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The pancreatic islet, also known as the Islets of Langerhans, contains different cell types that help regulate blood sugar levels. It contains alpha, beta, delta, gamma, and epsilon cells that produce various hormones such as glucagon, insulin, somatostatin, pancreatic polypeptide, and ghrelin respectively. The beta cells make up 75% of the islet and produce insulin which helps process and store glucose. Other cell types work to increase or decrease blood sugar levels as needed. The pancreas also contains acinar cells that synthesize digestive enzymes, interlobular connective tissue for support, interlobular ducts that secrete bicarbonate, and Pacinian corpuscles that detect
The pancreatic islet, also known as the Islets of Langerhans, contains different cell types that help regulate blood sugar levels. It contains alpha, beta, delta, gamma, and epsilon cells that produce various hormones such as glucagon, insulin, somatostatin, pancreatic polypeptide, and ghrelin respectively. The beta cells make up 75% of the islet and produce insulin which helps process and store glucose. Other cell types work to increase or decrease blood sugar levels as needed. The pancreas also contains acinar cells that synthesize digestive enzymes, interlobular connective tissue for support, interlobular ducts that secrete bicarbonate, and Pacinian corpuscles that detect
The pancreatic islet, also known as the Islets of Langerhans, contains different cell types that help regulate blood sugar levels. It contains alpha, beta, delta, gamma, and epsilon cells that produce various hormones such as glucagon, insulin, somatostatin, pancreatic polypeptide, and ghrelin respectively. The beta cells make up 75% of the islet and produce insulin which helps process and store glucose. Other cell types work to increase or decrease blood sugar levels as needed. The pancreas also contains acinar cells that synthesize digestive enzymes, interlobular connective tissue for support, interlobular ducts that secrete bicarbonate, and Pacinian corpuscles that detect
(a) Pancreatic It is also called as Islet of Langerhans. It has either
islet round or oval shaped that contains islands of small cells which helps in regulate blood sugar level by producing hormones. There are five different types produced by it, first and foremost, it is alpha cell that produces glucagon, it occupies approximately 15% of pancreatic islet. Alpha cell will produce hormone glucagon when our blood sugar level is low . Glucagon converts glycogen into glucose in order to raise the blood sugar level. Next, in the purpose of reducing our blood sugar level, beta cell produces insulin and amylin. Hormone insulin synthesizes the glycogen, protein and fatty acids followed by facilitating the uptake of glucose into cells and stimulates the liver cell to activate glucokinase (an enzyme that converts glucose into glucose-6 phosphate and acts as glucose sensor). Beta cells occupies the most in the pancreatic islet which is approximate 75% and mostly located in the centre. However, the amylin aids to slow down the speed of gastric emptying and prevents spikes in blood sugar level. Delta cells also locates in the pancreatic islet that play a role as secreting somatostatin to inhibit the release of alpha and beta cells. Other than that, gamma cell produces pancreatic polypeptide that stimulates gastric chief cells, supresses the production of bile and the secretion of bicarbonate. Lastly, epsilon cells produces ghrelin that makes us feel hungry. ("The Pancreas | Boundless Anatomy and Physiology", n.d.) (b) Interlobular It is dense and collagenous tissue. Interlobular connective connective ducts associates the interlobular duct to tissue support blood and lymph vessels, nerve ,ganglia and pancreatic duct. ( c) Interlobular It is also called as intercalated duct. It has the lining duct of cuboidal epithelial cells that secrete bicarbonate ions into the secretory products. This duct is extended to acinar lumen which stains centroacinar cells. It is also contains a small amount of connective tissues surrounds them which may lead to a larger interlobular duct that is prominent connective tissue septa. When the ducts are lined with a low columnar epithelium , it may contain goblet cells which plays vital roles in mucosal protection. (d) Acinar cell Acinar comes from the Latin word acinus which means berry .Indeed, it has a likely berry-shaped and located in the exocrine cells of pancreas. It synthesizes protein for exporting in a proactive way .Hence, it is reflected in their bizonal staining properties. Homogenzone which is the hemotoxylin commonly stains intensely the basal region of these secretory cells due to the presence of regimented endoplasmic reticulum which contains ribosomes that synthesize the protein . Zymogen zone which means that the presence of large amounts of zymogen granules containing high concentrations of protein is because of the intense eosin staining in the apical region of the secretory cells. After we took a meal ,there is least abundant of these granules in the acinar cell. ( e) Pacinian The It has oval-shaped and has a lining of corpuscle connective tissues. In its centre, there is an inner core that have a myelinated nerve ending. A resemble of layers of an onion is surrounded the core of layers of flattened cells.It is one of the major types of mechanoreceptor which has high density occurring in area that are for the sensitivity to touch. It is found within joint capsule carry information to the central nervous system regarding the differences of joint pressure, they triggers action potential to happen in the free nerve ending embedded within them. ("What Is the Function of the Pacinian Corpuscles?", n.d.) (f) Blood vessel As we know, blood vessels play a role of supplying nutrients and oxygen to all types of cells. However, it is also found that it helps in pancreas formation from early specification of the initial pancreatic bud which means maturation or growth of the pancreatic bud. It is essential for the endocrine specification at the onset of pancreatic budding .After a few days, blood vessels inhibit pancreatic branching and exocrine differentiation.