PHARMACEUTICAL

BIOTECHNOLOGY

BY
MS.S.SHYAMLA
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACEUTICS
PPG COLLEGE OF PHARMACY
COIMBATORE
 HISTORY He used sugar beets as
❖The term Biotechnology the source of food for
large scale production of
was introduced in 1917
PIGS

❖By, KARL EREKY

According to Ereky, all type of

work are biotechnology by which
products are produced from raw
materials using living organisms in
20th century
 HISTORY
• Traditional biotechnology has been used for thousands of
years to produce improved food and health care products.
Today, modern biotechnology enables us to develop improved
products more safely and more rapidly than ever before
• It is the Manipulation of living organisms, systems to develop
products.
• In past biotechnologists used yeast cells to ferment alcoholic
drinks and bacteria to make cheese and yoghurt
 DEFINITION
Pharmaceutical biotechnology consist of the combination of two
branches which are “Pharmaceutical Science” and
“Biotechnology”.

PHARMACEUTICAL SCIENCE: define as the branch of

science that deals with the formulation compounding and
dispensing of drugs

BIOTECHNOLOGY: define as the application of biological

system, living organisms, or their derivatives in making or
modifying products or processes for specific use.
 Aim of Pharmaceutical
Biotechnology
• To design, produce drugs that are adapted to
each persons genetic make up, which can give
the maximum therapeutic effect.
 Goals of Biotechnology
• To understand more about the processes of inheritance
and gene expression.
• To provide better understanding & treatment of various
diseases, particularly genetic disorders.
• To generate economic benefits, including improved
plants and animals for agriculture and efficient
production of valuable biological molecules.
Example: Vitamin A fortified engineered rice.
 Pharmaceutical Biotechnological
Product
The common pharmaceutical biotechnology
products that are made by the pharmaceutical
companies includes:
• Antibodies
• Proteins
• Recombinant DNA Products.
 Antibodies

• Antibodies are proteins that are produced by

white blood cells and are used by the immune
system to identify bacteria, viruses, and other
foreign substances and to fight them off.
• In the recent years, monoclonal antibodies are
one of the most exciting in developments
 Proteins
• Proteins made of amino acids are large, complex molecules
that do most of the work in cells and are required for the
structure, function, and regulation of the body’s tissues and
organs.
• Protein biotechnology is emerging as one of the key
technologies of the future for understanding the development
of many diseases like cancer or amyloidal formation for better
therapeutic intervention.
 Recombinant DNA Products
It is genetically engineered DNA created by recombining
fragments of DNA from different organisms. Some of
the Recombinant DNA Products includes:
• Recombinant DNA Insulin
• Recombinant DNA Vaccines
• Recombinant DNA Drugs
• Recombinant DNA Enzymes
• Recombinant DNA Growth Hormone
• Recombinant DNA Proteins
• Recombinant DNA Yeast
 RECOMBINANT DNA VACCINE
It is a vaccine produced through recombinant DNA technology. It involves
Inserting the DNA encoding

In an antigen (such as a bacterial surface protein)

stimulates an immune response
into bacterial or mammalian cells,

It expressing the antigen in these cells

Purification vaccine

Example :Hepatitis B infection is controlled through use of recombinant

hepatitis B vaccine.
 RECOMBINANT DNA DRUGS

NAME OF DRUG FORMULATED DRUG PHARMACODYNAMICS

OF THE DRUG

1. Humulin rInsulin Diabetes

2. Humatrope For Somatropin Deficiency

rHuman growth
hormone (hGH) Syndrome (SDS) in adults
and GHD in children

rParathyroid hormone
Treatment of osteoporosis in
3.Forteo
women and men
 RECOMBINANT DNA PRODUCTS

R-DNA PRODUCT EXAMPLE FUNTIONS

R-DNA ENZYME CHYMOSINE Essential to the

Nmanufacture of firm
cheeses

R-DNA GROWTH PROTROPIN Support growth and

HORMONE development

R-DNA INSULIN HUMULIN For the treatmentof

insulin-
Dependent diabetes

R-DNA PROTEIN Tissue plasminogen Involved in the

activato breakdown of blood clots
 Various Field of Biotechnology
Applications
❑Medicine
• Development of novel therapeutic Molecules for medical
treatments.
• Diagnostics
• Drug delivery systems
• Tissue engineering of replacement organs

• Gene therapy
❑ Food Industry
• Production of baker’s yeast, cheese, yoghurt and
fermented foods such as vinegar and soy sauce
• Brewing and wine making
• Production of flavors and coloring agents
❑ Veterinary Practice
• Vaccine production
• Fertility control
• Livestock breeding
 Future of Medicine
• Smart drugs for cancer and autoimmune diseases
(arthritis, psoriasis, diabetes).
• Gene-based diagnostics and therapies.
• Pharmacogenomics and personalized
medicine.
• Stem cells and regenerative medicine.
THANK YOU
QUESTIONS
SESSION
 ONE MARKS
1.List of Auto immune diseases
2.List the 2 pharmaceutical applications in biotechnology.
3.Write Function of Tissue plasminogen activator.
4.Elaborate –SDS
5.One drug _______for R-DNA growth hormone Product
6._______ Biotechnology is emerging technology for diseases like cancer
formation for better therapeutic intervention.
7. Pharmacodynamic activity of Forteo is ______
8. Karl Ereky is
9. Biotechnologists used _____to ferment alcoholic drinks and bacteria to
make cheese
10. what source are _____ used for large scale production of pigs
11. Hepatitis B is_____
12. List of any 4 Recombinant DNA Products
13. Who is Eduard Buchner_____
14. Who discover the types of fermentation_______
 ANSWER KEY
1. Arthritis, Psoriasis, Diabetes

2. Development of novel therapeutic Molecules for medical treatments, Diagnostics, Drug delivery
systems, Tissue engineering of replacement organs, Gene therapy

3. Involved in the breakdown of blood clots.

4.SDS- Somatropin Deficiency Syndrome

5. Humatrope, Protropin

6. Protein biotechnology

7. Treatment of Osteoporosis

8. KARL EREKY is Hungarian Engineer

9. Yeast

10. Sugar beets

11. Hepatitis B infection is controlled through use of recombinant hepatitis B vaccine

12. Recombinant DNA are Insulin, Vaccines, Drugs, Enzymes, Growth Hormone, Proteins, Yeast
13.Give the concept of Enzyme
14. Louis Pasteur