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A. I only
B. II only
D. I, II and III
(Total 1 mark)
2. A red blood cell is 8 μm in diameter. If drawn 100 times larger than its actual size, what
diameter will the drawing be in mm?
A. 0.08 mm
B. 0.8 mm
C. 8 mm
D. 80 mm
(Total 1 mark)
3. A cell has cytoplasm, a cell wall, naked DNA and ribosomes. Based on this information, what
type of cell could this be?
B. A grasshopper cell
D. A bacterium
(Total 1 mark)
4. What do diffusion and osmosis have in common?
C. Metabolism
D. Movement
(Total 1 mark)
A. Replication
B. Translation
C. Cytokinesis
8. Which pair of features is correct for both a human liver cell and an Escherichia coli cell?
A. ×0.0005
B. ×0.5
C. ×200
D. ×2000
(Total 1 mark)
10. PanI is a gene in cod fish that codes for an integral membrane protein called pantophysin.
Two alleles of the gene, PanIA and PanIB, code for versions of pantophysin, that differ by four
amino acids in one region of the protein. Samples of cod fish were collected from 23 locations
in the north Atlantic and were tested to find the proportions of PanIA and PanIB alleles in each
population. The results are shown in pie charts, numbered 1–23, on the map below. The
proportions of alleles in a population are called the allele frequencies. The frequency of an
allele can vary from 0.0 to 1.0. The light grey sectors of the pie charts show the allele frequency
of PanIA and the black sectors show the allele frequency of PanIB.
[RAJ Case et al. 2005. “Macro- and micro-geographic variation in pantophysin (PanI) allele frequencies in NE
Atlantic cod Gadus morhua.” MEPS. Vol 301. Pp 267–278. Figs 1 and 3.]
(a) (i) State the two populations with the highest PanIB allele frequencies.
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(1)
(ii) State the population in which the allele frequencies were closest to 0.5.
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(1)
(b) Deduce the allele frequencies of a population in which half of the cod fish had the
genotype PanIA PanIA, and half had the genotype PanIA PanIB.
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(1)
The graphs below show the latitude and the mean surface sea temperature in June of the
sampling locations and the frequency of the PanIA allele.
[RAJ Case et al. 2005. “Macro- and micro-geographic variation in pantophysin (PanI) allele frequencies in NE
Atlantic cod Gadus morhua.” MEPS. Vol 301. Pp 267–278. Figs 1 and 3.]
(c) State the relationship between
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(1)
(ii) mean surface sea temperature in June and the frequency of the PanIA allele.
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(1)
(d) Suggest how natural selection could have caused the relationships shown in the graphs.
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(2)
(e) The sites close to Iceland, at a latitude of 60–65°, had very varied allele frequencies, with
both PanIA and PanIB occurring. The water at these sample sites was highly stratified,
with much warmer water at the surface and much colder water below. Suggest reasons
for both PanIA and PanIB alleles occurring at these sites.
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(2)
(f) Using the data in this question, predict the effects of global warming on cod fish
populations.
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(2)
(Total 11 marks)
11. Up to two additional marks are available for the construction of your answers.
(2)
(a) Escherichia coli is a unicellular organism, so each cell must carry out all of the processes
required for life. Outline the functions of each of the structures in the cells of
Escherichia coli.
(9)
(c) Compare how pyruvate is used in human cells when oxygen is available and when
oxygen is not available.
(5)
(Total 20 marks)
12. The electron micrograph below shows the ultrastructure of part of an animal cell.
[Source: Reproduced with the kind permission of the Electron Microscopy Facility, Trinity College, Hartford,
Connecticut, USA, and Professor Daniel G. Blackburn.]
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(1)
(b) Explain briefly how materials produced in the structure labelled I are transported to the
plasma membrane.
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(2)
(c) Outline the function of the mitochondria in the cell.
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(2)
(d) Suggest why the two labelled mitochondria are different shapes in the micrograph.
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(1)
(Total 6 marks)
13. The electron micrograph below shows an organelle in a eukaryotic cell. What is the area
labelled X and what is the type of reaction occurring there?
[Source: http://scienceblogs.com/clock/2006/11/cell_structure.php]
X Reaction
A. matrix photolysis
B. stroma Krebs cycle
C. stroma photolysis
D. matrix Krebs cycle
(Total 1 mark)
14. In which of the following cells can more than one nucleus be found?
A. An unfertilized egg
B. Neuron
C. Sertoli cell
D. Muscle fibre
(Total 1 mark)
A. Replication
B. Translation
C. Cytokinesis
A. A
B. B
C. C
D. D
(Total 1 mark)
17. This question refers to the following micrograph of a liver cell.
B. Translation
C. mRNA production
D. Vesicle formation
(Total 1 mark)
18. The micrograph below shows an adult human stem cell.
(a) The cell cycle can be divided into two parts: interphase and mitosis.
(i) Identify, with a reason, whether the stem cell in the micrograph is in interphase or
mitosis.
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(1)
(ii) Deduce two processes that occur in human cells during this part of the cell cycle,
but not during the other part.
1. .......................................................................................................................
2. .......................................................................................................................
(2)
(b) State two characteristics of stem cells that can be used to distinguish them from other
body cells.
1. ..................................................................................................................................
2. ..................................................................................................................................
(2)
(c) Outline one therapeutic use of stem cells.
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(3)
(Total 8 marks)
DNA associated
70S ribosomes 80S ribosomes Naked DNA
with proteins
A. prokaryote eukaryote prokaryote eukaryote
B. eukaryote prokaryote eukaryote prokaryote
C. eukaryote prokaryote prokaryote eukaryote
D. prokaryote eukaryote eukaryote prokaryote
(Total 1 mark)
23. Which events occur during the G1 phase and S phase of the cell cycle?
G1 phase S phase
A. DNA replicates cell grows
B. mitosis begins cell divides
C. cell divides mitosis begins
D. cell grows DNA replicates
(Total 1 mark)
24. In a cell, what is the effect of a large surface area to volume ratio?
A. Nucleus
B. Nucleoid
C. Nucleolus
D. Nuclear membrane
(Total 1 mark)
A. Mitochondria
B. 70S ribosomes
C. Histones
D. Internal membranes
(Total 1 mark)
28. What happens during the G2 stage of interphase?
B. Synthesis of proteins
D. Replication of DNA
(Total 1 mark)
29. Up to two additional marks are available for the construction of your answers.
(2)
(a) Explain why DNA must be replicated before mitosis and the role of helicase in DNA
replication.
(4)
(b) Explain how the base sequence of DNA is conserved during replication.
(5)
30. Up to two additional marks are available for the construction of your answers.
(2)
(a) Plants are a diverse group of eukaryotic organisms. Describe the different characteristics
of the bryophyta, filicinophyta, coniferophyta and angiospermophyta.
(9)
(b) Plants store carbohydrate in the form of starch. Explain the reasons for starch being
digested by the human digestive system.
(4)
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(2)
(b) Explain how chemical bonding between water molecules makes water a valuable coolant
in living organisms.
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(2)
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(2)
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(2)
(Total 8 marks)
32. Up to two additional marks are available for the construction of your answers.
(2)
(a) Compare simple diffusion with facilitated diffusion as mechanisms to transport solutes
across membranes.
(5)
33. Which of the following take(s) place during either interphase or mitosis in animal cells?
A. I only
B. I and II only
A. To produce ADP
D. To synthesize proteins
(Total 1 mark)
35. Up to two additional marks are available for the construction of your answers.
(2)
(a) Eukaryotic cells have intracellular and extracellular components. State the functions of
one named extracellular component.
(4)
(c) Translation occurs in living cells. Explain how translation is carried out, from the
initiation stage onwards.
(9)
(Total 20 marks)
36. (a) The scanning electron micrograph below shows the surface of the nuclear envelope with
numerous nuclear pores.
[Source: adapted from D Nelson and M Cox, (2000), Lehninger Principles of Biochemistry, third edition, page 35]
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(1)
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(1)
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(1)
(c) Describe the importance of stem cells in differentiation.
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(3)
(i) Predict, with a reason, how the graphs will change if the woman becomes
pregnant.
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(2)
(ii) List two roles of testosterone in males.
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(1)
(Total 9 marks)
A. G1 → S → G2 → mitosis → cytokinesis
B. mitosis → G1 → G2 → cytokinesis → S
C. G1 → G2 → S → mitosis → cytokinesis
D. G1 → G2 → mitosis → cytokinesis → S
(Total 1 mark)
38. What is the difference between the structure of all prokaryotes and all eukaryotes?
Prokaryotes Eukaryotes
A. cell wall no cell wall
B. chloroplasts no chloroplasts
C. flagellum no flagellum
D. nucleoid nuclear envelope
(Total 1 mark)
39. What does facilitated diffusion across a cell membrane require?
40. The graph below represents the amount of DNA during the cell cycle. Which part of the graph
represents metaphase?
(Total 1 mark)
41. The following sequence of pictures, made using an electronic imaging technique, shows a cell
undergoing division.
[Adapted by permission from Macmillan Publishers Ltd, Fuller, B G et al. 2008. “Midzone activation of aurora B in
anaphase produces an intracellular phosphorylation gradient”. Nature. Vol 453.]
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(1)
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(2)
(c) State the process that results in tumour (cancer) formation or development.
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(1)
(d) Explain, using one example, how non-disjunction in meiosis can lead to changes in
chromosome number.
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(2)
(Total 6 marks)
42. When observing the behaviour of a vesicle in a cell, what identifies it as a vesicle only involved
in exocytosis?
C. Secretion of material
43. Up to two additional marks are available for the construction of your answers.
(2)
(b) Describe the events that occur in the four phases of mitosis in animals.
(6)
(c) Explain the process of aerobic cell respiration after glycolysis has occurred.
(8)
(Total 20 marks)
44. How does the surface area to volume ratio change with an increase in cell size?
(Total 1 mark)
A. By mitosis
B. By meiosis
C. By budding
D. By binary fission
(Total 1 mark)
46. What can the extracellular matrix of cells be made of?
I. Polysaccharide
II. Glycoprotein
III. Phospholipid
A. I only
B. I and II only
D. I, II and III
(Total 1 mark)
A. G1
B. S
C. G2
D. Mitosis
(Total 1 mark)
48. What is the difference between simple diffusion and facilitated diffusion?
A. Embryological development
D. Cell growth
(Total 1 mark)
A. Mitochondria
B. Cell walls
C. Chloroplasts
D. Ribosomes
(Total 1 mark)
A. Mitosis
B. Meiosis
C. Conjugation
D. Binary fission
(Total 1 mark)
52. Below is a micrograph of an E. coli bacterium undergoing reproduction.
[Source: www.bio.mtu.edu/campbell/prokaryo.htm]
The scale bar represents 0.5 μm. How long are both cells in total?
A. 5.0 × 10–6 m
B. 5.0 × 10–9 m
C. 2.5 × 10–6 m
D. 2.5 × 10–9 m
(Total 1 mark)
53. Below is a micrograph of an E. coli bacterium undergoing reproduction.
[Source: www.bio.mtu.edu/campbell/prokaryo.htm]
A. Nucleoid region
B. Chromatin
C. Histones
D. Endoplasmic reticulum
(Total 1 mark)
54. The diagram below shows a plasma membrane. What is molecule X?
A. Cholesterol
B. Peripheral protein
C. Glycoprotein
55. What is a difference between a cell in the G1 phase and a cell in the G2 phase of the cell cycle?
B. A cell in the G2 phase would have more mitochondria than a cell in the G1 phase.
C. A cell in the G1 phase would have more DNA in its chromosomes than a cell in the G2
phase.
[Source: www.microbiology.umaryland.edu/images/bact_em.jpg]
(a) Identify the structures labelled A and B in the electron micrograph above and state one
function of each.
A: Name .......................................................................................................
Function .......................................................................................................
B: Name .......................................................................................................
Function .......................................................................................................
(2)
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(3)
(Total 5 marks)
57. Up to two additional marks are available for the construction of your answers.
(2)
(b) Outline how vesicles are used to transport materials secreted by a cell.
(6)
(c) Explain how the structure of a villus in the small intestine is related to its function.
(7)
(Total 20 marks)
58. (a) State the property of stem cells that makes them useful in medical treatment.
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(1)
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(2)
(c) Outline some of the outcomes of the sequencing of the human genome.
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(3)
(Total 6 marks)
59. Up to two additional marks are available for the construction of your answers.
(2)
(b) Outline how three different environmental conditions can affect the rate of
photosynthesis in plants.
(6)
(c) Explain how the emission of gases, both naturally and through human activity, can alter
the surface temperature of the Earth.
(8)
(Total 20 marks)
60. Which of the following is not a function performed by a membrane protein?
B. Cell adhesion
C. Enzyme synthesis
61. Up to two additional marks are available for the construction of your answers.
(2)
62. If a Sequoia sempervirens tree is 100 m tall and a drawing of it is 100 mm tall, what is the
magnification of the drawing?
A. ×0.001
B. ×0.1
C. ×1.0
D. ×1000
(Total 1 mark)
63. Which of the following structures does Escherichia coli have?
I. 70S Ribosomes
II. Pili
III. Nucleus
A. I only
B. I and II only
D. I, II and III
(Total 1 mark)
64. What feature do plant cells have but not animal cells?
A. Plasma membranes
B. Mitochondria
C. Cell walls
D. 80S ribosomes
(Total 1 mark)
65. Cells in the adrenal gland produce the hormone epinephrine and store it in vesicles. To release
epinephrine these vesicles are carried to the plasma membrane and fuse with it. What process is
occurring?
A. Expulsion
B. Exchange
C. Excretion
D. Exocytosis
(Total 1 mark)
66. During reproduction in flowering plants an embryo sac is produced, containing one haploid
nucleus.
This haploid nucleus divides by mitosis three times. What is produced?
67. Up to two additional marks are available for the construction of your answers.
(2)
(a) Draw a labelled diagram to show the fluid mosaic structure of a plasma membrane,
indicating the hydrophilic and hydrophobic regions.
(5)
(b) Distinguish between active and passive movements of materials across plasma
membranes, using named examples.
(4)
(c) Explain how the properties of water are significant to living organisms.
(9)
(Total 20 marks)
A. Developing genetically identical cultures of human cells for use in drug testing
B. Helping infertile couples to conceive by injecting the father’s sperm into the mother’s
egg
(b) Distinguish between active and passive movements of materials across plasma
membranes, using named examples.
(4)
(c) Explain how chemiosmosis assists in ATP production during oxidative phosphorylation.
(9)
(Total 20 marks)
70. What is the correct order of increasing size for the following biological structures?
A. I III II IV
B. I III IV II
C. III I II IV
D. III II I IV
(Total 1 mark)
71. Which of the following structures are present in both plant and animal cells?
I. Cell wall
II. Chloroplast
III. Mitochondrion
A. I only
B. I and II only
D. III only
(Total 1 mark)
72. In viewing an electron micrograph of a cell, ribosomes, pili and a single circular chromosome
are observed. What other structure is likely to be present?
B. Mitochondria
C. A nuclear membrane
D. A plasmid
(Total 1 mark)
73. The DNA of a particular cell is damaged, so that the cell continues to divide uncontrollably.
What is the possible result?
B. AIDS
C. Tumour formation
D. Down syndrome
(Total 1 mark)
74. What is produced as a result of mitosis?
A. Two cells, each containing half the number of chromosomes of the original cell
B. Two cells, each containing the same number of chromosomes as the original cell
C. Four cells, each containing the same number of chromosomes as the original cell
D. Four cells, each containing half the number of chromosomes of the original cell
(Total 1 mark)
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(1)
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(2)
(c) Explain how the properties of phospholipids help to maintain the structure of cell
membranes.
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(3)
(Total 6 marks)
76. Up to two additional marks are available for the construction of your answers.
(2)
B. Vesicle formation
C. Use of ATP
D. Secretion
(Total 1 mark)
78. Up to two additional marks are available for the construction of your answers.
(2)
(b) Outline the role of chlorophyll and the effects of temperature, light intensity and carbon
dioxide concentration on the rate of photosynthesis.
(6)
(c) Explain the production of energy during aerobic respiration from pyruvate that has been
produced by glycolysis.
(8)
(Total 20 marks)