COMPUTATIONAL DOSIMETRIC EVALUATION USING A

RADIOACTIVE BONE CEMENT BASED ON PMMA+HAp WITH

OPTIMAL RADIOLOGICAL CONTRAST.

Carlos J. Montaño¹; Olga L. M. Moreno²; Bruno M. Mendes3; Tarcísio P.R. Campos¹*.

¹Postdoctoral Resident – Dpt. of Nuclear Engineering—UFMG, Belo Horizonte – MG. E-mail: carlmont@ucm.es
Código: 90224 ²MD. M. Sc. in Physiology and Pharmacology—ICB/UFMG, Belo Horizonte – MG. E-mail: olgamore3@yahoo.com
3Ph. D. – Researcher – CDTN, Belo Horizonte—MG, E-mail: bmm@cdtn.br
1*Ph. D. – Guidance professor – Chief of Laboratory – Dpt. of Nuclear Engineering—UFMG, Belo Horizonte – MG. E-mail:

tprcampos@yahoo.com.br
INTRODUCTION
Figure 1. TPS with IMRT
• Radiovertebroplasty is a treatment that has emerged as an alternative to technique to treatment
control bone metastases with low therapeutic response to conventional of infiltrating spinal cord.
treatments such as conformal radiotherapy or IMRT (Intensity Modulated
Radiotherapy) [1].

• The new therapeutic proposal is based on the use of a minimally invasive Figure 2. Minimally invasive
procedure known as Vertebroplasty and the use of a radionuclide coupled to a procedure - Vertebroplasty
bone cement for use in situ.

• The use of bone cements based on PMMA (Polymethylmethacrylate) and

biophosphates play an important role in the restoration of collapsed vertebrae
due to the compression provided by metastases development [2]. In many
cases, the aim is the palliative pain reduction [3-5].

MATERIALS AND METHODS

Computational vertebrae models and tomographic in MCNPx

1) bone tissue with red bone marrow, 2) soft tissue, 3) medullar

duct and spinal cord, 4) metastasis bone of mammary origin and
5) bone implant. Vertebral section of 10.50 x 8.80 x 2.3 cm3. The
dimensions of the voxels were 0.25 x 0.25 x 0.25 mm3. Array of 95 Figure 3. Radiological test in vertebral
models ex-vivo with bone implants.
planes in the Z direction.

CT vertebral lumbar model. A tomographic model of a lumbar

Figure 5. Tomographic
section of 10.80 x 9.24 x 8.76 cm3 composed of 45 planes in Z
images INPUT using
direction was prepared. The voxel size was 1.2 x 1.2 x 1.2 mm3. MCNPx code and
voxels geometry
Figure 4. Treatment of tomographic images with metastasis

RESULTS AND DISCUSSION

Figure 6. Spatial dose distribution in vertebrae Figure 7. Spatial dose distribution in vertebrae Figure 8. Dose vs. Volume Histograms for all
models with bone metastasis models without bone metastasis computational models

Table 1. Therapeutic Dose Deposited and Radiotoxicity for PTV and OAR – Volume percentage
estimated for 90% of the Reference Dose (72 Gy) concerning to TD 50/5 for each organ

VertA VertB
Model without metastasis
Tumor, Organs or Specific Activity 3 𝐺𝐺𝐺𝐺𝐺𝐺

Bone Cement Ho-166 Sm-153 Y-90

Ho-166 Sm-153 Y-90 Ho-166 Sm-153 Y-90
50 𝑀𝑀𝑀𝑀𝑀𝑀 72 𝑀𝑀𝑀𝑀𝑀𝑀 16,2 𝑀𝑀𝑀𝑀𝑀𝑀

Metastasis – PTV 62,77 24,47 80,91 76,49 35,22 94,30 ------- ------- -------

Spinal Cord – OAR 1 * 0.02/10 0.01/7 0.01/30 0.01/39 0.01/9 1.80/90 0.029/5 0,000 0.058/12

Bone Tissue – OAR 2 * 9.04/90 2.62/90 14.65/9 3.09/90 0.41/90 7.26/90 0.007/55 0,007/20 0.007/68

Bone Cement – PTV ------ ------ ------ ------ ------ ------ 90.05 98.09 89.25

CONCLUSION
In all simulations, it was confirmed that the spatial dose for the 90Y was distributed in a greater area compared to
166Ho and 153Sm. Both BC-90Y and BC-166Ho are quite promising for their protocol implementation in the

Radiovertebroplasty.
REFERENCES
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