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956
M.P. Santhosh Kumar /J. Pharm. Sci. & Res. Vol. 7(11), 2015, 956-959
957
M.P. Santhosh Kumar /J. Pharm. Sci. & Res. Vol. 7(11), 2015, 956-959
Tablel 2
958
M.P. Santhosh Kumar /J. Pharm. Sci. & Res. Vol. 7(11), 2015, 956-959
Almost all recorded cases of long term numbness or altered 10. Lewin NA, Nelson LH (2006). "Chapter 61: Antidysrhythmics". In
Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin
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anesthetic is used for dental use (no PubMed references for New York: McGraw-Hill. pp. 963–4.
paresthesia with articaine for other medical specialties), and 11. Thomson PD, Melmon KL, Richardson JA, Cohn K, Steinbrunn W,
only affect, in the vast majority of the reports, the lingual Cudihee R, Rowland M (April 1973). "Lidocaine pharmacokinetics
in advanced heart failure, liver disease, and renal failure in humans".
nerve. Ann. Intern. Med. 78 (4): 499–508.
Nonetheless, direct damage to the nerve caused by 4% 12. Collinsworth KA, Kalman SM, Harrison DC (1974). "The clinical
drugs has never been scientifically proven (24). pharmacology of lidocaine as an antiarrhythymic drug". Circulation
Some research points to needle trauma as the cause of the 50 (6): 1
13. Cowan A. Clinical assessment of a new local anesthetic agent –
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14. Yapp KE, Hopcraft MS, Parashos P. Articaine: a review of the
CONCLUSION: literature. Br Dent J. 2011;210:323–329.
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local anaesthetic drug – articaine. Aust Dent J. 2012;57:18–22.
between articaine and lidocaine was observed. An 16. Hintze A, Paessler L. Comparative investigations on the efficacy of
evidence-based approach to the current available literature articaine 4% (epinephrine 1:200,000) and articaine 2% (epinephrine
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anaesthetic for dental use when compared to lidocaine. randomised double-blind study. Clin Oral Investig. 2006;10:145–
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However, practitioners should be aware of a possible, as 17. Fritzsche C, Pässler L. Ultracain D-S und ultracain 2%-suprarenin-
yet unproven, link between 4% concentrations of local vergleichende untersuchungen zur lokalanästhesie in der
anaesthetic solution and nerve damage. zahnärztlichen chirurgie. Quintessenz. 2000;51:507–514.
18. Pogrel MA, Bryan J, Regezi J. Nerve damage associated with
inferior alveolar nerve blocks. J Am Dent Assoc. 1995
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