Abstracts / International Journal of Infectious Diseases 73S (2018) 3–398
A working group made up of pathogens, genomics and bioinfor-
matics experts ensures standardized, harmonized and improved
bioinformatics analyses among the different local organizations.
Results: BioinfoDB provides IT tools and data that are quickly
available, usable and helpful in outbreak situations allowing to link
molecular typing and bioinformatics analyses results with time and
position of sampling as well as the others epidemiological informa-
tion available. In this way it is possible to compare the classification
results obtained by WGS for two or more distinct isolates and to
measure their relatedness to support an epidemiological investi-
gation as experienced in 2015 during a severe listeriosis outbreak
in the Marche region.
Conclusion: Access to information allow to know the health
risk to which the livestock and food processing chain is exposed
and how the risks can affect the public health, perform real-time
assessments to adjust technical and organizational responses, plan
actions and check their effectiveness afterwards. The national plat-
form for the collection and analysis of complete genome sequence
together with the veterinary information systems adopted in Italy
during the years fully meet these needs.
https://doi.org/10.1016/j.ijid.2018.04.4090
UMP. 553
The zika epidemic and abortion in Latin
America: a scoping review
M. Carabali 1,∗ , N. Austin 2 , N.B. King 2 , J.S.
Kaufman 2
1 McGill University, Epidemiology, Montreal, QC,
Canada
2 McGill University, Epidemiology, Montreal, Canada
Background: Zika virus (ZIKV) has been linked to congenital
malformations collectively referred to as Congenital Zika Syndrome
(CZS). Latin America presently has the highest burden of ZIKV,
but there are unexplained differences in national rates of CZS in
the region. While factors like virulence and case detection likely
contribute to these differences, policy-related factors -particularly,
access to abortion–may also play an important role. However,
abortion is heavily restricted in the majority of Latin American
countries; even when permitted, social norms may interfere with
women’s likelihood of accessing services.
Methods & Materials: We searched PubMed, Scielo, and Google
Scholar for literature on ZIKV and/or CZS and abortion, published
between January 2015 and December 2016, written in English,
Spanish, Portuguese, or French, and used automated and manual
review methods to synthesize the existing information.
Results: From 628 documents returned by our search strategy,
36 publications met our inclusion criteria, the majority of which
were qualitative. Publications were generally in favor of increased
access to safe abortion as an option (policy-level response) for mit-
igating the impact of CZS, but issues with implementation were
referred as the main challenge. Aside from the reform of abortion
regulation in Colombia, we did not find evidence that the ZIKV
epidemic had triggered shifts in abortion policy in other countries.
Conclusion: Although the discussion was open, abortion pol-
icy in the region remained largely unchanged following the ZIKV
epidemic. Further empirical research about abortion access and
differential rates of CZS across Latin American countries is needed.
https://doi.org/10.1016/j.ijid.2018.04.4091
297
UMP. 554
Pittsburgh Sleep Quality Index (PSQI) and
Fatigue Severity Scale (FSS) assessment in
patients with post-Chikungunya chronic
inflammatory rheumatism: a comparative
study of a 2-year follow-up cohort in La
Virginia, Risaralda, Colombia
A.J. Rodriguez-Morales 1 , S.A. Ochoa-Orozco 2,∗ ,
D.M. Sánchez-Castaño 2 , J.D. Corzo-Romero 1 , J.X.
Erazo-Landázuri 1 , D.F. Lopez-Caicedo 1 , J.D.
Montoya-Bernal 1 , T. Franco-Duque 1 , J.A.
Gonzalez Ospina 1 , M. Marin-Peralta 1 , C.A.
Ramírez-Arango 1 , M. Suárez-Tabares 1 , J.C.
Gutiérrez-Segura 1 , A. Rodriguez-Morales 3 , G.J.
Lagos-Grisales 1
1 Public Health and Infection Research Group,
Faculty of Health Sciences, Universidad Tecnológica
de Pereira, Pereira, Risaralda, Pereira, Colombia
2 Psychiatry Postgraduate, Faculty of Health
Sciences, Universidad Tecnológica de Pereira, Pereira,
Risaralda, Pereira, Colombia
3 Neurology & Sleep Medicine, Perth Amboy, NJ,
United States
Background: Long-term consequences of chikungunya (CHIK)
and its chronic inflammatory rheumatism (pCHIK-CIR) are not
fully understood yet and include and increasing number of non-
rheumatological effects, among them, sleep disturbances and
fatigue.
Methods & Materials: In a cohort study among 62 cases serolog-
ically diagnosed in La Virginia, Risaralda, Colombia, followed-up by
2-years, demographic and clinical characteristics were collected at
baseline. Pittsburgh Sleep Quality Index (PSQI) (used with written
permission) and Fatigue Severity Scale (FSS), validated in Spanish
and for Colombia (Cronbach ␣=0.78 and 0.88, respectively), were
applied to patients with pCHIK-CIR (+) and without (-), all under
follow-up at 2 years. Score comparisons (Wilcoxon signed-rank
test) and prevalence proportion (␹2 ) significances were calculated
using Stata IC 14.0® licensed, p significant < 0.05.
Results: We compared 43 patients with persistent rheumato-
logical symptoms (pCHIK-CIR + ) and 19 without it (pCHIK-CIR-),
all them followed-up for 2 years. Mean age was 44.1 y-old, 69%
female. At the PSQI we found significant differences in the wake-up
time (item-3), pCHIK-CIR + do early (median 5:00am versus 6:00am
in those pCHIK-CIR-) (z = 2.699; p = 0.0069), sleep less time (item-
4) (mean 6.46 hours vs 7.79) (z = 2.51; p = 0.0121), they have more
somnolence from < 1 times/week to ≥3 times/week (item-8) (46.5%
vs 10.5%) (␹2 = 7.454; p = 0.006), have somewhat to very big prob-
lem keep up enough enthusiasm to get things done (item-9) (46.5%
vs 10.5%) (␹2 = 7.454; p = 0.006). FSS were significantly higher in
those with pCHIK-CIR + , 55.2 vs 37.5 (z = 2.303; p = 0.0213).
Conclusion: Sleep is significantly impaired among pCHIK-
CIR + patients as well they also presented with more fatigue,
compared to those that recovered during acute phase of disease.
This is the first study in screen these aspects with validated ques-
tionnaires, raising the relevance of such assessments in patients
with acute but also chronic chikungunya consequences. Findings
have significant implications in areas affected by chikungunya epi-
demics, as well later endemic areas with chronic disease.
https://doi.org/10.1016/j.ijid.2018.04.4092