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Acupuncture in stroke recovery: A literature review

Article  in  Complementary Therapies in Medicine · October 1996


DOI: 10.1016/S0965-2299(96)80087-2

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Complementary Therapiesin Medicine (1996)4, 258-263
©PearsonProfessionalLtd 1996

L I T E R A T U R E R E VIE W

Acupuncture in stroke recovery: a literature review

V. Hopwood
Hythe Hospital, Southampton, UK

SUMMARY. Acupuncture is commonly used in painful conditions but has a long history of use in traditional
Chinese medicine for many other illnesses, including neurological conditions. There is an upsurge of interest in
the treatment of hemiplegia by acupuncture and this review investigates the most recent research literature and
concludes that there are good grounds for further investigation within rigorous scientific guidelines.

INTRODUCTION: DOES ACUPUNCTURE authorities claiming that any type of acupuncture will
HAVE AN EFFECT ON STROKE RECOVERY? have some effect and cannot be a true placebo. 3
For the purposes of this review, a thorough search
The theories of traditional Chinese medicine (TCM) was made of the Centralised Information Service
claim that the symptoms and sequelae of stroke for Complementary Medicine (CISCOM) database
respond to treatment by acupuncture. It is defined as together with that of BIDS, Medline. Additional
windstroke and the recommended form of treatment information was obtained from the Acupuncture
is either to use body points alone, with or without Research Resource Centre, York. The key words
electrical stimulation, or combine these with scalp used were:
acupuncture. 1 Many studies have been done in China, CVA, Stroke, Hemiparesis, Hemiplegia, Sub-
comparing the different techniques and combinations Arachnoid Haemorrhage, Neurological Damage/
but, although very large numbers of patients are often Change, Acupuncture, and Scalp Acupuncture, and
involved, for instance Ge 2 who treated and assessed particular weight was given to references with clini-
684 cases of windstroke at the Air Force Hospital in cal trials.
Shengyang, since they are not usually controlled, they
can only have a limited validity. Where several types
of acupuncture are compared one with another, it is PREVIOUS STUDIES
interesting to see the differences, but the basic
assumption that acupuncture can affect recovery is The main questions arising from a study of the liter-
not proven unless there is a control group who do not ature about acupuncture used to treat stroke are as
receive it. follows:
Randomized, controlled clinical trials (RCTs) are 1. Is it effective?
the foundation of evidence-based medicine. The evi- 2. Should acute, sub-acute or chronic patients be
dence provided by RCTs is essential before any med- treated?
ical intervention is taken seriously these days. There 3. Should the treatment be confined to body points
is an increasing amount of evidence published or scalp points, or both?
with regard to acupuncture trials but by no means all 4. When should it commence?
the trials are appropriately controlled. The main 5. How frequent should it be and how long should it
trials discussed in this review were all controlled but be given for?
not all were blinded. This is in part due to the diffi-
culty of double-blinding an acupuncture trial. It is Only seven controlled studies have been reported in
relatively easy to keep the assessor from knowing recent years where acupuncture was used to treat
what treatment the patient has received but a patient paralysis due to stroke, and these will be discussed in
is well aware if he or she has received an invasive tech- some detail in order to answer the above questions,
nique like acupuncture. There is still much discussion where possible. (A summary is given in the Table)
over the validity of sham acupuncture, with some Interest in the possible effect of acupuncture on
stroke has been increasing over the last five years. The
recent work linking acupuncture with the treatment
Val Hopwood, MCSP, SRR DipAc (Nanjing), Physiotherapy of stroke is mainly being done in the Scandinavian
Department, Hythe Hospital, Southampton SO4 5ZB, UK. countries and the USA. Some research work has been

258
A c u p u n c t u r e in stroke recovery 259

Table Summary of significant studies on the use of acupuncture in stroke

Study Type Sample size Outcome measures Results

Zhang et al Randomized, controlled trial. Ac 53 Muscle strength 83% effective or markedly effective,
(1987)19 Not blinded Control 41 6 joints: hip knee ankle acupuncture group.
shoulder, elbow, wrist. 63% similar outcome in control group.
(P<.05)
Naeser et al Randomized, controlled trial. Ac 10 Range of movement at hip, Significant difference (> 10%) in
(1992)1° Double-blind Control 6 knee, ankle and shoulder, acupuncture group improvement
over controls

Naeser et al Randomized, controlled trial. Ac 20 Range of movement at hip, Good response P<013 with CT scan
(1993)15 Double-blind Control 3 knee, ankle and shoulder, lesionsite as a variable

Hu et al (1993)4 Randomized, controlled trial. Ac 15 Neurological deficit score. Neurological deficit for acupuncture
Pilot study Control 15 ADL Barthel Index. group significantly better at 1 and 3
Not blinded months. Score better in severe cases.
Johansson et al Randomized, controlled trial. Ac 38 Walking and balance Acupuncture group recovered faster and
(1993)7 Not blinded Control 40 ADL Barthel Index to a larger extent than controls.

Magnusson Randomized, controlled trial. Ac 22 Balance Balance, acupuncture group significantly


(1994) Not blinded Control 26 ADL Barthel Index better than controls
(Linked with ADL, lasting improvement tested at 2
previous trial) years
Naeser et a113 Randomized, controlled trial. Ac 8 Hand/finger dexterity Good response P<0003 with CT scan
(1994) Double blind Control 2 and strength lesion site as a variable
Chronic cases

Sfillstr6m et al Randomized, controlled trial. Ac 24 Motor Assessment Scale Acupuncture group completer and faster
(1995)I6 Not blinded Control 21 Sunnaas ADL Index recovery. Sustained rate for 12 months.
Nottingham Health

done in Taiwan, 4 but in China, where acupuncture is although b o t h the treatment and control groups
in general use, studies tend to be rather poorly con- showed improvement: 83% and 63% respectively.
trolled a l t h o u g h the groups o f patients involved are Some work was d o n e in Sweden in 1993, where a
always very large. neurologist, Barbro Johansson 7 conducted a r a n d o m -
Possibly the best controlled was that undertaken ized study which considered acupuncture simply as a
by H u et al 4 in Taiwan. Treatment was c o m m e n c e d in f o r m o f sensory stimulation. A group o f 38 subjects,
the acute patient within 36 hours o f the onset o f all acute stroke patients, i.e. starting at 4-10 days
symptoms, and continued three times per week for post-stroke, were given o r t h o d o x traditional Chinese
four weeks, together with all n o r m a l supportive ther- acupuncture together with all n o r m a l physiotherapy
apy. Assessment was at one m o n t h and three months. and occupational therapy care. T h e y were given a
In this study, with a total o f 30 patients aged 46-74, total o f 20 treatments, twice a week for ten weeks. The
a l t h o u g h the n u m b e r o f patients was relatively small, treatment was b o t h by dry needling and electro-
the neurological o u t c o m e for the acupuncture group acupuncture stimulation. The control group, 40
was significantly better than for the controls. The patients, received only the n o r m a l therapy treatment,
improvement in neurologic status was greatest in starting at the same time.
patients with a p o o r neurologic score at baseline. The Significantly greater improvement was observed in
Barthel Index was used for assessment - an interna- walking, balance, and activities o f daily living, quality
tionally recognized, if n o t wholeheartedly approved, o f life, mobility, and emotional state. To some extent,
measurement tool. 5 The authors conceded the small these factors must be supposed to be interdependent;
numbers and intended to use this as a pilot for a for instance, if the walking and balance improve, then
larger trial, for which no data are published as yet. mobility and general quality o f life should also
Z h a n g et al 6 conducted a study on the use o f improve and this will affect m o o d . The m o s t impor-
acupuncture in the treatment o f limb paralysis after tant conclusion drawn from this study was economi-
stroke, at the H u a Shah Hospital, Shanghai in 1987. cal, the acupuncture group had, overall, fewer days in
This was a controlled study with 94 patients. Change nursing homes and rehabilitation facilities with a sub-
in muscle strength was taken as the o u t c o m e measure. sequent saving over the control g r o u p o f $26 000 per
The acupuncture group received treatment, including patient. It m a y be that the cost o f rehabilitation med-
electro-acupuncture, six times per week for four weeks. icine in Sweden is high c o m p a r e d to that in the U K ,
The level o f significance for a g o o d result an increase but these figures were taken seriously by the Swedish
o f muscle strength o f 1 or 2 grades - was P<0.05, health authorities.
260 Complementary Therapies in Medicine

Johansson8 concluded that the mechanism was not The first s t u d y 10 w a s conducted with sub-acute
yet clear. Vascular factors should be relevant in the patients one to three months after the onset of stroke.
acute stage but would not be important in the sub- The study was randomized and double blinded for
acute and chronic stages of recovery. pre- and post-arm and leg motor evaluation by physi-
cal therapists. It was single-blind for the acupunctur-
Various kinds of sensory stimulation can enhance brain plasticity and
this might be a possible mechanism behind functional improvement... ists administering the real or sham acupuncture
Whether expectation (i.e. placebo) can by itself have a lasting effect treatment. The subjects included ten cases who
on brain reorganization is a possibility that has not been ruled out. received real acupuncture in addition to normal
However, it seems likely that factors related to the acupuncture-
induced sensory stimulation should at least have an additive effect. physiotherapy and six cases who were given sham
acupuncture and all normal therapy. There was a
The intervention in Johansson's study was made wide age range: from 44 to 74.
relatively early with what were undoubtedly acute The acupuncture treatment consisted of needling
patients. However, the effects seem to have been long- to recognized acupoints on the affected arm and leg.
lasting. The outcomes measured at one, three and These have been shown to exhibit decreased electrical
twelve months later all showed a continuing signifi- resistance. T M Scalp acupuncture was also used, along
cant improvement on the control group. A further the so-called 'motor cortex line' on the side opposite
randomized, controlled trial was undertaken by the paralysis. A low frequency stimulation (1-2 Herz)
Magnusson et al in 19939 investigating the normaliza- was used on the needles for twenty min but no high-
tion of postural control after stroke and using the frequency stimulation was used. A total of 20 treat-
same acupuncture treatment group. This group, now ments was given, five times per week for four weeks.
totalling 22, was matched again with 26 survivors The sham acupuncture utilized carefully located
from the original control group and a further 23 age- points of normal electrical resistance. Needles were
matched healthy subjects. Subjects had their balance inserted at these points on the unaffected side and left
disturbed by vibrators applied to calf muscles or by for 20 min. A sham electro-acupuncture unit was also
galvanic vestibular stimulation and postural control used, no current being transmitted. In this study,
was evaluated in terms of sway variance or sway when the 20 control treatments were completed, the
velocity using a model previously validated for patients were told that they had been part of the con-
human postural control. Significantly more patients trol group and offered the acupuncture treatment. It
in the treatment group than in the original control is not stated how many accepted.
group maintained stance during the stimulations A good response was defined as a 10% change in
(P<0.01) Among patients capable of maintaining bal- isolated active range of motion. Six ranges of move-
ance, the control group was characterized by a signif- ment were recorded: hip, knee, ankle, shoulder, elbow,
icant divergence from normal values in two of the and forearm pro- and supination. No improvement
three characteristic parameters of dynamic postural was recorded in the patients receiving the sham
control (i.e. swiftness and stiffness; P<0.05), com- acupuncture. Four out of the ten acupuncture
pared with treatment subgroup or the age-matched patients had a good result.
subjects. In this study, evidence from CT scans was intro-
The conclusion was that the acupuncture had duced and, when matched with the results, showed
enhanced the recovery of postural function in the that, where there was a lesion of less than half of the
original treatment group and this was still evident two motor pathway areas on the scan, particularly in the
years later. The original work done by Johansson7was periventricular white matter area, acupuncture was
a good demonstration of the effects of acupuncture, effective. Further work is necessary, however, to con-
both on physical and mental recovery. The scoring in firm what must only be speculation at present.
the Nottingham Health Profile showed a clear The total results showed that four out of ten
improvement in the quality of life, again with what patients given acupuncture achieved a good response
appeared to be an enduring effect, the last measure- where none of those with the sham intervention did.
ment being taken a year after the stroke. Johansson When the real and sham groups are each divided into
has postulated that the change in mood produced by two groups, one with less than half the motor path-
the acupuncture stimulation might be the most ways involved and one group with more than half
important aspect of the treatment. involved, then the results do look interesting. With
Margaret Naeser has done several detailed smaller less than half motor pathways damaged three out of
studies and also made an attempt at an overall analy- four of those treated with acupuncture achieved a
sis of the current work. In addition, she has investi- good response but none of the sham group did.
gated a lot of the anecdotal Chinese studies. Her own Naeser uses paired t tests in her analysis and claims
studies were carefully controlled but fail to convince some significant results. 10
fully because the numbers are small. She has intro- This study opens the way for a better analysis of the
duced two new elements in using laser acupuncture in link between CT scans and the efficacy or otherwise
one study and the inclusion of computed tomography of acupuncture treatment, but it is impossible to
(CT) scan data. generalize from so few patients. However, while it is
Acupuncture in stroke recovery 261

logical that those with less damage do better, these as shown by the Nottingham Health Profile scores.
results seem to be at odds with the work done by The control group also reported improved physical
Han-Hwa Hu g which showed that those patients with movement but, in addition, reported worsened sleep.
the poorer neurologic scores actually did significantly Johansson's theory that the change in mood and
better with acupuncture treatment. energy produced by the effects of the endorphin
Naeser's first two studies were followed in the next increase in acupuncture patients has much to do with
year with a different design. ~3The sham acupuncture their more successful rehabilitation would seem to
was abandoned and chronic cases were included have some support from the Siillstr6m study. It
with no control, using the cases themselves as control. would be interesting to do further work to see if any
This study observed that all stroke cases who had other form of mood-enhancer would have the same
hand paresis had a good response following 20-40 effect.
acupuncture treatments, even though the treatment
was started relatively late, between two and eight
years after the stroke. Good response was defined as a POSSIBLE MECHANISMS INVOLVED IN THE
clear improvement in timed finger dexterity and ACTION OF ACUPUNCTURE ON STROKE
strength tests which were now taken as a measure
both of progress and prognosis. TM A correlation was The effect of acupuncture needling on pain has been
attempted between the number of acupuncture treat- relatively well researched, and the possible mecha-
ments received and the number of improved hand/fin- nisms by which it could be acting have been postu-
ger tests. Significant results are claimed, but only lated, if not proved conclusively. Some of the work
eight chronic cases were treated, with a wide range of done has shown effects on the circulation. For exam-
age, 43-72 years, so it is difficult to see this work as ple, Omura 18 has shown that one effect of acupunc-
indicating more than an interesting direction for fur- ture was to alter haemodynamics by producing
ther research. She has begun to use the evidence from prolonged augmentation of the microcirculation in
CT scans 1° to demonstrate the exact site of the lesion the peripheral tissue and the brain. Not enough work
and use it to predict possible success with acupunc- has been done in this field as yet to justify more than
ture treatment. This could be very important in decid- speculation as to the physiological effect of acupunc-
ing whom to treat in the future. ture on stroke-damaged neural tissue.
In a study published in April 1995 Naeser 15 has Acupuncture in the restoration of motor function is
tested laser acupuncture on a small group of stroke thought by many practitioners to either increase mus-
patients. Again, she has achieved good results but cle power and/or decrease spasticity, but the underly-
with only seven patients, so no conclusions can be ing neurophysiology remains unknown and untested.
drawn. She used laser acupuncture, but this is not There are some reports which describe the use of
really a validated alternative to needle acupuncture acupuncture in cases of stroke, and study the possible
and needs further investigation as a modality. mechanisms, such as reduction of blood viscosity,
To date, the most recently published work is from increased cerebral blood flow, and improvement in
Sfillstr6m in Norway ~6 and, from the translation, it microcirculation~9 21 but these are uncontrolled stud-
would seem that similar good effects have been ies. Each has recorded the treatment of large numbers
observed. This was a study by physiotherapists of stroke patients with acupuncture including blood-
trained in traditional Chinese acupuncture. This was chemistry studies. Significant decreases in fibrinogen,
a controlled trial - the median time from stroke fibrin-degradation products and serum triglycerides
onset to inclusion in the trial was 40 days. All the were reported in all three studies.
patients underwent a comprehensive, multidiscipli- An interesting Danish research paper 22, describing
nary, individually adapted rehabilitation programme a randomized, double-blind, placebo-controlled
with acupuncture being added to the treatment of a study of the effects of citalopram, showed that the
group of 24 out of the total of 45 sub-acute patients. post-stroke depression occurring in 20-50% of
The 24 patients in the acupuncture group were patients responded very well to this drug. If, as is
treated three to four times per week for six weeks demonstrated by Mao et a123, electro-acupuncture
and assessed on entry and at the end of the six performed on patients with chronic pain also raises
weeks. Suzanne S/illstr6m tested motor function, the platelet serotonin level significantly, this may well
activities of daily living (ADL), and quality of life. be one of the ways in which acupuncture is able to
Both groups improved significantly in motor func- affect stroke recovery, since electro-acupuncture stim-
tion and ADL, not surprisingly given the natural ulation is usually part of the recommended treatment
history of the condition, 17 but the acupuncture for hemiplegia.
group improved significantly more, and only the Omura, TM showed an increase in local circulation to
acupuncture group rated a significantly improved the stroke side of the brain and the affected hand
quality of life. when the acupuncture point, Stomach 36, Zusanli,
The acupuncture group made significant progress was needled on the affected leg. He showed that there
for emotional reactions, pain and physical movement was an immediate circulatory response to the inser-
262 Complementary Therapies in Medicine

tion and manipulation of the needle, the recorded analysis would now seem to be indicated. With regard
phases were as follows: to the possible mechanisms whereby acupuncture
might have an effect on stroke recovery, no controlled
First phase: Vasoconstriction usually lasting between
trials were found, but some of the findings in the
15 and 30 seconds;
Chinese research could indicate useful direction for
Second phase: Quasi control, usually lasting between
new work.
10 s and 2 min;
With regard to the sub-questions, the answer is no
Third phase: Vasodilation lasting between 2 min and
clearer. It would seem reasonable, in the absence of
2 weeks.
any evidence to the contrary, to pursue the classic
This response was found locally in the affected form of treatment with both body acupuncture points
hand and also in the brain on the side of the lesion. He and scalp acupuncture. The average length of time for
tested a large number of patients (400) but there was treatment is six weeks and the frequency is three to
varying morbidity and a very wide age-range, from four times per week. The evidence of practice seems
5-85. However, the improvement in brain circulation to be in favour of a very early start to treatment, as
was seen only in the patients suffering from stroke, and soon as the patient is medically stable after the haem-
among these only in those who were less than seven orrhage and none of the studies has suggested that is
years from onset. N o significant effect was seen in detrimental.
patients who suffered from stroke longer than this. I f the CT scan evidence is reliable (very few cases
The strength of grip was also measured in this have been considered after all) taken together with
group and it was found that the m a x i m u m hand-grip Hu's results, 4 it may be possible to predict in future
of the affected hand improved significantly, particu- which patients will respond best to acupuncture.
larly in those who scored low before this acupuncture Acupuncture is a modality that is increasingly used
intervention. within Western medicine. Both doctors and physio-
Only one paper, by Y a m a m o t o and Ishiko) 4 has therapists are now using it commonly within the
been written with regard to the effect of scalp National Health Service for the treatment of pain-
acupuncture on the weight-lifting capacity of the related problems. 26 Physiotherapists, in particular, are
healthy and paralysed lower limb. These doctors much concerned in the treatment and rehabilitation
needled only one point on the scalp, corresponding of stroke patients and would welcome a W new tool
roughly to the lower end of the m o t o r line. They that could extend and improve the rehabilitation
demonstrated a marked increase in weight-lifting period, making the more orthodox therapy treatment
capacity of paralysed legs, although all their results even more effective.
showed considerable variation with healthy limbs
decreasing in capacity as well as increasing by +/-20%.
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The results seemed to show no apparent benefit in
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2. Ge Shuhan. The effect of acupuncture in cerebral
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4. Hu HH et al. A randomised, controlled trial on the treatment
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the world to make the question very intriguing. The Neuroepidem 1993;12:106 113.
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13. Naeser M A e t al. Acupuncture in the treatment of 20. Qi L Y et al. Observation on acupuncture treatment of 322
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L E T T E R TO T H E E D I T O R

Dear Sir potential for breakdown or recovery rather than as an


The study of iris diagnosis by Buchanan et al (Comp indicator of overt disease.
Ther Med 1996; 4(2) 98-102) highlights the draw- Setting aside the lack of anatomical evidence for
backs of applying a disease-orientated analysis to a connection between iris zones and body organs
what is essentially a qualitative, patient-orientated (a shortcoming of many well-established therapies,
tool. The authors found that there was no statistically such as acupuncture, auricular therapy, and foot
significant correlation between a number of signs reflexology) there are many practitioners who find
commonly used in iris diagnosis and several clinically observation of the iris a valuable guide to the
established systemic diseases. On the basis of their constitutional strengths and weaknesses of their
results, and those of other studies they cite - all of patients. (As to the contention that iridologists may
which used end-point pathologies as their compara- rely on information other than that gleaned from
tive criteria - the authors, wisely, do not suggest examination of the eyes, there are some German
that iris diagnosis is worthless but there is a danger of experts who even prescribe solely on the basis of iris
others jumping too hastily to negative conclusions. diagnosis without resort to anamnesis or other exam-
Many practitioners who use iridology as a diag- inations, reputedly with great success.)
nostic adjunct would concur with the findings of this Clearly there is now a need to find new ways of
skillfully designed analysis; the classical iris signs do testing the validity of the iris signs as an aid to assess-
not always equate with known pathologies and may ing the functional integrity of body tissues and to
even contradict them. An investigation making such selecting appropriate therapeutic interventions.
comparisons, however, ignores a fundamental princi-
pal of complementary medicine, which is that it is R. Newman Turner BAc, ND, DO,
concerned with assessing and treating patients, not Practising Osteopath and Naturopath,
diseases. In other words, if the iris reveals anything 111 Norton Way South,
about a patient, it may be in terms of tissue tone and Letchworth, Herts, UK.

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