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D
espite the thousands of published articles on anterior cruciate agement.3,5,29,39 Nearly 25 years ago, the
ligament (ACL) injury, how to determine which individuals well-known “rule of thirds” was proposed
for ACL injuries treated with rehabilita-
may or may not be candidates for surgical intervention remains
Copyright © 2011 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.
Director, Jerusalem Sports Medicine Institute, Lerner Sports Center, Hebrew University of Jerusalem, Jerusalem, Israel. Address correspondence to Yonatan Kaplan, Jerusalem
1
Sports Medicine Institute, Lerner Sports Center, Hebrew University of Jerusalem, Churchill Str 1, Mount Scopus, Jerusalem, Israel. E-mail: sportmed@zahav.net.il
758 | october 2011 | volume 41 | number 10 | journal of orthopaedic & sports physical therapy
shown that ACL reconstruction actually EMBase, CINAHL, and the Musculosk- and Arthroscopy. Removal of duplicates
restores dynamic knee stability (more eletal Injuries Group’s specialized regis- left a total of 96 potential articles, from
simply understood as not giving-way) or ter. The subject-specific search was based which 12 articles were excluded for not
enables full return to preinjury activity on the terms “anterior cruciate ligament meeting the inclusion criteria, as set forth
level in most individuals.20,62 surgery versus conservative treatment,” in the Methods section, and a further 19
The primary objectives of this nar- “copers,” and “noncopers.” The search was articles were excluded for their poor re-
rative literature review are as follows: restricted to studies that included human search quality. The balance of 65 full-text
to explore the differences and the out- participants and were published in Eng- articles were thus reviewed, of which 5
comes between individuals who have lish. The reference list of relevant articles were randomized controlled trials (RCTs)
ACL reconstruction and those who have was also reviewed to identify additional dealing specifically with the topic of oper-
not undergone surgical intervention; to publications not identified in the formal ated versus nonoperated individuals and
review the evidence related to the ability search strategy. copers versus noncopers.
to identify individuals who may or may
not need surgery after an ACL rupture; RESULTS Definitions: Copers, Noncopers, and
and to describe the differences between Adapters
T
copers and noncopers. he results of the literature ACL injury potentially has deleterious
search are summarized in FIGURE effects on knee muscle function, knee ki-
METHODS 1. The literature search identified nematics, knee stability, and propriocep-
84 articles, and 16 additional articles tion.40 While the majority of individuals
T
he author undertook a comput- were identified through other sources, with an ACL-deficient knee lack dy-
erized bibliographic database search such as communication with content ex- namic knee stability, some seem to have
within the medical and allied health perts in the field of ACL screening and the ability to dynamically stabilize their
literature. The following databases were rehabilitation and the 2010 conference knee, even during pivoting sports activi-
searched from their inception to April proceedings of the American College of ties.10,21,32,37 These individuals may be de-
journal of orthopaedic & sports physical therapy | volume 41 | number 10 | october 2011 | 759
injury, without complaint of instabil- shear forces versus controls.1 Copers per- coper group preferentially used a par-
ity.24,25,40 Noncopers, on the other hand, formed better (P<.05) than noncopers on ticular vastus lateralis and medial ham-
have been defined as individuals who all 4 hop tests.16 Diminished quadriceps strings activation pattern at a frequency
either did not return to their previous control was observed when people with more than twice that observed in the
activity level or experienced giving-way ACLD performed static and dynamic control group.33,34 The noncoper group,
episodes on resumption of preinjury tasks.58 The most striking feature of this compared to the control group, also pref-
Copyright © 2011 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.
activities.16,49,57,58,64 A third category of impaired control was failure to turn the erentially used a medial hamstrings acti-
those described as “adapters” consists quadriceps off when performing flexion vation pattern more than twice as often
of individuals who have been defined as tasks in which the knee extensors are and utilized a distinct medial hamstrings
demonstrating more than 3 mm of side- usually silent. The findings suggest that and lateral hamstrings activation pattern.
to-side difference in ACL laxity at initial poor control of quadriceps activation
examination.15 This definition is, howev- after ACL injury is relatively consistent. Can Noncopers Become Copers?
er, problematic, as laxity measurements Noncopers exhibit a stiffening strategy, Currently, most noncopers are referred
have been reported to have little predic- consisting of lower sagittal plane knee for surgery35,49 without testing whether
tive value in differentiating between cop- motion and knee moments and higher it might be possible for them to become
Journal of Orthopaedic & Sports Physical Therapy®
ers and noncopers.16,56,64 These so-called muscle cocontraction, in comparison true copers and to avoid a surgical proce-
adapters represent the vast majority of with their contralateral limb and indi- dure and the ensuing lengthy rehabilita-
individuals with ACLD who are man- viduals without injuries, to maintain tion process. The first published RCT on
aged nonoperatively and are able to avoid knee stability in the absence of ligamen- the topic indicated that noncopers who
evoking episodes of instability by modify- tous support. Conversely, potential cop- received perturbation training combined
ing their activity levels. ers have movement patterns somewhere with a standard nonoperative ACL reha-
between those of individuals without bilitation program had a greater increase
Differences Between Copers and injuries and those of noncopers.56 In a in Lysholm Knee Rating Scale scores af-
Noncopers recent publication,9 it was reported that, ter training than subjects who received
Researchers have investigated whether at 4 months postinjury, noncopers had only the standard program.7 A more
differences exist between copers and poorer gait performance compared to recent RCT trial studied 26 individuals
noncopers and whether clinicians can copers for kinematics and time-distance with acute ACL injury or rupture of an
identify those patients who may be able variables. Noncopers seem to utilize a ACL graft, who were randomly assigned
to cope with ACLD.31 Evidence suggests common abnormal movement pattern of to either a standard rehabilitation pro-
that potential copers, identified by a lower knee extensor loading even during gram (standard group) or the standard
screening examination, have movement unanticipated tasks. 33 Functional out- program augmented with a perturbation
patterns consistent with those of indi- comes further suggest that a subgroup of training program (perturbation group).22
viduals who have good functional knee noncopers require additional supervised Results of this study led to the conclusion
stability (ie, not giving way), as opposed rehabilitation to pass stringent criteria to that augmenting nonoperative ACL re-
to noncopers.12 It has been reported that return to sports.28 habilitation programs with perturbation
true copers had significantly less ante- Studies have revealed significant dif- training techniques may enhance the
rior tibiofemoral knee joint laxity, fewer ferences in angle-specific knee torque probability of a successful return to high-
giving-way episodes, significantly higher values between potential copers and level physical activity by reducing the risk
activity level, and greater improvement in noncopers (P<.05).6,17 Moderate to strong of continued episodes of giving-way of
760 | october 2011 | volume 41 | number 10 | journal of orthopaedic & sports physical therapy
This allows individuals to maintain their was no existing high-level evidence to copers, and noncopers were retrieved,
functional status for longer periods. More advise current practice management. A only 3 RCTs compared surgical and non-
recently, following a preoperative pertur- more recent systematic review explored surgical treatment. The first 2 RCTs as-
bation training program, it was shown the prognosis of conservatively managed sessed surgical reconstruction of the torn
that noncopers who received perturba- ACL injury.51 The authors concluded ACL,4,59 and the most recently published
tion training and progressive quadriceps that, on average, individuals with an iso- RCT26 compared 2 strategies for manag-
strength training had more symmetrical lated ACL tear or an ACL tear with an ing an ACL tear in a population of non-
strength and knee movements 6 months associated injury (eg, torn meniscus) elite athletes. The authors of the latter
postoperatively compared to noncopers reported good knee function (87/100 concluded that in young, active adults
who received strength training alone.27 A on the Lysholm Knee Scale) at a 12- to with acute ACL tears rehabilitation plus
similar study was conducted using per- 66-month follow-up. On average, func- early ACL reconstruction was not superi-
turbation training on potential copers.11 tional performance assessed with the or to rehabilitation plus optional delayed
It was found that perturbation training hop-for-distance test was in the normal ACL reconstruction. The latter strategy
reduced quadriceps femoris hamstring range. From preinjury to follow-up, there substantially reduced the frequency of
muscle and quadriceps femoris gastroc- was a reduction in Tegner activity level surgical reconstructions. Two observa-
nemius muscle cocontractions and nor- of 21.3%. According to the methods used tional studies have shown similar out-
malized knee kinematics. in the assessed studies, individuals with comes for patients who underwent ACL
a conservatively managed ACL tear have reconstruction.48,49
Surgery Versus Conservative Treatment a good short- to medium-term prognosis
In 2005, a Cochrane review published by in terms of self-reported knee function Algorithms and Screening Examination
a Finnish group44 concluded that there and functional performance. However, As some individuals have the potential to
was insufficient evidence from random- individuals reduced their activity levels manage well without an ACL reconstruc-
ized trials to determine whether surgery by 21%, on average, following injury. tion following an ACL injury, the chal-
or conservative management was best for A closer look at the literature involv- lenge in the management of patients with
journal of orthopaedic & sports physical therapy | volume 41 | number 10 | october 2011 | 761
Chondral defect/repairable
MRI
meniscus, n = 167
Unresolved
Downloaded from www.jospt.org at on November 23, 2015. For personal use only. No other uses without permission.
ACLR , n = 198
Screening examination, n = 345 NC, n = 199
No ACLR, n = 1
Copyright © 2011 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.
ACLR, n = 53
PC, n = 146
Lost to follow-
up, n = 5
Failed
Rehabilitation, n = 88 rehabilitation, ACLR , n = 5
n=5
Unknown RTS,
Journal of Orthopaedic & Sports Physical Therapy®
ACLR, n = 2
n=2
Pass rehabilitation, n = 83
Failed RTS,
ACLR, n = 13
n = 13
FIGURE 3. Treatment and screening examination algorithm outcomes. Abbreviations: ACLR, anterior cruciate ligament reconstruction; MRI, magnetic resonance imaging; NC,
noncoper; PC, potential coper; RTS, return to sports. Reprinted with permission from Hurd et al.35
ACL injury is to develop an algorithm or the use of an algorithm and screening ex- nonreconstructed ACL tears (FIGURE 2).40
screening examination that effectively, amination with that goal in mind,35,40,50 Their main hypothesis was that good
soon after injury, identifies copers and and are specifically discussed below. knee function and a satisfactory activity
noncopers.35 The intention would be to level could be achieved by early activity
create a tool that could potentially identify The Swedish Group Study modification and neuromuscular reha-
those individuals who, early after an ACL A team of Swedish investigators fol- bilitation, thereby limiting the need for
tear, may have the potential to return to lowed 200 individuals with ACL inju- reconstruction surgery.
preinjury activity level for a limited time.23 ries over a 15-year period and reported Their primary findings were that good
Three published papers have reported on on the individuals who had unilateral subjective results and a satisfactory activ-
762 | october 2011 | volume 41 | number 10 | journal of orthopaedic & sports physical therapy
journal of orthopaedic & sports physical therapy | volume 41 | number 10 | october 2011 | 763
examination was 60% (95% CI: 41%, conducting the screening examination training would enable noncopers to walk
78%), while the negative predictive value after 10 sessions of progressive exercise in a manner similar to copers and thereby
of the classification was 30% (95% CI: therapy gave the overall highest explana- improve their knee joint stability.
16%, 49%). This showed that, for all ele- tory values, suggesting that the screening We still do not have the optimal set
ments of the prognostic accuracy profile, examination should be conducted sub- of criteria to correctly assign individuals
the results were not statistically signifi- sequent to a short period of rehabilita- with an ACL tear to the correct treatment
Copyright © 2011 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.
cant, as the 95% CIs included the null tion to inform decision making for ACL early after injury. No single outcome
values for the statistics. The null values reconstruction. measure is sufficient to determine the
for sensitivity, specificity, and positive functional status of individuals with
and negative predictive values were all DISCUSSION ACLD. Consequently, the KOS-Sport,
50%, indicating that the level of prognos- Global Knee Function Rating, hop tests,
C
tic accuracy was no different than ran- ontroversy still exists over and Quadriceps Index should all be in-
dom occurrence. Therefore, the screening whether good functional perfor- cluded when assessing these patients.31
examination had a poor predictive value mance can be achieved in the short Although perturbation training positively
for correctly classifying copers and non- and long term in individuals with ACLD influenced the negative effects following
Journal of Orthopaedic & Sports Physical Therapy®
copers at the 1-year follow-up, bringing who choose a conservative (nonsurgical) ACL injury, it remains uncertain how
into question the use of this screening ex- management approach following injury. long these changes may last and what the
amination and criteria to determine who The primary issue is whether these indi- long-term outcomes are.
should have surgery after ACL injury. viduals can return to preinjury level of A few comments are warranted on
Their investigation provides prelimi- play. outcomes for young active adults with
nary support for the possibility that a There is reasonable evidence to rec- an acute ACL tear who underwent reha-
significant proportion of individuals who ommend that all individuals who sus- bilitation followed by early ACL recon-
are initially considered as potential non- tain ACL injury undergo preoperative struction. Outcomes in this group were
copers may be able to regain dynamic intervention, which includes the timely not superior to those who underwent
knee stability similar to potential copers. application of the algorithm for an evi- rehabilitation followed by optional de-
One year after the screening examina- dence-based determination of the indi- layed ACL reconstruction. In fact, in that
tion, 60% of those originally classified as cation for surgical reconstruction. The study, the latter strategy substantially
potential copers were true copers, while results presented above indicate that a reduced the frequency of surgical recon-
70% of the individuals initially classi- large percentage of individuals identified structions. However, long-term obser-
fied as potential noncopers were also as rehabilitation candidates, using the vational studies of early versus delayed
true copers. Individuals who underwent treatment algorithm and screening ex- ACL reconstruction have shown that
ACL reconstruction, as well as those who amination, who elect nonoperative care delayed surgery may be associated with
followed a conservative rehabilitation were able to delay surgery without expe- a significantly greater rate of damage to
program, showed excellent results on riencing further knee instability. Reha- the meniscus, the articular cartilage, or
functional questionnaires at the 1-year bilitation of the injured knee takes time, both.3,5,29,38,39,54,61
follow-up exam. Thus the Norwegian and there is a concern that excluding po- Given the growing evidence that ear-
group’s study has provided a scientific tential copers from nonoperative treat- ly-onset knee osteoarthritis is a risk after
rationale for not excluding potential non- ment may lead to unnecessary surgery ACL rupture, whether the injury is man-
copers from nonoperative treatment soon in a number of individuals and exclude aged operatively or nonoperatively,38,45,65
764 | october 2011 | volume 41 | number 10 | journal of orthopaedic & sports physical therapy
F
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766 | october 2011 | volume 41 | number 10 | journal of orthopaedic & sports physical therapy