Precipitating factors Predisposing factors

• Vitmain D • Age

• Increase • Sex
calcium
• Sedentary
• Hypothyroidis lifestyle

Supersaturation of
urine,

urine acid and

decrease formation of turbid/cloudy

bladder motility small urine
crystallites

decrease formation of Excretion of

urinary output large tiny stones
crystallites
from deposited
distended
bladder
calculistones

movements of
calculi to stones to
the ureters by the
increase pressure
of urine

Stimulation of nociceptors Release of

through mechanical force excretion of erythropeitin fr.
exerted by increase pressure RBC to the Adrenal gland
 Lab. increase
Transformation RBC rate
of stimulus to Cell death on the Release Stimulation of the
damage to the vasoconstricti
impulse up to the surrounding of bone marrow to
surrounding tissue/ on affected
spinal cord tissue/bladder/kidney chemical increase RBC
bladder/ kidney area mediator production
Stimulates
hypothalamu
vasodilati
monocyte fibrinoge s
impulse Impulse to on
activate to n
reach limbic
macropha
thalamus system
ge Clot body Anorexia
and spinal
affected temp.
activate area
pain Grimace Increase
T-helper
perception capillary Body
permeability weakness
Activate
Immune Edema
Rerespone

Allow colonization RB
Decrease Release UTI of bacterial
Acidity urine urease C
infection

Sepsis

bacterial Systemic No supply 02

infection infection in the brain

Ascending bacterial Affect organ

Infection to the Brain
Pyelonephrit
pylum Ex. peritonitis, damage
is meningitis
Organ
failure
urosepsis
cardiac arrest,
respiratory failure
DEATH