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DRUG NAME MECHANISM OF INDICATION / CONTRAINDICATION ADVERSE EFFECT

NURSING RESPONSIBILITIES
ACTION

GENERIC: Ampicillin INDICATIONs: CNS: Before:


Ampicillin bactericidal activity Lethargy, Dx:
via inhibition of  Treatment of infections caused by susceptible hallucinations,
BRAND: bacterial cell wall strains of Shigella, Salmonella, Escherichia coli, seizures a. Check doctor’s order
Ampicin synthesis by binding Haemophilus influenzae, Proteus mirabilis, b. Assess history of
Omnipen one or more of the Neisseria gonorrhoeae, enterococci, gram- GI: allergies to penicillins,
Principen penicillin binding positive organisms (penicillin G–sensitive Glossitis, stomatitis, cephalosporins or
UL Ampicillin proteins (PBPs). staphylococci, streptococci, pneumococci) gastritis, sore other allergens
Exerts bacterial  Meningitis caused by Neisseria meningitidis mouth, furry c. monitor renal function
CLASS autolytic effect by  Unlabeled use: Prophylaxis in cesarean section in tongue, black tests
inhibition of certain certain high-risk patients “hairy” tongue, Tx:
THERAPEUTIC: PBPs related to the nausea, vomiting, d. Inspect skin daily and
Anibiotic activation of a CONTRAINDICATION and PRECAUTIONS: diarrhea, instruct patient to do
bacterial autolytic abdominal pain, the same.
PHARMACOLOGIC: process.  Contraindicated with allergies to penicillins, bloody diarrhea, Edx:
Penicillin derivative cephalosporins, or other allergens. enterocolitis, e. Teach that mpicillin
SOURCE:  Use cautiously with renal disorders. pseudomembrano rash is believed to be
DOSAGE: http://www.antimicr us colitis, nonallergenic and
162 mg IV q12hr obe.org/drugpopup nonspecific therefore its
/ampicillin.htm hepatitis appearance is not an
ROUTE: DRUG TO DRUG INTERACTION: absolute
IV You should not take ampicillin if you are taking GU: contraindication to
Theracrys [BCG live (intravesical)]. Nephritis future therapy.
Hematologic: Ane During:
Medications that have serious interactions with mia, Dx:
ampicillin include the following: thrombocytopenia a. Check IV site carefully
, leukopenia, Tx:
 Vivotif (live typhoid vaccine) neutropenia, b. Administer the right
 Warfarin (Jantoven, Coumadin) prolonged drug in the right route and
 Methotrexate (Trexall, Rasuvo, Otrexup) bleeding time dosage at the right time
c. Check the patency of
 Magnesium citrate (Citroma, Citrate of Hypersensitivity: the IV site and IV line
Magnesia) Rash, fever, Edx:
 Exenatide (Byetta, Bydureon) wheezing, d. Explain the purpose
 Acid reflux drugs, such as anaphylaxis and importance of the
 Local: Pain, drug to the patient
like Prevacid (deslansoprazole), Prilosec (omepr
azole), Nexium (esomeprazole), and Protonix phlebitis,
thrombosis at After:
(pantoprazole) injection site Dx:
 Tramadol, (Ultram, Ultracet) (parenteral) a. Check IV site for signs
 Other: Superin of thrombosis or drug
 Doxycycline (Vibramycin, Doryx) fections—oral reaction
 Tiagabine (Gabitril) and rectal Tx:
 Bupropion (Wellbutrin, Zyban, Forfivo XL) moniliasis, b. Notify physician if no
vaginitis improvement is noted
 Allopurinol (Zyloprim, Lopurin, Aloprim) within a few days after
therapy is started.
DRUG TO FOOD INTERACTION:
Edx:
Grapefruit interacts with some antibiotics, but it's not c. This antibiotic is specific
clear whether this includes ampicillin. Be safe, and to your problem and
avoid eating grapefruit or drinking grapefruit juice should not be used to self-
while taking the medication
treat other infections.

d. Report pain or
discomfort at sites, unusual
bleeding or bruising,
mouth sores, rash, hives,
fever, itching, severe
diarrhea, difficulty
breathing.