PHARMACOLOGY

CYCLOSPORINE

BRAND CLASSIFICATION DOSAGE DRUG ACTION ADVERSE SPECIAL ABSORPTION

NAME AND REACTION CONSIDERATION
FREQUENCY
Neoral, Polypeptides 25mg 2-tab Inhibits normal CNS: Monitor serum Erratically
Sandimmune, (Cyclic) daily, 8am- immune Seizures, creatinine level, absorbed
Gengraf 8pm responses tremor, flushing, intake and output (range 10-60%)
(cellular and headache. ratios, daily after oral
humoral) by weight, and blood administration,
inhibiting GI: pressure during with significant
interleukin-2, a Diarrhea, nausea, therapy. Report first-pass
factor necessary vomiting, significant metabolism by the
for initiation of abdominal changes. liver.
T-cell activity. discomfort,
anorexia, Prevention of
pancreatitis. Transplant
Rejection:
Hemat: Assess for
Anemia, symptoms of
leukopenia, organ rejection
thrombocytopenia throughout
therapy.

Psoriasis: Assess
skin lesions prior
to and during
therapy.
COTRIMOXAZOLE

BRAND CLASSIFICATION DOSAGE DRUG ACTION ADVERSE SPECIAL ABSORPTION

NAME AND REACTION CONSIDERATION
FREQUENCY
Bactrim, Folate 200/40/5ml, Sulfamethoxazole CNS: Assess for Well absorbed
Cofa-trim, antagonists, 20 ml daily, (SMZ) interferes Headache infection (vital from the GI tract.
Cotrim, sulfonamides 8am-8pm with bacterial insomnia, signs appearance
Septra biosynthesis of hallucinations, of wound,
proteins by depression, sputum, urine,
competitive vertigo. and stool; WBC)
antagonism of at beginning of
PABA when GI: and during
adequate levels Diarrhea, nausea, therapy.
are maintained; vomiting,
trimethoprim hepatitis, Assess patient for
(TMP) blocks stomatitis. allergy to
synthesis of sulfonamides.
tetrahydrofolic Hemat:
acid; combination Aplastic anemia, Inspect IV site
blocks 2 leukopenia, frequently.
consecutive steps thrombocytopenia, Phlebitis is
in bacterial common.
synthesis of
essential nucleic
acids and protein.