Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Dr C. Handique
PGT,Dept of
“ When the solution
becomes the problem”
Hypersensitivity refers to undesirable reactions produced
by the normal immune system, including allergies
and autoimmunity.
C D
Chronic effects Delayed effects
E
End of treatment
effects
It is an immunologically mediated reaction producing
symptoms unrelated to the pharmacodynamic profile of the
drug, generally occuring with much smaller doses and have
a different time course of onset and duration.
Urticaria is typically a
manifestation of a truly allergic,
Type I reaction, but it may appear
with Type III or pseudoallergic
reactions as well.
Severe nonallergic, hypersensitivity cutaneous reactions
include erythema multiforme, Stevens-Johnson syndrome,
and toxic epidermal necrolysis.
RAST testing
Serum Tryptase
Lab tests done for type II cytolytic reactions
Lab tests for type III immune complex reactions include
ESR
CRP
ANA
AHA
Complement studies
Tissue immunofluroscence studies
Lab tests for type IV
hypersensitivity reaction
Patch test
Immediate Reactions
Urticaria and Angioedema - acetaminophen, and aspirin
Allergic Anaphylaxis - ibuprofen, ketorolac, indomethacin,
acetaminophen, aspirin, diclofenac and celecoxib.
Delayed Reactions
Fixed-drug Eruptions.
Stevens-Johnson Syndrome