Application for

Summer Research Program

The Tsukuba University, July 23th – August 3th 2018

Motivation Letter

Yogyakarta, Indonesia
18th April 2018

Dear Sir/Madam,
Committee of The Summer Research Program Tsukuba University,

My name is Elvira Rosana. I am writing to support my motivation letter for a place in

Summer Research Program Tsukuba University. I am a medical doctor and currently the young
lecturer at Department of Biology and Immunology, Faculty of Medicine and Health Sciences,
University of Bengkulu, Indonesia. Now, I am first semester student of postgraduate program in
Faculty of Medicine, Public Health, and Nursing of Gadjah Mada University in major of Biomedical
Sciences and interest in Medical Molecular.
I am interest in this course because my major study is about molecular especially in cancer
study. In my thesis project I will explore about epigenetic which have association with growth of
cancer. Focus in my thesis is about biomarker for cancer that analize epigenetic side especially
microRNA in the biofluid of cancer patient. In patient’s who have cancer, example the micro-RNA
which regulate mRNA tumor suppressor gene is down regulation attached in some reference. Beside
that, I also study about current diagnostic and therapy for cancer.
So, at this program I want participate at Regenerative Medicine and Stem Cell Biology or
Hematology Laboratory. I hope at this laboratory, I can explore about basic of stem cell technology
for current therapy especially in cancer and participate on going research there. Because the stem cell
technology is developing in my country and have good prospected especially adult stem cell. The
second laboratory that I want participate is Hematology. In this laboratory, I hope can upgrade my
knowledge about hematology malignancy that is the one high prevalence cancer in my country,
Indonesia. With the program training hematopoetic cell culture, flow cytometry and egipenetic
approach or sequence procedure and immunostaining procedure, I want make mini project about
epigenetic aspect especially microRNA that regulate malignancy of lymphoma. Because microRNA
play a crucial role in hematopoiesis, for instance mir-155 and mir-181 as tumor suprressor mir.
Research in vitro find that both mir-155 and mir-188 are key regulators of germinal centre (GC)
B-cell differentiation. In Lymphoma Malignancy, both mir-155 and mir-188 in previous study
showed down-regulation. I hope the result of my mini project can make me more understand about
epigenetic regulatory and may contribute for cancer pathway that may develop for biomarker
and therapy.
After accomplishing master program, my next steps are doctoral program and post-doctoral
education. Beside the knowledge and research from master program, the knowledge and experience
from this course will be a strong basis for me to continue a deeper research in stem cell and molecular
of cancer. In the future, I also interested become part of big project or multicenter project which is
assotiation in molecular and stem cell study especially in cancer.
With regard of above, as the current technology and methodology in molecular diagnostic and
therapy, I am sure the Regenerative Medicine And Stem Cell Biology or Hematology laboratory at
The Summer Research Program Tsukuba University will helps me to realize all of these plans. It will
be the chance for me in order to pursue my goals and my future academic career. With my
qualification and planning, I believe I am one of the suitable candidates for this program.