Subject: Chem 121 (lec) Topic 4 (4.

5 hours)
Course Description: Organic Chemistry I ACIDS AND BASES
(Lecture) A. Introduction to Bronsted-Lowry Acids
Prerequisite: Chem 101 (lec and lab) and Bases
Course credit: 3.0 (3.0 hours per week) B. Flow of selection density: Curved
arrow notation
TOPIC 1 (4.5 hours): C. Bronsted-Lowry Acidity:
WMSU VMGO, Classroom Policies, Course D. Quantitative and Qualitative
Overview, Course Requirements, Grading Perspective
System E. Position of equilibrium and choice
of reagents
INTRODUCTION TO ORGANIC CHEMISTRY F. Levelling and Solvation Effects
AND A REVIEW OF GENERAL CHEMISTRY G. Counter Ions
A. The Structural Theory of Matter H. Lewis acids and bases
B. Electrons, Bonds, and Lewis Structures
C. Identifying Formal Charges Topic 5 (4.5 hours)
D. Induction and its Effects to Reactivity of ALKANES AND CYCLOALKANES
Organic Compounds A. Introduction to alkanes
E. Atomic Orbitals B. Isomerism of alkanes and its
F. Valence Bond Theory stability
G. Molecular Orbital Theory C. Sources and uses
H. Hybridized Atomic Orbitals D. Newmann projection and
I. VSEPR Theory: Predicting Geometry conformational analysis of ethane and
J. Dipole Moments and Molecular butane
K. Polarity E. Cycloalkane, substituted
L. Intermolecular Forces and Physical F. Cycloalkanes and polycyclic Systems:
Properties 1. conformations
2. cis-trans isomerism
TOPIC 2 (3.0 hours)
MOLECULAR REPRESENTATIONS Topic 6 (3 hours)
A. Molecular Representations STERIOISOMERISM
B. Bond-Line Structures A. Overview
C. Identifying Functional Groups B. Cahn-Ingold system
D. Carbon Atoms with Formal Charges C. Optical activity
E. Identifying Lone Pairs D. Enantiomers and diastereomers
F. 3-D Bond-Line Structures E. Symmetry and Chirality
G. Introduction to Resonance F. Fisher Projections
H. Curve Arrows G. Conformationally mobile systems
I. Formal Charges in Resonance H. Resolution of enantiomers
J. Drawing Resonance Structures Via
K. Pattern Recognition
L. Assessing Relative Importance of
Resonance Structures

Topic 3 (4.5 hours)

NOMENCLATURE OF ORGANIC
COMPOUNDS
A. Hydrocarbons
B. Hydrocarbon Derivatives
C. Polyfunctional Compounds
Topic 7 (3 hours) Topic 11 (4.5 hours)
CHEMICAL REACTIVITY AND ALKYNES
MECHANISMS A. Introduction to alkynes
A. Enthalpy, entropy and Gibbs B. Acidity of terminal alkynes
B. Energy C. Preparations and reactions of
C. Equillibria and kinetics D. alkynes
D. Reading energy diagrams E. Synthesis strategies
E. Nucleophiles and electrophiles
F. Mechanisms and arrow pushing FINAL EXAM
G. Patterns of curved arrows
H. Drawing curved arrows
I. Rearrangements of carbocations
J. Reversible and irreversible reaction
K. arrows

Topic 8 (6 hours)
SUBSTITUTION REACTIONS AND ALKYL
HALIDES
A. Introduction to substitution
B. Reactions
C. Alkyl halides
D. Mechanisms for substitution
E. SN2 and Sn1 mechanisms
F. Determination of predominant
G. mechanisms
H. Reagents to accomplish functional
I. group transformation

MIDTERM EXAM

Topic 9 (6 hours)
ALKENES AND ELIMINATION REACTIONS
A. Alkenes in nature and industry
B. Stereoisomerism and stability
C. Introduction to elimination
D. Reactions and its mechanisms
E. E2 and E1 mechanisms
F. Substitution vs. elimination
G. Reactions

Topic 10 (6 hours)
ALKENES AND ADDITION REACTIONS
A. Introduction to addition reactions
B. Addition vs. elimination reactions
C. Reactions
D. Types of addition reactions
E. Predicting products in addition
F. Reactions
G. Synthesis strategies