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Abstract
CN1066652A
The present invention provides a new method of preparing thioglycolic acid. It makes sodium
China
thiosulfate react with sodium monochloroacetate in water so as to produce carboxy methyl sodium
thiosulfate, and then makes that react with sul de or hydrosul de so as to synthesize thioglycolic
acid. Said method is simple in equipment and technological process, its contamination is less, and Download PDF Find Prior Art Similar
as compared with thiourea method its product cost is less than 30, therefore it can be directly used
as chemicals for ore-dressing. Other languages: Chinese
Inventor: 刘增方
Worldwide applications
1991 CN
A thioglycolic acid production methods, sodium thiosulfate and sodium monochloroacetate reaction into water and the resulting carboxymethylcellulose sodium thiosulfate,
characterized in that the resulting compound and then with the sul de or hydrosul de The reaction was to produce thioglycolic acid.
2. A method as described in claim, wherein said sul de may be sodium sul de, potassium sul de, ammonium sul de, said sulfur hydride may be sodium hydrosul de,
potassium hydrosul de, ammonium hydrosul de.
The present invention is a novel method for producing a chemical product of thioglycolic acid.
Thioglycolic acid and derivatives thereof, are widely used as hair, depilatories, pharmaceutical processing, the synthetic polymer additives. Currently, the production
thioglycolate There are three main ways: First, thiourea, this method is simple device, easy to operate, but because of the use of expensive raw materials, so the higher
cost of the product; Second sodium hydrosul de method, the method using inexpensive starting materials , so that the product cost is low, but the complexity of the
device, strict operation, and the generation of hydrogen sul de contamination; Third method sodium thiosulfate. Published in 1983, "Chemical Abstracts" 99:53146c,
discloses a technique similar to the present invention - Soviet Union Patent No. 1014829, the technology is: a rst thiosulfate and sodium monochloroacetate into the
water so that the reaction solution at 70 ~ 75 ℃ carboxymethylcellulose sodium thiosulfate, then cooled, nitrogen gas was blown to the reaction injection sulfate and the
sulfuric acid content in the reaction mixture is from 20 to 24.5%, nally, rapidly heated, and hydrolysis at 100 ~ 110 ℃, it generates thioglycolic acid. This method of
production of thioglycolic acid, low price, simple equipment, but the process is still too complicated, and because the product solution contains more sulfate, corrosive,
should not be directly used as a pharmaceutical processing and the like.
Object of the present invention is to overcome the above-described production of thiosulfate is less than the thioglycolate, simplifying the process, reducing production
costs.
The present invention is implemented as follows: After the sodium thiosulfate and sodium monochloroacetate into the water, the reaction of carboxymethylcellulose
sodium thiosulfate, and then subjected to a chemical reaction with a sul de or hydrosul de thus prepare thioglycolic acid . Sul de can be used sodium sul de, potassium
sul de, ammonium sul de; sulfur hydride may be sodium hydrosul de, potassium hydrosul de, ammonium hydrosul de.
The method of making the present invention is thioglycolic acid, the process equipment is simple, low pollution, low product cost, product strongly alkaline solution is
neutral, can be used directly to pharmaceutical processing and the like.
Here are two embodiments of the invention: Example 1, 147.6 g sodium thiosulfate taken (Na2S2O3 · 5H2O) and 140 g of a 41.2% sodium monochloroacetate solution,
put into a beaker, stirred and heated to 70 ~ 75 ℃, for 20 minutes at this temperature, carboxymethylcellulose sodium thiosulfate generated. After cooling, was added
14.2% | g / ml | 300 ml of sodium sulphide, 20 min, thioglycolic acid to prepare 43.70 g, yield 95.8%.
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Example 2, take 140 g of 41.2% sodium monochloroacetate aqueous solution and 147.6 g sodium thiosulfate, placed in a beaker, stirred and heated to 70 ~ 75 ℃,
reacted at this temperature for 20 minutes so as carboxymethyl thio sodium. After cooling, was added 30% | g / ml | aqueous sodium hydrosul de 120 ml, for 20 minutes,
to obtain 44 g of thioglycolic acid, 96.5% yield.
Cited By (4)
CN102584657A * 2011-12-27 2012-07-18 杭州海虹精细化工有限公司 Preparation method of persul de/sul de zinc acetate
CN104059003A * 2014-06-06 2014-09-24 湖北犇星化工有限责任公司 Preparation method of aqueous solution of thioglycollic acid
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Priority Applications (1)
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2000-07-05 C19 Cessation of patent right (cessation of patent right due to non-paymentof the annual fee)
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