 4, 12, and 24 hours
1, 2, 3, 6, 8, 12, 16 and 24 hours
5, 10, 15, 20 and 30

Acid stage: 120; Buffer stage: 15, 30, 60, 90, 120, 240 and 360
15, 30, 45, 60 and 90

10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15, 20, 30, 45, 60 and 75
1, 2, 4, and 7 hours or until at least 80% released
15, 30, 60, and 120
10, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 20, 30, 45 and 60

5, 10, 15, 20, 25 and 30
5, 10, 15, 30, and 45
Acid stage: 1 and 2 hours; Buffer stage: 1, 2, 4, 6, 10, 14 and 16 hours

1, 2, 3, 6, 9, 12, 16, 20 and 24 hours
Acid stage: 1 and 2 hours; Buffer stage: 1, 2, 4, 6, 10, 14 and 16 hours
10, 20, 30 and 45

5, 10, 15, 20 and 30
5, 10, 15, 20, and 30
5, 10, 15, 20 and 30
Cobi: 5, 10, 15, 20 and 30; Drv: 10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15, 30 and 45

Acid stage: 2 hours; Buffer stage: : 5, 10, 20, 30 and 45 minutes
10, 20, 30, 45 and 60
10, 20, 30, 45, 60 and 90
10, 20, 30 and 45

Acid stage: 2 hours; Buffer stage: : 5, 10, 15, 20 and 30 minutes
10, 20, 30, and 45
10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
0.5, 1, 2, 4, 6, 8, 10 and 12 hours
0.5, 1, 2, 3, 5 and 10 minutes

10, 20, 30, 40 and 60
5, 10, 15, 20 and 30
Dapagliflozin: 5, 10, 15, 20, 30 and 45 minutes: Metaformin: 0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours
1, 4, 8, 12, 16, 20 and 24 hours

15, 30, 45, 60, 75 and 90
5, 10, 15, 20, 30 and 45
10, 20, 30, and 45
Ombitasvir/ Paritaprevir/ Ritonavir: 10, 15, 20, 30, 45, 60 and 90 minutes;Dasabuvir: 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24 hours
10, 15, 30 and 45
10, 20, 30 and 45
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
15, 20, 30 and 45
3, 6, 10, 15
For Desloratadine: 10, 20, 30 and 45; For Pseudoephedrine Sulfate: 1, 2, 6 and 8 hours
For Desloratadine: 10, 20, 30 and 45; For Pseudoephedrine Sulfate: 1, 2, 4, 8, 16 and 24 hours
10, 20, 30 and 45
1, 2, 4, 8, 12, 16, 20 and 24 hours

0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours
12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours
0.5, 1, 2, 3, 4, 6 and 8 hours

Acid Stage: 120; Buffer Stage: 10, 20, 40, 50, 60 , 75, 105 and 120
Acid Stage: 120; Buffer Stage: 10, 15, 20, 30, 50, 60, 75 and 90
10, 15, 30, and 45
0.5, 1, 2, 4, 6, and 10 hours
10, 20, 30, 45 and 60
1, 4, 8 and 12 hours
1, 2, 6, and 12 hours
5, 10, 15, 20 and 30
30, 60, 90 and 180
5, 10, 15, 30 and 45
5, 10, 20, 30 and 45

15, 30, 45, 60, 90, 120 and 180
2.5, 5, 7.5 and 10
10, 15, 20, 30 and 45
10, 20, 30, 45, 60 and 90
Diclo.: 120 (acid) 15, 30, 45 and 60 (Buffer). Miso:10, 20 and 30
10, 20, 30 and 45

Acid stage: 60, 90 and 120; Buffer stage: 10, 20, 30, 45 and 60
10, 15, 20, 30 and 45
1, 3, 5, 7 and 9 hours
2, 8, 14, and 24 hours
Acid stage: 2 hours; Buffer stage: 5, 10, 20, 30 and 45
0.25, 0.5, 1, 2, 2.5, 3, 3.5, 4 and 5 hours

10, 20, 30 and 45
10, 20, 30 and 45
15, 30, 45, 60, 75, 90, 105, and 120
10, 15, 30 and 45
10, 15, 20, 30, 45 and 60

5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
Donepezil: 5, 10, 15, 20 and 30 minutes; Memantine: 1, 2, 3, 4, 6, 8, 10 and 12 hours
10, 20, 30 and 45
1, 2, 3, 4, 6, 8 and 10 hours
10, 20, 30, 45 and 60
1, 2, 4, 6, 8, 12 and 16 hours
5, 10, 15, 20, 30 and 45
5, 10, 15 and 20
1, 2, 2.5 , 3 and 4 hours
Acid stage: 10, 20, 30, 45 and 60; Buffer stage: 5, 10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
Acid stage: 5, 10, 15, 20 and 30; Buffer stage: 5, 10, 15, 20 and 30
Acid stage: 5, 10, 15, 30, 60, 120 minutes; Buffer stage: 5, 10, 15, 20 and 30 minutes
5, 10, 15, 30, 45, 60, and until at least 80% of the labeled content is released
10, 15, 20, 30, 45, 60, 90 and 120
10, 20, 30, and 45
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
15, 30, 45 and 60

Dutasteride: 15, 30, 45 and 60 minutes. Tamsulosin: Acid Stage: 2 hours Buffer stage: 0.5, 1, 2, 3, 5, 7 and 10 hour
15, 30, 45 and 60
10, 15, 30, 45, 60
10, 20, 30, and 45
10, 15, 20, 30, 45 and 60
5, 10, 15 and 30
10, 15, 20, 30 and 45
4, 8, 12, 15 and 20
10, 15, 20, 30, 45, and 60
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
Metformin: 1, 2, 4, 6, 8, 10 and 12 hours: Empagliflozin: 10, 15, 20, 30, 45 and 60 minutes;
10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 20, 30 and 45
5, 10, 15, 20, 30 and 45
Emtricitabine and Tenofovir: 5, 10, 15, 20 and 30; Rilpivirine: 10, 20, 30, 45, 60, 75, 90 and 120
5, 10, 15, 20, 30 and 45
5, 10, 15, 30 and 45
10, 20, 30 and 45

10, 20, 30, and 45
10, 15, 20, 30 and 45
10, 20, 30 and 45
15, 30, 45 and 60
10, 20, 30 and 45
15, 30, 45, 60 and 90
5, 10, 15, 20, 30 and 45
10, 20, 30, 45 and 60
10, 20, 30 and 45

10, 20, 30 and 45
5, 10, 15, 20, 30 and 45

10, 20, 30 and 45
15, 30, 45, 60, 90, 120 and 180
1, 9, 16, 17, 18, 19, 45 days
1, 2, 3, 5, 8, 10 and 12 hours
1, 2, 4, 6, 8, 10 and 12 hours
6, 12, 18, 24, 36, 48, 60, 72 and 96 hours
1, 2, 4, 6, 10, 12, 18, 24 and 36 hours
10, 20, 30 and 45

10, 20, 30, 45 and 60
10, 20, 30 and 45
1, 2, 3, 5, 8, 10 and 12 hours
2, 5, 8 and 12 hours
10, 20, 30 and 45
10, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 20, 30, 45, 60 and 75

10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 20 and 30
10, 20, 30 and 45
10, 20, 30, 45, 60 and 90
0.25, 0.5, 1, 2, 4, 8, 12, 16, 20 and 24 hours
10, 20, 30, 45 and 60
Phase 1: No Sampling. Phase 2: 5, 10, 20, 30, 45, 60 and 90

Phase 1: No Sampling. Phase 2: 5, 10, 20, 30, 45, 60 and 90
10, 20, 30 and 45
10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 20 and 30
5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 15, 30 and 45
2, 5, 10, 15 and 20
10, 20, 30, 45 and 60
5, 10, 15, 20, 30 and 45

5, 10, 15, 20 and 30
5, 10, 15 and 30
15, 30, 45, 60, 90 and 120

10, 20, 30, 40 and 60
5, 10, 20, 30, 45 and 60
5, 10, 20, 30, 45 and 60
5, 10, 20, 30, 45 and 60
5, 15, 30, 45 and 60
0.5, 1, 2, 4 and 24 hours

1, 3, 5, 7, 10, 15 and 20
5, 10, 20, 30 and 40
3, 5, 7.5, 10, 15 and 20
3, 5, 7.5, 10, 15 and 20
5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 20, 30 and 45
1, 2, 4, 6, 8, 10, 12, 16 and 20 hours

10, 20, 30 and 45
5, 10, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 15, 30 and 45
10, 15, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 20 and 30
5, 10, 15, 20 and 30

10, 20, 30, 45 and 60
10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30 and 45
0.5, 2, 4, 6 and 8 hours
1, 2, 4, 6, 8 and 12 hours
10, 20, 30 and 45
10, 20, 30 and 45
5, 10,15 and 20
10, 20, 30 and 45
5, 10, 15, 20 and 30
0.5, 1, 2, 4, 6, 8, 12 and 24 hours
1, 4, 10 and 12 hours
10, 20, 30, 45 and 60
10, 20, 30, 45 and 60
10, 20, 30 and 45
5, 10, 15 and 30
For Pioglitazone: 10, 15, 20, 30 and 45; For Glimepiride: 10, 15, 20 and 30
5, 10, 15, 30, 45 and 60
1, 2, 4, 8, 16 hours and until at least 80% dissolved
10, 20, 30, 45 and 60

10, 20, 30, 45 and 60
3, 14, 35, 56 and 84 days (10.8 mg strength); 7, 14, 17, 21 and 28 days (3.6 mg strength)
2, 6, 12, 24, 36, 48, 60, 72 and 96 hours

10, 20, 30, 45 and 60
10, 20, 30 and 45
10, 20, 30 and 45
1, 2, 4, 6 and 12 hours
1, 2, 6, and 12 hours
1, 2, 4, 6, 8, 10, 12, 16, 20 and 24 hours
10, 20, 30 and 45
10, 20, 30 and 45

10, 20, 30, 45 and 60
10, 20, 30, 45 and 60
Hydrochlorothiazide: 10, 15, 20, 30, and 45 minutes; Metoprolol succinate: 1, 2, 4, 6, 8, 12, 16, 20 and 24 hours
5, 10, 15 and 30
5, 10, 15, 20, 30, 45 and 60
5, 10, 20 and 30
1, 2, 4, 6, 8, 10 and 12 hours
1, 2, 4, 8, 12, 16, 20 and 24 hours
5, 10, 15 and 30
1, 2, 4, 6, 8, 10, 12, 16, 20 and 24 hours

5, 10, 15, 30 and 45
5, 10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15 and 20
5, 10, 20, 30 and 45

5, 10, 20 and 30
5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 20, 30 and 45
10, 15, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15 and 30
comparative evaluation by the Agency.
5, 10, 15, 20 and 30
5, 10, 15, 30, 45 and 60
5, 10, 15, 20 and 30
30, 60, 90, 120, 150 and 180
10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 20, 30, 45, 60, 75 and 90

10, 20, 30, 45 and 60
10, 15, 20, 25, 30 and 45

5, 10, 15 and 30
15, 30, 45, 60 and 90

10, 20, 30, 45 and 60
2, 4, 8, 12, 16 and 24 hours
2, 4, 8, 12, 16 and 24 hours
10, 20, 30, 45, 60 and 90
5, 15, 30, 45, 60, 75 and 90
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
5, 10, 15, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
15, 30, 45, 60 and 90
10, 20, 30, 45 and 60
10, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 40

10, 15, 20, 30 and 45
10, 20, 30, 45 and 60
10, 20, 30, and 45

10, 15, 30, 45 and 60
10, 15, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
60 (Acid), 10, 20, 30 and 45 (Buffer)

10, 20, 30 and 45
10, 15, 30 and 45
5, 10, 15, 20, 30, 45 and 60
10, 20, 30 and 45
10, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 15, 20, 30, 45 and 60
5, 10, 15, 20, 30 and 45
by the Agency
1, 2, 4, 6, 8 and 12 hours
2.5, 5, 10, 15 and 20
5, 10, 15 and 30
10, 20, 30 and 45
1, 2, 4, 6, 8, 12, 16, 20 and 24 hours

10, 20, 30, 45, 60 and 90
10, 20, 30, 60, 120 and 180

5, 10, 15, 20 and 30
5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
Linagliptin 10, 15, 20, 30 and 45 minutes; Metformin: 1, 2, 4, 6, 8 and 12 hours
5, 10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15 and 20
10, 20, 30 and 45
5, 10, 20, 30 and 45
10, 20, 30, 45, 60, 75 and 90

5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
10, 15, 30 and 45
2, 4, 6 and 10
10, 20, 30, 45 and 60
15, 30, 45 and 60
Loratadine:10, 15, 20, 30 and 45; Pseudoephedrine: 1, 2, 4, 8, 12, 16, 18 and 24 hours
Loratadine:15, 20, 30, 45, 60 and 90; Pseudoephedrine: 1, 2, 4, 8, 12 and 16 hours
1, 2, 4, 5, 8 12, 16 and 20 hours

5, 10, 15, 20 and 30
10, 20, 30 and 45
1, 2, 4, 6, 8, 12, 16 and 20 hours

For Niacin: 0.5, 1, 2, 3, 6, 9, 12, 20 and 24 hours; For Lovastatin: 15, 30, 45 and 60 min
15, 30, 45, 60, 90 and 120
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
15, 30, 45, and 60
15, 30, 45, 60 and 90
10, 15, 20, 30 and 45
15, 30, 45, 60, 90 and 120
5, 10, 15, 30, 45 and 60 minutes
10, 20, 30, 45 and 60

10, 20, 30, 45 and 60
Test 1: 5, 10, 15, 20, 30, 40, 50, 60, 70, 80 and 90; Test 2: 5, 10, 15, 30, 60, 90, 120, 240, 360, 1440 and 2880
10, 20, 30, 45 and 60
5, 10, 15 and 30
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
1, 2, 3, 4, 6, 8, 10 and 12 hours
10, 20, 30 and 45
10, 20, 30, 60, 120, 150 and 180
5, 10, 15, 20 and 30

20, 30, 45, 60, 90 and 120
30, 60, 90, 120 and 150
Phase 1: 120; Phase 2: 60; Phase 3: 20, 30, 45, 60, 75, 90 and 120
Acid stage (A): 2 hours; Buffer stage (B): 1 hour; Buffer stage (C): 1, 2, 4, 6 and 8 hours
Acid stage: 2 hours; Buffer stage: 0.5, 1, 2, 4, 7 and 9 hours
5, 10, 15, and 30

5, 10, 15, 20 and 30
0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours
10, 20, 30 and 45

Metformin: 1, 2, 3, 4, 6, 8, 10 and 12 hours. Saxagliptin: 5, 10, 15, 20 and 30 minutes
10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
5, 10, 15, 20 and 30

1, 2, 4, 6, 8, 12 hours and until at least 80% released
0.5, 1.5, 3, 4 hours and until at least 80% released
Acid Stage: 15, 30, 60, 120 minutes; Buffer Stage: 1, 2, 3, 4, 6 and 8 hours
0.5, 1, 3, 6, 8 and 10 hours
15, 30, 45 and 60

0.5, 1, 2, 4, 6, and 10 hours
0.25, 0.5, 1, 2, 3, 4, 6 and 8 hours
0.25, 0.5, 1, 2, 3, 4, 6, 8 hours
15, 30, 45, 60, 90 and 120
10, 20, 30, 45, 60 and 75

5, 10, 15, 20, 30 and 45
30, 60, 90, 120 and 150

10, 20, 30 and 45
1, 2, 4, 6, 8, 10 and 12 hours
15, 30, 45 and 60
5, 10, 15 and 30
5, 10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
10, 20, 30, and 45
10, 20, 30 and 45
10, 15, 30, 45 and 60
5, 10, 15, 20 and 30
0.25, 0.5, 1.0, 1.5, 2, 3 and 4 hours
1, 2, 4, 6 hours and until 80% of drug released
15, 30, 45, 60, 90, 120, 180 and 210
1, 3, 5, 7, 8.5, 10 and 12 hours

5, 10, 15 and 30
5, 10, 15, 20 and 30
5, 10, 20 and 30
10, 20, 30, 45 and 60

5, 10, 15 and 30
5, 15, 20 and 30
5, 10, 20 and 30
5, 10, 20 and 30
0.25, 0.5, 1, 1.5, 2, 4, 6 and 8 hours
5, 15, 20 and 30
1, 2, 3, 6, 9 and 12 hours
1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 hours
1, 2, 4, 6, 8, 10 and 12 hours
Morphine Sulfate: Acid stage: 1 hour; Buffer stage: 1, 3, 5, 8 and 10 hours. Naltrexone HCl: Acid stage: 1 hour; Buffer stage: 1,
15, 30, 45 and 60
5, 10, 20 and 30
5, 10, 20 and 30
5, 10, 15 and 30
120 (Acid), 10, 20, 30, 45 and 60 (Buffer)
15, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
C. Develop an in vitro release method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Paddle) or any other appropriate m
0.5, 1, 1.5, 2, 3, 4, 6 and 8 hours
0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 14 hours
10, 15, 20, 30 and 45

5, 10, 15, 20 and 30
5, 10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
Naproxen:: Acid stage: 120; Buffer stage: 10, 20, 30, 45, 60, 75 and 90; Esomeprazole::10, 20, 30, 45, 60, 75 and 90
10, 20, 30 and 45

10, 20, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
5, 10, 15, 20, 30, 45, 60 and 90
5, 10, 15, 20, 30, and 45
15, 30, 45 and 60
Netupitant: 10, 20, 30, 45, 60 and 75; Palonosetron: 5, 10, 15, 20, 30 and 45
1, 2, 3, 4, 5, 6, 8, 10, 12, 16 and 20 hours
10, 20, 30, 45 and 60
1, 3, 6, 9, 12, 15, 20 and 24 hours

Niacin: 1, 3, 6, 9, 12, 15, 18, 20 and 24 hours; Simvastatin: 10, 20, 30, 45 and 60
0.5 , 2 and 6 hours
10, 20, 30 and 45
0.5, 1, 2, 3, 6 and 8 hours

5, 10, 20 and 30
15, 30, 45, 60 and 90
10, 15, 30 and 45
10, 20, 30, and 45

10, 15, 20, 30, 45 and 60
10, 15, 20, 30, 45 and 60
1, 4, 8, 12, 15, 18 and 24 hours
10, 20, 30, 45 and 60
10, 20, 30, 45, 60
5, 10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
10, 15, 20, 30, 45, 60, 75 and 90
15, 30, 60, 120 and 180

10, 20, 30, 45, 60, 90, 120 and 180
1, 3, 5, 8, and 10
5, 10, 20, 30, 45 and 60

15, 30, 45, 60 and 90
5, 10, 15, 20, 30 and 45
by the Agency
10, 20, 30 and 45
10, 20, 30, 45, 60, 75, 90, 105, 120, 150, 180, 240, 360, 480, 600, and 720
10, 20, 30, 45 and 60
10, 20, 30 and 45

Ombitasvir, paritaprevir, ritonavir: 10, 20, 30, 45, 60, 90, 120 and 150; Dasabuvir: 5, 10, 15, 20 and 30
10, 20, 30, 45, 60, 90, 120, 150 and 180
omparative evaluation by the Agency.

Sampling started at the buffer stage 10, 20, 30, 45 and 60
5, 10, 15, and 30
15, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 15 and 30
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 20, and 30
10, 15, 20, 30 and 45
10, 20, 30, 45, 60 and 75
1, 2, 4, 6, 8 and 10 hours
10, 20, 30 and 45
10, 20, 30, 45, 60 and 90
10, 20, 30, 45, 60 and 90
10, 20, 30, 45, 60 and 90
1, 4, 24 hours
1, 2, 4, 6, 8, 12, 16, 20 and 24 hours

5, 10, 15, 20 and 30
0.25, 0.5, 1, 2, 4, 6, 8, 10 and 12 hours

10, 20, 30 and 45
1, 2, 4, 6, 8 and 10 hours
10, 15, 20, 30 and 45
1, 2, 4, 6, 8, 12, 14, 18 and 24 hours
1.5, 5, 8, 10, 15, 20, 30 and 45
5, 30, 60, 90, 120, 180, 240, 300 and 360
10, 15, 30, 45 and 60
10, 20, 30, 45 and 60

5, 10, 15, 20 and 30
Acid stage: 60, 90 and 120; Buffer stage: 10, 20, 30, 45 and 60
20, 30, 45, 60

5, 10, 15, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15, 20, 30 and 45

5, 10, 15, 20 and 30
10, 15, 30, 45 and 60
10, 20, 30, 45, 60 and 90
5, 15, 30, 45 and 60
5, 10, 15, 20 and 30

5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 20 , 30 and 45
1, 2, 4, 6 and 8 hours
10, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30

Phentermine: 10, 15, 20, 30 and 45; Topiramate: 0.5, 1, 2, 3, 4, 6 and 8 hours
10, 20, 30, 45 and 60

5, 10, 15, 20 and 30
5, 10, 15 and 30
5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45
5, 10, 15, 20, 30 and 45

10, 15, 20, 30 and 45
10, 15, 20, 30, 45 and 60
Acid Stage: 120; Buffer Stage: 10, 15, 20, 30 and 45
10, 20, 30 and 45
1, 2, 4, 6, 9, 12, 16, 20 and 24 hours

5, 10, 15, 30 and 45
10, 15, 20, 30 and 45
5, 10, 20 and 30
5, 15, 30, 45 and 60
1, 2, 3, 3.5, 4, 4.5, 5, 5.5, 6, 7, 8 and 10 hours

10, 20, 30 and 45
1, 2, 4, 6, 8, 10, 12, 16 and 24 hours
10, 20, 30, 45 and 60

10, 20, 30 and 45
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
1, 2, 4, 6, 8 and 12 hours
10, 20, 30 and 45

1, 2, 4, 6, 8, 10, 12, 16, 20, and 24 hours
Acid Stage: 120; Buffer Stage: 10, 15, 20, 25, 30 and 45
Acid stage: 120; Buffer stage: 10, 20, 30, and 45
10, 20, 30 and 45
5, 10, 15, 20 and 30
15, 30, 45, 60 and 120
10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15 and 30
10, 20, 30 and 45
10, 15, 30 and 45

10, 15, 20, 30 and 45
10, 20, 30 and 45

10, 20, 30 and 45
10, 15, 20, 30, 45 and 60
10, 20, 30, 45, 60 and 90

10, 20, 30, 45, 60, 90 and 120
10, 20, 30, 45, 60, 90 and 120
10, 20, 30, 45 and 60
10, 20, 30, 45 and 60
10, 20, 30, and 45
5, 10, 15, 20 and 30

Acid stage: 120; Buffer Stage: 10, 15, 20, 30 and 45
10, 20, 30, 45 and 60

5, 10, 15
by the Agency
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45

10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
1, 2, 4, 7, 9 and 12 hours
10, 20, 30 and 45
5, 10 and 15
5, 10, 15 and 30
5, 10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
1, 2, 4, 6, 8, 12, 16, 20 and 24 hours

10, 20, 30 and 45
10, 20, 30 and 45
15, 30, 60, 90, 120, 150 and 180
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
5, 10, 15, 30, 45 and 60
2.5, 5, 7.5, 10 and 15
5, 10, 15 and 20
10, 20 , 30 and 45
5, 10, 15, 20, 30 and 45

1, 2, 4, 6, 12, 18, 24, 36, 48, and 72 hours
0.5, 1, 1.5, 2, 2.5, 3, 3.5 and 4 hours
1, 2, 4, 8, 12, 16, 20 and 24 hours

1, 2, 4, 8, 12, 16, 20 and 24 hours
5, 10, 15 and 20
5, 10, 15, 20 and 30
10, 20, 30 and 45
10, 20, 30, 45 and 60

5, 10, 15 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 15 and 30
10, 20, 30, 45, 60 and 120

5, 10, 15, 20 and 30
5, 10, 15, 20, 30, and 45
5, 10, 15 and 30
15, 30, 45, 60 and 90
20, 30, 45, 60 and 90
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
10, 15, 30 and 45
15, 30, 45, 60, and 90 minutes
5, 10, 15, 20 and 30
10, 20, 30, 45, 60 and 90

10, 20, 30 and 45
15, 30, 45, 60, 180, 240 and 480
10, 15, 20, 30, 45 and 60
10, 20, 30, 45, 60 and 90

15, 30, 45, 60 and 90
5, 10, 15 and 30
10, 15, 30 and 45
5, 10, 15, 20, 30 and 45
0.5, 1, 2.5, 4.5, 6.5, 8.5 and 12 hours
30, 60, 90 and 120
10, 20, 30 and 45
1, 2, 3, 6, 8, and 10 hours
10, 20, 30, 45 and 60
0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
15, 30 and 45
10, 20, 30 and 45
10, 20, 30, and 45

5, 10, 15, 20 and 30
10, 20, 30, 45, 60 and 75
10, 20, 30, and 45
10, 20, 30, 45 and 60
10, 20, 30, 45, 60 and 90
10, 20, 30 and 45
15, 30, 45, 60, 90, 120 and 150
5, 10, 15, 20, 30 and 45
1, 3, 5, 7, 11, 16, 20 and 24 hours
1, 2, 4, 6, 10, 12 and 24 hours

5, 10, 15, 30 and 45
10, 20, 30, 60 and 90
1, 4, 8, 12 hours
1, 4, 8, 12 hours
1, 2, 4, 8, 12 and 24 hours
5, 10, 15, 20 and 30

10, 20, 30, 45, 60 and 75
10, 20, 30, 45 and 60
10, 20, 30 and 45

10, 15, 20, 30 and 45
5, 10, 15, 20 and 30
15, 30, 45 and 60
5, 10, 15 and 30
5, 10, 15 and 30
1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours
5, 10, 15, 20 and 30
5, 10, 15 and 30
1, 3, 7 hours
10, 15, 20, 30 and 45
1, 2, 3, 4, 6 and 8 hours
10, 20, 30, 45 and 60
0.5, 1, 2, 4, 6 and 8 hours
5, 10, 20 and 30
5, 10, 20, 30 and 45
10, 20, 30 and 45
5, 10, 15 and 30
0.5, 1, 2, 3, 5, 7, 9, 12, 16, 20 and 24 hours
10, 20, 30 and 45
2, 4, 8, 10 and 16 hours
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60
For Trandolapril: 5, 10, 20, 30 and 45; For Verapamil: 1, 2, 3.5, 5 and 8 hours
15, 30, 45, 60, 90 and 120
1, 2, 3, 5, 8, 10, 12, 16, 20 and 24 hours

1, 2, 4, 6, 8, 12, 16, 20 and 24 hours
10, 15, 20, 30 and 45
by the Agency
1, 2, 4, 8, 12, 16, 24, 36, 48, 72, 96 and 120 hours
10, 20, 30, 45, 60 and 90

1, 6, 12, 24, 48 and 72 hours
1, 8, 24, 96, and 168 hours
2, 3, 4, 6, 8, 12 and 16 hours
10, 20, 30 and 45
5, 10, 15, 20 and 30
10, 20, 30, 45 and 60

5, 10, 15, 20 and 30
10, 20, 30 and 45
5, 10, 15, 20 and 30

5, 10, 15 and 30
5, 10, 15 and 30
5, 10, 15 and 30
10, 15, 20, 30 and 45
0.25, 0.5, 0.75, 1, 1.5, 2, 3, 3.5 and 4 hours
1, 2, 4, 6, 8, 12, 16, 20 and 24 hours
2, 4, 8, 12 and 20 hours
5, 10, 15 and 30
5, 10, 15, 20 and 30

10, 15, 20, 30 and 45
10, 15, 20, 30 and 45
5, 10, 20, 30, 45 and 60
10, 20, 30 and 45
10, 20, 30 and 45
5, 15, 30, 45 and 60
10, 15, 20, 30 and 45
10. 30, 30 and 45
5, 10, 20, and 30
10, 20, 30, 45 and 60

1, 2, 4, 6, 8, 10 and 12 hours
10, 20, 30 and 45
10, 20, 30, 45 and 60
5, 10, 15, 20 and 30
5, 10, 15, 20 and 30
5, 10, 15 and 30
1, 3, 5, 7, 10 and 15
1, 3, 5, 7, 10 and 15
10, 20, 30 and 45
Date Updated
03/22/2006
05/28/2015
01/03/2007
01/03/2007
11/16/2017
02/28/2013
02/08/2018
12/20/2005
03/22/2006
08/17/2006
03/03/2011
06/25/2015
01/03/2007
01/14/2008
05/15/2014
07/25/2007
01/03/2007
08/15/2013
01/14/2008
11/19/2015
01/12/2004
01/15/2010
01/15/2010
03/04/2006
07/21/2011
01/15/2010
07/14/2008
07/28/2016
09/22/2011
01/12/2004
02/20/2004
01/05/2012
06/18/2007
08/27/2015
04/10/2008
05/28/2015
08/15/2013
03/17/2016
09/03/2008
04/09/2007
03/17/2016
01/14/2008
11/25/2008
06/18/2007
09/03/2008
02/08/2018
06/07/2012
06/07/2012
10/08/2009
12/23/2010
07/25/2007
01/20/2006
02/14/2014
11/19/2015
01/26/2006
02/08/2007
06/18/2007
10/06/2008
01/29/2010
10/21/2010
01/12/2004
12/23/2010
05/20/2009
06/07/2012
06/07/2012
08/27/2015
07/14/2008
01/12/2004
01/12/2004
01/14/2008
01/14/2004
10/06/2008
04/02/2009
06/20/2007
07/21/2011
07/28/2016
08/11/2008
03/17/2016
08/05/2010
07/28/2016
06/06/2013
01/31/2013
01/31/2013
10/21/2010
02/28/2013
02/28/2013
01/14/2008
10/04/2012
01/14/2004
07/28/2016
12/22/2016
07/25/2007
11/25/2008
11/16/2017
08/17/2006
07/28/2016
01/03/2007
02/19/2008
01/14/2004
01/03/2007
05/09/2013
05/18/2017
03/17/2016
01/20/2006
06/30/2016
06/25/2015
08/11/2008
01/14/2008
05/09/2013
05/28/2015
10/20/2016
12/22/2016
06/24/2010
06/24/2010
08/27/2009
01/15/2004
10/09/2007
01/15/2004
01/15/2004
01/15/2004
01/15/2010
01/20/2006
12/24/2015
02/14/2014
02/14/2014
12/20/2005
01/15/2004
05/15/2014
07/21/2009
06/18/2007
08/17/2006
12/22/2016
01/15/2004
04/02/2015
08/14/2014
09/03/2008
04/08/2010
05/09/2013
05/09/2013
08/17/2006
04/15/2008
12/22/2016
12/22/2016
07/14/2008
12/15/2009
07/31/2013
01/26/2006
06/06/2013
01/16/2004
01/16/2004
07/25/2007
12/24/2015
06/20/2007
01/16/2004
04/08/2010
10/06/2008
11/16/2017
08/17/2006
12/15/2005
03/02/2017
10/06/2008
06/18/2007
01/20/2004
01/31/2013
09/02/2010
11/16/2017
06/25/2015
10/20/2016
11/02/2017
01/15/2015
09/01/2011
07/28/2016
07/25/2007
04/02/2015
02/25/2015
07/14/2008
05/09/2013
07/28/2016
10/20/2016
04/09/2007
07/01/2010
10/31/2013
08/15/2013
07/25/2007
06/10/2009
07/21/2009
07/14/2008
01/20/2004
07/28/2016
06/02/2016
10/20/2016
06/03/2008
01/14/2008
07/21/2009
06/02/2016
12/22/2016
05/28/2015
06/20/2007
06/20/2007
01/29/2010
01/29/2010
11/02/2017
10/20/2016
01/14/2008
01/20/2004
09/01/2011
12/24/2015
12/23/2010
08/14/2014
01/03/2007
08/15/2013
01/14/2008
10/20/2016
04/07/2016
07/25/2007
06/02/2016
08/15/2013
06/30/2016
01/29/2010
12/24/2015
01/21/2004
10/31/2013
04/02/2009
03/03/2011
03/03/2011
03/03/2011
09/02/2010
09/02/2010
07/25/2007
07/25/2007
04/09/2007
01/15/2010
04/09/2007
12/23/2010
12/23/2010
08/15/2013
12/20/2005
07/25/2007
07/25/2007
10/04/2012
10/04/2012
01/21/2004
01/21/2004
07/25/2007
07/01/2010
07/25/2007
04/02/2009
08/27/2015
01/15/2015
03/04/2006
03/17/2016
06/18/2007
01/26/2006
08/17/2006
03/02/2017
03/07/2019
07/25/2007
10/20/2016
06/25/2015
02/20/2004
03/17/2016
11/25/2008
06/30/2011
01/05/2012
04/15/2008
01/14/2008
03/17/2016
07/01/2010
03/25/2010
08/17/2006
01/26/2006
03/25/2010
03/17/2016
01/14/2008
09/02/2010
09/01/2011
01/14/2008
03/17/2016
01/14/2008
10/06/2008
10/06/2008
01/23/2004
07/25/2007
09/01/2011
07/31/2013
07/31/2013
08/15/2013
08/27/2015
04/08/2010
07/25/2007
02/18/2009
01/26/2012
07/01/2010
06/18/2007
08/27/2015
07/25/2007
01/31/2013
01/24/2004
10/06/2008
07/21/2011
05/28/2015
06/09/2011
08/27/2015
10/20/2016
10/20/2016
06/25/2015
06/30/2016
09/01/2011
08/05/2010
12/22/2016
10/28/2010
04/14/2016
06/02/2016
10/20/2016
07/25/2007
01/24/2004
05/09/2013
03/17/2016
01/14/2008
05/28/2015
01/24/2004
08/27/2015
09/22/2011
05/28/2015
03/17/2016
06/07/2012
06/18/2007
03/02/2017
01/27/2004
05/28/2015
08/27/2015
07/28/2016
12/23/2010
01/20/2006
01/30/2020
06/25/2015
09/13/2007
10/20/2016
10/30/2009
06/21/2006
11/02/2017
03/17/2016
06/25/2015
11/16/2017
12/03/2007
07/25/2007
07/25/2007
01/31/2013
03/04/2006
06/18/2007
04/02/2009
04/02/2009
12/15/2005
11/04/2008
04/02/2009
11/02/2017
04/02/2009
10/21/2010
02/15/2018
04/02/2009
05/28/2015
08/05/2010
07/28/2016
06/18/2007
01/14/2008
01/31/2013
11/25/2008
11/25/2008
01/05/2012
10/06/2008
07/25/2007
04/02/2009
02/14/2014
06/25/2015
10/21/2010
10/21/2010
10/21/2010
01/27/2004
06/10/2009
06/10/2009
12/15/2005
06/18/2007
01/26/2004
01/26/2004
06/07/2012
05/20/2009
04/15/2008
06/18/2007
02/19/2008
02/19/2008
02/19/2008
02/19/2008
06/02/2016
10/04/2012
09/01/2011
01/14/2008
01/14/2008
06/18/2007
09/03/2008
11/04/2008
06/18/2007
06/30/2016
06/30/2016
07/25/2007
01/20/2006
07/01/2010
02/08/2018
10/18/2018
10/18/2018
10/18/2018
05/28/2015
03/04/2006
03/17/2016
12/23/2010
01/27/2004
01/03/2007
09/02/2010
08/05/2010
06/03/2008
10/04/2012
09/03/2008
10/06/2008
03/07/2019
03/17/2016
07/14/2008
03/27/2018
05/28/2015
05/28/2015
05/28/2015
01/19/2017
01/31/2007
02/25/2015
01/03/2007
07/28/2016
07/28/2016
05/28/2015
03/17/2016
08/05/2010
01/26/2012
03/22/2006
06/18/2007
01/03/2007
07/28/2016
04/02/2009
05/28/2015
10/20/2016
06/07/2012
03/17/2016
12/24/2015
05/28/2015
01/19/2017
12/24/2015
06/30/2016
10/20/2016
12/16/2005
07/28/2016
01/15/2015
07/28/2016
01/03/2007
09/03/2008
01/29/2004
06/21/2006
05/28/2015
12/19/2005
07/14/2008
02/19/2008
08/05/2010
10/18/2018
12/24/2015
10/31/2013
06/30/2016
01/27/2004
09/02/2010
02/20/2004
10/06/2008
08/27/2015
08/27/2015
10/20/2016
09/02/2010
01/27/2004
02/19/2008
01/03/2007
07/21/2009
10/28/2010
10/28/2010
10/28/2010
10/28/2010
10/31/2013
01/05/2012
07/09/2004
01/30/2020
07/15/2009
09/02/2010
12/24/2015
10/06/2008
09/13/2007
12/23/2010
01/14/2008
09/22/2011
07/14/2008
01/31/2013
02/19/2008
02/19/2008
11/04/2008
01/14/2008
07/15/2009
07/15/2009
02/15/2018
12/24/2015
02/14/2014
01/14/2008
01/14/2008
01/28/2004
05/20/2009
01/31/2013
04/15/2008
06/18/2007
01/14/2008
06/24/2010
06/24/2010
06/30/2011
08/14/2014
07/01/2010
08/17/2006
01/14/2008
01/03/2007
08/15/2013
04/09/2007
11/25/2008
10/06/2008
01/29/2004
06/18/2007
12/15/2009
08/15/2013
08/15/2013
08/15/2013
01/28/2004
01/14/2008
02/19/2008
06/03/2008
10/21/2010
10/21/2010
10/21/2010
08/05/2010
11/25/2008
06/09/2011
08/15/2013
05/20/2009
11/20/2009
11/20/2009
12/15/2009
12/15/2009
08/27/2015
01/30/2020
03/17/2016
08/15/2013
11/25/2008
02/19/2004
01/29/2004
09/03/2008
04/02/2009
04/14/2016
03/17/2016
07/25/2007
08/15/2013
01/29/2004
12/15/2009
06/30/2016
03/04/2006
01/30/2004
01/30/2004
06/24/2010
06/07/2012
05/20/2009
07/25/2007
09/02/2010
04/14/2016
08/17/2006
11/02/2017
01/31/2013
09/22/2011
01/14/2008
01/15/2010
01/03/2007
12/16/2005
12/03/2007
07/20/2017
01/30/2004
08/11/2008
11/04/2008
08/05/2010
06/03/2008
06/03/2008
01/31/2013
08/11/2008
01/20/2006
02/02/2004
10/28/2010
07/25/2007
01/03/2007
07/23/2004
04/02/2009
01/03/2007
04/10/2008
08/05/2010
12/18/2008
02/02/2004
02/02/2004
01/14/2008
07/25/2007
11/04/2008
12/22/2016
03/03/2011
06/05/2006
10/28/2010
10/28/2010
01/15/2010
11/04/2008
01/03/2007
11/25/2008
07/01/2010
11/25/2008
10/30/2009
04/10/2008
02/03/2004
07/25/2007
09/24/2008
02/03/2004
02/03/2004
10/31/2013
01/05/2012
02/10/2004
07/09/2007
02/03/2004
08/27/2009
06/30/2016
07/31/2013
07/28/2016
10/06/2008
05/28/2015
04/14/2016
02/04/2004
05/09/2013
07/25/2007
05/26/2016
09/03/2008
07/25/2007
04/02/2009
04/02/2009
01/03/2007
06/25/2015
02/04/2004
11/04/2008
11/04/2008
07/25/2007
05/09/2013
02/04/2004
06/25/2015
01/03/2007
04/09/2007
01/05/2012
03/04/2006
02/04/2004
08/15/2013
08/27/2015
08/05/2010
09/22/2011
01/14/2008
01/14/2008
04/15/2008
02/04/2004
07/25/2007
05/28/2015
05/28/2015
08/11/2008
03/17/2016
02/04/2004
04/15/2008
06/25/2015
06/25/2015
06/25/2015
06/10/2009
02/04/2004
11/25/2008
10/06/2008
02/25/2004
02/25/2004
02/25/2004
02/04/2004
08/15/2013
05/18/2017
06/25/2015
03/17/2016
03/07/2019
02/04/2004
10/20/2016
01/03/2007
02/05/2004
07/25/2007
04/15/2008
08/27/2009
06/07/2012
02/07/2019
01/03/2007
10/20/2016
01/03/2007
11/02/2017
01/03/2007
01/03/2007
01/03/2007
02/18/2016
03/04/2006
01/14/2008
11/04/2008
11/04/2008
01/03/2007
10/30/2009
08/27/2015
02/05/2004
05/31/2007
04/15/2008
03/17/2016
03/17/2016
02/08/2018
04/10/2008
03/07/2019
07/14/2008
01/15/2010
04/02/2009
03/02/2017
02/05/2004
08/27/2015
08/11/2008
07/28/2016
05/28/2015
02/05/2004
02/14/2014
07/25/2007
01/03/2007
12/24/2015
08/15/2013
05/15/2014
07/28/2016
01/14/2008
01/14/2008
06/18/2007
10/06/2008
01/14/2008
01/14/2008
04/10/2008
07/25/2007
02/05/2004
06/25/2015
12/24/2015
06/25/2015
06/25/2015
06/25/2015
06/25/2015
08/27/2015
06/18/2007
01/15/2015
07/14/2008
02/28/2013
07/14/2008
08/05/2010
08/05/2010
01/14/2008
10/20/2016
12/22/2016
02/06/2004
01/05/2012
06/30/2016
01/31/2013
02/07/2019
01/14/2008
08/19/2010
01/31/2013
05/28/2015
02/19/2008
10/06/2008
10/21/2010
10/06/2008
12/22/2016
02/15/2018
04/08/2010
08/27/2009
10/31/2013
12/24/2015
02/08/2018
12/15/2009
02/06/2004
12/15/2009
01/26/2006
02/20/2004
06/30/2016
07/14/2008
03/02/2017
12/16/2005
01/31/2013
11/25/2008
12/24/2015
02/06/2004
01/30/2006
06/30/2016
06/10/2009
06/10/2009
06/10/2009
11/05/2010
06/18/2007
02/09/2004
03/25/2010
10/20/2016
01/30/2020
04/10/2008
12/12/2008
01/03/2007
01/26/2012
10/06/2008
10/30/2009
07/14/2008
05/28/2015
07/31/2013
01/14/2008
08/15/2013
04/02/2009
03/25/2010
02/15/2018
03/17/2016
10/20/2016
04/15/2008
04/15/2008
11/16/2017
02/14/2014
07/25/2007
03/25/2010
10/20/2016
06/02/2016
03/17/2016
01/29/2010
10/08/2009
07/31/2013
07/31/2013
04/08/2010
07/15/2009
02/10/2004
07/25/2007
07/25/2007
08/05/2010
02/09/2004
12/24/2015
02/15/2018
01/30/2020
10/28/2010
10/08/2009
02/06/2004
11/02/2017
01/14/2008
03/17/2016
03/03/2011
01/03/2007
08/05/2010
03/17/2016
06/02/2016
01/14/2008
04/15/2008
07/25/2007
11/02/2017
04/15/2008
05/09/2013
02/10/2004
03/04/2006
02/10/2004
06/10/2009
02/10/2004
02/10/2004
07/25/2007
09/24/2008
04/09/2007
03/04/2006
10/20/2016
01/15/2010
08/11/2008
12/23/2010
08/14/2014
12/23/2010
01/26/2012
06/18/2007
02/10/2004
02/10/2004
02/10/2004
12/19/2008
07/14/2008
07/25/2007
04/02/2009
11/02/2017
05/28/2015
09/01/2011
04/15/2008
12/22/2016
09/03/2015
11/16/2017
12/15/2009
07/25/2007
04/08/2010
10/04/2012
05/28/2015
06/25/2015
05/28/2015
07/01/2010
06/06/2013
07/25/2007
01/03/2007
01/15/2010
10/20/2016
01/03/2007
01/03/2007
09/13/2007
01/14/2008
08/14/2014
09/03/2015
01/31/2013
02/11/2004
09/13/2007
06/10/2009
01/15/2010
07/14/2008
02/11/2004
01/31/2013
12/23/2010
01/05/2012
03/09/2017
07/25/2007
03/03/2011
10/30/2009
05/20/2009
04/09/2007
09/03/2015
11/02/2017
04/02/2009
10/21/2010
01/03/2007
11/02/2017
12/22/2016
02/15/2018
04/02/2009
04/02/2009
04/08/2010
01/15/2010
01/14/2008
10/08/2009
08/27/2009
09/03/2015
10/28/2010
01/03/2007
11/02/2017
12/23/2010
02/12/2004
01/15/2015
01/15/2015
12/24/2015
06/02/2016
11/02/2017
02/12/2004
08/27/2015
06/30/2016
03/17/2016
06/18/2007
02/28/2013
02/08/2018
02/07/2019
01/03/2007
06/20/2007
07/14/2008
06/18/2007
01/26/2012
02/12/2004
02/12/2004
08/27/2009
07/15/2009
01/03/2007
10/20/2016
06/02/2016
03/17/2016
08/15/2013
02/12/2004
02/12/2004
02/12/2004
02/12/2004
01/03/2007
12/24/2015
07/28/2016
05/28/2015
03/17/2016
01/14/2008
12/22/2016
01/14/2008
02/14/2014
03/17/2016
08/27/2009
09/01/2011
03/17/2016
08/05/2010
03/17/2016
06/02/2016
10/20/2016
10/30/2009
07/21/2009
06/18/2007
02/13/2004
11/19/2015
02/13/2004
01/14/2008
03/07/2019
02/14/2014
08/05/2010
02/13/2004
06/24/2010
09/03/2008
06/09/2011
06/09/2011
04/15/2008
06/09/2011
05/15/2014
12/22/2016
03/04/2006
06/20/2007
12/15/2009
05/20/2009
06/10/2009
06/10/2009
03/25/2010
04/10/2008
08/27/2009
07/15/2009
12/24/2015
07/31/2013
06/06/2013
06/18/2007
01/14/2008
06/18/2007
03/25/2010
01/20/2004
07/28/2016
02/19/2008
12/24/2015
02/13/2004
03/27/2018
09/03/2015
10/04/2012
12/23/2010
05/28/2015
09/03/2015
06/25/2015
12/03/2007
12/24/2015
07/25/2007
08/05/2010
09/02/2010
10/09/2007
10/04/2012
02/13/2004
06/25/2015
11/25/2008
05/15/2014
09/03/2008
12/24/2015
07/31/2013
01/15/2015
02/08/2018
05/28/2015
01/14/2008
01/14/2008
08/17/2006
10/04/2012
04/08/2010
07/25/2007
10/20/2016
11/02/2017
11/02/2017
07/25/2007
03/03/2011
06/07/2012
01/14/2008
01/30/2020
01/14/2008
01/15/2010
10/20/2016
06/10/2009
06/10/2009
06/25/2015
02/18/2004
01/31/2013
07/25/2007
01/14/2008
05/15/2014
09/22/2011
02/18/2004
05/28/2015
04/02/2009
04/02/2009
02/18/2004
09/03/2008
02/18/2004
04/08/2010
07/25/2007
02/07/2019
01/29/2010
06/25/2015
07/25/2007
02/18/2004
02/18/2004
11/02/2017
12/15/2009
06/18/2007
02/25/2004
07/21/2011
07/21/2011
08/15/2013
02/18/2004
01/03/2007
06/30/2016
12/24/2015
01/26/2012
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07/01/2010
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07/23/2004
01/15/2010
11/16/2017
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01/15/2015
01/15/2015
01/15/2015
02/07/2019
06/10/2009
01/03/2007
02/18/2004
02/18/2004
08/15/2013
10/20/2016
05/15/2014
08/27/2009
02/24/2004
11/10/2010
07/15/2009
01/19/2017
08/15/2013
08/15/2013
06/25/2015
10/24/2019
11/02/2017
06/02/2016
10/06/2008
09/13/2007
09/13/2007
08/15/2013
07/15/2009
11/16/2017
01/15/2015
07/15/2009
07/15/2009
10/06/2008
03/17/2016
02/20/2004
10/06/2008
04/09/2008
04/09/2008
02/25/2004
03/04/2006
05/28/2015
06/07/2012
05/28/2015
12/22/2016
09/03/2008
06/18/2007
03/14/2007
07/01/2010
10/31/2013
07/14/2008
04/02/2009
01/15/2010
05/28/2015
10/20/2016
02/19/2008
03/17/2016
06/10/2009
04/15/2008
06/18/2007
02/20/2004
03/04/2006
04/02/2009
11/02/2017
07/14/2008
01/14/2008
02/25/2004
12/15/2009
12/15/2009
08/17/2006
03/04/2006
10/30/2009
09/03/2015
06/30/2016
02/20/2004
01/26/2006
04/02/2009
03/26/2007
10/28/2010
10/31/2013
09/03/2015
06/02/2016
05/09/2013
04/02/2009
01/03/2007
01/05/2012
01/14/2008
08/11/2008
01/19/2017
01/31/2013
01/03/2007
02/20/2004
02/20/2004
02/20/2004
10/08/2009
05/15/2014
06/30/2011
11/25/2008
01/03/2007
09/01/2011
06/24/2010
01/29/2010
03/04/2006
10/06/2008
10/06/2008
10/06/2008
10/06/2008
07/15/2009
01/03/2007
06/25/2015
02/19/2004
07/31/2013
01/03/2007
03/02/2017
11/02/2017
12/03/2007
02/20/2004
02/20/2004
07/28/2016
06/25/2015
05/09/2013
02/20/2004
06/18/2007
02/14/2014
08/14/2014
02/19/2004
06/25/2015
02/19/2004
04/27/2009
02/20/2004
02/20/2004
09/03/2015
02/19/2004
01/03/2007
12/24/2015
02/20/2004
12/19/2008
12/23/2010
10/31/2013
12/15/2009
03/02/2017
06/02/2016
08/05/2010
01/15/2010
02/08/2018
06/18/2007
07/31/2013
01/29/2010
03/04/2006
07/14/2008
11/16/2017
07/15/2010
12/03/2007
01/31/2013
07/21/2009
04/15/2008
08/27/2009
11/02/2017
01/15/2015
12/15/2009
12/13/2004
07/28/2016
01/14/2008
06/25/2015
12/20/2005
05/15/2014
12/03/2007
05/28/2015
07/28/2016
02/14/2014
01/03/2007
02/19/2004
06/24/2010
08/27/2015
11/04/2008
08/14/2014
06/25/2015
08/14/2014
05/28/2015
12/24/2015
11/25/2008
01/03/2007
09/03/2008
05/28/2015
01/29/2010
10/09/2007
02/19/2008
01/03/2007
07/25/2007
06/18/2007
02/19/2004
08/15/2013
02/19/2004
03/04/2006
07/21/2009
06/18/2007
01/05/2012
02/19/2004
08/14/2014
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01/03/2007

Dissolution Methods

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Dissolution Methods

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Drug Name

II (Paddle) with sinker

II (Paddle) with sinker

II (Paddle) with sinker

VI (Cylinder) with adapter, if needed

III (Reciprocating Cylinder)

II (Paddle) with sinker

II (Paddle) with sinker

II (Paddle) with sinker

VII (with reciprocating 50 mesh baskets)

III (Reciprocating Cylinder)

II (Paddle) (diclo) II (Paddle) (miso)

VI (Cylinder) attach the patch to a disk at the bottom of the cylinder

VII (Reciprocating holder)- cylinder.

II (Paddle) with sinker

VII (Reciprocating holder) (Sample holder-Cage)

II (Paddle) with sinker

I (Basket, with 20 mesh)

II (Paddle) with sinker

Paddle over Disk (Apparatus 5)

IV (Flow-Through Cell-Open system)

I (Basket) (100 mesh)

IV (Flow through cell), 22.6 mm cell

V (Paddle over Disk) with a stainless steel disk (120 mesh screens)

II (Paddle) with sinker

II (Paddle) with sinker

I (Basket -100 mesh)

Paddle over Disk (Apparatus 5)

Basket (20 mesh)

II (Paddle, may use sinker)

For Alendronate: 50; For Cholecalciferol: 75

50 mg, 100 mg and 200 mg: 50 rpm; 400 mg: 75 rpm

30 cycles per min

100 (diclo) 50 (miso)

30 cycles per minute. amplitude of about 2m.

Swirl orbit of 50 mm at 205 rpm for 6 seconds

30 cycles per min

Lamivudine and Zidovudine: 75 Efavirenz: 50

RIB: 50; LET: 75

Acid Stage: 75 rpm; Buffer Stage: 60 rpm

For Alendronate: 900; For Cholecalciferol: 500

0-2 hrs: 750 mL. After 2 hrs: 950 mL

500 mL (10 mg) or 1000 mL (20mg)

Acid Stage: 500 mL ; Buffer Stage: 1000 mL

Tier 1: 1000 mL Tier 2: 750 mL (initial) 1000 mL (final)

Row 1: 250 mL. Row 2: 250 mL

500 mL for 50 mg capsule; 900 mL for 250 mg capsule

Acid stage: 500; Buffer stage: 500

Acid stage: 500; Buffer stage: 500

Diclo: Acid: 750 Buffer:1000 Miso: 500

Acid stage: 500; Buffer stage: 500

plicate for 12 dosage vials.

Acid stage: 900 mL; Buffer stage: 900 mL

Acid stage: 300; Buffer stage: 1000

1000 (phase 1): 1800 (phase 2)

500 (for 300 mg); 900 (for 600 mg)

Lamivudine and Zidovudine: 1000 Efavirenz: 900

500 (Acid), 900 (Buffer)

RIB: 900; LET: 900

Acid stage: 750 mL; Buffer stage: 1000 mL

0-2 hrs: 500. 2-10 hrs:500

Netupitant: 900; Palonosetron: 500

use Open Mode

Acid stage: 750; Buffer stage: 1000