New Nexera Series

David Chan
Senior Product Specialist
Shimadzu Asia Pacific

David Chan
Senior Product Specialist
Shimadzu Asia Pacific
Next-Era (Nexera) of Digital Technology in a Laboratory

Versatile Working Information Storage

Increased connectivity Massive amounts of
allows remote working information in relatively
environment small spaces
Flexible working Data security through
practices become full proof data storage
increasingly common platform
Easy learning and Access to information
knowledge expansion from any location

Automation Investment
Automation workflow Effective asset
requires less human management to ensure
operation return of investment
Machine learning makes Flexible design to allow
machines smarter easy expansion
Better standards of Maximized uptime
operation and results allows greatest
productivity
First AI Enabled & IoT-driven Analytical LC

The digital technology has been growing rapidly

People have been starting to require more

assistance from digital technology...
an·a·lyt·i·cal in-tel-i-juhns

A smart analytical platform that incorporates state-of-the-art IoT, AI and

machine learning algorithms functionality

Automation workflow includes Auto -monitoring, Auto-controlling, Auto-

diagnostics, and Auto-recovery functions release the user from routine
instrument operation

Minimizing system downtime; Optimizing efficiency; Maximizing productivity

The New Nexera Series

EXPERIENCE NEW BENCHMARKS

A New Benchmark of Intelligence

Incorporation of AI, IoT for Smart System Automation

A New Benchmark of Efficiency

Flexible system expandability for maximized efficiency

A New Benchmark of Design

Futuristic & sleek design with excellent performance
INTELLIGENCE

9
Routine Workflow

Start-
up

Mobile
Shut- Phase
down
Set-up

Post-run
Column
System
Equil.
monitoring

Start
Analysis
System
Check
Mobile
Phase
Check
A New Benchmark of Intelligence

Auto
Start-
up
Checking
Mobile mobile phase level
Auto
Shut- Phase
down Set-up Alerts the mobile
phase running out

Post-run
Column Mobile
Remote
Equil. phase
monitoring monitor

Start
Analysis
System
Check
Mobile
Phase
Check
Advanced Real-Time Mobile Phase Monitoring
The gravimetry of the mobile phase is observed through smart devices
Automatically calculate mobile phase reservoir volume
An alert is sent in case of shortage

MPMChecker LabSolutions

Sends the data to PC

or smart devices

Bottle holder with

gravimetric sensor

System dry-up; column damage; sample wastage preventions

Real Mobile Phase Monitoring = Maximum Up-Time
Intelligent Workflow

Auto
Start-
up
Checking
Mobile mobile phase level
Auto
Shut- Phase
down Set-up Alerts the mobile
phase running out

Post-run
Column Mobile
Remote
Equil. FlowPilot phase
monitoring monitor

Start
Analysis
System
Check
Mobile
Phase
Check
FlowPilot Protects Column

FlowPilot ramps the mobile phase flowrate gradually to the set point automatically
Avoid sudden surge of excessive pressure applied on the column, to protect the column
in the automated start-up.

Without FlowPilot Flow With FlowPilot

Pressure ① Gradually increases flow to the half of set value.
Pressure jump Temp. ② Stays until the temp reaches to the set value.
③ Gradually increases flow again to the set value.

Prevent extra
pressure
1mL/min
1mL/min
③

0.5 ②
mL/min
①

Start Heating Stable (Time) Heating Stable

Start (Time)
temperature temperature
Automated Column protection; extend life span of delicate HPLC column
Maximized return from cost of operation
Intelligent Workflow

Auto
Start-
up
Checking
Mobile mobile phase level
Auto
Shut- Phase
down Set-up Alerts the mobile
phase running out

Post-run
Column Mobile
Remote
Equil. FlowPilot phase
monitoring monitor

AI SAKit

Start
Analysis
System
Check Checking
Auto-
mobile phase level
Mobile
diagnostics Phase
& recovery Check
Alerts the mobile
phase running out
Auto-Diagnostics and Auto-Recovery

Air bubbles formation may occur by mixing of solvents

The air bubble interfusion brings for a drop in the flow rate and disturb analysis flow

Detect the
fluctuation

Sample 1 Sample 2 Auto purge Sample 2

(Failure) (Retry)

Chemist does not need to be physical present when abnormal condition appears
Nexera Series can perform auto-correction; ensure maximum system up-time
Intelligent Workflow

Auto
Preventive Start-
maintenance up
Checking
Mobile mobile phase level
Auto
Shut- Phase
Smart
Service
down Set-up Alerts the mobile
Net phase running out
Lab
Management

Post-run
Column Mobile
Remote
Equil. FlowPilot phase
monitoring monitor

Easy
Access
from all
locations AI SAKit

Start
Analysis
System
Check Checking
Auto-
mobile phase level
Mobile
diagnostics Phase
& recovery Check
Alerts the mobile
phase running out
Smart Service Net

Gives the appropriate maintenance timing by predicting from the use history
Good Laboratory Management practice

The maintenance
Predicted date date is predicted.

History
Prediction curve
2018/09/01 2019/05/01
2020/01/01
Email about the
maintenance
The use history of consumable part is shown.

Service engineer Lab manager

• Schedules to visit for • Schedules to stop the
the maintenance system for the
• Prepare the needed maintenance
The error history is displayed. consumable part
Intelligent Workflow

Auto
Preventive Start-
maintenance up
Checking
Mobile mobile phase level
Auto
Shut- Phase
Smart
Service
down Set-up Alerts the mobile
Net phase running out
Lab
Management

Post-run
Column Mobile
Remote
Equil. FlowPilot phase
monitoring monitor

Easy
Access
from all
locations AI SAKit

Start
Analysis
System
Check Checking
Auto-
mobile phase level
Mobile
diagnostics Phase
& recovery Check
Alerts the mobile
phase running out
EFFICIENCY

20
A New Benchmark of Efficiency

Autosampler: SIL-40 series

•Ultra-fast injection speed
•Ultra-low carryover
•Air-circulation temperature control
•Automated sample preparation
Autosampler

Autosampler: SIL-40 series

•Ultra-fast injection speed

Ultra-fast injection Ultra-huge sample capacity

Ultra-high throughput is achieved with the fastest injection speed in the

industry: 6.7 sec; Maximum sample capacity: up to 16800 samples
Autosampler

Autosampler: SIL-40 series

•Ultra-fast injection speed
•Ultra-low carryover
•Air-circulation temperature control
•Dual injection

(x10,000,000) (x10,000)
1.5
2.0 Carry over:
0.0002%
1.0 (MS/MS detection)

0.5 1.0
400mg/L x 1uL
Caffeine in water

Blank
0.0

0.0 1.0 2.0 min 1.5 min

Zero-volume connection between the sample loop and the needle

ensures no-sample-residue; ideally designed to achieve lowest
carryover
 Autosampler

Autosampler: SIL-40 series

•Ultra-fast injection speed
•Ultra-low carryover
•Air-circulation temperature control
•Dual injection

255 days X 10 min NexeraBlocking Seriesthecool samples

air from outside quickly, going from ambient to 5 ˚C.

= 43 h saved/ year
Minimizing the temp change Temp-
10 unit
contorolling minAmbient
fasterairthan other instruments
Dry & cool air
255Dry
days
& cool X
air 10 min
Add more samples.
X 5 times/ day = 10 min faster than other autosamplers
256 h saved/ year
Radiatior

Fan
A bump to change the direction of airflow

Dry air flow control technology effectively prevents dew condensation.

The Autosampler is delicately designed to consider airflow direction
within the sample compartment to make sure stable temperature and
effective cooling.
Autosampler

Autosampler: SIL-40 series

•Ultra-fast injection speed
•Ultra-low carryover
•Air-circulation temperature control
•Automated sample preparation
preparation

Reagent addition Overlap injections

functions
Sampler

Dilution Stack injections

Co-injection Mixing
Online-dissolution Derivatization

The patented technology designed Nexera Series Autosampler and

user-friendly LabSolutions graphical user interface offers simple
operation as it eliminates the need for complicated programming of
pretreatment methods.
DESIGN

26
 Photodiode Array Detector

PDA detector: SPD-M40

•Advance TC-Optics for excellent
baseline stability
•UV-cut-off filter to prevent the
photolytic degradation
Room Temp. 25 ℃

20 ℃
mAU Area RSD:
2.5 SPD-M40 0.62% Heat
discharger
0

-2.5
spectrom
-5.0 Lamp eter
Area RSD:
-7.5
1.87% Flow
cell Advanced
-10.0
Other vendor’s TC-Optics
-12.5 PDA

0 50 100 150 200 250 300

Advanced TC-Optics technology that controls the temperature of lamp,
min

flow cell and spectrometer eliminates the influence of room

temperature drift.
Photodiode Array Detector

PDA detector: SPD-M40

•Advance TC-Optics for excellent
baseline stability
•UV-cut-off filter to prevent the
photolytic degradation

2.5 AU of Dynamic Range Ketoprofen Purity Test

Peak height (AU) (AU) Ch1 256nm,4nm

3.0
Ketoprofen 2.5
(mAU)
R2 = 0.9998

Ketoprofen
2.5

Impurity A
5.0
2.0
0.245 mg/L (lowest conc)
4.0
2.0 Bias of QC: Δ -2.1%

Impurity B
RSD: 0.72 %（n=6） 1.5 3.0

（Ketoprofen）

Impurity C
1.5
0.04 2.0
1.0
1.0 1.0
0.02
0.5 0.0
0.5
2.00 2.50 3.00 (min)
0 5 10 0.0
0.0
Excellent
0 250
dynamic
500
range
750
Conc.(mg/L) linearity
0.0 ensures
1.0 excellent2.0precision,3.0
and
(min)

allows simultaneous analysis of target component and trace impurities

 Photodiode Array Detector

PDA detector: SPD-M40

•Advance TC-Optics for excellent
baseline stability
•UV-cut-off filter to prevent the
photolytic degradation
Molecules derived
withrout Flow cell (magnification) from the photo-
UV-cut-off filter degradation affects
the UV absorption
property.
5 mg/L QC Average Conc:
4.474 mg/L (Δ -10.4%)

(mg/L) (n=6)

With
UV-cut-off Flow cell (magnification)

The UV-cut-off filter eliminates the strong UV light

5 mg/L QCshorter than 240 nm.
Average Conc:
4.995 mg/L (Δ -0.44%)
To avoid changing the peak intensity caused by the fragment that
(n=6)
might have the different UV absorption property.(mg/L)
 Autosampler

Autosampler: SIL-40 series

•Ultra-low carryover
•Ultra-fast injection speed
•Air-circulation temperature control
•Dual injection Multi Data
Report (MDR)
Sample 1 Sample 2 function
Conventional

Path 1 summarizes the

method

Analysis Analysis Analysis Analysis Analysis Analysis quan results of

Organic acids
Switching Flow path 1
1 1 1 2 2 2
multiple
substances in all
samples.

Path 1 Time-saving
New Nexera

Analysis Analysis Analysis

design
1 1 1
Flow path 2
Amino acids

Analysis Analysis Analysis

2 2 2

Patj 2

Integrated two analytical systems into the single platform; enables analysis of
two independent samples through independent flow channels resulting in twice
the amount of samples processed in the same time
A New Benchmark of Design

The futuristic & sleek design of Nexera Series promises no compromise on performance

40% Space saving 68% Power saving

Realizing Our Wishes for the Well-being
of Mankind and the Earth
Variants of Nexera Systems
Configurable Modular Design
Nexera Receives the Red Dot Design Award 2019
The Shimadzu Nexera series has been awarded Red Dot Award 2019 winner prizes in the
product design category of the Red Dot Design Award. The award ceremony will be held in
Essen, on 8 July 2019. An actual Nexera series instrument will be displayed in the Red Dot
Museum for 1 year.

Results of the Red Dot Award: Product Design 2019

Entries
more than 5,500
Red Dot awards granted 1,549

Based on the quest for “excellent design and innovation,” experienced

designers in various fields judge products based on innovation,
functionality, quality, ergonomics, and durability.

The Red Dot Design Award is one of the 3 major design awards in the world,
alongside the German iF Design Award and the US IDEA Award.

2013 2018 2018 2019

Frost & Sullivan Global Award

• New Nexera Series was award Frost & Sullivan 2019 Global High
Performance Liquid Chromatograph New Product Innovation
Award
• Award was presented by Dr. Satish Lele Senior Vice President,
Frost & Sullivan Asia Pacific
Brand statement “Excellence in Science”
We in the Shimadzu Group have delivered products and services to enable our customers around the world to develop a diverse range of
new products, to protect and improve the environment, and to improve the health and lives of mankind. This brand statement represents our
sense of pride in this endeavor. It is our commitment to society and ourselves that Shimadzu remains dedicated in our pursuit of technology
and accumulation of knowledge, so that we can offer even more outstanding technologies, products, and services, so as to be recognised
for excellence in the field of science.