Sei sulla pagina 1di 3

9/24/2019 CN1066652A - Mercaptoacetic acid preparation method - Google Patents

 Patents Sign In

Mercaptoacetic acid preparation method

Abstract
CN1066652A
The present invention provides a new method of preparing thioglycolic acid. It makes sodium
China
thiosulfate react with sodium monochloroacetate in water so as to produce carboxy methyl sodium
thiosulfate, and then makes that react with sul de or hydrosul de so as to synthesize thioglycolic
acid. Said method is simple in equipment and technological process, its contamination is less, and Download PDF Find Prior Art Similar
as compared with thiourea method its product cost is less than 30, therefore it can be directly used
as chemicals for ore-dressing. Other languages: Chinese

Inventor: 刘增方

Worldwide applications

1991 CN

Application CN 91103042 events

1991-05-14 Application led by 西安有色金属研究所

1991-05-14 Priority to CN 91103042

1992-12-02 Publication of CN1066652A

1997-09-24 Application granted

1997-09-24 Publication of CN1035943C

Info: Cited by (4), Legal events, Similar documents, Priority and


Related Applications

External links: Espacenet, Global Dossier, Discuss

Claims (2) Hide Dependent


translated from Chinese

A thioglycolic acid production methods, sodium thiosulfate and sodium monochloroacetate reaction into water and the resulting carboxymethylcellulose sodium thiosulfate,
characterized in that the resulting compound and then with the sul de or hydrosul de The reaction was to produce thioglycolic acid.

2. A method as described in claim, wherein said sul de may be sodium sul de, potassium sul de, ammonium sul de, said sulfur hydride may be sodium hydrosul de,
potassium hydrosul de, ammonium hydrosul de.

Description translated from Chinese

The present invention is a novel method for producing a chemical product of thioglycolic acid.

Thioglycolic acid and derivatives thereof, are widely used as hair, depilatories, pharmaceutical processing, the synthetic polymer additives. Currently, the production
thioglycolate There are three main ways: First, thiourea, this method is simple device, easy to operate, but because of the use of expensive raw materials, so the higher
cost of the product; Second sodium hydrosul de method, the method using inexpensive starting materials , so that the product cost is low, but the complexity of the
device, strict operation, and the generation of hydrogen sul de contamination; Third method sodium thiosulfate. Published in 1983, "Chemical Abstracts" 99:53146c,
discloses a technique similar to the present invention - Soviet Union Patent No. 1014829, the technology is: a rst thiosulfate and sodium monochloroacetate into the
water so that the reaction solution at 70 ~ 75 ℃ carboxymethylcellulose sodium thiosulfate, then cooled, nitrogen gas was blown to the reaction injection sulfate and the
sulfuric acid content in the reaction mixture is from 20 to 24.5%, nally, rapidly heated, and hydrolysis at 100 ~ 110 ℃, it generates thioglycolic acid. This method of
production of thioglycolic acid, low price, simple equipment, but the process is still too complicated, and because the product solution contains more sulfate, corrosive,
should not be directly used as a pharmaceutical processing and the like.

Object of the present invention is to overcome the above-described production of thiosulfate is less than the thioglycolate, simplifying the process, reducing production
costs.

The present invention is implemented as follows: After the sodium thiosulfate and sodium monochloroacetate into the water, the reaction of carboxymethylcellulose
sodium thiosulfate, and then subjected to a chemical reaction with a sul de or hydrosul de thus prepare thioglycolic acid . Sul de can be used sodium sul de, potassium
sul de, ammonium sul de; sulfur hydride may be sodium hydrosul de, potassium hydrosul de, ammonium hydrosul de.

The method of making the present invention is thioglycolic acid, the process equipment is simple, low pollution, low product cost, product strongly alkaline solution is
neutral, can be used directly to pharmaceutical processing and the like.

Here are two embodiments of the invention: Example 1, 147.6 g sodium thiosulfate taken (Na2S2O3 · 5H2O) and 140 g of a 41.2% sodium monochloroacetate solution,
put into a beaker, stirred and heated to 70 ~ 75 ℃, for 20 minutes at this temperature, carboxymethylcellulose sodium thiosulfate generated. After cooling, was added
14.2% | g / ml | 300 ml of sodium sulphide, 20 min, thioglycolic acid to prepare 43.70 g, yield 95.8%.

https://patents.google.com/patent/CN1066652A/en 1/3
9/24/2019 CN1066652A - Mercaptoacetic acid preparation method - Google Patents
Example 2, take 140 g of 41.2% sodium monochloroacetate aqueous solution and 147.6 g sodium thiosulfate, placed in a beaker, stirred and heated to 70 ~ 75 ℃,
reacted at this temperature for 20 minutes so as carboxymethyl thio sodium. After cooling, was added 30% | g / ml | aqueous sodium hydrosul de 120 ml, for 20 minutes,
to obtain 44 g of thioglycolic acid, 96.5% yield.

Cited By (4)

Publication number Priority date Publication date Assignee Title

CN102229548A * 2011-05-16 2011-11-02 潍坊益华化工有限公司 Method for producing thioglycollic acid

CN102584657A * 2011-12-27 2012-07-18 杭州海虹精细化工有限公司 Preparation method of persul de/sul de zinc acetate

CN104059003A * 2014-06-06 2014-09-24 湖北犇星化工有限责任公司 Preparation method of aqueous solution of thioglycollic acid

CN104193658A * 2014-08-21 2014-12-10 湖南立新环保科技发展有限公司 Method for preparing mercaptoacetic acid

Family To Family Citations

* Cited by examiner, † Cited by third party, ‡ Family to family citation

Similar Documents

Publication Publication Date Title

US3159640A 1964-12-01 Process for preparing 2-mercaptopyridine-nu oxide

Owen 1967 Amino-alkanethiols from amino-alcohols via aminoalkyl sulphates and thiazolidinethiones

JPS62253626A 1987-11-05 Production of polyarylene sul de

US2500019A 1950-03-07 Method of producing polycarboxylic amino acids

US3383170A 1968-05-14 Process for the recovery of sulphur dioxide and ammonia

SE8200513L 1982-09-17 Process for the tell up of a binder consisting of modi ed vegetable protein

GB963089A 1964-07-08 Process for the production of uorine compounds from uosilicic acid

SE7904257L 1979-11-19 Seen to be stella pure alumina by the attack of chlorine wheat aluminous ores and avlegsnande of pollution by a sulfuric acid treatment

Gresham et al. 1952 β-Propiolactone. XIII. Reactions with Sodium Nitrite, Sodium Dithionite, Sodium Cyanide, Sodium Thiocyanate, Sodium Succinimide and
Aryl Sul nic Acids and Their Salts1

JPH04145127A 1992-05-19 Production of polyarylene sul de

TW228504B 1994-08-21 Regeneration of sulfuric acid from sulfate by-products of 2-hydroxy-4-(methylthio) butyric acid manufacture

JPH03215526A 1991-09-20 Production of polyarylene sul de

CN100590069C 2010-02-17 Method for preparing boron nitride coating carbon nano-tube/nano-wire and boron nitride nano-tube

US3411875A 1968-11-19 Process for the production of anhydrous hydrosul tes

GB1084096A 1900-01-01

CN1024124C 1994-04-06 Prepn. method for lithium carbonate by using precipitate of ammonium carbonate

JPH01272564A 1989-10-31 Production of inner ole n sulfonate

CN1007350B 1990-03-28 Process for degradation of alkyl polysul de to polysul de of low sulfur

JPH02124880A 1990-05-14 Production of ebselen in highly pure form

US2277778A 1942-03-31 Process for producing salts

US3036885A 1962-05-29 Process for the production of caro's acid salts and solutions thereof

CN1390786A 2003-01-15 Process for preparing standard sodium carbonate from sodium sulfate

JPS5738768A 1982-03-03 Preparation of optically active mercaptocarboxylic acid

US2722473A 1955-11-01 toland

US3663623A 1972-05-16 Preparation of iodomethylsulfones

Priority And Related Applications

https://patents.google.com/patent/CN1066652A/en 2/3
9/24/2019 CN1066652A - Mercaptoacetic acid preparation method - Google Patents
Priority Applications (1)

Application Priority date Filing date Title

CN 91103042 1991-05-14 1991-05-14 Mercaptoacetic acid preparation method

Applications Claiming Priority (1)

Application Filing date Title

CN 91103042 1991-05-14 Mercaptoacetic acid preparation method

Legal Events

Date Code Title Description

1992-12-02 C06 Publication

1994-02-23 C10 Request of examination as to substance

1997-09-24 C14 Granted

2000-07-05 C19 Cessation of patent right (cessation of patent right due to non-paymentof the annual fee)

About Send Feedback Public Datasets Terms Privacy Policy

https://patents.google.com/patent/CN1066652A/en 3/3

Potrebbero piacerti anche