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CASE STUDY
Abstract
The ability of amnesic patients to learn and retain non-declarative information has been consistently demonstrated in the
literature. This knowledge provided by basic cognitive neuroscience studies has been widely neglected in neuropsychological
rehabilitation of memory impaired patients. This study reports the case of a 43 year old man with severe amnesia following
an anterior communicating artery (ACoA) aneurysm rupture. The patient integrated a comprehensive (holistic) day
treatment programme for rehabilitation of brain injury. The programme explored the advantages of using preserved
For personal use only.
non-declarative memory capacities, in the context of commonly used rehabilitation approaches (i.e. compensation for lost
function and domain-specific learning). The patient’s ability to learn and retain new cognitive and perceptual-motor skills
was found to be critical for the patient’s improved independence and successful return to work.
Correspondence: Sara Cavaco, Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Avenida Prof. Egas Moniz, 1649-035
Lisboa, Portugal. Tel: þ351217805217. Fax: þ351217942060. E-mail: sara.cavaco@mail.telepac.pt
ISSN 0269–9052 print/ISSN 1362–301X online # 2005 Taylor & Francis Group Ltd
DOI: 10.1080/01449290500109917
854 S. Cavaco et al.
Preserved non-declarative memory capacity in the low average level for both literal and semantic
amnesiacs introduces new possibilities in the fluency tasks. Screening of visual-spatial and con-
rehabilitation of these patients, i.e. in the reduction structional skills showed functioning to be within
of the effects of their handicap on their everyday func- normal range. His basic and higher order attention/
tioning. There have been some limited attempts to use concentration abilities as well as higher level execu-
skill learning methods and other non-declarative tive reasoning/problem-solving abilities were within
methods in clinical settings [9–16]. However, such the average range. Mild residual weakness was
resources still remain largely untapped. evident in cognitive processing speed/efficiency.
This case report demonstrates the contribution of During the interview, the patient showed very limited
the non-declarative memory capacity to the rehabili- insight into the impact of his impairments on his
tation of a patient with severe amnesia for declarative activities and daily life.
material due to probable basal forebrain damage. Patient’s neuropsychological profile is consistent
As indicated in previous studies [11–14], the with damage to the posterior sector of the orbito-
patient’s non-declarative memory capacity played frontal area, including the basal forebrain.
a crucial role in his successful use of external aids
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MH was a 43 years old right-handed man, with MBIOP 5 months after the neurological event
13 years of education, who developed a severe and graduated the comprehensive day programme
persistent headache. Ultimately he was diagnosed 8 months later. The MBIOP offers an integrated
with sub-arachnoid haemorrhage. He underwent and multi-modal rehabilitation. It emphasizes the
clipping of an anterior communicating artery importance of community education, the importance
(ACoA) aneurysm. Subsequently, he underwent providing and receiving feedback from others and
multiple surgeries for hydrocephalus, including left the importance of self-evaluation based on indivi-
frontal ventriculostomy. Due to the clipping it was dualized goals to enhance the self-awareness and the
not possible to obtain an MRI nor perform a detailed sense of involvement in the rehabilitation process.
anatomical analysis. However, ruptures of the ACoA The importance of using the patient’s preserved
aneurysms are known to damage primarily the basal non-declarative memory capacities was most notice-
forebrain. able on the rehabilitation of memory impairment and
return to work. This report focuses on these two
Neuropsychological assessment major areas of intervention.
Patient MH was first evaluated by the Mayo Brain
Injury Outpatient Programme (MBIOP) 5 months Memory impairment
after the clipping. At that time, the patient’s The memory rehabilitation process of patient
neuropsychological profile was most notable for the MH focused primarily on compensation for lost
presence of significant deficits in learning and function and substitution of intact function. These
memory for both visual and verbal information, as two approaches target disability (i.e. the lack of
demonstrated by the patient’s performance on the ability to undertake an activity at a normal level)
Wechsler Memory Scale III (WMS-III), the Visual rather than impairment (i.e. lack of a body part or
Spatial Learning Test and Rivermead Behavioural function) and attempt to achieve specific functional
Memory Test (Table I). During interviews and outcomes (Table II).
spontaneously the patient showed confabulatory
tendencies.
Compensation for lost function
The neuropsychological assessment reflected
verbal and non-verbal intellectual abilities within Use of external aids. The efficient use of a notebook
the lower portion of the average range. In language to compensate for MH’s memory impairment was
functioning, the patient showed normal performance believed to be of major importance for his functional
in visual naming and auditory comprehension. independence. The training on the use of the
Verbal fluency performance was slightly weaker, at notebook was based on the method proposed
Non-declarative memory in the rehabilitation of amnesia 855
Tests Scores
WAIS-III
Verbal IQ 97
Performance IQ 86
Full scale IQ 91
Verbal comprehension 93
Perceptual organization 91
Working memory 90
Processing speed 84
COWAT 30 (12–22%ile)
Category fluency 32
MAE naming 58
MAE token 44 (82%ile)
WRAT3 arithmetic SS ¼ 100
WMS-III
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Number of categories 6
Perseverative responses 12 (T score ¼ 51)
Perseverative errors 12
Category test (Russell’s short form) T score ¼ 42
Trail making test
A 2700 (T score ¼ 50)1
B 6700 (T score ¼ 47)1
Beta mazes SS ¼ 8
Beck depression inventory 7
1
According to the Mayo’s Older Americans Normative Studies (MOANS) standards.
by Sohlberg and Matter [20]. The training process and photographs to compensate for his memory
went through three major phases: acquisition, impairment. Rapidly it was clear that these external
application and adaptation. Based on the patient’s aids were neither adequate nor efficient, because
accomplishments and consolidation of target behav- the patient frequently failed to carry these aids.
iours, the level of demands from phase-to-phase After a small period of assessment of the patient’s
increased progressively. With the patient’s inability needs, he was recommended to use a pocket-size
to use declarative memory functions, it was believed notebook composed of a 2-page-per-day planner,
his training on the use of the memory notebook had specific sections (e.g. medical section, vocational
to rely heavily on non-declarative memory functions. section, telephone section, family section) and cue
As a consequence, during the training, the number cards (i.e. reminders of important information
of repetitions that MH needed to learn and the designed to be quickly accessible).
amount of time the patient spent on each phase were A significant part of the rehabilitation team’s
inevitably higher than other patients with less efforts were focused on training detailed recording
declarative memory impairment that have partici- of information in the notebook. People without
pated in the programme. The training was based on memory problems are often able to retrieve the
extensive practice, cueing and feedback. necessary information from minimally detailed
The size and composition of the external aids notes, because supported by their episodic memory
are important aspects for its adequate and efficient they can fill the missing parts and reconstruct the
use. Upon admission to the programme, the patient message. When a patient has memory impairment
used both a pocket-size month-at-a-glance planner for episodic information, the quality of the notes
and a large notebook of personal information on the notebook becomes a central point.
856
S. Cavaco et al.
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Restoration of damaged function—attempts to Practice and rehearsal Meaningful or elaborative rehearsal, Achieve general mnemonic benefits Learn specific pieces of
restore damaged memory processes; targets distributed practice, over-learning, information
underlying impairment spaced retrieval
For personal use only.
Optimization of residual function—attempts to Mnemonic strategies Visual imagery, verbal organization Achieve general mnemonic benefits Learn arbitrary associations,
retrain normal memory processes; targets and association strategies, including or learn specific information sequences of actions and text
underlying impairment story mnemonics, first-letter cueing,
chaining and PQRST
Compensation for lost function—compensates Environmental supports and Labels, instructions, notebooks, Solve everyday memory problems Assist in independent living
for or bypasses memory deficits; targets external aids diaries, calendars, alarm watches, and in prospective memory
functional deficits timers, electronic organizers, pagers
Substitution of intact function—uses intact Domain-specific learning Vanishing cues, errorless learning Learn specific knowledge relevant Learn skills or tasks that can be
memory processes to substitute for damaged in everyday life performed implicitly
ones; targets functional deficits
1
Based on Glisky and Glisky [22].
Non-declarative memory in the rehabilitation of amnesia 857
document task completion for future reference. dual needs, he and the staff within the first month
MH was able to slowly transfer these learned skills developed some specific long-term treatment goals
to the working setting. The routine of recording (e.g. I will use my planner and fact sheet throughout
information and referring to it on a regular basis the day to compensate for my memory so I can get
appeared to be a key factor in job performance. things done efficiently). These long-term goals were
then broken down in small behaviour anchors,
Environmental supports. Acknowledging that the i.e. short-term goals (e.g. ‘with 0–1 direct cues,
environment where MH lived and worked could I will write specific details to remember information
potentiate or jeopardize his improvements, the staff on the right page of my planner’). Attending to MH’s
considered it critical to intervene thoroughly in the achievements and/or difficulties, the amount and
environment. The family, other supportive people quality of cueing aimed on the short-term goals
involved in his life and the employers were educated were periodically reviewed and gradually reduced
about his significant memory difficulties, his dimini- by the patient and the staff throughout the
shed awareness, on the use of cueing techniques and programme.
the importance of structure and routine.
The patient underwent a complete change of Return to work
wardrobe in order to accommodate the consistent
transport of the notebook. New pants with pockets From the beginning, the patient identified as his
of the size of the notebook facilitated the acquisition most important personal goal to return to work.
of the behaviour of picking the notebook from the A comprehensive and individualized return-to-work
pocket to record and/or retrieve information every plan was developed for him. The programme’s
time it was necessary. It also facilitated the acquisi- vocational service addressed patient’s functional
tion of the behaviours of reliably placing the note- limitations, helped him to identify realistic goals
book in the pocket and carrying it everywhere and bridged the gap between hospital and
(including leisure situations). As an example, the community services.
patient’s tendency to confabulate about the cause Patient MH like any person with moderate-to-
of his brain injury was addressed with a ‘fact sheet’ severe memory impairment for declarative informa-
placed on the first page of his notebook. The patient tion was hindered from performing certain types
was trained to refer to it every time he had to of work that required continuous tracking of new
introduce himself to a visitor. The automatization information. Some jobs may prove to be too
of this behaviour was rapidly acquired through the challenging or too hazardous for someone with
method of vanishing cues. amnesia. This was the case for the job that MH
858 S. Cavaco et al.
had before his injury. Prior to his injury, he had a When the patient entered the programme he was
stable working history, operating his own business not working, rating 1 on the five points’ Vocational
as a landscaper and logger for 20 years. Independence Scale [21]. At discharge and at
Despite his defective acquisition, retention and 2 months follow-up the patient was working part-
retrieval of new declarative information, he was able time in a community-based job with permanent
to successfully learn to perform some jobs that relied support, rating 3 on the same scale. Despite working
heavily on non-declarative information. at a competitive level, he still needed a permanent
Six months after the beginning of the programme, job coach support.
the patient started the vocational evaluation with a Upon admission to the programme the patient
5 week centre-based situational assessment, followed lived with his relatives and required extensive super-
by a community based situational assessment. vision. At completion of the programme and at
The rehabilitation process benefited from the 2 months follow-up the patient was independent
patient’s high motivation to work and his natural with his self-cares and living in Adult Foster Care.
interest on physical labour. He fully engaged on all He still required moderate assistance with managing
sheltered workshop-based and community-based responsibilities of independent living (e.g. meet
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vocational evaluations (e.g. ‘sort, pack and prepare transportation needs, manage money and finances).
forensic kits for shipping’; ‘operate a commercial
dryer’; ‘sort, fold and pack laundry’). All these job Discussion
trials relied heavily on cognitive and perceptual-
motor skill learning through extensive practice with The distinction between declarative and non-
little demands on episodic learning. Two months declarative memory systems was clearly demon-
after discharge, the patient was still working in a strated in this case. MH showed preserved capacity
nursery garden department store. The patient was to acquire and retain new procedures, while demon-
adequately performing this job (i.e. unload, water, strating significant declarative memory impairment.
Patient MH’s severe memory dysfunction interfered
For personal use only.
had a significant positive impact on his sense of 8. Sohlberg MM, Mateer CA. Cognitive rehabilitation: An
integrative neuropsychological approach. New York: The
self-esteem and functional independence.
Guilford Press; 2001.
This case report shows the need to reduce the 9. Glisky EL, Schacter DL, Tulving E. Computer learning
declarative memory demands from an amnesiac’s by memory-impaired patients: Acquisition and retention of
day-to-day life and shows the usefulness of exploring complex knowledge. Neuropsychologia 1986;24:313–328.
the patient’s non-declarative memory capacities to 10. Suhr J, Anderson S, Tranel D. Progressive muscle relaxation
in the management of behavioural disturbance in Alzheimer’s
reach functional independence and vocational reinte-
disease. Neuropsychological Rehabilitation 1999;9:31–44.
gration. As expected, the vanishing cues technique 11. Donaghy S, Williams W. A new protocol for training severely
and the errorless learning environment facilitated impaired patients in the usage of memory journals. Brain
the acquisition and retention of target behaviours. Injury 1998;12:1061–1076.
It was demonstrated that a combination of 12. Kime SK, Lamb DG, Wilson BA. Use of a comprehensive
programme of external cueing to enhance procedural
different memory rehabilitation methods (i.e. use
memory in a patient with dense amnesia. Brain Injury
of external aids, environmental supports and 1996;10:17–25.
domain-specific learning) and an individualized 13. Andrewes D, Gielewski E. The work rehabilitation of a herpes
vocational reintegration plan were efficacious in the simplex encephalitis patient with anterograde amnesia.
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