Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
to Joint Disease
in Archaeology
A Field Guide
to Joint Disease
in Archaeology
JULIET ROGE RS
University of Bristol, UK
TONY WALDRON
Institute of Archaeology, London, UK
J IN Wl Y & SO NS
c l il t IH..:II 'r • N!'W Yorl • ll ri: h:11H· • Toronto • Si ngaporP
Copyright © 1995 by John Wiley & Sons Ltd,
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viii Preface
joints are the organs which form the junction between different
I1ones and in skeletal material are most frequently the site of
pn thological change. As well as the two bone ends, joints have
n l'lubstantial soft tissue component which can also be involved
11 joint disease; however, evidence for this can only be inferred
Imm the bone.
'I'here are three types of joint:
JOINT SPACE - - -
'll•ntified from the tophi (swellings) found in patients with
11out. The introduction of X-rays in 1895 quickly allowed the
P pansion of the classification of joint disease using the results
LIGAMENTOUS
THICKENING obtained from their radiographic examination. By looking for
OF THE MUSCLE
ll ll' first time directly at the bony changes involved in live
1"1 Licnts it was seen that there were two main categories of joint
HYALINE ARTICULAR
pn thology and that these coincided with two types of joint
-----J
CARTILAGE
........ RA I atlanto-axial l
sclerosis of "~··A~;;;~--"""""=
OA C/4/5 I eburnation I
osteophyte
DISH
OA uncommon.::......
RA GOUT
bone noc>K···....fl
OA········ pararticular ·
RA•;J.i.~·:·. marginal erosion
OA-... .'.'.
Psoriatic_...,...
ADVANCED ANKYLOSIS
PSORIATIC occasional feature
AR THROPATHY of Psoriatic/Reiters
or AS of
peripheral joints
c up & pencil
............ RA deformity
NEVER In RA
AREA OF CHANGE
JOINT MARGIN
2 ARTICULAR SURFACE
PERIARTICULAR
The Palaeopathological
JUXTA-ARTICULAR
Classification of Disease
Figure 2.1 Diagram of a typical synovial joint showing areas in which
pathological changes may be obse rved
In normal living bone there is a dynamic equilibrium between this is obviously also true; and our advice, especially to the
the cells that make bone (the osteoblasts) and those which beginner is, if there is not much bone, do not say much about
resorb it (the osteoclasts), and this serves to maintain the it.
integrity of the skeleton. This equilibrium is disturbed in bone
affected by disease, but since bone has only a limited capacity
to react to disease processes, one may greatly oversimplify the FIRST STEPS IN CLASSIFICATION
outcome by saying that diseased bone is characterised by there
being too much or too little present. The diseases which affect The first step in classifying joint diseases must be to make an
bone, however, rarely do so in isolation. For example, the joint inventory of all the bones which are present in the well washed
diseases may not have their origin in the bone, but in the other skeleton and note which joints are present. The \!Se of fixatives,
tissues of the joints, the articular cartilage or the synovial which might impart a shine to the joints should be noted; and
membrane (see Figure 2.1), and it may be difficult to under- occasionally archaeologists or finds assistants will write the
stand the changes seen in the skeleton unless some thought is skeleton number on the joint surface; this is a practice strongly
also given to what is going on in the surrounding soft tissues. to be discouraged. If, as sometimes happens, the age and sex of
the skeleton are to be determined by another worker you
Another general point which needs to be clearly understood is
should agree criteria in advance if only to ensure that joint
that diseases may affect the skeleton in a selective manner.
hanges are not used as an ageing criterion, since if they are,
Thus in some joint diseases the distal interphalangeal joints
1 otentially useful epidemiological information w ill be lost.
(DIP) will be found to be involved, whereas in others it will be
the proximal interphalangeal (PIP) joints; one arthropathy w ill It is essential to use forms devised specially for recording
present with multiple symmetrical changes, another with a 1 urposes and not rely on free-form notes otherwise details will
lesion affecting only a single joint. Because of this, the more in vitably b mis ed off. An example of the recording forms
complete the skeleton, the better the chance of b ing r hably w hi I w · ro11fi1 ' 'Y us ar hown in the app ndix. The joint
able to classify the disea es whi h ar pr s nt. Th nvcrs of lnvt·nlor l lll't 't 't nr w l t'n o n~o; id <' rin r th pa l t rn of joint
10 A Field Guide to joint Disease in Archaeology The Palaeopathological Classification of Disease 11
involvement and for providing the denominator data for wherever possible; this is especially important if the skeletons
subsequent epidemiological analyses (see below). are to be reburied or cremated.
There are relatively few supplementary examinations that are of DETERMINING THE FREQUENCY OF DISEASE
value to the bone specialist and the only one which is used
frequently is radiography. Radiography is most likely to be Reporting on disease in the skeleton can take one of two forms:
helpful with the classification of the erosive arthropathies and the case report or the population model. Case reports, where
we would go so far as to say that under normal circumstances I h number of subjects is small- perhaps even a single case--
there is no virtue in X-raying joints with OA since little further Ir often used when dealing with rare or unusual diseases but
information is likely to emerge which would cause you to Ih ·y provide no useful information about the frequency of
change your classification, assuming that the proper procedures 'llRcas in pa t populations. If this is the aim, then population
have been followed in the first place. The advice of an experi- d tn hnv to b u A d and "om stimate of th frequ ncy of tb
enced skeletal radiologist is absolutely essential in drawing dit-~(' 1 'C' ond N con 'idNnllon hn to b mod ; this is o hi •v<>d y
conclusions from the films which are taken. 1 tll'!tllling lr jH't •y tlt •t)l 't ',
I() A Fi Id Guide to joint Disease in Archaeology The Palaeopathological Classification of Disease 17
The prevalence of a disease is expressed simply as the ratio of onsider for a moment a simple example. You have a group of
the number of those with the disease to the total population; 175 skeletons and you find that nine have OA of the hip. The
that is apparent prevalence of this condition is 9/175 = 51.4/103; this
i referred to as the crude prevalence. Suppose, however, that 26
p = .!!__ of the skeletons are so badly damaged that they have no hip
N joints, then it is clear that they should not appear in the
denominator and the prevalence now can be calculated as
where P = prevalence, 9/{175-26) = 60.4/103 . However, there is yet a further compli-
n = the number of cases with the disease, and ation to consider befpre one can let the matter finally rest. We
N = the total population. now have 149 skeletons with hip joints, but what if 13 of these
have only one normal joint present? We know nothing about the
You may see the frequency of a disease in skeletal populations Htatus of the missing joint-it might have been either diseased
referred to as an 'incidence' or an 'incidence rate'; epidemio- or normal, but as we do not know, we are obliged to exclude
logically this is incorrect for reasons which are gone into more lhese 13 from the denominator and so the final calculation
fully elsewhere; suffice it to say, incidence should never be used becomes 9/{149-13) = 6.2/103 . (It should be noted that this
when referring to the frequency of a disease in a skeleton 1 rocedure can be somewhat simplified by considering the left
population. · nnd right joints separately, but this would be an unusual
•pidemiological practice.)
As it is a simple ratio, the prevalence of a disease is strictly
speaking not a rate, but the term 'prevalence rate' is often used What should be remembered from this exercise is that the total
as the normal expression. Whether the correct or incorrect term number of skeletons in a group may not be the appropriate
is used, however, prevalence is almost never given as a denominator when calculating the prevalence of joint disease;
percentage but depending on the size of the base population nlmost never in the case of OA, which is far and away the most
(the denominator), as so many cases per 103 -10 6; the size of 'Ommon disease seen in the skeleton, and this is why it is so
skeletal populations would generally preclude referring to a vital to have an accurate inventory of the number of joints
base population greater than a thousand. 1 resent.
In contemporary populations the calculation of prevalence is an Prevalence can be calculated for the different sexes and for
extremely straightforward exercise-in so far as anything is different age classes, in which case one refers to sex-specific and
simple in epidemiology; just count the number of cases, the nge-specific prevalence, respectively. It would generally not be
number in the base population and divide the first by the worthwhile to do this with the less common joint diseases but it
second. When trying to carry out this elementary aritlunetic on · •rtainly is when dealing with OA and if, for example you were
skeletal populations, one very soon comes across a diffi ulty lo find th t th pr val ne of OA did not increase considerably
which relates to the number to put in th d nomi:na t r; in other wi lh ngl 11 mi)"ht ho s tor vi w th ag s all o at d to your
words, what is th population? (' (i'IOII H,
18 A Field Guide to joint Disease in Archaeology The Palaeopathological Classification of Disease 19
COMPARING PREVALENCE IN DIFFERENT It is perfectly respectable to compare age-specific prevalence
SKELETAL GROUPS between populations using appropriate techniques, including
that of comparing odds or risk ratios. One can also use the so-
One reason to study skeletons is to compare the frequency of called method of direct standardisation. Any of these methods
disease in different groups and investigate whether variations can produce a summary statistic which can be compared
in frequency may be related to environmental, social or other between populations. You should be aware of how these
factors. Comparisons such as this will be made using the procedures are carried out but this is not within the remit of the
prevalence of the disease but, if the crude prevalence is used, present book and we must refer you elsewhere.
like may not always be compared with like, and the reason for
this lies in the fact that the age structure of different popu-
lations may be dissimilar. This point can be illustrated simply
by considering a disease where the prevalence is highly age-
related; OA or diffuse idiopathic skeletal hyperostosis (DISH;
see Chapter 5) would be good examples.
Imagine we have two skeletal populations (A and B) each of
350 individuals. In A there are 19 cases of a disease in which
we are interested, whereas in B there are 46. The apparent
prevalences of the disease in A and Bare 19/350 and 46/ 350 =
54.3 and 131.4/ 103 respectively; these are known as the crude
prevalences. It appears that the disease is almost 2lh times more
common in B than in A. When we look at the age-specific
prevalences, however, there is an anomaly as the age-specific
prevalences are identical in both populations; see Table 2.1. The
reason for the apparent excess in B is that there are more older
individuals in this population, in whom the disease is much
more frequent, than in A, where young individuals with a low
prevalence predominate. By comparing the age-specific
prevalences it is clear that the frequency of the disease is
exactly similar in the two populations.
Table 2.1 Age-specific prevalence of disease in two populations
A B
3
Age-group n N P/10 n N P/103
25-34 4 200 20 1 50 20
35-44 5 100 50 5 100 50
45+ 10 50 200 40 200 200
Total 19 350 54.3 46 350 1 1.4
n = number of inviduals with the disease
N = tota.l number in age-group
P = pr •va lcn c
Osteophytes 21
articular cartilage, that is, at the joint margins. On occasion the
osteophyte forms a complete ring around the joint, demarcating
it exactly from the surrounding normal bone and a normal joint
tourface. The degree of bone formation can vary enormously
from a minute rim to an massive outgrowth which may some-
times form a phlange several millimetres deep around the joint.
3 Large osteophytes are likely to be seen especially around the
margins of a concave joint such as the acetabulum or the
Osteophytes glenoid; very rarely we have seen the head of a femur so
nclosed by osteophytes arising from the acetabulum that the
two could not be separated.
In the spine, osteophytes on the vertebral bodies are somewhat
different from those in other sites (Figure 3.1) in that they take
their origin from the point of attachment of the fibres of the
Osteophytes are growths of new bone which arise round the , nnulus fibrosa. Osteophytes here tend to develop horizontally,
margins of a joint and which may vary considerably in size and I ut may turn vertically if they become sufficiently large (Figure
shape. They are extremely common in any skeletal population ~ . 2).
and their prevalence increases markedly with age, and almost any
skeleton over the age of 50 or so will be found to have osteo- ,'ince there is such variation in the degree of osteophytosis
phytes around at least one joint if examined carefully enough. nround joints, some workers have devised rating scales to
r cord its presence. These usually have three or four points,
nnd individual joints are rated either as 0, when no osteophyte
DISTRIBUTION is present, or from 1 to 3 (or 4) when it is, depending on the
ize and extent of the new bone formation. These scales may
1 rovide useful information for individual observers but they
Osteophytes may be found around any joint but they appear
11 re not particularly helpful for interstudy comparisons as it is
around some more commonly than others. For example, they tmlikely that there will be a high level of concordance between
occur round the knee and hip joints more often than around the
1he ratings of different observers since they reflect qualitative
ankle, around the DIP joints more frequently than the PIP joints.
rather than quantitative differences. The discrepancies are noted
They are especially common around the margins of the vertebral
1 articularly with specimens which are considered to be
bodies but are found more often in the cervical and lumbar
'borderline' between the categories and many observers experi-
vertebra regions than in the thoracic. Osteophytes are also
t•nce a problem with knowing exactly when to rate minimal
commonly seen around the margins of the facet joints of the
change as being of significance, that is, worthy of inclusion into
spine and, especially in older individuals, on the odontoid peg. I h lowest category. Rating scales are sometimes used to
rn. asure the 'severity' of the degree of osteophytosis present,
but this concept has very little meaning since it implies that the
MORPHOLOGY OHt phytes may have impaired the individual to lesser or
gr '( t r d gr s during life and there is no evidence that this is
Osteophytes around joint generally tak th ir origin nt the rdua lly th as . It is b tter not to use rating scales in this way
point at whi h th . ynov ia'l m mbrnr is onlinuot tH wi th llw 111d tlwr~· 114 g~'n<'n ll r ot much to omm -nd th ir use at all,
22 A Field Guide to joint Disease in Archaeology Osteophytes 23
•
NORMAL ANKYLOSING
SPONDYLITIS
squaring of
corners of
vertebrae · ··· · · ·r~='""""'==~
•
OSTEOPHYTOSIS
DISH
or
Forrestiers
Disease
Figure 3.2 Spinal osteophytosis
huge
paravertebral osteophyte. They may or may not be associated with OA. They
bone extensions \:':::::::::::::::::::::::::::::::::::::::::::::::: are not often referred to clinically as they do not usually show
up on an X-ray.
Growths of new bone may also be found elsewhere on the
skeleton and are often associated with injury as it is assumed
t- hat they represent the calcification or ossification of hae-
Figure 3.1 Characteristic changes in the vertebral bodies in some spinal
diseases
matomas. For example, fractured ribs may be found joined by
thin bands of bone that can be interpreted to be the results of
ossification of a bleed which occurred at the time of the
except where some particular research interest is being fracture. These growths of new bone are sometimes referred to
pursued. lS osteophytes, but ought more correctly to be called exostoses.
Occasionally large, curiously shaped exostoses may be found
1rising from the shafts of long bones-the femur seems often to
OSTEOPHYTES AT OTHER SITES I) • involved-and these are considered to be ossification into
bleeds that have taken place into the body of a muscle which
Osteophytes occur at sites other than around joint margins and was damaged by some unusually strenuous exertion. This
although their significance is outside the scope of the p resent mndition is frequently referred to as myositis ossificans but
book, it is, nevertheless, worth giving them a passing mention. tHtg ht p rhaps to be qualified as myositis ossificans traumatica
They may occur on joint surfaces, appearing as flat, irr !lady lo diff r nti t it clearly from the rare, hereditary condition,
hap d plaqu · of bon u u ally in a"' o iation with m nrgin nl 111 oHi liH (or fibrodyspla ia) o sifi ans progr s iva. Th ·
A Field Guide to joint Disease in Archaeology
Osteophytes 25
24
Table 3.1 Types of bony outgrowth in the spine
Type of outgrowth Morphology Associated with
Ossification of annulus Vertical outgrowth Ankylosing spondylitis
fibrosa (syndesmophyte) extending from the
edge of adjacent
vertebral bodies
Osteophyte Horizontal outgrowth Degenerative disc
from edge of vertebral disease
body
Anterior ossification Flowing growth along DISH
anterior border of the
spine into the anterior
longitudinal ligament
Paravertebral ossification Outgrowth of bone Psoriatic arthropathy
separated from the Reiter's syndrome
edge of the vertebral
body and the
intervertebral disc
Figure 3.3 Enthesophyte on olecranon process of the ulna at the point of
insertion of the triceps muscle
exostoses are sometimes considered to be indicators of occu- but they are also found as a concomitant of other diseases and,
again, their interpretation as indicators of occupation or activity
pational stress or injury.
needs carefully to be qualified; this is discussed further in
In the spine, bony outgrowths may be seen as a result of Chapter 11.
ossification of the annulus fibrosa of the intervertebral disc, as a
longitudinal, flowing ossification into the anterior longitudinal
ligament, intervertebral disc and the paravertebral connective SIGNIFICANCE OF OSTEOPHYTES
tissue, and as ossification of the paravertebral tissues alone.
These are all generally referred to as osteophytes and although There is no difficulty in recognising the presence of osteophytes
some authorities might object to this usage, it is so ingrained in in the skeleton and there are no diagnostic problems in that
the literature that it would be perverse to try to change it. The respect. The question is to what extent do they represent
characteristics of these different types of spinal bony disease in the skeleton? In the absence of any other ·abnormali-
outgrowths and some of their causes are shown in Table 3.1. ties in the skeleton, then marginal osteophytes are probably not
pathological. Indeed, they appear to be a normal accompani-
ment of ageing; the prevalence of osteophytosis increases
Enthesophytes markedly with age and in some joints-the spine and the hip,
for example-they appear to be independent of other signs of
Osteophytes may also be seen at the site of tendon insertion~, OA. Because their frequency increases with age there is a
the area known as the enthesis; the preferred term for them IS lt·mptation to use the presence of osteophytes as a means of
enthesophytes (Figure 3.3). They may re ult from r p at d ng ing; this is at best an imprecise method and we would not
trauma to t ndon ons qu nt 11pon r p t d • u R ul. r <· N I ion Hlvo at its u e. If one is trying to study the age-specific
26 A Field Guide to joint Disease in Archaeology Osteophytes 27
Table 3.2 Some conditions associated with Degenerative disc disease
osteophytosis or new bone formation
Ageing Degenerative, or intervertebral disc disease is diagnosed by
Osteoarthritis
Intervertebral disc disease coarse pitting, sometimes associated with new bone growth, on
DISH the superior or inferior surfaces of the vertebral bodies (Figure
Trauma 3.4). It is most commonly found in the mid- and lower cervical,
Ankylosing spondylitis
Psoriatic arthropathy upper thoracic and lower lumbar regions of the spine and may
Reiter's syndrome be on one or both surfaces of an individual vertebra. Marginal
Acromegaly osteophytosis is an almost invariable accompaniment and these
Fluorosis
Ochronosis changes are presumed to reflect degeneration in the inter-
Neuroarthropathy vertebral disc. In some cases osteophyte may be observed
encroaching on to the intervertebral foramen, through which
the nerve roots leave the spinal cord, and in some instances the
foramen is so narrowed that it seems likely that the nerve root
prevalence of osteophytes then their presence is absolutely must have been compressed during life. This is the course of
contra-indicated as an ageing technique. events which gives rise to cervical spondylitis which is a
OA is by far the most common condition in which osteophytes condition commonly met with in clinical rheumatology or
are seen and they are one of the minor criteria for classifying neurology.
this disorder (see Chapter 4) but they may be seen in many
other conditions, some of which are shown in Table 3.2. The
conditions are listed in probable order in which they might be Schmorl's nodes
expected to be found in the skeleton and none but the first five
is at all common.
These are recognised in the skeleton as indentations in the
Although they are common in OA, osteophytes must not form superior or anterior surfaces of the vertebra, and are most
the basis of the palaeopathological diagnosis if there are no common in the lower thoracic and lumbar regions. They
other signs such as eburnation, new bone on the joint surface, represent the herniation of material from the intervertebral disc
pitting on the joint surface or change in joint contour. Although through the end plate and they are pressure defects. They are
the presence of osteophytes around a joint is used radio- often irregular in shape and have a lining of intact cortical bone
logically to diagnose OA, there is no justification for doing so in and may be found in any position on the vertebra depending
palaeopathology and those who use this as the sole criterion for in which direction the disc has herniated. With posterior
classifying OA in the skeleton are in error. herniation the lesions may be found in communication with
the spinal canal, and if anteriorly there may be some associated
kyphosis and osteophytosis, in which case the condition is
D EGENERATIVE DISC DISEASE AND referred to as Scheuermann's disease.
SCHMORL'S NODES
Osteophytosis and Schmorl's nodes are both common con-
These conditions are so common in the skeleton and so oft n ditions and so both are frequently found together. However,
associated with osteophytes that this ms an appropri. t Lh re is no evidence that, with the exception noted above, they
pla to consid r th m . 1r ausally r lated.
28 A Field Guide to joint Disease in Archaeology Osteophytes 29
OSTEOCHONDRITIS DISSECANS AND
METATARSAL PITTING
Figure 3.4 Characteri stic changes of degenerative disc disease showing plll'lng D must be differentiated from small pits or other lesions
and rough ning f th nd plat· s and som • ost·corhyto. ls whi h ar ornrnonly seen on the concave surfaces of joints and
Osteophytes 31
10 A I i£ Id Guide to joint Disease in Archaeology
haracteristics of osteophytes
Figure 3.7 Pitting on inferior surface of third metatarsal and lateral cuneiform.
Scale in cm
Metatarsal pitting
Local
biomechanical
factors
Predisposition
Systemic factors ~
toOA
Spavin
OA IN ANIMALS
This is OA of the tarsus of the horse and sometimes the ox. The
disease usually begins first in the joint between the second and
OA is common in animals and is probably the disease found t·hird tarsal bones but may spread to involve all the joints.
most frequently in animal bones from archaeological sites.
There is no difference in the pathology between species,
although the rate of progress may be extremely rapid,
especially in large animals. Some forms of OA in animals have PATHOLOGY
particular names in the veterinary literature and archaeological
bone specialists should perhaps be aware of them. The initial pathological change in OA is fibrillation of the
artilage, which may lead to complete degradation. Where this
h< ppens, the bony articular surfaces become bare and rub
together forming a dense shiny surface which is referred to as
Ringbone 1•burnation (from the Latin eburnea, meaning ivory); this tends
to ccur at the point of maximum mechanical loading of the
joint. New bone is formed around the margin of the joint and it
This refers to OA of the interphalangeal joints of ungulates, tfl, y 1 o b form d on the joint surface. This new bone
especially horses. It principally affects the joints of the forelimb. n·1 r \ nts an att mpt f th joint to tabilise itself and although
Th 'ringbone' is osteophyte which may ompletely n ir lt' th t i r of 'IT· I to HI-I Ol-!1('01 hytt•, it Rh ul b cliff r ntiated from
joint. tlu· oHl!·oph lt• which i ottnd nroun th joints a a
](> A Field Guide to joint Disease in Archaeology
OA COMPLICATING OTHER DISEASES 'l'h cardinal sign of OA on an X-ray is narrowin~ of the no~al
joint space which is taken to represent loss of articular cartil~ge
Manifestation of osteoarthritic changes, in particular ebmna- (Pigure 4.6). This sign is no help at all .to the pa~aeopa~holo?Ist,
tion, are frequently observed where a joint has been damag hut other less important signs can confirm the diagnosiS arnved
by other diseases or by trauma. For example, eburnation may 11 from visual inspection of the bones. The presence of
be noted in an erosive arthropathy such as RA, wh nth join t 1
•burnation is recognised radiologically by the _Presence of
has been disrupted so that the me hanics ar di tort . ;\ clerosi that is dense white subchondral bone (Figure 4.7a &
may also complicate an infectious ro ss or follow tr 111nn. h) . In H~m a ' s, ub h ndral cysts may be seen _which may
Po t-traumatic OA m t y aris w h n Ilw In H of • bonl' h11 1 Iu 'I' ll 1
·on 1111 unk. t<-' with 1 ltling 0 1 th surface. Changes m the bony
A n •Id Guide to joint Disease in Archaeology Osteoarthritis
(a)
Figure 4.8 Mushroom-shaped femora l head
(b)
Figure 4.7 Archaeological specimen with osteoarthritis of the humeral head
with (a) eburnation, pitting on the joint surface, change in bony contour and
marginal osteophyte; (b) subchondral sclerosis with marginal osteophyte
Figure 4.10 Post-mortem specimen showing area with total loss of articular
cartilage on the patellofemoral joint and subsequent eburnation
5
Diffuse Idiopathic Skeletal
Hyperostosis
Figure 4.12 Osteoarthritis of the odontoid peg with eburnation and p'tf rn 1950 Forestier and Rotes-Querol described a disease of the
1
the joint surface mg on
spine in old people with a form of fusion different from anky-
losing spondylitis (AS) and which they called senile ankylosing
hyperostosis of the spine. The disease was relatively painless
and was thought to be a variant of OA, under which heading it
is still sometimes included. The spines of affected individuals
have typical and striking X-ray changes with fusion on the
anterolateral aspect of adjacent thoracic vertebral bodies, almost
invariably on the right-hand side. After the original description
of the condition in the spine it came to be referred to
ponymously as Forestier' s disease.
Resnick subsequently reported that many of those with
Forestier's disease also had ossification of ligament insertions
(or entheses) at peripheral sites in addition to the typical
changes in the spine. Resnick referred to this set of signs as
diffuse idiopathic skeletal hyperostosis (DISH) and considered
that it was an enthesopathy in which there was ossification of
the entheses and fusion of at least four adjacent thoracic
vertebrae. Fusion was often present in more than four thoracic
v rt brae and could also occur in the cervical and lumbar
Figure 4.13 Skeleton ~n .situ ~rior to
lifting showing osteoarthritis of th r ion , although in these regions it was not limited to the
JOint With margin al osteophytosis left hip rip·ht-hnnd sid . The facet joints of the spine are not usually
invo lv d . nd 1'11 dis s a s r maintained unl ome other
pin tl di t>n t• iH ol. o 1 rl' l'lll..
Diffuse Idiopathic Skeletal Hyperostosis 4
1111 A Field Guide to joint Disease in Archaeology
Jn the 1970s Julkunnen carried out a survey of several
thousand people in Finland and confirmed the prevalence of
DISH to be between 6 and 12% as others had shown before
him. He found that males were affected more often than
females and that 85% of those with the condition were over 50
years of age. He also confirmed that symptoms were minimal
and, where present, usually confined to some stiffness and
aches and pains. In 25% of cases of DISH Julkunnen found an
association with adult-onset diabetes and there was an
association also with obesity.
In the palaeopathologicalliterature, especially before the 1950s
when DISH was first described clinically, skeletons with the
condition were frequently misclassified as having AS. This is
especially the case in some of the earlier reports of Egyptian
material. Re-reading some of the detailed descriptions of the
distribution and form of the ·spinal fusion, however, it is clear
that the majority of these cases are actually DISH. DISH has
been found in skeletal material from all archaeological periods
from Neanderthal to the most recent.
The prevalence of DISH in most skeletal populations is, in
general, similar to that in modem populations but there are
some striking variations within burial grounds. At Wells
Cathedral all the cases of DISH were found buried in side
chapels with a prevalence of 20-30%, confirming a trend noted
earlier at Merton Priory that there was a notably high preva- rigure 5.1 Spine showing typical ~hanges of diffuse id!opathic s~eletal
lence of DISH in monastic and often high status burial grounds, hyp rostosis with flowing candle-wax-lrke new bone on the nght-hand s1de of
such as those where benefactors of ecclesiastical institutions the thoracic vertebrae
might be buried. Although this is a trend which has been noted
elsewhere in skeletal assemblages, care must be taken not to
assign a particular status to an individual skeleton on the basis
of the presence of DISH, nor inferences drawn about its t>nth.eses. The development of new bone in the skeleton may
association with other conditions such as diabetes or obesity; n·n h prolific proportions and has been likened to candle w~x
this can be attempted only at a population level. llowin down the spine and may reach up to 20 mm m
thi kn (Figures 5.1 & 5.2). In the thoracic spine the restriction
of ·h ng to the right side is said to be due to the presence of
PATHOLOGY t I w pulH ting d s nding aorta on the left. There .have bee~
,.,. orL · of I ft-Aid d 'fSH in pati nts whose descendmg aorta IS )
1
DISH is characterised by ossification of th ant ri or longi- m 1 tlw rl gh l Hid t• bul to our kr c wl dg th r hav b n no su h
tudinal spinal ligament and by o sifi < li n ir t·o l' I rn 1 in d n•pm t ~ In n flkc h•lon to d lit •.
',() A Field Guide to joint Disease in Archaeology
Figure 5.2 Radiograph of specimen shown in Figure 5.1 . Note the normal disc
spaces and normal facet joints Figure 5.3 Fusion of sacro-iliac joint by ossification of sacral ligaments in a
case of DISH
Other spinal ligaments may also become ossified; it is common keletons which have been well excavated with good bone
to find the ligamentum flavum, the supraspinous ligaments and recovery it is not uncommon to find ossified tracheal rings. ~nd
the ligaments around the sacrum ossified. When the sacral laryngeal cartilages; the costal cartilages are. also often oss1fie~.
ligaments are ossified they may bridge across the joint line, These features are also found in skeletons w1thout DISH and m
completely or not, bilaterally or unilaterally, and in this way themselves are not diagnostic.
fuse the joint (Figure 5.3). This type of fusion may be dis-
tinguished from that which is found in the seronegative
arthropathies (Chapters 7 and 8) since in the latter, the fusion is PALAEOPATHOLOGICAL DIAGNOSIS
the result of intra-articular pathology.
DISH is one of the easiest conditions to diagnose in skeletal
Outside the spine, any enthesis may become ossified but the material. The fused block of thoracic vertebrae with exuberant
common sites are around the elbow, particularly the triceps new bone flowing down the right side of the vertebral bodies
insertion, the insertion of the quadriceps femoris into the should be immediately obvious. To conform to the clinical
patella, the insertion patellar ligament into the tibia and the de cription of DISH, at least four adjace~t vertebrae sho~d be
insertion of the Achilles tendon into the calcaneum (Figure 5.4). fu ed, but it is not at all uncommon m skeletal matenal to
It is important to remember, however, that entheses may find skeletons which obviously have DISH in which less than
become ossified for other reasons, including mechanical four are fused although the ossification of the anterior longi-
trauma, such as occurs in tennis elbow. tudinal Jigament involves many contiguous vertebrae. The
In p atients with DISH there is often evid ne of al ifi lion pol-llC'rior v rt brc I joinlA . nd th disc spa~es are preserved
into soft tissues including artil ~g • and b l od Vl'RI·w l nnd in 111
d llw(• ft• tlll l'l 'l e H\ n•Hii l b onfumd on X-ray.
A Field Guide to j oint Disease in Archaeology Diffuse Idiopathic Skeletal Hyperostosis !d
Figure 5.4 Enthesophytes on the patella and Achilles tendon insertion of the Figure 5.5 Florid marginal osteophytosis in a case of diffuse idiop~thic skeletal
calcaneum characteristic of diffuse idiopathic skeletal hyperostosis or bone hyperostosis without osteoarthritis. Also note enthesophytes on t1b1al tubercles
forming
Where DISH is coexistent with OA the degree of osteophyt w have termed bone formers. Some of these md1v1duals may
around the affected joints may be considerable (Figure 5.5) and go on to develop DISH, which in itself may be ~art of the
we have seen a single case of DISH in which the detach d 11
p tt:um of bone forming (Figure 5.6). Hypertrophic OA ~~y
lamina of a lumbar vertebra with spondylolysis had b om t!Ho fit into this category. If bone formers develop another JOIDt
reunited to the vertebra with new bon whi h h, d form I <1h-1 'nH u h ~ RA, its morphology may w ell b e altered or
around the sit s of th (Ta tur . 1110dlfil' I by tl ir bon formin t nd n y.
A Field Guide to joint Disease in Archaeology
6
Rheumatoid Arthritis
Figure 5.6 Excess bone formation after rib fracture in a case with diffuse
RA is one of the diseases which is generally considered to be
idiopathic skeletal hyperostosis of recent origin. It was first described clinically in a thesis in
L800 by Landre-Beauvais who believed that it was a variant of
gout and referred to it as goutte asthaenique primitive: There
Characteristics of DISH have been very few cases recorded in the palaeopathological
literature, although some are now beginning to come to light
rmd we have described two recently. Claims such as those of
• disease of ligaments and entheses Wood Jones that RA was the most common disease to afflict
• ossification of anterior longitudinal spinal ligament the skeletons which he examined from Nubia are explained by
produces candle wax appearance the fact that he was actually referring to what we now call OA,
• spinal fusion with preservation of facet joints and disc and not RA.
spaces
• ossification of entheses at extraspinal sites fn modem populations, RA is a common condition, affecting
• prevalence increases with age about 1% of the total population. Women are more likely to be
• more common in males than females affected than men in a ratio of about 3:1, and perhaps as many
• associated with diabetes and obesity as 5% of the female population over the age of 65 has the
disease. The disease is universal in occurrence, although some
populations, such as those of black Africa are relatively spared.
fn the countries of western Europe, the disease is declining in
incidence but it is becoming more common in the developing
·ountries. In some developing countries, such as Pakistan and
Malaysia, the expression of RA is different from that in the
W st. For example, the feet are relatively spared compared with
West rn ea es. It is quite likely the expression and distribution
of RA in past population w r different from those in con-
lt'nq Ol'fli'Y rorul. lion nd l'his is an important con ideration
Rheumatoid Arthritis 7
1
)(, A Fi Id Guide to joint Disease in Archaeology
for p alaeopathologists. The same stricture almost certainly
applies for other diseases also.
The disease has its onset most commonly in the fourth and fifth
d ecades but no age-group seems to be exempt and classic
ad ult-type disease may be found in children and it may also
make its first appearance in the elderly. There is a tendency for
the disease to run in families but this probably reflects a shared
environment rather than hereditary factors.
r The cause of the disease is not known with any certainty
although the modem tendency is to consider it to be multi-
factorial in origin which is to say that any number of different
possibilities have been considered. As with AS there is some
evidence of a link between tissue antigens and a predisposition
towards the disease. In the case of RA there is an association
between the possession of some of the subtypes of the HLA-
DR4 antigen and the occurrence of the disease.
PATHOLOGY
I
progresses, the joints become deformed and may dislocate; 11 uall symmetrical and the sacro-iliac joint IS almost never
however, it is rare for joints other than the wrist or the tarsus to nffect~ and when it is, the lesions ~re seldom severe. Other
fuse in RA. Patients in the end stage of RA may be extremely .oints become affected as the dise~se progresses, most I
disabled with crippling deformities of the hands and such I mmonly the wrist, knee, cervical spme, shoulder, subtalar
individuals are still not uncommonly seen. It is hard to imagine joint, elbow and hip (Figures 6.4-6.6).
that such extreme manifestations of the disease would have
escaped the attention of writers or artists in the past had they It is usual for bones around an affected i?~t to b~co~~
been as common as they are now. ost o aenic and eburnation may supervene ~~thin an ~ ec e
. . t ~ th wake of the destruction of the articular cartilage.
1otl'l · m
The onset of RA characteristically involves the small joint of
( th hands and feet, especially the PIP, the m ta arpoph~ lang a t ( 'I'tnt. lly , ut thr ·<.·- lh rt rs f pati nts with RA are found
• 1 ) I ol ul s
1 an th m tatarsophalang al (MTP); th Tl jointA n• tnu h to h wt• .ml ibodil• (tt l4 tt dl of tlw lgM a. 8 to g m .
1\ I i •Id Guide to joint Disease in Archaeology Rheumatoid Arthritis
Figure 6.2 Carpals, one metacarpal and one proximal phalanx from the same
case as shown in Figure 6.1 showing non-proliferative erosions
Figure 6.3 X-ray of Saxon skeleton with erosions at the metacarpophalangeal
joint typical of rheumatoid arthritis
Figure 6.4 Elbow joint from the case shown in Figure 6.1 with non-
proliferative erosions Figure 6.6 Erosions on the facet joints of a thoracic vertebra from the case
shown in Figure 6.1
isolated large joints but in the absence of the hands and feet we
have been reluctant to make a definite classification.
Figure 6.7 Head of humerus with remodelled erosion at the joint margin.
There are numerous 'pseudo-erosions' in the floor of this lesion • disease of the synovium
( • non-proliferative symmetrical erosions beginning at the
\ margins of the joint
Many of the large joints can be symmetrically affected as we • proximal interphalangeal, metacalf'~phalangeal and
have mentioned above, but the sacro-iliac joint is usually metatarsophalangeal joints charactenstically affecte~.
• may also affect wrist, knee, shoulder, subtalar JOmt,
spared and the cause of erosive lesions in a skeleton with
disease of the sacro-iliac joints is not likely to be RA cervical spine, elbow and hip
• sacro-iliac joints not usually affected
There are no signs in the skeleton which are pathognomonic of • bony ankylosis not common except occasionally at
RA, but it is possible that RF survives in the bone as many carpus
other bone proteins are now known to do. If this were to be the • osteopaenia common
case-and this possibility is presently being investigat d- then • may be eburnation on affected joints
finding RF in a skeleton which was thought to hav · RA would • annat be diagnosed confidently if hands and feet are
be strong supporting evidence; the abs n of RP, I .ow v r, miRAing
could not b tak n to prov tht~t th diH a. c wnH 110/ RI\ .
Ankylosing Spondylitis
THE SACRO-ILIAC JOINT
ILIOLU MBAR
LIGAM ENT
INTEROSSEOUS
7
SACRO - ILIAC
LIGAMENT
l.UMBOSACRAL
LIGAMENT
Ankylosing Spondylitis SYNOVIAL
SAC RO-ILIAC
JOINT
VENT RAL
!l ACRO - ILIAC
l iGAM ENT
Figure 7.3 Fused spine from an archaeological case of ankylosing spondyl itis.
Figure 7.2 Radiograph of mo~ern patient with ankylosing spondylitis to show Note complete fusion of vertebrae with no skip lesions . Several ribs have been
typ1cal bamboo spine' fused to the vertebrae, although subsequently damaged; the sacro-i liac joints
are fused
8
In the cases which we have observed there may be very little
change outside the spinal column, although conversely there
may be prominent entheses at almost any muscle insertion; it is
unusual to find other joints affected but, of course this cannot
be ruled out.
Other Seronegative
Radiography may be helpful in demonstrating the typical Spondlyoarthropathies
bamboo spine (Figure 7.2) and there may be some virtue in
trying to obtain radiographs of the sacro-iliac joints to demon-
strate the presence of erosions, although those inexperienced at
X-raying dry bones may find some difficulty in lining the joints
up in the correct position.
It is possible that in the future HLA antigens may be
extractable from bone and the presence of HLA-B27 would be
confirmatory evidence of AS but its absence could not preclude The seronegative spondyloarthropathies are a group of erosive,
the diagnosis. We are some way off being able to do this, inflammatory polyarthropathies, which also affec: entheses.
however, and even if the technique becomes available, it would Thus the inflammatory process involves the ligamentous
probably not be widely available. The extension of palaeo- insertions (the entheses) as well as the internal s~ctures of the
immunology to the study of the rheumatic diseases in joints. They were originally consider~d to b~ vanants of ~.but
antiquity, however, is something which should be welcomed it was when it was found that patients with these condit~ons
and may provide useful information in the future. did not have RF in their blood they were categonsed
eparately. They all have overlapping clinical features . .~~d
Characteristics of ankylosing spondylitis which, so far as the skeleton is concerned, include sacro-iln~IS,
pondylitis and peripheral arthritis. There . are ~ee maJOr
• disease of synovium and entheses seronegative spondyloarthropathies: AS (considered m Chapter
• sacro-iliac joints affected symmetrically 7), PA and Reiter's disease.
• sacro-iliac joints often fused in the skeleton
• X-ray of sacro-iliac joints may show erosions Pathologically and radiologically, PA and Reiter's disease sh~re
• erosions may occur in large joints everal features in common although they can be readily
• spinal fusion begins in lower lumbar region and pro- distinguished clinically. In the absence of clinical informa.tion It
gresses steadily upwards may be difficult to differentiate one from ~e other ~ the
• no 'skip' lesions s k 1 ton, although in typical cases there are differences ~ t~e
• kyphosis is often a feature morph logy of the lesions and in their distribution, both within
• ribs may be fused to vertebrae th, fl in an riph rally, which may enable a palaeo-
patho logi . I linpno i to b mn
70 A Field Guide to joint Disease in Archaeology Other Seronegative Spondlyoarthropathi s 71
PATHOLOGY
\ _
Figure 8.3 X-ray of the foot from case as 8.2 showing fusion of the tarsus and
the tarsometatarsal joints. There are erosions at the first distal interphalangeal
Figure 8.2 Psoriatic arthropathy showing fusion and shortening of the proximal
joint with expansion of the proximal end of the first distal phalanx
and middle phalanges. Note also the erosion at the proximal end of the
proximal phalanx
attack a single joint or more than one. The attacks are If-
limiting but nowadays are treated to speed recovery. Betw en
attacks the patient is unaffected, but as time passes attacks may
occur more frequently and each can last longer and affect more
joints.
Figure 9.3 Phalanges, metatarsals and navicular from a skeleton from Barton
on Humber with extensive marginal erosions. Note Martell hook on the left-
hand side of the proximal joint surface of the first metatarsal
continued - - - - - - - - - - - - - - - - - - - - - - - - ,
• may be proliferation of new bone around margins of
lesion
• X-ray usually shows sclerotic margin around lesions and
confirms overhanging edges-Martell hook
• osteoporosis uncommon
116 A Field Guide to joint Disease in Archaeology
10
Infections Causing Joint
Disease
OSTEOMYELITIS
Figure 9.7 Single large erosion on the posterior surface of the distal femur. The
rest of the skeleton showed changes characteristic of treponema! disease and
this lesion is likely to have been the result of a gumma
Osteomyelitis is an infection of the bone and bone marrow
most usually with bacteria and the most common infectious
organism is Staphylococcus aureus, a bacterium most frequently
encountered when it causes boils. The organism may gain entry
to the bone by one of three routes:
TUBERCULOSIS
PYOGENIC ARTHRITIS
Tuberculosis is caused by a mycobacterium and there are two
principal species which affect humans, Mycobacterium bovis and
A pyogenic organism can spread to a joint through any of the M. humanis. The first organism is contracted from cattle by the
three routes described above, but in general only a single joint ingestion of contaminated milk or dairy products. It spreads
is affected. The process is highly destructive; the erosive lesions from the gut to the lymph nodes throughout the body and may
tend to appear first at the margins of the joint but eventually come to be lodged in other tissues, including bone. The human
virtually all the joint surface may be destroyed. The disease organism probably evolved from the bovine type and it is
stimulates the production of much new bone and the end stage pr ad through the air and so the site of entry is the lungs.
of the disease is usually bony ankylosis of the joint (Figur Wh n inhnl d, fh organism provok s what is known a a
10.2). prirnnr n•HponHt', which 11 unll rc•su ltR inn AmL 111 Rion in th
10
1 A I i •Id Guide to joint Disease in Archaeology Infections Causing joint Disease 91
L1hll• I 0.1 Features of osteomyelitis at different ages
Infant Child Adult
(<1 year) (1-16 years) (>16 years)
loacae Uncommon Variable Common
Sequestra Common Common Uncommon
Involucrum Common Common Uncommon
Joint involvement Common Uncommon Common
Pathological fractures Uncommon Uncommon Common
Fungal diseases affecting bone and joints are rare in Europe but
they are much more common in North and South America, and
those who examine skeletons from sites in those countries
should be aware of them. The two fungi which account for
most skeletal disease are Blastomyces dermatitidis and Cocci-
dioides immitis causing blastomycosis and coccidioidomycosis,
respectively. In blastomycosis the vertebrae, ribs, tibia, tarsus
and carpus may be involved with areas of moth-eaten bony
destruction. Vertebral collapse may be seen which may be
difficult to distinguish from tuberculosis. The joints are usually
affected by the spread of the disease from adjacent sites but
occasionally a monoarthritis is observed most frequently
involving the knee or ankle joints. In coccidioidomycosis
Figure 10.5 Lumbar vertebrae showing erosive lesions on the end plate_s ~~th multiple symmetrical lesions are found in the spine, ribs and
considerable proliferation of new bone. Probable case of tuberculous d1sc1tls pelvis and sometimes in other bones; spinal collapse is
uncommon. As with blastomycosis, joint involvement usually
results from direct spread but a monoarthritis may also be
tuberculosis. There are no pathognomonic signs, however, and found, and again the ankle and knee are the commonest sites.
it is possible that some cases of vertebral lesions may, in the There may be great difficulty in distinguishing fungal diseases
past, have been wrongly diagnosed as tuberculosis. With from other infectious diseases, and in the case of coccidioido-
advances in the technique of polymerase chain reaction applied mycosis sclerotic changes in the vertebral bodies may simulate
to bacterial DNA, it may be possible to differentiate the two prostatic carcinoma. In the future, fungal DNA studies may
d iseases in the skeleton. help in the diagnosis of these conditions.
102 A Field Guide to joint Disease in Archaeology Implications for Archaeologists 103
-
'iii b' in a skeleton can be used to predict the occupation or activity of
(])
the individual. We recognise that this is a perfectly laudable
0
~ cu attempt on the part of palaeopathologists and anthropologists
·;::
(])
to extract the maximum amount of information from the rather
>
(]) meagre amount of data at their disposal, but it is mistaken. If
(J)
q we refer back to Figure 4.1 we can see that there are several
a' . bu factors which determine the development of OA; these include
- -QJ age, sex, race, genetic disposition and activity. Now in no case
could one start with a skeleton which shows the presence of
OA and say with any confidence which of the aetiological
factors was responsible for the development of its disease.
Moreover, even if we could be sure that activity were the prime
mover, how would it be possible to say what activity was the
cause?
Let us pursue this a little further with a consideration of OA of
the hip. We know from recent epidemiological work that
Figure 11.3 Progression of hypothetical lesion in three cases, p, q and r.
farmers are much more likely to develop this condition than the
Assume that p dies at time a, rat time b and q at time c, then the presumed general population; their risk is approximately nine times that
order of severity will be given as b"', a', c", although, in fact, this temporal of the general population. If we encountered OA of the hip in a
relationship is incorrect male skeleton it is reasonable to consider whether he might
have been a farmer. However, although farmers are more at
risk of getting OA of the hip, they are by no means the only
knowing the rate of progress of that disease. That is to say, we people in whom it appears and if there were five male
do not know-in the case in point-whether an individual skeletons with OA of the hip (see Figure 11.4), only one of
skeleton is like p, q or r in respect of the speed of development whom really was a farmer during life, there is no way at all by
of the lesion, or if he/she died at a, b or c. The problem is well which we could say which he was. In Figure 11.4 we have
recognised in epidemiology and it is that one cannot make shown the farmer as the shaded figure of the five, but we have
inferences about a dynamic process from a series of stati no m ans at our disposal by which we can determine which he
observations; to be able to do so r quir s that individuals an is; H'w now A in th diagram ar all unidir tional, and . o it i.
b follow d up ov r tim . How v r, in r· I. o nth lopy, we . re In 1~ t1 "'"I, llholog ; nil our nrrOW H 1oin t fr'Oi11 ouR' to (•ffN :t,
106 A Field Guide to joint Disease in Archaeology Implications for Archaeologists 107
EPIDEMIOLOGY
CHAPTER 2
CHAPTER 5
J. Rogers, T. Waldron, P. Dieppe & I. Watt, Arthropathies in
palaeopathology: the basis of classification according to most J. Forestier & J. Rotes-Querol, Senile ankylosing hyperostosis of the
probable cause, Journal of Archaeological Science, 1989, 16, 611-625. spine, Annals of the Rheumatic Diseases, 1950, 9, 321-330.
T. Waldron, Counting the Dead. The epidemiology of skeletal populations, H. Julkunen, O.P. Heinonen & K. Pyor~ila, Hyperostosis of the spine
Chichester, John Wiley & Sons, 1994. in an adult population, Annals of the Rheumatic Diseases, 1971, 30,
605-612.
T. Waldron, DISH at Merton Priory: evidence for a 'new' occupational
CHAPTER 3 disease? British Medical Journal, 1985, 291, 1762-1763.
T. Waldron & J. Rogers, An epidemiologic study of sacroiliac fusion
S. Ahlback, Osteoarthrosis of the knee. A radiographic investigation, in some human skeletal remains, American Journal of Physical
Acta Radiologica, Supplementum 277, 1968. Anthropology, 1990, 83, 123- 127.
CHAPTER 4 CHAPTER 6
P. Dieppe, Osteoarthritis. A review, Journal of the Royal College of P. Hacking, T. Alien & J. Rogers, Rheumatoid arthritis in a medieval
Physicians, 1990, 24, 262-267. skeleton, International Journal of Osteoarchaeology, 1994, 4, 251-255.
J. Rogers & P.A. Dieppe, Ridges and grooves on the bony surfaces of B.H. Rothschild, K.R. Turner & M.A. DeLuca, Symmetrical erosive
osteoarthritic joints, Osteoarthritis and Cartilage, 1993, 1, 167- 170. peripheral polyarthritis in the late archaic period of Alabama,
J. Rogers & P.A. Dieppe, Is tibiofemoral osteoarthritis in the knee joint ien e, 198 , 241, 1498-1501.
a new disease? Annals of Rheumatic Diseases, 1944, 53, 612- 613. T. W ~t ld mn, J. Rog rs & I. Watt, Rheumatoid arthritis in an En li h
J. Rogers, T. Waldron & I. Watt, Erosive osteoarthritis in n m di vnl •n••d ••v tl lt•h ·lo••, lllli'rna l ional Joumal of steoar haeolo&y, 1 4, IJ.,
skeleton, International Journa.l of Osteoar ha olo8y, 19 1, 1, 1')1 1 3. 1!1 11 111'/
114 Further Reading
CHAPTER 7
CHAPTER 8
Index
P.A. Dieppe & J. Rogers, The Antiquity of the Erosive Arthropathies,
Conference Proceedings No. 5, Arthritis & Rheumatism Research
Council, 1988.
CHAPTER 9
Alibert, J.L., 70 Calcium pyrophosphate, 36
Ankylosing spondylitis, 5, 64-9, Coccidioidomycosis, 95
C. Wells, The human burials. In: Romano-British Cemeteries at
Cirencester, edited by A. McWhirr, L. Viner & C. Wells, Cirencester, 100
Cirencester Excavation Committee, 1982, pp. 135-196. characteristics of, 68
diagnosis of, 66- 8 Degenerative disc disease,
esthesopathy in, 64, 68 26-7
CHAPTER 10 osteophytes and, 27
HLA-antigens in, 64, 68
Diagnosis in palaeopathology,
in animals, 64
J. Rogers & T. Waldron, Infections in palaeopathology: the basis of 98- 100
kyphosis in, 67 Diffuse idiopathic skeletal
classification according to most probable cause, Journal of
pathology, 65-6 hyperostosis, see DISH
Archaeological Science, 1989, 16, 611 - 625.
D. Morse, D.R. Brothwell & P.J. Ucko, Tuberculosis in ancient Egypt, prevalence of, 64 DISH, 36, 47- 54, 67-8, lOO
American Review of Respiratory Diseases, 1964, 90, 524- 541. radiography in, 65- 6, 68 at Merton Priory, 48
A. Stirland & T. Waldron, The earliest cases of tuberculosis in Britain, bamboo spine, 65, 68 at Wells Cathedral, 48
Journal of Archaeological Science, 1990, 17, 221 - 230. sacro-iliitis in, 64, 65- 6 bone formers and, 53
skip lesions in, 66 characteristics of, 54
vertebrae in, 65- 6 diagnosis of, 51 - 3
CHAPTER 11 Annulus fibrosa, 24 entheses in, 49-50
Arthritis, see joint diseases marginal osteophytes and,
H . Bush & M. Zvelebil, Health in Past Societies, Oxford, BAR, 1991. 53
Arthritis mutilans, 71, 75
pathology, 48- 51
Articular cartilage, 1, 8
prevalence of, 48
radiology of, 50
sacro-iliac fusion in, 52
!31rH;torny si , 95 DIP, 8
)ltl lll ' fol'llwr , , 4 in psoriatic arthropathy, 71
lltllt 'l' lh t 1 1):1 /) in rh umatoid c rthriliH, ,
l llld 11 11 Ill o. ll 'OJ h to, L of, 0
116 Index Index 117
Distal interphalangeal joints, see Hallux valgus, 82 Metatarsal pitting, 30 of the knee joint, 42-3
DIP HLA-antigens, 56, 64, 68 Metatarso-phalangeal joint, see osteophytes and, 15
DNA, 96 MTP pathology of, 35-6
MTP prevalence of, 44, 98
Impingement syndrome, 42 hallux valgus of, 80 radiology of, 37-40, 43, 101-2
Eburnation, 13, 35-6, 43, 99 in gout, 78 joint-space narrowing, 43
in osteoarthritis, 13 in rheumatoid arthritis, 56 sclerosis, 37
in rheumatoid arthritis, 57 Joint capsule, 1 in psoriatic arthropathy, 71 sub-chondral cysts, 37
pathognomonic of Joint(s) Mushroom head, of femur, 38, 41 rheumatoid arthritis and, 36
osteoarthritis, 43 cartilaginous, 1 Myositis ossificans, 23 severity of, 101-5
compound, 14, 42-3 trauma and, 36
Enthesopathy, 42
counting and recording, 8-11 Osteoblasts, 8
in ankylosing spondylitis, 64,
diseases, 2 Odds ratio, 19 Osteochondritis dissecans,
68
acute, 3 Odontoid peg, 20, 46 28-30
in DISH, 48-9 atrophic, 3
rotator cuff disease and, 42 Ossification, 24 location of, 28-9
classification of, 4, 8-15 into anterior longitudinal Osteoclasts, 8, 12, 13
Enthesophytes, 24-5 chronic, 3 ligament, 24 Osteomyelitis, 87-9, 90
in DISH, 52 diagnostic criteria for, 4 paravertebral, 25 cloacae in, 88
Erosions, 11, 12 hypertrophic, 3 Osteoarthritis, 3, 26, 32-47, 98 diagnosis of, 95
in gout, 79 fibrous, 1 atrophic, 36 features of, 93
in psoriatic arthropathy, 73 infections of, 87-96 at the shoulder joint, 40, 42 involucrum in, 88
in Reiter's disease, 74 pathology at unusual sites, 33 new bone formation in, 88
in rheumatoid arthritis, 58-62 classification of, 15 calcium pyrophosphate crystals Osteophytes, 20-31, 66
in sero-negative recording forms for, 10 and,36 bicipital groove and, 42
spondylarthropathies, 70 patterns of skeletal changes in joint contour and, causes of, 26
marginal, 12 involvement in, 6-7 38 characteristics of, 31
Exostoses, 23 structure of, 1 characteristics of, 45 degenerative disc disease and,
synovial, 1 classification of, 43-5 27
Julkunen, H ., 48 criteria for, 43-5 distribution of, 20
Forestier, J., 47 Juxta-articular area, 2 common sites of, 32 marginal, 21, 30, 44
complicating other diseases, classification of osteoarthritis
36-7 and,44
Knee joint, 42 eburnation in, 35, 43-4 in DISH, 53, 68
Gout, 3, 78-82
compartments of, 42 erosive, 33-4 morphology of, 20-2
characteristics of, 83-4
osteoarthritis of, 41, 42-2 gull-wing appearance in, 33 of DIP, 20
diagnosis of, 80-1
erosions in, 79 grooving of joint surfaces in, of odontoid peg, 20
36- 8 of PIP, 20
of MTP, 78 Landre-Beauvais, A.J., 55 hyp rtrophic, 35, 45, 53 osteoarthritis and, 25
radiology of, 80-1 Lawrence, J.S., 98 in onirna ls, 34- 5 rating scales for, 21 -2
Martell hook, 80 Leprosy, 71, 94 joint· difl lc Lion , nd, 37 s v rity of, 21
tophi, 79 occ ttp lll o tt ttttl , ((),) 7 Hignifi 011 f, 2r: - 6
uric acid in, 78, 81, 83 lruttnlll nnd , 23
of odtHtlt~ d fi' ')',, '~''
Gumma, 86 Martell hook, 80 ell lftt• h l' r l0 1c '/ Vt•l'lc•lll' d, ' ()
I Ill Index Index 11 9
Ost oporosis, 13-14, 93, 100 sacro-iliitis in, 72 Rheumatoid factor, 57, 62, 69 Synovial membrane, 1, 8
in sero-negative spinal fusion in, 72 Ring-bone, 34 in rheumatoid arthritis, 57
spondylarthropathies, 70 Pyogenic arthritis, 88 Risk ratio, 19 in sero-negative
in rheumatoid arthritis, 57 characteristics of, 96 Rotes-Querol, J., 47 spondylarthropathies, 70
Pigmented villonodular synovitis, Radiography Sacro-iliac joints, 52-3, 65-6 Tuberculosis, 89-93
82, 85 in ankylosing spondylitis, 65-6 in ankylosing spondylitis, 64 bacterial DNA in, 96
PIP, 8 in DISH, 50 in psoriatic arthropathy, 72 characteristics of, 96
in psoriatic arthropathy, 71 in osteoarthritis, 14, 37-40 in Reiter's disease, 74 in the fingers, 91
in rheumatoid arthritis, 56 in psoriatic arthropathy, 71 in rheumatoid arthritis, 57 in the spine, 90
osteophytosis of, 20 in Reiter's disease, 76 Scheuermann' s disease, 27 of the joints, 92
Pott's disease, 91, 96 in rheumatoid arthritis, 61 Schmorl's nodes, 27, 93 Tuberculous arthritis, 92
Prevalence, 15, 107 Rating scales Sclerosis, 37 dactylitis, 91
age-specific, 17 for osteophytes, 21-2 Skeleton, recording forms for, 10 diagnosis of, 95-6
calculation of, 16-17 for proliferation, 11 Skip lesions, 65 - 6, 74-5 discitis, 92-3
comparison between groups, Reiter, H., 73 Spavin, 35 features of, 93
18 Reiter's disease, 66, 69, 73 - 7 Spondylarthropathy, 3
crude, 18 diagnosis of, 74- 7 sero-negative, 3, 69 - 77
definition of, 16 enthesis in, 75 characteristics of, 77 Uric acid, 36, 78, 81, 83
of DISH, 48 erosions in, 74 pathology of, 70
of osteoarthritis, 4 radiology of, 76 Spondylolysis, 52
of rheumatoid arthritis, 55 sacro-iliitis in, 74 Sub-chondral cysts, 37 Wells, C., 79
sex-specific, 17 skip lesions in, 74-5 Synovial chondromatosis, 82, 85 Wood Jones, F., 55
Proliferation, 11 Resnick, D., 47
in psoriatic arthropathy, 73 Rheumatoid arthritis, 3, 36, 53,
in sero-negative 55- 63, 69-70, 100
spondylarthropathies, 70 characteristics of, 63
rating scales for, 11 diagnosis of, 58- 63
Proximal interphalangeal joints, distribution of affected joints,
see PIP 56- 7
Pseudo-erosions, 30, 61, 63 eburnation in, 57
Psoriatic arthropathy, 66, 69, erosions in, 58- 62
70- 3 HLA-antigens and, 56
arthritis mutilans, 71, 75 osteoarthritis in, 36
diagnosis of, 74- 7 osteopaenia in, 57
distribution of, 71 - 2 pathology of, 56- 8
erosions in, 73 prevalence of, 55
prevalence of, 70 radiology in, 61
proliferation in, 73 rheumatoid factor (RF) in,
radiology in, 71, 73 57-8, 62
cup and pencil deformity, sacro-iliac joints and, 57
71 synovial m mbranc in, 5 1
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