Rheumatology Orthopedics 2019 PDF

177th Conference
Scientific Federation
2nd World Congress on
Rheumatology & Orthopedics

September 26-27, 2019 at Paris, France
Scientific Federation
Panjagutta, Hyderabad, Telangana-500082, India
E: contact@scientificfederation.com
http://scientificfederation.com
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177th Scientific Federation
Conference

Previous & Upcoming

Conferences
Page 4
2018 Conferences
February 2nd World Congress and Expo Traditional & Alternative

3rd Global Summit and Expo on Dental & Oral Diseases Medicine
February 26-27, 2018 Abu Dhabi, UAE June 14-16, 2018 Rome, Italy
Global Summit on Chemistry & Chemical Engineering 2nd Global Summit & Expo on Laser Optics & Photonics
International Conference & Expo on Aerospace & 3rd Global Congress & Expo on Materials Scince &
Aeronautical Engineering Engineering
March 3rd International Congress & Expo on Biotechnology and
Bioengineering
3rd World Congress & Expo on Pharmaceutics & Drug June 25-26, 2018 Kuala Lumpur, Malaysia
Delivery Systems
March 19-20, 2018 London, UK July
2nd Global Conference and Expo on Vaccines Research World Conference & Expo on Biomedical Engineering
March 19-20, 2018 London, UK July 16-17, 2018 Miami, USA
2nd World Congress on Public Health and Health Care Metabolomics Global Summit
Management July 16-17, 2018 Miami, USA
March 19-20, 2018 London, UK World Congress on Medicine and Medical Science
April July 16-17, 2018 Miami, USA
4th Global Nanotechnology Congress and Expo 2nd International Conference & Expo on Green Chemistry
April 16-18, 2018 Dubai, UAE and Engineering
July 23-24, 2018 Barcelona, Spain
World Congress on Mechanical and Mechatronics
Engineering World Conference on Analytical & Bioanalytical Chemistry
April 16-17, 2018 Dubai, UAE July 23-24, 2018 Barcelona, Spain
World Congress & Expo on Oil, Gas & Petroleum Engineering Global Summit on Stem Cell & Tissue Engineering
April 16-17, 2018 Dubai, UAE July 23-24, 2018 Barcelona, Spain
World Summit on Cancer Research & Therapy International Conference on Computer Science & Cloud
April 19-21, 2018 Dubai, UAE Computing
International Summit on Dermatology
April 19-20, 2018 Dubai, UAE World Conference on Robotics & Artificial Intelligence
International Meeting on Cosmetology & Trichology
April 19-20, 2018 Dubai, UAE International Conference on Electronics & Electrical
Engineering
May July 26-27, 2018 Barcelona, Spain
2nd World Congress on Cell Science and Molecular Biology Global Conference on Magnetism and Magnetic Materials
May 21-22, 2018 Valencia,Spain July 23-25, 2018 Osaka, Japan
International Hematologists Summit International Conference on Atomic & Nuclear Physics
Annual International Pathology Conference World Congress & Expo on Chemical Engineering & Catalysis
2nd International Conference on Women Health and Breast August
Cancer
International Congress and Expo on Agriculture &
May 24-25, 2018 Valencia,Spain Horticulture
2nd Global Summit on Diabetes and Endocrinology August 13-14, 2018 Amsterdam, Netherlands
May 24-25, 2018 Valencia,Spain International Summit on Fisheries & Aquaculture
2nd Global Summit on Nutritional Science & Food Chemistry August 13-14, 2018 Amsterdam, Netherlands
May 24-25, 2018 Valencia,Spain International Conference on Earth Science & Geo Science
June August 13-14, 2018 Amsterdam, Netherlands
2nd World Conference and Exhibition on Forensic Science 2nd International Congress and Exhibition on Pharmacy
June 11-12, 2018 Rome, Italy August 20-21, 2018 Mahsa University, Malaysia
2nd World Congress on Surgery & Anesthesia 4th International Congress on Dentistry & Prosthodontics
June 11-12, 2018 Rome, Italy August 20-21, 2018 Mahsa University, Malaysia
World Summit on Toxicology
June 11-12, 2018 Rome, Italy Global Conference on Physiotherapy
August 20-21, 2018 Mahsa University, Malaysia
International Conference on Semiconductors, Optoelectronics 3rd Global Summit on Obesity & Diet Management
and Nanostructures October 18-20, 2018 Amsterdam, Netherlands
August 20-21, 2018 Paris, France 3rd World Congress and Expo on Immunology
International Congress and Expo on Flu Science & Infectious October 18-20, 2018 Amsterdam, Netherlands
Diseases Global Summit on Occupational Health & Safety
August 20-21, 2018 Paris, France October 18-20, 2018 Amsterdam, Netherlands
International Conference on Medicinal Chemistry & Drug 3rd World Conference & Expo on Petrochemistry & Natural
Design Resources
August 20-21, 2018 Paris, France October 22-23, 2018 Prague, Czech Republic
World Congress on Gerontology & Palliative Care 3rd International Conference on Biopolymers & Polymer
August 23-24, 2018 Paris, France Chemistry
International Conference on Alzheimer's Diseases & October 22-23, 2018 Prague, Czech Republic
Psychology International Congress on Urban & Civil Engineering
International Conference on Addiction Therapy & Clinical 2nd World Summit and Expo on Food Technology &
Reports Probiotics
September International Summit on Microbiology & Parasitology
2nd International Conference & Expo on HIV & AIDS October 25-26, 2018 Prague, Czech Republic
September 17-18, 2018 Toronto, Canada Global Conference on Plant Biology
2nd World Congress on Clinical Research & Biomarkers October 25-26, 2018 Prague, Czech Republic
September 17-18, 2018 Toronto, Canada November
International Conference on Pharmacognosy & 5th World Congress on Nursing & Healthcare
Pharmacovigilance November 12-14, 2018 Toronto, Canada
September 17-18, 2018 Toronto, Canada 3rd World Congress & Expo on Dementia & Neuroscience
World Congress on Gynecology & Obstetrics November 12-14, 2018 Toronto, Canada
September 20-21, 2018 Toronto, Canada 3rd Global Summit & Expo on Materials, Photonics & Optical
2nd International Congress and Expo on Cardiology Instruments
September 20-21, 2018 Toronto, Canada November 12-14, 2018 Toronto, Canada
2nd International Conference on Nephrology 2nd International Congress on Gastroenterology &
September 20-21, 2018 Toronto, Canada Hepatology
4th International Congress & Expo on Biotechnology and November 19-20, 2018 Houston, USA
Genetic Engineering 2nd Global Summit in Otolaryngology
September 24-25, 2018 Madrid, Spain November 19-20, 2018 Houston, USA
International Conference on Respiratory Medicine & 2nd Global Summit and Expo on Proteomics
Pulmonology November 19-20, 2018 Houston, USA
September 24-25, 2018 Madrid, Spain 2nd International Conference on Renewable & Non
World Congress on Rheumatology & Orthopedics Renewable Energy Sources
Global Summit on Physics 2nd International Conference on Ophthalmology
World Congress on Quantum and Nuclear Engineering 2nd International Congress and Expo on Bacteriology
Global Summit on Geological and Environmental December
Engineering 5th Global Nanotechnology Congress and Expo
September 27-28, 2018 Madrid, Spain December 03-05, 2018 Valencia, Spain
October Global Biofuels & Bioenergy Congress & Expo
2nd Global Conference and Expo on Applied Science, December 03-05, 2018 Valencia, Spain
Engineering and Technology World Congress on Waste Management & Recycling
October 15-17, 2018 Amsterdam, Netherlands December 03-04, 2018 Valencia, Spain
2nd International Conference and Expo on Condensed 3rd Global Virology Congress & Expo
Matter Physics December 06-08, 2018 Valencia, Spain
October 15-17, 2018 Amsterdam, Netherlands 5th World Congress and Expo on Oncology & Radiology
4th Global Congress & Expo on Materials Science & December 06-08, 2018 Valencia, Spain
Nanoscience
October 15-17, 2018 Amsterdam, Netherlands Global Conference on Global Warming
December 06-07, 2018 Valencia, Spain
2019 Conferences
February 3rd International Conference on Women Health and Breast
5th Global Summit and Expo on Dental & Oral Diseases Cancer
February 18-19, 2019 Frankfurt, Germany May 30-31, 2019 Nice, France
2nd Global Summit on Chemistry & Chemical Engineering 3rd Global Summit on Diabetes and Endocrinology
February 18-19, 2019 Frankfurt, Germany May 30-31, 2019 Nice, France
2nd International Conference & Expo on Aerospace & 2nd International Hematologists Summit
Aeronautical Engineering May 30-31, 2019 Nice, France
February 18-19, 2019 Frankfurt, Germany June
6th World Congress on Nursing & Healthcare 3rd World Conference and Exhibition on Forensic Science
February 25-26, 2019 Durban, South Africa June 03-04, 2019 Berlin, Germany
3rd International Conference & Expo on HIV & AIDS 3rd World Congress on Surgery & Anesthesia
February 25-26, 2019 Durban, South Africa June 03-04, 2019 Berlin, Germany
International Conference & Expo on Animal Science & 2nd World Summit on Toxicology
Veterinary Medicine June 03-04, 2019 Berlin, Germany
February 25-26, 2019 Durban, South Africa 3rd World Congress and Expo Traditional & Alternative
March Medicine
4th World Congress & Expo on Pharmaceutics & Drug June 06-08, 2019 Berlin, Germany
Delivery Systems World Congress & Expo on Sports & Emergency Medicine
March 25-26, 2019 Milan, Italy June 06-08, 2019 Berlin, Germany
3rd Global Conference and Expo on Vaccines Research & 2nd Global Summit on Stem Cell & Tissue Engineering
Development June 06-08, 2019 Berlin, Germany
March 25-26, 2019 Milan, Italy 5th Global Congress & Expo on Materials Science &
2nd International Summit on Dermatology Engineering
March 25-26, 2019 Milan, Italy June 10-12, 2019 Osaka, Japan
World Congress on Mechanical, Metallurgy and Materials 2nd World Conference on Robotics & Artificial Intelligence
Science June 10-12, 2019 Osaka, Japan
March 28-29, 2019 Milan, Italy 3rd Global Summit on Nutritional Science & Food Chemistry
Global Conference on Carbon Nanotubes and Graphene June 10-12, 2019 Osaka, Japan
Technologies 5th International Congress & Expo on Biotechnology and
March 28-29, 2019 Milan, Italy Bioengineering
5th World Congress & Expo on Oil, Gas & Petroleum June 17-18, 2019 London, UK
Engineering 3rd Global Summit on Pediatrics & Neonatology
March 28-29, 2019 Milan, Italy June 17-18, 2019 London, UK
April 7th World Congress on Nursing & Healthcare
6th Global Nanotechnology Congress and Expo June 17-18, 2019 London, UK
April 15-17, 2019 Dubai, UAE July
4th Global Summit & Expo on Laser Optics & Photonics 2nd World Conference & Expo on Biomedical Engineering
April 15-17, 2019 Dubai, UAE July 08-09, 2019 Las Vegas, USA
2nd World Congress on Mechanical and Mechatronics 2nd Global Summit on Metabolomics
Engineering July 08-09, 2019 Las Vegas, USA
April 15-17, 2019 Dubai, UAE
2nd World Congress on Medicine and Medical Science
6th World Summit on Cancer Research & Therapy July 08-09, 2019 Las Vegas, USA
3rd International Conference & Expo on Green Chemistry
3rd World Congress on Public Health and Health Care and Engineering
Management July 11-12, 2019 Las Vegas, USA
2nd World Conference on Analytical & Bioanalytical
2nd International Meeting on Cosmetology & Trichology Chemistry
April 19-20, 2019 Dubai, UAE July 11-12, 2019 Las Vegas, USA
May 4th International Conference on Biopolymers & Polymer
3rd World Congress on Cell Science and Molecular Biology Chemistry
May 13-14, 2019 Kuala Lumpur, Malaysia July 11-12, 2019 Las Vegas, USA
2nd Annual International Conference on Pathology and Case 2nd International Conference on Computer Science & Cloud
Reports Computing
May 13-14, 2019 Kuala Lumpur, Malaysia July 22-23, 2019 Rome, Italy
Global Congress & Expo on Biomaterials International Conference on Oceanography & Marine Science
May 13-14, 2019 Kuala Lumpur, Malaysia July 22-23, 2019 Rome, Italy
2nd International Conference on Electronics & Electrical 2nd World Congress on Gynecology & Obstetrics
Engineering September 19-20, 2019 Miami, USA
July 22-23, 2019 Rome, Italy 3rd International Congress and Expo on Cardiology &
2nd Global Conference on Magnetism and Magnetic Hypertension
Materials September 19-20, 2019 Miami, USA
July 25-26, 2019 Rome, Italy
4th World Congress & Expo on Public Health, Epidemiology
2nd International Conference on Atomic & Nuclear Physics and Nutrition
July 25-26, 2019 Rome, Italy September 19-20, 2019 Miami, USA
2nd World Congress & Expo on Chemical Engineering &
Catalysis 7th International Congress & Expo on Biotechnology and
July 25-26, 2019 Rome, Italy Genetic Engineering
2nd World Congress & Expo on Chemical Engineering & September 23-24, 2019 Paris, France
Catalysis 2nd International Conference on Respiratory Medicine &
July 25-26, 2019 Rome, Italy Pulmonology
August September 23-24, 2019 Paris, France
2nd International Congress and Expo on Agriculture & 2nd World Congress on Rheumatology & Orthopedics
Horticulture September 23-24, 2019 Paris, France
August 12-13, 2019 Prague, Czech Republic 2nd Global Summit on Physics
2nd International Summit on Fisheries & Aquaculture September 26-27, 2019 Paris, France
August 12-13, 2019 Prague, Czech Republic 2nd World Congress on Quantum and Nuclear Engineering
2nd International Conference on Earth Science & Geo Science September 26-27, 2019 Paris, France
August 12-13, 2019 Prague, Czech Republic 2nd Global Summit on Geological and Environmental
3rd International Congress and Exhibition on Pharmacy Engineering
August 15-16, 2019 Prague, Czech Republic September 26-27, 2019 Paris, France
International Congress and Exhibition on Industrial and October
Manufacturing Engineering 3rd Global Conference and Expo on Applied Science,
August 15-16, 2019 Prague, Czech Republic Engineering and Technology
2nd Global Conference on Physiotherapy October 07-09, 2019 Dubai, UAE
August 15-16, 2019 Prague, Czech Republic 3rd International Conference and Expo on Condensed Matter
2nd International Conference on Semiconductors, Physics
Optoelectronics and Nanostructures October 07-09, 2019 Dubai, UAE
August 19-20, 2019 Barcelona, Spain 6th Global Congress & Expo on Materials Science &
Nanoscience
2nd International Congress and Expo on Flu Science &
October 07-09, 2019 Dubai, UAE
Infectious Diseases
August 19-20, 2019 Barcelona, Spain 4th Global Summit on Obesity & Diet Management
October 11-12, 2019 Dubai, UAE
2nd International Conference on Medicinal Chemistry & Drug
Design 4th World Congress and Expo on Immunology
August 19-20, 2019 Barcelona, Spain October 11-12, 2019 Dubai, UAE
6th International Congress & Expo on Biotechnology and 2nd Global Summit on Occupational Health & Safety
Nanotechnology October 11-12, 2019 Dubai, UAE
August 22-23, 2019 Barcelona, Spain International Conference on Infrastructure and Construction
2nd International Conference on Alzheimer's Diseases & October 11-12, 2019 Dubai, UAE
Psychology International Conference on Textile Engineering
August 22-23, 2019 Barcelona, Spain October 21-22, 2019 Bangkok, Thailand
2nd International Conference on Addiction Therapy & 4th World Congress and Expo Traditional Medicine & Herbals
Clinical Reports October 21-22, 2019 Bangkok, Thailand
August 22-23, 2019 Barcelona, Spain 2nd International Congress on Urban & Civil Engineering
September October 21-22, 2019 Bangkok, Thailand
4th International Conference & Expo on HIV & AIDS 4th World Summit & Expo on Food Technology & Probiotics
September 16-17, 2019 Miami, USA October 24-25, 2019 Bangkok, Thailand
3rd World Congress on Clinical Research & Biomarkers
September 16-17, 2019 Miami, USA 2nd International Summit on Microbiology & Parasitology
2nd International Conference on Pharmacognosy & October 24-25, 2019 Bangkok, Thailand
Pharmacovigilance 2nd Global Conference on Plant Biology
September 16-17, 2019 Miami, USA October 24-25, 2019 Bangkok, Thailand
November 3rd International Conference on Ophthalmology
4th World Congress & Expo on Dementia & Neuroscience November 21-22, 2019 Dubai, UAE
November 04-05, 2019 Kuala Lumpur, Malaysia 3rd International Congress and Expo on Bacteriology
3rd International Conference on Renewable & Non November 21-22, 2019 Dubai, UAE
Renewable Energy Sources December
November 04-05, 2019 Kuala Lumpur, Malaysia 7th Global Nanotechnology Congress and Expo
December 02-04, 2019 Kuala Lumpur, Malaysia
5th Global Summit & Expo on Materials, Photonics & Optical
Instruments 2nd Global Biofuels & Bioenergy Congress & Expo
November 04-05, 2019 Kuala Lumpur, Malaysia December 02-04, 2019 Kuala Lumpur, Malaysia
3rd International Congress on Gastroenterology & 2nd World Congress on Waste Management & Recycling
Hepatology December 02-04, 2019 Kuala Lumpur, Malaysia
November 18-19, 2019 Dubai, UAE 4th Global Virology Congress & Expo
December 06-07, 2019 Kuala Lumpur, Malaysia
3rd Global Summit in Otolaryngology
November 18-19, 2019 Dubai, UAE 7th World Congress and Expo on Oncology & Radiology
3rd Global Summit and Expo on Proteomics December 06-07, 2019 Kuala Lumpur, Malaysia
November 18-19, 2019 Dubai, UAE 2nd Global Conference on Global Warming & Climate
8th World Congress on Nursing & Healthcare Change
November 21-22, 2019 Dubai, UAE December 06-07, 2019 Kuala Lumpur, Malaysia
2020 Conferences
February Global Congress and Expo on Biochemistry and
8th World Conference and Expo on Nanoscience and Molecular Biology
Nanotechnology March 26-27, 2020 | Krakow, Poland
February 17-18, 2020 | Philadelphia, USA Global Congess and Expo on Biosensors & Bioelectronics
3rd Global Summit on Chemistry & Chemical Engineering March 26-27, 2020 | Krakow , Poland
February 17-18, 2020 | Philadelphia, USA Global Congress and Expo on Energy Engineering and
3rd International Conference & Expo on Aerospace & Power Technology
Unmanned Aerial Systems March 26-27, 2020 | Krakow , Poland
February 17-18, 2020 | Philadelphia, USA April
9th World Congress on Nursing & Healthcare 9th Global Nanotechnology Congress and Expo
February 20-21, 2020 | Philadelphia, USA April 13-14, 2020 | Miami, USA
5th International Conference & Expo on HIV & AIDS 6th Global Summit & Expo on Laser Optics & Photonics
February 20-21, 2020 | Philadelphia, USA April 13-14, 2020 | Miami, USA
2nd International Conference & Expo on Animal Science &
Global Congress and Expo on Solid State Devices and
Veterinary Medicine
Materials
February 20-21, 2020 | Philadelphia, USA
April 13-14, 2020 | Miami, USA
5th World Congress & Expo on Pharmaceutics & Drug
Delivery Systems 8th International Meet on Cancer
February 10-11, 2020 | Lisbon, Portugal April 16-17, 2020 | Miami, USA
4th Global Conference and Expo on Vaccines Research & 5th World Congress on Public Health and Health Care
Development Management
3rd International Summit on Dermatology 3rd International Meeting on Cosmetology & Trichology
2nd World Congress on Mechanical, Metallurgy and Global Congress and Expo on Medical Imaging and Case
Materials Science Reports
February 13-14, 2020 | Lisbon, Portugal April 20-21, 2020 | Vancouver, Canada
2nd Global Conference on Carbon Nanotubes and Graphene Global Congress and Expo on Battery and Fuel
Technologies Cell Technology
February 13-14, 2020 | Lisbon, Portugal April 20-21, 2020 | Vancouver, Canada
5th World Congress & Expo on Oil, Gas & Petroleum
2nd Global Congress and Expo on Industrial Engineering
Engineering
and Applications
February 13-14, 2020 | Lisbon, Portugal
April 20-21, 2020 | Vancouver, Canada
March
5th Global Congress and Expo on Neurology & Mental
Global Congress and Expo on Radiology, Nuclear Medicine Disorders
and Imaging
March 16-17, 2020 | Valencia, Spain
Global Congress and Expo on Physical, Inorgonic and
Global Congress and Expo on Nano/Molecular Medicine and
Analytical Chemistry
Engineering
4th Global Congress and Expo on Pediatrics & Neonatology 4th Global Congress and Expo on Engineering Technology
and Applied Science
3rd World Conference and Expo on Biomedical Engineering April 23-24, 2020 | Vancouver, Canada
March 19-20, 2020 | Valencia, Spain May
Global Congress on Nephrology & Urology 2nd Global Congress on Advanced Composite Materials
March 19-20, 2020 | Valencia, Spain May 04-05, 2020 | Porto, Portugal
Global Congress & Expo on Crystallography & Novel Global Congress on Genetics and Genome Research
Materials May 04-05, 2020 | Porto, Portugal
March 19-20, 2020 | Valencia, Spain Global Congress & Expo on Pure and Applied Chemistry
6th Global Summit and Expo on Dental and Oral Health May 04-05, 2020 | Porto, Portugal
March 23-24, 2020 | Krakow, Poland Global Conference on Cardiology and Cardiovascular
3rd Global Congress on Agriculture & Horticulture Medicine
March 23-24, 2020 | Krakow, Poland May 07-08, 2020 | Porto, Portugal
4th Global Congress and Expo on Condensed Matter and 3rd World Conference on Analytical & Bioanalytical
Materials Physics Chemistry
March 23-24, 2020 | Krakow, Poland July 16-17, 2020 | Houston, USA
4th World Congress on Cell Science and Molecular Biology 4th International Conference & Expo on Green Chemistry
May 11-12, 2020 | Lisbon, Portugal and Engineering
3rd World Congress on Mechanical and Mechatronics July 16-17, 2020 | Las Vegas, USA
Engineering 3rd World Conference on Analytical & Bioanalytical
May 11-12, 2020 | Lisbon, Portugal Chemistry
2nd Global Congress & Expo on Biomaterials July 16-17, 2020 | Las Vegas, USA
May 11-12, 2020 | Lisbon, Portugal 5th International Conference on
4th International Conference on Women Health and Breast July 16-17, 2020 | Las Vegas, USA
Cancer 3rd International Conference on Computer Science & Cloud
May 14-15, 2020 | Lisbon, Portugal Computing
4th Global Summit on Diabetes and Endocrinology July 20-21, 2020 | Montreal, Canada
May 14-15, 2020 | Lisbon, Portugal 2nd International Conference on Oceanography & Marine
3rd International Conference on Nuclear and High Energy Science
Physics July 20-21, 2020 | Montreal, Canada
May 14-15, 2020 | Lisbon, Portugal 3rd International Conference on Electronics & Electrical
June Engineering
4th World Conference and Exhibition on Forensic Science July 20-21, 2020 | Montreal, Canada
June 15-16, 2020 | Saint Petersburg, Russia 3rd Global Conference on Magnetism and Magnetic
Materials
5th World Congress on Surgery & Anesthesia
July 23-24, 2020 | Montreal, Canada
June 15-16, 2020 | Saint Petersburg, Russia
3rd International Conference on Atomic, Molecular and
3rd World Summit on Toxicology & Applied Pharmacology
Optical Physics
July 23-24, 2020 | Montreal, Canada
3rd International Hematologists Summit
3rd World Congress & Expo on Chemical Engineering &
June 18-19, 2020 | Saint Petersburg, Russia Catalysis
3rd Global Summit on Stem Cell Biology & Regenerative July 23-24, 2020 | Montreal, Canada
Medicine
August
Earth Science & Geo Science
3rd world conference on Robotics and Artificial Intelligence
August 10-11, 2020 | Atlanta, USA
Fisheries & Aquaculture
4th Global Summit on Nutritional Science & Food Chemistry
June 22-23, 2020 | Toronto, Canada
Agriculture & Horticulture
8th International Congress & Expo on Biotechnology and
Bioengineering August 10-11, 2020 | Atlanta, USA
June 22-23, 2020 | Toronto, Canada Pharmacy
Geriatrics and Gerontology August 13-14, 2020 | Atlanta, USA
June 22-23, 2020 | Toronto, Canada Industrial and Manufacturing Engineering
10th World Congress on Nursing & Healthcare
Physiotherapy
June 25-26, 2020 | Toronto, Canada
Global Congress on Infectious Diseases and Clinical
Microbiology Biopolymers & Polymer Chemistry
June 25-26, 2020 | Toronto, Canada August 17-18, 2020 | Venice, Italy
5th World Congress and Expo Traditional & Alternative Medicinal Chemistry & Drug Design
Medicine August 17-18, 2020 | Venice, Italy
June 25-26, 2020 | Toronto, Canada Advanced Energy Materials
July August 17-18, 2020 | Venice, Italy
International Conference on Critical Care and Intensive Care Biotechnology and Biomaterials
Medicine August 20-21, 2020 | Venice, Italy
July 13-14, 2020 | Las Vegas, USA Addiction Therapy and Clinical Reports
7th Global Congress and Expo on Materials Science and August 20-21, 2020 | Venice, Italy
Engineering Semiconductors, Optoelectronics and Nanostructures
July 13-14, 2020 | Las Vegas, USA August 20-21, 2020 | Venice, Italy
3rd Global Summit on Metabolomics and Enzymylogy
July 13-14, 2020 | Las Vegas, USA
Septembe 3rd Global Conference on Plant Biology
4th World Congress on Clinical Research & Biomarkers October 19-20, 2020 | Lisbon, Portugal
September 14-15, 2020 | Vancouver, Canada 8th Global Congress and Expo on Materials Science and
3rd International Conference on Herbalism & Nanoscience
Pharmacognosy October 19-20, 2020 | Lisbon, Portugal
September 14-15, 2020 | Vancouver, Canada November
3rd World Congress on Gynecology & Obstetrics
5th World Congress and Expo on Immunology
September 17-18, 2020 | Vancouver, Canada
November 16-17, 2020 | Budapest, Hungary
4th International Congress on Heart & Cardiology 5th World Congress & Expo on Dementia & Neuroscience
September 17-18, 2020 | Vancouver, Canada November 16-17, 2020 | Budapest, Hungary
6th World Congress & Expo on Public Health, Epidemiology 4th International Conference on Renewable & Non
and Nutrition Renewable Energy Sources
September 17-18, 2020 | Vancouver, Canada November 16-17, 2020 | Budapest, Hungary
10th International Congress & Expo on Bioscience and 6th Global Summit & Expo on Materials, Photonics & Optical
Biotechnology Instruments
September 21-22, 2020 | Prague, Czech Republic November 19-20, 2020 | Budapest, Hungary
6th Global Summit on Surgery & Surgical Techniques 4th International Congress on Gastroenterology &
September 21-22, 2020 | Prague, Czech Republic Hepatology
3rd World Congress on Rheumatology & Orthopedics November 19-20, 2020 | Budapest, Hungary
September 21-22, 2020 | Prague, Czech Republic 4th Global Summit in Otolaryngology
3rd Global Summit on Physics November 19-20, 2020 | Budapest, Hungary
September 24-25, 2020 | Prague, Czech Republic 4th Global Summit and Expo on Proteomics
3rd World Congress on Quantum Mechanics and Nuclear November 23-24, 2020 | Budapest, Hungary
Engineering
12th World Congress on Nursing & Healthcare
September 24-25, 2020 | Prague, Czech Republic
November 23-24, 2020 | Budapest, Hungary
11th World Congress on Patient Care for Chronic Diseases
September 24-25, 2020 | Prague, Czech Republic 4th International Conference on Ophthalmology
October November 23-24, 2020 | Budapest, Hungary
4th Global Conference and Expo on Applied Science, Aerospace & Aeronautical Engineering
Engineering and Technology November 26-27, 2020 | Budapest, Hungary
October 12-13, 2020 | Bangkok, Thailand
Global Congress on Polymer and Composite Materials
4th International Conference and Expo on Condensed Matter
Physics November 26-27, 2020 | Budapest, Hungary
October 12-13, 2020 | Bangkok, Thailand Biomedical Engineering and Medical Physics
5th Global Summit on Obesity & Diet Management November 26-27, 2020 | Budapest, Hungary
October 12-13, 2020 | Bangkok, Thailand December
3rd Global Summit on Occupational Health & Safety Carbon (C-2019)
October 15-16, 2020 | Bangkok, Thailand December 07-08, 2020 | Bucharest, Romania
2nd International Conference on Infrastructure and
Advanced Ceramics and Composite Materials
Construction
December 07-08, 2020 | Bucharest, Romania
Nanotechnology
2nd International Conference on Textile Engineering
December 07-08, 2020 | Bucharest, Romania
Virology
6th World Congress and Expo Traditional Medicine & Herbals December 10-11, 2020 | Bucharest, Romania
October 19-20, 2020 | Lisbon, Portugal Oncology & Radiology
3rd International Congress on Urban & Civil Engineering December 10-11, 2020 | Bucharest, Romania
October 19-20, 2020 | Lisbon, Portugal 4th Global Summit in Otolaryngology
4th World Summit and Expo on Food Technology & November 19-20, 2020 | Budapest, Hungary
Probiotics Global Warming & Climate Change
October 19-20, 2020 | Lisbon, Portugal December 10-11, 2020 | Bucharest, Romania
3rd International Summit on Microbiology & Parasitology Pathology and Forensic Medicine
October 19-20, 2020 | Lisbon, Portugal December 14-15, 2020 | Istanbul, Turkey
Toxicology and Pharmacology Robotics and Artificial Intelligence
December 14-15, 2020 | Istanbul, Turkey December 17-18, 2020 | Istanbul, Turkey
Vaccines & Immunology Pediatrics & Neonatology
December 14-15, 2020 | Istanbul, Turkey December 17-18, 2020 | Istanbul, Turkey
Surfaces, Coatings and Films
December 17-18, 2020 | Istanbul, Turkey
Conference

Plenary Forum
(Day 1)
Page 14

Jorge de las Heras Romero

University Reina Sofia Hospital, Spain
Ankle Arthodiastasis as a Treatment for Osteoarthritis Secondary to Fracture
A lthough not as common as osteoarthritis of the hip and knee, osteoarthritis of the ankle can cause considerable disability for
those who suffer from it; since it usually produces pain when walking and significant loss of joint mobility. Posttraumatic
arthritis is the main cause of osteoarthritis in the tibiofibular joint, which is why it is common to find it in young patients.
The surgical alternatives classically are:
- Arthroscopy. It is a minimally invasive technique that is performed in cases not very severe. It tries to regularize the joint
surface by removing some osteophytes, being able to associate a synovectomy. It usually provides improvement, but rarely
complete resolution.
- Osteotomies of alignment. They try to recover the normal alignment of the deformed ankle to relieve pain.
- Ankle arthrodesis. Fixation of the joint the improvement of pain is very important, being able to be definitive. An important
range of mobility is lost, although numerous physical activities can be performed.
- Total ankle prosthesis. It has more complications than arthrodesis, but it also produces a very important improvement in pain
while retaining a much greater range of mobility. They usually require replacement in about 10-15 years.
However, at present, certain techniques that seem to achieve a considerable improvement in pain while preserving joint mobility
are in the process of being analyzed. One of them is joint distraction or arthodiastasis.
Arthodiastasis is used as an alternative to total prosthesis or arthrodesis in young patients. It consists on the placement of a
circular ring fixator for 8-12 weeks during which a partial cyclic load is allowed. There are several theories that try to explain
the beneficial effects of this technique, both mechanical and biochemical. However, in what seems to coincide all the literature
is that the distraction of the joints favors mechanisms of fibro cartilage generation. Therefore, arthodiastasis provides the
advantages of being a closed technique that achieves clinical improvement, with few complications and without limiting joint
mobility.
Biography
Dr. Jorge de las Heras Romero is a recognized expert in the area of Orthopaedics and Trauma Surgery, specialized in knee, foot and ankle
reconstruction at University General Reina Sofia in Murcia, Spain. He finished a Master’s Degree in Clinical Medicine Research at Elche Miguel
Hernandez University and a Master’s Degree in Bioethics at the University of Murcia Medical School, where he finally received his Orthopaedic
and Trauma Medicine PhD. He worked in the NHS England for 4 years after his MD, finalizing a basic training surgical rotation. Afterwards, he
completed his surgical residency in Orthopaedics and Trauma Surgery (MIR) at the University Clinical Hospital of Valencia. Fellow member
of the Trauma & Orthopaedic Surgery Spanish Society (SECOT), Foot and Ankle Spanish Society (SEMCPT), Orthopaedic Sport Surgery
Spanish Society, European Society of Sport Traumatology, Knee Surgery & Arthroscopy (ESSKA) and European Foot and Ankle Society (EFAS).
Dr. Jorge de las Heras Romero have authored several articles and book chapters in his field and he is the Director of Foot & Ankle Surgery
Update Conference held annually in Murcia. His researches Interest are: knee sport injuries and foot and ankle surgery. He is also Editor of
Orthopaedics, Traumatology and Sports Medicine International Journal (OTSMIJ), MOJ Orthopaedics & Rheumatology and EC Orthopaedics
Journal.
2nd World Congress on Rheumatology & Orthopedics Page 15


Henning Bliddal
The Parker Institute, Denmark
Intra-Articular Polyacrylamide Hydrogel for the Treatment of Knee Osteoarthritis
O bjectives: There is a drought of effective treatments of knee osteoarthritis (OA) and new therapies are needed. The present
study has been conducted to establish an initial estimate of effectiveness of intra-articular (IA) injection of a proprietary
2.5% cross-linked polyacrylamide hydrogel (PAAG) for the treatment of knee OA symptoms and signs.
Methods: Patients with knee OA were invited into a prospective open-label cohort study. The patients received up to two IA
injections of 3 ml of PAAG 1 month apart. The WOMAC questionnaire was used to estimate effectiveness, and was collected
at baseline and after 4, 7 and 13 months. Primary outcome was change from baseline for the WOMAC pain subscale after 4
months (Normalized to 0-100 points; 100 worst). Data was analyzed using a mixed-effect model without imputation of missing
data.
Results: 84 patients (48 females) received IA PAAG. Of these WOMAC data were available from 62 after 4 months, 59 after 7
months, and 56 after 13 months. There were statistically and clinically significant reductions in WOMAC pain after 4 months
(mean change -14.6 points [95% CI: -18.9 to -10.2]; p<.0001). Similar results were found in WOMAC stiffness, physical
function, and WOMAC total. The improvement was sustained throughout the observation period.
Conclusions: These results suggest beneficial effects of IA injection of PAAG on knee OA symptoms, even in the long term
(1 year). This initial estimation of effectiveness is promising but needs to be confirmed in a randomized study with adequate
measures taken to reduce risk of bias.
Biography
Henning Bliddal became a doctor in 1978, MD. in 1986 and specialist in 1987. In 1991 he became chief physician in rheumatology at the
Copenhagen Municipal Hospital, and from 1997 the chief physician and research professor at Frederiksberg Hospital, where he and Bente
Danneskiold-Samsøe have built the Parker Institute. HB was the principal teacher and course leader for 15 years as the specialist specialist in
rheumatology and is expert in the Legal Counsel. HB has assessed professorships at home and abroad, PhD and theses. At the Parker Institute,
HB is the supervisor of PhD students and generally initiates research projects. In addition to chapters for textbooks in rheumatology, HB has
co-authored over 200 articles with peer-review and has lectured at congresses and professional meetings nationally and internationally. HB has
been chairman of the National Board of Health's committee for the preparation of a national program for the treatment of knee arthrosis, and
from 2010 has been appointed professor of rheumatology with osteoarthritis as a special field of research at the University of Copenhagen. HB
is appointed head of the Parker Institute from March 1, 2011.


Edward R. Laskowski
Mayo Clinic Sports Medicine, USA
The Role of Movement Analysis in the Rehabilitation and Prevention of Sports Injuries
I t is not practice that makes perfect, it is “perfect practice” that is important. Research has demonstrated specific movement
patterns related to upper and lower extremity sports injuries. These include dynamic medial knee valgus and its relation to
lower extremity sports injury, and suboptimal throwing technique and its relation to upper extremity injury in throwing athletes.
Suboptimal movement patterns can predispose to injury, and correction of these patterns is essential for both injury prevention
and appropriate rehabilitation. This lecture will discuss some of the means of analysis employed to identify suboptimal
movement patterns, what the research tells us about optimal movement and sports technique, and the methods of incorporating
optimal technique and movement patterns in sports injury rehabilitation and prevention.
Keywords: Movement analysis; Rehabilitation; Injury prevention
Biography
Dr. Laskowski is Co-director of Mayo Clinic Sports Medicine and a Professor in the Department of Physical Medicine and Rehabilitation.
Nationally and internationally recognized for his expertise in fitness and sports medicine, Dr. Laskowski studies and promotes best practices
for general fitness, injury prevention and injury rehabilitation, strength training, and stability training. Collectively, Dr. Laskowski’ s work has
produced several hundred publication credits, including scientific papers, abstracts, books, book reviews, book chapters, and popular media
and multimedia. His articles have appeared in The Wall Street Journal, The New York Times, The Washington Post, The Chicago Tribune, Golf
Digest, Prevention, Time, Men’s Health, Esquire, and GQ Magazine. He has appeared on the NBC Nightly News, ABC World News Now, and
Good Morning America as a trusted voice in sports medicine and fitness. He has been recognized for exceptional contributions to his field, and
has been annually acknowledged as one of the Best Doctors in America. His teaching expertise has been recognized by his election to the Mayo
Clinic Teacher of the Year Hall of Fame, and he also has been selected as Outstanding Faculty Member and Co-Director of the Outstanding
Course in the Mayo School of Continuous Professional Development. From 2006 to 2010, he was appointed by President George W. Bush
to serve as a member of the President's Council on Physical Fitness and Sports; he received a special commendation from the Department
of Human Services for his contributions to the Council. He also received the American Academy of Physical Medicine and Rehabilitation’s
Distinguished Public Service Award in 2016, Dr. Laskowski is a Fellow in the American College of Sports Medicine, and he was one of the first
physiatrists to receive Subspecialty Certification in Sports Medicine. He currently serves as a Consultant to the National Hockey League Players'
Association, and he is a Charter Member of the American Medical Society for Sports Medicine.


Sergio Marcucci
A. T. Still University, USA
Sacroiliac Joint Posterior Ligaments Biomechanics and Clinical Implication for the Clinician
T he sacroiliac joint (SIJ) is organized by articular surfaces between the sacral and iliac bones. The SIJ include different
functions, among which to connect the spine to the pelvic bone, which permits for a better transmission of vertical forces
from the spine to the pelvis and lower extremities. The first purpose of the SIJ is to provide stability, which is promoted partly
by the muscles attached to the SIJ, and is provided by a multiple mechanism, embracing the complex of ligaments fixed to the
SIJ. The range of motion of SIJ is estimated around 2 to 4 degrees. Additionally, there are 35 muscles attaching to the sacrum
or innominate, which work in combined effort with the fascial and ligaments, thus to ensure movement and simultaneously
stability of the trunk and lower extremities.
The SIJ also is an important generator for pelvic and low back pain (LBP) in the differential diagnosis of referred map pain in
the lower extremities, and should be considered in the differential diagnosis of pelvic and LBP. There is an underestimation of
the prevalence of SIJ pain, because there is a lack of research done on the SIJ posterior ligaments. In the United States and rest
of the world, there is an augmented prevalence of LBP and its related costs. In Europe, the increase of adult patients with LBP is
associated to the sedentary activities as working with a computer behind a desk. Marcucci, Alexander, and Matthews observed
in a pilot study composed of a sample with 20 patients having LBP or pelvic, and or lower extremities pain, after applying two
different osteopathic release techniques on the posterior SIJ ligaments, a reduction of the pain in 18 patients, from which 12 had
no pain anymore, 6 had only a reduction of the intensity of their pain. In two cases, the techniques did not provide any effect
on the pain intensity. There is a necessity to assess the potential function of the SIJ posterior ligaments in producing LBP and
referred map pain in the lower extremities.
Keywords: Low back; Sacroiliac joint; Posterior sacroiliac joint ligament; Biomechanics
Biography
Sergio Marcucci has completed his Doctorate in Health Sciences (DHSc) at the age of 47 years from A. T. Still University, College of Graduate
Health Studies, Mesa, and USA; He received his MSc from A. T. Still University of Kirksville USA and his D.O. from Sutherland College of
Osteopathic Medicine, Belgium, He is practicing osteopathic medicine since 15 years. He had 10 oral presentations and one poster presentation.
He has published 2 papers in reputed journals and has been serving as a reviewer board member of three repute journals.


Munaf A Hatem
Hepavita Medical Center/Poland, Peace land Medical services/Oman
Role of Minimally Invasive Spine Endoscopy, Advance in Spine Surgery
M edical science greatly developing day by day, every day we wake up on new technology, innovations and procedures,
Spine and brain, had high chance of this development and advance technology. Most of the surgeon nowadays, seeking
patients safety and satisfaction, that why Minimum Invasive Surgery become the first goal to be achieved from most of surgeon
Minimum Invasive surgery, including Microscopic spine and brain surgery, Endoscopic Brain and spine surgeries, in addition
to all of that ,navigation system started to play role in helping surgeon to obtain best possible results. More or less introduction
of Robotics to be part of new modulates of treatment in all surgeries, including Brain and spine.
The development of endoscopy techniques in the treatment of the brain and spine disorders have followed to significantly
improve outcome, moreover, endoscopic procedures a less invasive technique consequently minimizes a possibilities of intra
and post-operative complications.
In addition a neuro endoscopic can replace, in many cases, traditional neurosurgical procedures in brain and spine, with less
complication and good outcomes. In this presentation we will discuss the outcome of given sample for patients who undergoes
minimally invasive spine surgeries, the patients evaluates by using VAS and SF- MPQ scaling.
Biography
Dr. Munaf A Hatem studied and practice in Republic of Iraq. He graduated from Medical school at 1998, and then he joined orthopedic programs
in different Iraq hospitals. Since 2006 he decided to travel and live in Sultanate of Oman, then he started my practice their since 2010. He
decided to pursue his ambition, he joined fellowship and PhD program in Medical University of Lodz, Republic of Poland, now he practice his
specialization in both of Sultanate of Oman and Poland. He is member and follow of many orthopedic organizations and committees, most of
them are global, e.g. AAOS, ESSKA, SICOT, he is member in scientific committee of some of this organization; recently he is participated in first
Rheumatology and orthopedic congress in Spain as keynote speakers and chairman for some sessions. He is proud to be member in scientific
committee of this congress. He had published some papers in Iraq, Oman, and republic of Poland, he presented paper in last ESKA meeting in
London, right now am interested doing some research and work in some papers, in addition to my practice as an Orthopedic doctor.

Conference

Scientific Sessions
(Day 1)
Page 20
Sessions Day 01
September 26, 2019
Chair
C. Stephen Foster, Harvard Medical School, Massachusetts Eye Research and Surgery
Institution (MERSI), USA
Co-chair
Munaf A Hatem, Hepavita Medical Center/Poland, Peace land Medical services/Oman
Session Introduction
Title: Systemic Lupus Erythematosus Ocular Manifestations
C. Stephen Foster, Harvard Medical School, Massachusetts Eye Research and Surgery Institution
(MERSI), USA
Title: Ocular Complications of Rheumatoid Disease
William Ayliffe, Lister Hospital, London
Title: Juvenile Idiopathic Arthritis Associated Uveitis
Frances Foster, Uveitis Foundation, USA
Title: Ocular Behcet’s Disease: from Diagnostic Challenges to Therapeutic Progress
Bahram Bodaghi, Sorbonne University, France
Title: Granulomatosis with Polyangiitis and Relapsing Polychondritis
C. Stephen Foster, Harvard Medical School, Massachusetts Eye Research and Surgery Institution
(MERSI), USA
Title: Suppression of Methotrexate-Induced Elevations in the Serum Alanine Aminotransferase
Level of Patients with Rheumatoid Arthritis Who had Prior Hepatitis B Infection
Osamu Noguchi, Gennoki Clinic, Japan
Title: Study of Anti-Inflammatory Effect by Cucurbitacin E via Modulation of PI3K/Akt/NF- Kb
Pathways
Peng Zhang, Translational Medicine R&D Center, Shenzhen Institutes of Advanced Technology,
Chinese Academy of Sciences, China
Title: Natural Antibodies against Serum Amyloid A – A Novel Endogenous Regulatory System
or Accessible Therapeutic Option for Inflammatory Rheumatic Diseases"
Snezna Sodin-Semrl, University Medical Centre Ljubljana, Slovenia
Title: The Influence of Training Surface on Achilles Tendon Structure, Jumping and Balance
Performance Among Runners
Gali Dar, Haifa University, Israel
Title: Use of Intravenous Pamidronate in Pediatric Leukemia Patients with Osteonecrosis Results
in Reduced Pain and May Halt Osteonecrosis Progression
Paivi Miettunen, Alberta Children’s Hospital and University of Calgary, Canada

Systemic Lupus Erythematosus Ocular Manifestations

C. Stephen Foster
Harvard Medical School, Massachusetts Eye Research and Surgery Institution, USA
S ystemic Lupus Erythematosus has many ocular manifestations; including Discoid Lupus associated blepharitis,
conjunctivitis and episcleritis, Lupus scleritis, keratitis, Uveitis and retinal vasculitis. And while the latter three can be sight
threatening, none is commonly considered to be life threatening. In my 40 years on the Harvard faculty I have collaborated
in the care of many patients with SLE, two of whom died of CNS complications of the disease. Other ophthalmologists have
witnessed this too. The patients' rheumatologists felt that our recommendations for more aggressive therapy when retinal
vasculitis emerged were too aggressive, since the patients' other SLE manifestations appeared to be under good control.
I wish to emphasize to each of you how sensitive the eye is as a barometer for potentially lethal occult vasculitis. One of my
cases, co-managed with rheumatologists at the Massachusetts General Hospital is highly illustrative. This 34 year old woman
was hospitalized by her MGH rheumatologist no because of renal failure or any other non-ocular problem, but because she
abruptly developed bilateral vision loss. Fluorescein angiography disclosed bilateral widespread retinal vasculitis. The patient
had already received intravenous SoluMedrol (she had been on prednisone and hydroxychloroquin as an outpatient). What
might be the most appropriate strategy now?
Biography
Dr. Foster was born and raised in West Virginia, received his Bachelor of Science Degree in Chemistry at Duke University, with Distinction and Phi
Beta Kappa in 1965, and received his Doctor of Medicine Degree at Duke University Medical Center, in 1969, being elected to Alpha Omega Alpha.
He trained in Internal Medicine at Duke University Hospital from 1969-1970, and at the National Heart and Lung Institute, at the National Institutes
of Health in Bethesda, Maryland, from 1970 to 1972, during which time he also taught Internal Medicine, with an appointment as Instructor in
Medicine at the George Washington University Hospital in Washington, DC. In 1972, Dr. Foster entered his Ophthalmology Residency training
program at Washington University (Barnes Hospital), in St. Louis, Missouri, and having completed that in 1975, traveled to Boston to do two
additional Fellowship trainings in Cornea and External Diseases, and in Ocular Immunology. He completed this training in 1977 and was invited
to join the full-time faculty of the Department of Ophthalmology of Harvard Medical School, where he was a member of the Cornea Service and
Director of the Residency Training Program at the Massachusetts Eye and Ear Infirmary. He began his independent research in 1977 and has
since been continuously funded by grants from the National Institutes of Health.


Ocular Complications of Rheumatoid Disease

William Ayliffe
Lister Hospital, London
A mongst the most devastating extra-articular manifestations of rheumatoid disease are those affecting the eye.
These vary from dry eye to vasculitic complications with systemic implications.
Furthermore, a number of treatments for rheumatoid have significant ocular side effects, from steroid induced glaucoma and
cataract to retinopathy caused by chloroquine.
Improved management of rheumatoid disease with disease modifying drugs seems to have reduced the incidence of vasculitis
affecting the eye, but rheumatologists still need to be aware of the various and subtle ways by which this disease can affect
the eye and vision.
Fig. 01
Peripheral Ulcerative Keratitis in Rheumatoid disease.
Dry eye disease alone has a significant impact on the quality of life. More serious complications may herald a systemic relapse
and their recognition can prevent irrecoverable damage not only to the eye but also to general health.
This presentation will illustrate conditions that physicians need to recognise, and how to manage them with the ophthalmologist.


Juvenile Idiopathic Arthritis Associated Uveitis

Frances B. Foster
Massachusetts Eye Research and Surgery Institution, USA
J IA associated uveitis is the leading cause of uveitis in children. It accounts for only 10% of all uveitis; yet it accounts for
33% of all legal blindess in developed societies. Why? Because of delayed diagnosis and because of inadequate systemic
therapy. Incidence = 7-21 cases per 100,000 persons per year.
Risk factors: Female
Oligoarticular
Ana Positive
Age 2-5 at Onset
Hla-Dr 1
Lack of Steroid Sparing Systemic Immunomodulatory Therapy
Delayed Referral to An Ocular Immunologist
Ocular complications - 0.33 eye-years, i.e., slow, progressive accumulation of damage. IT DOES NOT BURN OUT! Cataract,
glaucoma, macular edema, band keratopathy and macular pathology are the most common vision robbing complications over
time.
Early use of IMT reduces the risk of ocular complications and of blindness.


Ocular Behcet’s Disease: from Diagnostic Challenges to Therapeutic Progress

Bahram Bodaghi1*, AC. Desbois2, K. Julian3, D. Saadoun2, P. Cacoub2 and P. LeHoang1
1
Department of Ophthalmology, IHU Foresight, Sorbonne University, France
2
Department of Internal Medicine, IHU Foresight, Sorbonne University, France
3
Eye Institute – Cleveland Clinic, Abu Dhabi
B ehcet’s disease (BD) is a systemic relapsing obliterative vasculitis, affecting arteries, veins and mainly capillaries. Even
though almost all organs can eventually be involved, uveitis makes the disease’s prognosis guarded and usually urges to
start proper treatment. There’s no specific test to diagnose Behcet’s disease. Acute bilateral panuveitis is the most common
clinical presentation of the disease with dense vitritis, severe retinal vasculitis, areas of retinal necrosis and hemorrhages.
The main differential diagnosis includes toxoplasmic retinochoroiditis, ocular tuberculosis, acute retinal necrosis syndrome
and primary vitreoretinal lymphoma. Imaging techniques such as fluorescein angiography and optic coherence tomography
are important to evaluate disease severity and complications. It is important to exclude ocular findings such as papilledema,
which may be associated with neuroBD. Therapeutic management is very rapidly initiated, requiring a close collaboration
between ophthalmologists, internists or rheumatologists. It follows the revised EULAR recommendations. Any patient with
BD and inflammatory eye disease affecting the posterior segment should be on a treatment regimen such as azathioprine,
cyclosporine-A, interferon-alpha or monoclonal TNF-alpha antagonists. Systemic glucocorticoids should be used only in
combination with azathioprine or other systemic immunosupressants. Patients presenting with an initial or recurrent episode
of acute sight threatening uveitis should be treated with high dose glucocorticoids, infliximab or interferon-alpha. Intravitreal
glucocorticoid injection is an option in patients with unilateral exacerbation as an adjunct to systemic treatment. For patients
with isolated anterior uveitis, systemic immunosuppressants could be considered for those with poor prognostic factors such
as young age, male sex and early disease onset. The use of biologic agents has dramatically improved the visual outcome of
patients with BD.
Biography
Bahram Bodaghi, MD, PHD, FEBO is Professor of Ophthalmology at Sorbonne University in Paris, France. He is a Board member of the FOReSIGHT
Hospital University Institute and serves as Vice President of the French Society of Ophthalmology. He chairs the national University Council of
Ophthalmology since 2013 and is actively involved in undergraduate and postgraduate teaching programs at the University of Paris. He has been
elected President of the International Ocular Inflammation Society. During the last decade, he mainly focused his efforts in the understanding of
infectious agents associated with different forms of intraocular inflammation but also new therapeutic strategies in autoimmune uveitis.


Granulomatosis with Polyangiitis and Relapsing Polychondritis

C. Stephen Foster
Harvard Medical School, Massachusetts Eye Research and Surgery Institution (MERSI), USA
G ranulomatosis with Polyangiitis (GPA) and Relapsing Polychondritis and both life threatening rheumatologic disorders,
and both can affect the eye. About 60% of patients with GPA will develop an inflammatory eye problem, and 25% of
those cases have the eye inflammation as the first manifestation of the disease. Bringing them into the medical system. Control
of the dacryocystitis or scleritis or peripheral ulcerative keratitis or retinal vasculitis depends entirely upon control of the
underlying GPA. Thus, the ophthalmologist is dependent upon the rheumatologist to do whatever it takes to induce remission,
whether that be with rituximab or with cyclophosphamide. But it is to be emphasized that the eye involvement is a powerful
signal that any therapy less than one of those two immunomodulatory agents is doomed to fail. Induction of remission of the
eye inflammation will be a very strong indicator of therapy success.
The same may be said of relapsing Polychondritis. Further, the RP patient who appears to be in remission with systemic
prednisone and a non-steroidal anti-inflammatory agent and Dapsone who develops de novo ocular inflammation (scleritis or
PUK) is destined to develop other more serious non-ocular manifestations of the disease if the vigor of therapy is not increased
significantly. Just as in all of the other acquired connective tissue disorders, so too in RP the eye is an exquisitely sensitive
barometer of subclinical vasculitis which may be lethal if not addressed before vital organ involvement occurs.
Biography
Dr. Foster was born and raised in West Virginia, received his Bachelor of Science Degree in Chemistry at Duke University, with Distinction and Phi
Beta Kappa in 1965, and received his Doctor of Medicine Degree at Duke University Medical Center, in 1969, being elected to Alpha Omega Alpha.
He trained in Internal Medicine at Duke University Hospital from 1969-1970, and at the National Heart and Lung Institute, at the National Institutes
of Health in Bethesda, Maryland, from 1970 to 1972, during which time he also taught Internal Medicine, with an appointment as Instructor in
Medicine at the George Washington University Hospital in Washington, DC. In 1972, Dr. Foster entered his Ophthalmology Residency training
program at Washington University (Barnes Hospital), in St. Louis, Missouri, and having completed that in 1975, traveled to Boston to do two
additional Fellowship trainings in Cornea and External Diseases, and in Ocular Immunology. He completed this training in 1977 and was invited
to join the full-time faculty of the Department of Ophthalmology of Harvard Medical School, where he was a member of the Cornea Service and
Director of the Residency Training Program at the Massachusetts Eye and Ear Infirmary. He began his independent research in 1977 and has
since been continuously funded by grants from the National Institutes of Health.


Suppression of Methotrexate-Induced Elevations in the Serum Alanine Aminotransferase Level of

Patients with Rheumatoid Arthritis Who had Prior Hepatitis B Infection
Osamu Noguchi1*, Yukio Nakamura2 and Hiroyuki Kato2
1
Departments of Rheumatology, Gennoki Clinic, Japan
2
Departments of Orthopedic Surgery, School of Medicine, Shinshu University, Japan
B ackground: Hepatitis after the reactivation of hepatitis B virus (HBV) has been recognized serious in the patients with
rheumatoid arthritis (RA) treated with biologics.
Objectives: The objective of the present study was to search some common background which might be relevant to the host
factors that provoke such a serious hepatitis.
Methods: We retrospectively collected and analyzed all data of serum Alanine Aminotransferase (ALT) levels in selected
patients with RA at random.
Results: A significant association (P < 0.001) between Methotrexate (MTX) therapy and elevated serum ALT level was found
only in the anti-HBcAb-negative RA group. The mean serum ALT level was significantly higher (P < 0.001) in patients with
than without MTX therapy in the anti-HBcAb-negative RA group, although no significant difference was found (P = 0.73) in
the anti-HBcAb-positive RA group. In addition, the anti-HBcAb-positive RA patients showed significantly lower mean serum
level of ALT (P < 0.01) than anti-HBcAb-negatives provided they are naïve with biologics. But no significant difference
between anti-HBcAb-positives and -negatives in the mean serum level of ALT was found among patients experienced with
biologics (P < 0.8).
Conclusions: The anti-HBcAb-positive RA group showed the suppression of MTX-induced elevations in serum ALT level.
However, this suppression was not found in patients experienced in the treatment with biologics, although it was preserved in
those who had not experienced biologics. Failure of this suppressive mechanism of ALT In anti-HBcAb-positive RA patients
treated with biologics could be possibly associated with serious hepatitis after the reactivation of HBV infection.
Biography
Dr. Noguchi, Osamu graduated Nippon Medical College in 1975 and move to Musashino Red Cross Hospital (Tokyo), and studied practical Internal
Medicine, Pediatrics, Surgery and Anesthesiology under the position of medical intern for three years. After that, he completed the postgraduate
course of Keio University with specialty of Rheumatology in 1980, while he worked at Murayama Byouin National Sanatorium as the head
physician of the third branch of Internal Medicine. I also studied Nephrology, Tuberculosis and Thermo logy during this era. He took the post of
Director at Takato-Machi Osafuji Clinic in Nagano Prefecture, Japan in 1989. And he opened Gennoki Clinic with the specialty of Rheumatology
in the area of Ina City in 1997.


Study of Anti-Inflammatory Effect by Cucurbitacin E via Modulation of PI3K/Akt/NF- Κb

Pathways
Peng Zhang*, Wenxiang Cheng, Jianhai Chen and Zhengtan Zheng
Translational Medicine R&D Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
O bjective: Increasing studies indicate that Cucurbitacin E (CuE), a derivative isolated from Cucurbitaceae plants may
exert anti-inflammatory effect. In this study we explore the effect of CuE on TNF-α-induced inflammatory cytokines
production in human synoviocytes MH7A cells, and further explore the detailed molecular mechanism involved in its anti-
inflammatory effect.
Materials and Method: MH7A cells were stimulated with TNF-α in the presence or absence of CuE, The expression of pro-
inflammatory cytokines was determined by quantitative real-time PCR and enzyme-linked immunosorbent assay (ELISA).
Signal-transduction protein expression was determined by Western blot. Nuclear translocation of NF-κB p65 was determined
by a confocal fluorescence microscopy.
Result: CuE suppresses TNF-α-induced interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) mRNA and
protein expression in MH7A cells in a dose-dependent manner with no apparent cytotoxicity. CuE also suppressed TNF-
α-induced phosphorylation of NF-κB p65, IKKα/β, IκBα as well as NF-κB p65 nuclear translocation in a dose-and time-
dependent manner. Furthermore, CuE suppresses the TNF-α-induced activiation of PI3K/Akt similarly as the PI3K inhibitor
LY294002,which also decreases the activation of NF-κB as well as mRNA and protein expression of IL-1β, IL-6, and IL-8 in
TNF-α-induced MH7A cells.
Conclusion: These findings demonstrate that Cucurbitacin E as a potential therapeutic agent for Rheumatoid arthritis can
inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via modulation of PI3K/Akt/
NF- κB pathway.
Biography
Dr. Zhang Peng had degree of Clinical Medicine of Bone and studied from well-known orthopedic experts Dai Kerong academicians, mainly
engaged in the experimental study of the pathogenesis and treatment of rheumatoid arthritis; During his postdoctoral research in Zhejiang
university, he received the first class aid of postdoctoral fellowship; Then, he entered the Chinese University of Hong Kong Department of bone
trauma continue to engage in bone and joint Study on mechanism of inflammation and its transformation and application.


Natural Antibodies against Serum Amyloid A

– A Novel Endogenous Regulatory System or Accessible Therapeutic Option for
Inflammatory Rheumatic Diseases
Snezna Sodin-Semrl1,3*, Tadeja Kuret1,2, Katja Lakota1,3, Polonca Mali4, Sasa Cucnik1,2, Sonja Praprotnik1 and Matija Tomsi1,5
1
University Medical Centre Ljubljana, Slovenia
2
Faculty of Pharmacy, University of Ljubljana, Slovenia
3
Faculty of Mathematics, Natural Science and Information Technologies, University of Primorska, Slovenia
4
Blood Transfusion Centre of Slovenia, Slovenia
5
Faculty of Medicine, University of Ljubljana, Slovenia
T he acute phase response is an ancient, evolutionarily conserved defense system of vertebrates regulating homeostatic
disturbances caused by infections, injuries, traumas, cancer and/or immunologic disorders, ultimately leading to resolution
of inflammation and healing. One of the major acute phase proteins in humans is serum amyloid A (SAA), levels of which
can dramatically increase during the acute phase. Persistently elevated levels of SAA in patients with chronic inflammatory
diseases (e.g. rheumatoid arthritis) can cause tissue damage and may lead to amyloidosis. The resolution of the acute phase
and SAA reduction following the acute phase are well-documented, however the exact mechanism remains elusive. Antibodies
against SAA have been identified in sera of healthy blood donors, intravenous immunoglobulin (IVIg), as well as in patients.
A novel bead-based Luminex assay has recently been developed for quantitative detection of autoantibodies against SAA1,
which could be combined with simultaneous detection of antibodies against other acute phase proteins. Furthermore, enriched
fractions of anti-SAA1 antibodies have been isolated from IVIg and were shown to decrease interleukin-6 protein levels
released from SAA1-treated peripheral blood mononuclear cells from healthy blood donors. In conclusion, naturally occurring
antibodies against SAA1 could play a physiological role in down-regulating their antigen, as well as other proinflammatory
cytokines, leading to the resolution of the acute phase. These natural autoantibodies could be endogenous immune-regulators
of the acute phase response and may also represent a potential and attractive therapeutic option in patients with chronic
inflammatory diseases.
Biography
Prof. Snezna Sodin-Semrl completed her PhD at the University of Illinois at Chicago, USA and postdoctoral studies at the same institution, with an
Arthritis Foundation Fellowship. She received a Marie Curie-International Reintegration Grant, with which she returned to the University Medical
Center in Ljubljana, Slovenia, where she is currently leader of the National Research Programme “Systemic Autoimmune Diseases”. She has
published more than 60 original and review scientific articles and book chapters and is regularly called upon, as an expert to evaluate Horizon
2020 grant proposals.


The Influence of Training Surface on Achilles Tendon Structure, Jumping and Balance Performance
among Runners
Gali Dar1,2 and Nili Steinberg3
1
Department of Physical Therapy Faculty of Social Welfare & Health Studies University of Haifa, Israel
2
Physical Therapy Clinic, The Ribstein Center for Sport Medicine Sciences and Research, Wingate Institute, Israel
3
The Wingate College of Physical Education and Sport Sciences, Wingate Institute, Israel
L oad and joint kinematics change with differences in running surface. Running regularly on trails compared to road might
influence the load on the Achilles tendon and its adaptations along with other factors such as balance, strength and
proprioception. The aim of ths study was to investigate Achilles tendon structure and functional tests in road and trail runners.
The study included 26 road and17 trail runners. All running at least 3 times per week with a minimum of 20km per week
and had participated in running competitions over 2 years. Each participant was examined for Achilles tendon structure (via
ultrasound tissue characterization (UTC) imaging) and functional tests in addition to demographical questionnaire. Main
Outcome Measure included: The percentages of Echo types I, II, III and IV within the tendon, tendon length and width, tendon
cross sectional area (via UTC imaging); ankle inversion movement discrimination ability (via AMEDA device); dynamic
postural balance (via Y balance test); jumping performance (by triple hop distance test) and hip muscle abduction muscle
strength (by hand held dynamometry).
Significant difference in the distributions of the four echo-types in the UTC examination was found between groups. Percentage
of echo-types I was significantly lower while echo-types II was higher in the road group compared with trail group (67.3%,
28.9% and 74.15%,22.1%, respectively)(p<0.001). No significant differences between groups was found for other tests.
We concluded that tendon integrity as examined with UTC is different between road and trail runners. This suggest an influence
of running surface on Achilles tendon structure.
Biography
Dr. Gali Dar has completed her PhD from the Department of Anatomy, Tel-Aviv University, Israel. She is a physiotherapist in her Bachler degree
(B.PT). She is working as a physiotherapist in “Wingate Institute” which is the national institute for physical education and sport in Israel. She is
a full member in the Physical Therapy Department in Haifa University, Israel. Her research focuses on the musculoskeletal system in order to
better understand function, injuries and treatment. Her research deals with the basic anatomy of the structure in addition to physical therapy and
rehabilitation. She has published more than 50 papers in reputed journals.


Use of Intravenous Pamidronate in Pediatric Leukemia Patients with Osteonecrosis Results in

Reduced Pain and May Halt Osteonecrosis Progression
Paivi Miettunen*, C. M. Stephenson, S. L. Stephenson, S.Haider, V. Moorjani and R.Anderson
Alberta Children’s Hospital and University of Calgary, Canada
B ackground: Osteonecrosis (ON) is a complication of acute pediatric lymphoblastic leukemia (pALL), with severe pain
and poor functional outcome. ON affecting weight bearing joints may eventually need arthroplasty, with juxta-articular
lesions being at highest risk. Intravenous Pamidronate (IV-PAM) is postulated to reduce pain and prevent joint collapse in ON.
Objective: To study if IV-PAM was effective in 1) reducing ON related pain and 2) preventing joint ON progression in pALL.
Methods: All consecutive pALL patients (0-18 years) with bone pain were assessed by whole body MRI (WB-MRI). Patients
with ON received two 9-month courses of once/monthly IV-PAM (1 mg/kg/dose, max 11.5mg/kg/year). Visual analogue
score for pain (VAS) (0 = no pain and 10 = the worst possible pain) was administered at baseline, 6 and 12 months and yearly.
Radiologic outcome was assessed by serial WB-MRIs.
Results: Out of 40 patients with bone pain, 24/40 (60%) had ON (9F:15M). Mean pre-IV-PAM VAS was 8.5/10 (range
8-10/10); 0.1/10 (range 0-1/10) at 6 months, and unchanged at 0. 08/10 at 12 months and at final follow-up. ON was multisite
in 24/24; with upper limb and lower limb involvment. ON affected 26 large joints (shoulders [10], hips [4], knees [12]). Four
hips, knees and ankles had >50% articular surface involvement. Mean duration of follow-up was 7 (range 3-15) years. Two
femoral heads developed minor collapse; other ON lesions remained stable or resolved; no surgery was required.
Conclusions: IV-PAM controlled ON related pain in pALL patients and appeared to halt ON progression.
Biography
Dr. Paivi Miettunen is an Associate Professor and Pediatric Rheumatologist in the Division of Pediatric Rheumatology at the Alberta Children’s
Hospital and the Cumming School of Medicine, University of Calgary. She is Clinical Investigator at the McCaig Institute and University of Calgary.
Her research interests are in use of pamidronate in bone diseases, macrophage activation syndrome and rare auto-immune and auto-inflammatory
diseases. She is a member of large international research groups in pediatric inflammatory diseases, including Pediatric Rheumatology International
Research Organization (PRINTO), Chilhood Arthritis and Related Research ( CARRA), Steroid Induced Osteoporosis in Pediatric Patients (
STOPP).

Conference

Keynote Forum
(Day 2)
Page 32

Nadia Benkirane-Jessel
INSERM “French National Institute of Health and Medical Research”
University de Strasbourg "Regenerative Nanomedicine" Laboratory, France
A Therapeutic Wound Dressing Technology to Prevent Early Osteoarthritis Development Following

Traumatic Knee Injuries Artithera
I n our group we explore a new generation of smart living implants combining not only active therapeutics but also stem cells,
as a novel strategy to regenerate stabilized cartilage and avoid prosthesis, by achieving regeneration of its subchondral bone
foundation, requirement which is failing today in the clinic.
In our group, a unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings:
nanoreservoirs, covering nanofibres of implantable nanofibrous membranes for bone and cartilage regeneration. Upon contact
with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide,
and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn,
stimulate further cell proliferation. The nanoreservoirs technology enables to reduce the quantities of required therapeutic agent
(compared to soaked membranes for instance) thereby reducing costs.
Clinical trial: phase 1, (FR, UK, SP, and SW) will be submitted
Feasibility and safety assessment of a therapeutic implant based on an active polymeric wound dressing and autologous
mesenchymal stem cells derived from bone marrow for the treatment of femoral cartilage isolated lesions
1. Mendoza-Palomares, S. Facca, C. Cortez, C, N. Messadeq, A. Dierich, A.P.R. Johnston, D. Mainard, J.C. Voegel, F. Caruso,
N. Benkirane-Jessel, Active multilayered capsules for in vivo bone formation.Proc. Natl. Acad. Sci. USA. 2010, 107, 3406.
2. Facca S, Lahiri D, Fioretti F, Agarwal A, Benkirane-Jessel N, In vivo osseointegration of Nano-designed composite coatings
on titanium implants. ACS Nano 2011, 5: 47904799.
3. C. Mendoza, A. Ferrand, S. Facca, F. Fioretti, D. Mainard, N. Benkirane-Jessel, Smart hybrid materials equipped by
nanoreservoirs of therapeutics. ACS Nano. 2012, 6, 483.3.
4. Eap S, Ferrand F, Schiavi J, Keller L, Fioretti F, Ladam G. Benkirane-Jessel N. Collagen implants equipped by “fishscale”-
like nanoreservoirs of growth factors for bone regeneration. Nanomedicine. 2014, 9, 1253–1261
5. Keller L, Wagner Q, Pugliano M, Breda P, Ehlinger M, Schwinté P and Benkirane-Jessel N. Bi-layered Nano Active Implant
with Hybrid Stem Cell Microtissues for Tuned Cartilage Hypertrophy. Journal of Stem Cell Research and Therapeutics. 2015.
1(1): 00004. DOI: 10.15406/jsrt.2015.01.00004
6. Keller L, Wagner Q, Schwinté P, Benkirane-Jessel N. Double Compartmented and Hybrid Implant Outfitted with Well-
Organized 3D Stem Cells for Osteochondral Regenerative Nanomedicine. Nanomedicine (Lond) 2015 10, 2833-2845
7. Keller L, Schwinté P, Gomez-Barrena E, Arruebo M, Benkirane-Jessel N. Smart Implants as Novel Strategy to Regenerate
Well-Founded Cartilage. Trends in Biotechnology, 2017, 35, 8–11


Biography
Dr. Nadia Benkirane is Research director and head of the “Regenerative Nanomedicine” laboratory, at INSERM (French National Institute for
Health and Medical Research). She was leader of “Active Biomaterials and Tissue Engineering” team INSERM 977. She received her Ph.D.
from University Louis Pasteur, ULP, and Strasbourg, France for the work on Development of pseudo peptides as synthetic vaccines. Dr. Jessel
(Benkirane) then held a postdoctoral position in collaboration with the Institute Pasteur, Paris, France, working on Immunotherapy HIV, and
another postdoctoral position on the application of modified peptides as vaccines against FMDV (Plum Island Animal Disease Centre, ARS,
USDA, Greenport, NY 11944-0848, USA). She joined the INSERM U595 in 2002 as a post-doc, and received the diploma to direct the research
(HDR) in 2004. Dr. Jessel got the permanent position (CR1) in the INSERM 595 laboratory in 2004 and Research Director (DR2) position in
the INSERM 977 and head of “active Biomaterials and Tissue Engineering team from 2009 until 2012). Currently Research Director (DR1) and
head of the INSERM UMR 1260 (Regenerative Nanomedicine" Dr. Jessel possesses expertise in diverse fields of molecular and cellular biology,
immunochemistry, tissue engineering and biomedical engineering. In the last 10 years, she focused her research on the bio-fictionalization of
multilayered polyelectrolyte architectures with emphasis on the use of these architectures to induce specific cellular responses and gain control
over cell proliferation and differentiation. Dr. Benkirane has more than 138 publications (h index: 36) with peer-reviewed publications in high
impact factor journals (Proc. Nat. Acad. Sci. USA; Adv. Mater.; Adv. Funct. Mater. Small; Nanoletters, Biomaterials, ACS Nano), 5 chapter’s
reviews and 5 international patents, she is a regular referee for a number of scientific journals (Nature nanotechnology, Nature Materials, ACS
Nano, Biomaterials, Nanoletters…). She was under the contract (Interface INSERM/Clinic 2008-2013) and she got also “Prime d ‘Excellence
Scientifique” from the INSERM, 2010-2014 and the PEDR from the INSERM on 2016 for 4 years.


Aouatef Bellamine
Lonza Inc., USA
UC-II for Joint Health
D espite the availability of different pharmacological entities for the management of osteoarthritis (OA), joint health remains
an unmet need across generations ranging from active millennials to older adults. The American College of Rheumatology
recommends a healthy life style (e. g. exercise and weight loss) before moving to drug treatment. Dietary supplements have
been used with more or less success either alone or in conjunction with pharmacological treatments. The undenatured type
II collagen (UC-II) contained in chicken sternum cartilage has been shown in human clinical trials to mitigate joint pain in
osteoarthritis subjects and also to increase flexibility in healthy subjects at risk of developing OA. Further, in an OA animal
model, UC-II has been shown to improve cartilage and bone structure at the level of joint deterioration. This presentation will
focus on discussing the benefits of UC-II supplementation as a measure to maintain joint health in both healthy subjects and
osteoarthritis patients. In addition, because of its unique mechanism of action, the oral tolerance, the UC-II dose of 40 mg can
be given once daily, which may improve consumer compliance.
Biography
Dr. Aouatef Bellamine earned her Ph.D. in life science with honors from the University of Sorbonne in France. She is a pioneer in the field of lipid
metabolism where she was the first to purify and characterize enzymes involved in cholesterol synthesis in Mycobacterium tuberculosis. Her
research brought her from academia (Vanderbilt University) to industry where she led a program at Bristol-Myers Squibb looking at lip dystrophy
resulting from the use of protease inhibitors and anti-psychotic drugs. Later on at BMS, she joined the metabolic disease team where she
contributed to the launch of several diabetic drugs. She also led a work stream looking at the attributes of DPP-4 inhibitors and their beneficial
effects on cardiovascular outcomes, as part of the SAVOR trial. Currently at Lonza, Dr. Bellamine is a leading member of the R&D organization
in the Consumer Health and Nutrition Business Unit, where she is involved in the research and clinical development of the Nutrition portfolio. She
has a proven track record and has authored over 25 peer reviewed articles and book chapters in the fields of lipid metabolism, endocrinology and
Nutrition. She also authored several patents both in the US and Europe. She has been invited as a lecturer in many scientific conferences and
has been involved in several advisory boards as a spokesperson. Dr. Bellamine is a member of the American Association for the Advancement
of Science, the American Society of Nutrition, the Council for Responsible Nutrition as a senior member, the American Diabetes Association
and the Society of Toxicology.


Zehra Gok Metin

Hacettepe University, Turkey
The Effects of Education and Psychological Interventions in Patients with Rheumatoid Arthritis within
the Framework of Rehabilitation
I n rehabilitation, treatment is focused primarily on the functional consequences of the disease, with the accent on non-
pharmacological treatment interventions. Both physicians and a variety of health professionals may be involved in
rehabilitative treatment programs. Comprehensive multidisciplinary team care programs are aimed at improving disease
activity, physical and psychosocial functioning, with the ultimate goal of assisting patients to achieve and maintain maximum
personal independence. Treatment modalities may consist of optimization of antirheumatic drug therapy and intra-articular
injections with corticosteroids, general rest, local immobilization of inflamed joints, the application of local heat or cold,
exercise and occupational therapy, education and psychosocial support. Within the framework of rehabilitation, the goal of
education and psychosocial support programs for patients with Rheumatoid Arthritis (RA) is to give patients the strategies
and tools necessary to make daily decisions to cope with the disease. The education of patients may consist of information
only, counselling, or a behavioral approach. In a recent systematic review on the education of RA patients, a positive effect
on disability, joint counts, patients' global assessment, psychological status and depression was found. The benefits were,
however, modest and short-lived. The literature indicated a possible superiority of behavioral treatment. These positive effects
were confirmed in another review that focused merely on behavioral interventions for RA, and included trials on interventions
such as relaxation, biofeedback, stress management and cognitive-behavioral therapy. It remains unclear whether the results of
educational and psychological interventions can be improved by ‘booster sessions’, the involvement of spouses or other family
members, or a more explicit tailoring of the timing and contents of the program to the individual's needs and motivation.
Biography
Zehra Gok Metin has completed her PhD from Hacettepe University Faculty of Nursing, Turkey and postdoctoral studies from University of
Alabama, USA. She is currently working an assistant professor in Medical Nursing Department at Faculty of Nursing of Hacettepe University.
She has conducted several high quality clinical trials, has published more than 20 papers in reputed journals, and has been serving as an
editorial board member of reputed journals.


Olivier Godeaux1*, Marie Bettonville1, Anne-Sophie Delmarcelle1, Marc Leon2, Bogdan

Ster3, Jean-François Kaux4, Thierry Appelboom5, Joelle Margaux6, Didier Urbin-Choffray7,
Emilie Theunissen8, Tatiana Besse-Hammer9, Philippe De Greift10, Jiangang Qu11, Yves
Fortems12 and Severine Verlinden13
Bone Therapeutics S.A., Belgium
1
2
CHU Ambroise Pare, Belgium
3
CHU Saint-Pierre, Belgium
4
University and University Hospital of Liege, Belgium
5
Hopitaux Iris Sud Moliere Long champ, Belgium
6
CUB Erasme, Belgium
7
CHR Citadelle, Belgium
8
Clinique Saint-Pierre Ottignies, Belgium
9
CHU Brugmann, Belgium
10
CHR de Namur, Belgium
11
Hopitaux Iris Sud Etterbeek-Ixelles, Belgium
12
AZ Sint Jozef, Belgium
13
CHR Haute Senne, Belgium
Safety and Efficacy of Intra-Articular Injection of JTA-004, a Novel Viscosupplement, In Symptomatic

Knee Osteoarthritis: A Randomized, Double-Blind Controlled Phase II/III Study
O bjective: The objective was to assess the safety and efficacy of a single intra-articular administration of JTA-004, a novel
viscosupplement, in patients suffering from symptomatic knee osteoarthritis (OA) at 6 months.
Design and Methods: In this prospective, multicenter, double-blind phase II/III trial (NCT02740231), 164 patients with
primary OA knee pain were randomly assigned to one of the three JTA-004 strengths or the comparator treatment (Hylan G-F
20) in a 1:1:1:1 ratio. Safety was assessed by monitoring and reporting vital signs, physical examination, adverse events and
concomitant medications. The primary efficacy endpoint was the change from baseline at 6 months in WOMAC VA3.1 pain
subscale.
Results: JTA-004 was shown to be well tolerated at all strengths evaluated. At 6 months, patients in the three JTA-004 groups
showed a better improvement in pain compared to patients in the comparator group although statistical significance was not
achieved. As the three JTA-004 strengths had a similar efficacy, a post hoc analysis was subsequently performed between the
pooled JTA-004 treated patients and the comparator group. The exploratory analysis showed a 26.1±2.4 (adjusted mean ± SE)
mm improvement in pain in the pooled JTA-004 group vs. 15.6±4.1 mm in the comparator group at 6 months, demonstrating a
statistically significant superiority of JTA-004 over the comparator (p = 0.030).
Conclusions: This study provides first evidences of safety and efficacy of JTA-004 in the treatment of symptomatic knee OA.
Efficacy will be further confirmed in a subsequent pivotal Phase III study.
Biography
Dr. Olivier Godeaux is a seasoned biopharmaceutical industry executive with a proven track record in advancing drug candidates through all
phases of development to regulatory approval and commercial launch. Dr. Godeaux held various senior positions in clinical development at fast-
growing biotechnology companies, clinical research organizations and global pharmaceutical companies such as Johnson & Johnson, GSK and
UCB, where he led several complexes, large-scale Phase III clinical studies involving 1,000+ patients in Europe, US and Japan. Olivier Godeaux
received his Doctor of Medicine and his Master in Public Health degrees from the University Catholique de Louvain (UCLouvain), Belgium. As
Chief Medical Officer of Bone Therapeutics S.A., Olivier Godeaux is responsible for the development and execution of the Company’s clinical
development strategy, advancing its late-stage products through clinical development towards commercialization, while playing a crucial role in
the interactions with regulatory authorities, clinical experts and key opinion leaders.

Conference

Workshop
(Day 2)
Page 38

Yahia Falih Mohammad

Al Diwaniya Teaching Hospital, Diwaniya, Iraq
Evaluation of Use of PRP Injection in ACL Partial Injury
Introduction: PRP was used firstly in treatment of osteoarthritis joints and have very nice effect in it, but actually I found
that some patient whom got some problem of instability due to injury to ACL got benefit from injection so I try to use it in
ACL partial injury.
Methods: We carried out an audit on ACL partial injury diagnosed by MRI and Arthroscopies between April 2014–April 2018;
we inject 3-5 ml PRP in the different type of injured ACL. Fellow up for 3-6 month clinically the ability to return to playing
football.
Result: 178 patients admit to Orthopedic Department Al Diwaniya Teaching Hospital 67% returned to play football, 6%
missing in fellow up , 2% got infection , 4% got restriction of movement , 21% they got no benefit from injection.
Conclusions: In this study we found that PRP play a good role in patients got a sport injury of the knee in general and as well
as Partial injury of ACL.
Keywords: Anterior Cruciate Ligament (ACL); Arthroscopy; Plasma Rich Platelets (PRP); Injection; Return to Play; Football
Biography
Yahia Falih Mohammad Consultant Orthopaedic Surgeon. Chairman of Continuous Medical Education in Al Diwaniya Teaching Hospital. Head
of CME and Training and Development Center Al Diwaniya Health Office .Lecturer in Al Diwaniya College of Medicine. Lecturer in Al Diwaniya
College of Sport Education. Head of Iraqi Union of Sport Medicine. Supervised PHD researches/ thesis for post graduates .

Conference

Scientific Sessions
(Day 2)
Page 40
Sessions Day 02
September 27, 2019
Chair
Munaf A Hatem, Hepavita Medical Center/Poland, Peace land Medical services/Oman
Session Introduction
Title: Knowledge and Practice in the Management of Asymptomatic Hyperuricemia Among
Primary Health Care Physicians in Jeddah, Western Region of Saudi Arabia
Norah A. Alqarni, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia
Title: Treatment of Tibial Plateau Fractures Schatzker Type V an VI with Ilizarov External
Circular Frame
Vaso Kecojevic, Clinical Center Novi Sad, Yugoslavia
Title: Therapeutic Contribution of Iyengar Yoga in Physiotherapy
Marc Michnowski, Physiotherapist, France
Title: A Prospective Study of 17 Consecutive Pediatric Patients with Chronic Non-Bacterial
Osteomyelitis Treated with Intravenous Pamidronate Over a 15-Year Period at a Single
Center Reveals Excellent Clinical and Radiologic Outcome
Paivi Miettunen, Alberta Children’s Hospital and University of Calgary, Canada
Title: Irreducible Knee Dislocation, What to do?
Bandar Abdullah Ahmed, King Saud Medical City, Saudi Arabia
Title: Effects of Specific Versus General Exercise on Neck Proprioception in Patients with Chronic
Non-specific Neck Pain
Manizheh Saberi, Shiraz University of Medical Sciences, Iran
Title: Estella Humanoid Robot: An Anatomical Replicant
Behnam Rahnama, USWR, Iran

Knowledge and Practice in the Management of Asymptomatic Hyperuricemia among Primary

Health Care Physicians in Jeddah, Western Region of Saudi Arabia
Norah A. Alqarni* and Abdul H. Hassan
King Fahad Armed Forces Hospital, Kingdom of Saudi Arabia
O bjectives: To assess knowledge and practice levels in asymptomatic Hyperuricemia (AH) and investigate predictors of
urate-lowering therapy (ULT ) misprescribing among primary health care (PHC) physicians.
Methods: A cross-sectional study was conducted among 201 PHC physicians from December 2017 to May 2018. A based
clinical guidelines for Hyperuricemia management from American Professional Organizations, a semi-structured questionnaire
was administered to collect demographic and professional data; knowledge and practice levels in management of AH; and
barriers to the management of Hyperuricemia and gout, with focus of the misprescribing of ULT in AH. A 2-stage stratified
sampling technique was used to select 4 PHC centers were from each of the 5 advisory sectors in Jeddah, Kingdom of Saudi
Arabia; and to recruit a minimum of 10 eligible participants per primary health care center (PHCC). Binary logistic regression
was used to analyze predictors of ULT misuse in AH.
Results: Only 32.8% participating physicians had adequate knowledge about AH. Regarding practice, while majority
(88.1%) correctly recommended a low-purine diet and lifestyle changes to patients, almost half misprescribed ULT and
10.9% misprescribed non-steroid anti-inflammatory drugs. Lack of knowledge and awareness about guidelines were the most
frequently self-reported barriers to adequate practice. Predictors of ULT misuse included the percentage of patients having gout
(1-10%: OR=5.40, p=0.047) or receiving ULT (>10-20%: OR=20.02, p=0.001) among patients seen in clinic, attendance of
rheumatology conferences (OR=2.55, p=0.017), and having a close relative with Hyperuricemia or gout (OR=2.45, p=0.026).
Conclusion: There are inadequate levels of knowledge regarding AH among Saudi PHC physicians increasing risk of
malpractice including misprescription of ULT and anti-inflammatory medications.
Biography
Dr. Norah A. Alqarni is a Saudi Family Medicine Doctor. Graduated from King Abdulaziz University Medical School at 2011 working at King Fahad
Armed Forces Hospital (Family & preventive Medicine) department since 2012.


Treatment of Tibial Plateau Fractures Schatzker Type V an VI with Ilizarov External Circular
Frame
Vaso Kecojevic*, Ivica Lalic, Vladimir Harhaji and Milan Stankovic
Clinical Center Vojvodina, Serbia
T ibial plateau represent one of the most critical weight-bearing surfaces in human body; fractures of impact the stability,
mobility and knee joint line. Proper treatment of these fractures are crucial for decrease disability and risc of documented
complications, specialy posttraumatic osteoarthritis. Tibial plateau fractures (Schatzker type V and VI) are complex fractures
caused by high energy, often associated with soft tissue damage and are at the high risk for wound comlications after open
reduction and internal fixation (ORIF). Another dificulty is to estabilsh stable fixation of comminuted fractures.Clasical
operative technique with two plates is related with potentional complications such as failed fixation, malunion, nonunion,
joint stifness, posttraumatic arthritis, infection, and most of all soft tissue complications tha range from 23%-87.5%. Veri
and.all compared internal and external fixation in double cohort studies, and recorder high degree of wound complications
and reoperations in ORIF group through single incision and two plates. Also, their resutls suggested efficasy and safety, with
low degree of wound complications and early functional recovery in external hybrid fixation group. Ilizarov method for
treatment of such a fractures at our Clinic is used since 2005. This paper presents operative technique and results of treatment
of comminuted tibial plateau fractures by Ilizarov method.
Biography
Vaso Kecojevic has completed his residency of orthopaedic surgery and traumatology in 2002 at Medical Faculty, University of Novi Sad, Serbia.
He is the president of ASTAS (Association for Sports Traumatology and Artroscopy of Serbia), member of EBOT Writing Committee, member of
ESSKA Education Commity 2010.-2014, member of ESSKA Arthroscopy Committee 2014-2016, rewiewer in Journal of Clinical Orthopaedics
and Trauma. He has published chapters in 7 books, and more than 10 papers in journals and has several oral presentations at national and
international meetings.


Therapeutic Contribution of Iyengar Yoga in Physiotherapy

Marc Michnowski
Physiotherapist, France
M illennial practice and physical part of traditional Indian medicine, yoga uses, like physiotherapy, but for much longer,
body gymnastics to prepare, maintain, heal the body and free the mind. Crossing centuries and continents the practice of
yoga has decayed to become a physical activity with too many varieties, very popular in the West. In parallel, it was enriched
and medicalized in India under the actions of BKS Iyengar, who proposes an authentic method of care.
Medical gymnastics used in physiotherapy is it, validated by science.
However, it uses exactly, all of part of exercises as those used to build the traditional yoga (Hatha) postures but, in a more
fragmented and more analytical way.
Iyengar proposes a therapeutic yoga with very codified postural constructions. He aligns the skeletal parts one after another
from head to toe and sets the joints by stimulating the muscles precisely. Thus, He reaches a solid and profitable global stance.
Let us study three simple yoga postures, fundamental and accessible by all, constructed in this way, so analytical, to understand
the interest of this technique.
Should physiotherapists be inspired by the Iyengar method to be more effective?
In any case, yoga has such a variety of postures that its study is not a waste of time. It can only enrich the knowledge of
physiotherapists.
Currently, a growing number of scientific studies are proving the benefits of yoga practices on health.
For lack of means, they do not yet include enough patients to claim to be validated. Certainly a union between the western
approach of the physiotherapist and that of oriental yoga experts would be beneficial for a faster validation and the good of
the patients.
Keywords: Physiotherapy; Iyengar therapeutic yoga; Medical gymnastics; Postures; Scientific studies


A Prospective Study of 17 Consecutive Pediatric Patients with Chronic Non-Bacterial Osteomyelitis

Treated with Intravenous Pamidronate over A 15-Year Period at a Single Center Reveals Excellent
Clinical and Radiologic Outcome
Paivi Miettunen1*, C.M. Stephenson1, A.M. Stephenson1 and C. Wei2
1
Department of Pediatrics, Pediatric Rheumatology, Alberta Children’s Hospital and University of Calgary, Canada
2
Department of Pediatrics, Diagnostic Imaging, Alberta Children’s Hospital and University of Calgary, Canada
O bjectives: To describe a prospective series of pediatric patients with Chronic Noninfectious Osteomyelitis (pCNO)
treated with IV-Pamidronate (IV-PAM) regarding 1) pain, 2) Whole Body Magnetic Resonance Imaging (WBMRI)
documented inflammation, 3) flares, and 4) spinal outcome.
Methods: All pCNO patients (<18 years at diagnosis) with WBMRI confirmed active CNO, treated with IV-PAM, between
years 2003-2018, were included. IV-PAM was administered once monthly x 9 (max dose 11.5 mg/kg/year), and after flare.
Visual analogue scale (VAS) (“0” = no pain and “10” = maximum pain) was administered at baseline, at each IV-PAM, and
at suspected flare. WBMRI was performed at baseline, at 6 and 12 months, and at suspected flare. Complete resolution (CR)
was defined as > 95% resolution of WBMRI signal.
Results: 17 pCNO patients (9F) were included with median [range] age at diagnosis 10.3[4-15] years; at IV-PAM 11.6[4-
20] years. Median [range] follow-up was 9.2[1-15] years. CNO was multifocal in 7/17; 4 patients had spinal involvement
with baseline fractures in 2/4. Baseline VAS was 10/10, and decreased to 0-1/10 after 1st IV-PAM. All patients reached CR
at 6 months. Twelve patients relapsed and 11/17 received 2nd course of IV-PAM. With flare, VAS ranged from 4-9/10 and
decreased to 0-3/10 after 1st IV-PAM. On final WBMRI, 12/17 (70%) had CR; 5/17 stable increased signal but no clinical
symptoms. No new spinal fractures developed. At last follow-up, 10/17 (59%) patients required no medications.
Conclusion: Long-term follow-up confirms that initial beneficial effects of IV-PAM are sustained with flares with no further
spinal fractures.
Biography
Dr Paivi Miettunen is an Associate Professor and Pediatric Rheumatologist in the Division of Pediatric Rheumatology at the Alberta Children’s
Hospital and the Cumming School of Medicine, University of Calgary. She is Clinical Investigator at the McCaig Institute and University of Calgary.
Her research interests are in use of Pamidronate in bone diseases, macrophage activation syndrome and rare auto-immune and auto-inflammatory
diseases. She is a member of large international research groups in pediatric inflammatory diseases, including Pediatric Rheumatology
International Research Organization (PRINTO), Childhood Arthritis and Related Research (CARRA), Steroid Induced Osteoporosis in Pediatric
Patients (STOPP).


Irreducible Knee Dislocation, What to do?

Bandar Abdullah Ahmed
King Saud Medical City, Saudi Arabia
K nee dislocation is a rare orthopedic emergency that requires special care. The incidence of knee dislocation is estimated
to be low, accounting for less than 0.02% of the total number of annual trauma. The majority of knee dislocation injuries
occur in high-energy trauma that causes stress in the anteroposterior direction in the sagittal plane of the knee and varus valgus
angulation in the frontal plane, inducing a rotational dislocation of the tibia in relation to the femoral condyles.
Kennedy’s classification of knee dislocations is based on the direction of tibial dislocation in relation to the femur, such as
anteromedial, poster medial, anterolateral, and poster lateral. Poster lateral rotatory dislocation occurs infrequently and most
of the cases are considered irreducible by closed reduction because of incarceration of soft tissues, such as the medial capsule,
retinaculum, vastus medialis muscle, and medial meniscus. The ‘Pucker sign’ or ‘Dimple sign’ is a physical characteristic of
irreducible knee dislocation, which is caused by invagination of the skin and soft tissues into the medial joint space
Keywords: Knee; Dislocation; Vastus medialis; Interposition
Biography
Bandar Ahmed is orthopedic surgeon. He is graduated from college of medicine, king Saud University in 2012. Associate Consultant Orthopedic
Surgeon at King Saud Medical City Department of Orthopedic Surgery, Riyadh, Saudi Arabia, Saudi Board in Orthopedic Surgery (2014-2018)
Resident of The Year (2016-2017) in Orthopedic Training Program, Ministry of National Guard- Health Affairs, Riyadh , Kingdom of Saudi Arabia
Chapter leader for sport medicine and upper extremity in Saudi Orthopedic Surgery Program Residents Educational Activity 2017
Chapter leader for sport medicine in Saudi Orthopedic Surgery Program Residents Educational Activity 2018
Speaker in the 1st Arthroscopy and Sport Medicine meeting of Saudi Orthopedic Association in Riyadh , KSA , February 2018
Speaker in the 2nd Sport Surgery meeting of Saudi Orthopedic Association in Riyadh, KSA, April.


Effects of Specific versus General Exercise on Neck Proprioception in Patients with Chronic Non-
specific Neck Pain
Manizheh Saberi1,2*, Pegah Kashfi3, Mahsa Rahnama2, Mehrab Saberi2 and Leila Rahnama3,4
1
National University of Medical Sciences, Spain
2
Shiraz University of Medical Sciences, Tehran
3
Department of Physiotherapy, University of Social Welfare and Rehabilitation Sciences, Iran
4
Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Iran
C hronic neck pain is associated with proprioceptive deficit and deep muscles morphological changes. It is believed that
deep neck muscles have extremely high density of muscle spindles. This characteristic may make them play an essential
role in neck proprioception. However, it is not clear if therapeutic exercises targeting deep neck muscles have superiority
in improving proprioceptive deficit or general exercises which is frequently recommended to patients. In this preliminary
randomized clinical trial 20 patient with chronic non-specific neck pain were recruited and allocated into two groups. One
group received specific exercises including deep neck muscles strengthening and the other group received neck general exercise
including neck and shoulder free active range of motions (ROM). Absolute repositioning error in neck rotation was measured.
Repeated measures ANOVA was used to analyze data. The level of significance was set at 0.05.The main effect of time was
found significant (F=4.42, p=0.04) indicating both general and specific exercises improved neck proprioception significantly,
although the main effect of group was not significant (F=1.101, p=.32). Furthermore, the group by time interaction was
not significant (F=0.67, p=0.42) demonstrating similar effects of both specific and general exercise on neck proprioception.
Results of the present study indicate that both deep neck muscles strengthening and general ROM exercises improved neck
proprioception challenging the belief of more essential role of deep neck muscles in proper neck proprioception compared to
superficial muscles.
Biography
Manizheh has completed her doctor of Physiotherapy (DPT) from National University of Medical Sciences, Spain. She has been working as the
representative of physiotherapists and physicians in Iranian Medical Council for ten years. She is currently managing her own Physiotherapy clinic
and has evaluated, examined and managed thousands of rheumatologic and orthopedic patients. Her area of interest is on orthopedic conditions.
She has been awarded as the best physiotherapist in Iran in 2016.


Estella Humanoid Robot: An Anatomical Replicant

Behnam Rahnama1*, Leila Rahnama2 and Fatemeh Heiran1
1
Semantic Robotics Lab, Medis Inc. Shiraz, Iran
2
Department of Physiotherapy, USWR, Iran
H umanoid robots try mimicking humanlike moves. Scientists design joints, links and actuators in such a way that robots
move like humans. In Estella robot, a 165 centimeter height humanoid robot, we designed and developed a mechanical
structure similar to human anatomy with flexible spine. The Estella’s spine including five vertebral joints (including neck) to
shape the human spine configuration which, each of vertebrae joints are an 3 − RSS actuation redundant parallel robot with
three orientation-based degrees of freedom. The clavicle of the Estella connects cervical and thoracic spine to each other from
up and down and also it connected to scapula using a spherical joint in both sides. This spherical joint is restricted by two
actuators to imitate elevation/depression motions and protraction/retraction motions. The glenoid joint is designed with three
actuators to support flexion/extension, adduction/abduction and longitudinal rotation motions. The design of lower arm of
Estella supports pronation/supination motions in elbow joint which is constructed in a way to mimic the rotation of ulna and
radius bones around each other. The elbow and wrist joints have all motions in sagittal and frontal planes including flexion/
extension and radial/ulnar abduction. Considering anatomical position, the lower arms in frontal plane have 7 degrees angle
deviation with longitudinal axis which is the result of the ratio of hip width to waist width in human anatomy. Estella’s hand
is the scale-down 3D printed you bionic hand. Each hand is controlled by 11 micro actuators and it can imitate all the motions
of a human hand. In the future, we wish to develop Estella’s lower limbs mechanisms and also its face to become a complete
humanoid robot.
Biography
Behnam Rahnama received PhD (2010) and MSc (2005) in Computer Engineering at Eastern Mediterranean University and his BSc degree - in
Computer Software Engineering - (2003) at Shiraz Azad University of Iran. He has published various papers, book chapters and couple of books
in the fields of Intelligent Systems, Robotics, Semantic Web Services, Data Structure, and Security (more than 55 publications). His research
interests include Distributed Collaborative Autonomous Semantic Robotic Systems, Semantic Reasoning, and Semantic Intelligence, Efficient
Hierarchical Schemas for RDBMS, Security and Cryptography, Embedded OS/Hardware for Robotics and partially solving and parallelization of
ultra dense linear matrices on GPGPU based supercomputers. He is reviewer of many international journals and refereed conferences in addition
to co-chairing COMPSAC-MEDIS, SINCONF, IJRCS, and biannual EEECS symposiums. Within last recent years, he has been actively working
on startup companies, running and participating incubation centers in both US and Iran. Working as a Senior Software Engineer at ScaleDB Inc.
in US and Founding Medis Holding as the foremost Innovation Center in Iran, in addition to receiving full professorship degree in less than 7 years
after PhD, and designing the planet most powerful exascale supercomputer with more than 2 exaflops of computational power are some of major
examples of such enthusiasm.

Conference

Poster Presentation
Page 49

Carbon Nanotube Application and Safety in Artificial Hip Joints

N. Saito*, N. Nishimura and K. Aoki
Shinshu University, Japan
T he number of revision total hip arthroplasty (THA) procedures is on the rise, which is a problem since these surgeries are
more technically demanding and increase the risk of infection and additional bone degeneration. We are therefore aiming
to reduce the need for revision surgery with better implants. Our current focus is on the polyethylene (PE) socket. The non-
cross-linked PE initially used by surgeons had high fracture toughness, but a softness that led to an increased wear rate. To
improve this, gamma irradiation was applied to cross link the PE molecules and produce stronger materials with lower wear
patterns. However, the harder sockets were also more brittle and prone to breaking. We are at the threshold of developing the
first biomedical application of carbon nanotubes (CNTs). Abrasion tests are currently being planned to simulate long-term
wear and tear on the new CNT-PE sockets. There remains speculation on the safety of CNTs, especially regarding inhaled
particles, which may behave similarly to asbestos in terms of pathogenicity. In this regard, it will be imperative to establish
that the safety or danger of inhaled CNTs is completely different from that of implanted CNTs. We believe the new artificial
joints will be safe for patients, and envision a bright future for CNT-based biomedical materials for THA and other prosthetic
applications.
Biography
Naoto Saito has completed his PhD from Shinshu University, Japan. He is the director of Institute for Biomedical Sciences, Interdisciplinary Cluster
for Cutting Edge Research, Shinshu University.

Conference

Accepted Abstracts
Page 51

Functional Biologic Augmentation in Arthroscopic Rotator Cuff Repair: Concomitant Superior

Capsular Reconstruction with Arthroscopic Rotator Cuff Repair to Treat Massive Atrophic Rotator
Cuff Tear Pathology
William T. Pennington*, Brian A. Bartz, Joann M. Pauli and Steven Chen
Institute of Wisconsin, USA
P urpose: To present our outcome analysis of 46 consecutive shoulders (44 patients) presenting with massive, retracted
rotator cuff tears that we treated with arthroscopic rotator cuff repair with concomitant superior capsular reconstruction
utilizing an acellular dermal allograft. We report our experience that this technique theoretically restores superior capsular
integrity and decreases superior capsular distance therefore decreasing tension on the repair. The use of concomitant superior
capsular reconstruction with repair has allowed repair of seemingly irreparable tears to the native footprint possible. We also
present the concept of superior capsular distance to quantitatively measure the decreased distance present with restoration of
superior capsular integrity, which we believe facilitates repair in these tears. We believe this technique also provides biologic
augmentation in these large tears with poor tissue quality.
Methods: Forty-six shoulders in forty-four consecutive patients (mean age 58.8) presented with massive rotator cuff tear
(Co field Classification, >5cm), retraction (>5 cm, and atrophy (Goutalier Grade 3 or 4). The tears involved the supraspinatus
or both the supraspinatus and infraspinatus tendons. All tears, upon initial arthroscopic evaluation, appeared to be massive
retracted rotator cuff tears with poor tissue quality that upon arthroscopic mobilization and attempted repair we were unable
to re-approximate the native rotator cuff or superior capsule to the native footprint. While performing superior capsular
reconstruction with an a cellular dermal allograft in these patients, it was noted that the rotator cuff was able to then be re-
approximated under very little tension over the native footprint to the greater tuberosity of the humerus over the superior
capsular reconstruction graft. All patients in this outcome analysis underwent an arthroscopic superior capsular reconstruction
with concomitant rotator cuff repair. Outcome analysis was performed via an internet based outcome-tracking system to
evaluate visual analog score, ASES score, and simple shoulder test scores. These scores were obtained preoperatively as
well as intervals of 2 weeks, 3 months, 6 months, 1 year, and 2 year postoperatively. Radiographic analysis of standard
AP radiographs were analyzed to assess acromio-humeral interval, displacement of the geometric center of the humeral
head from the geometric center of the glenoid, and superior capsular distance preoperatively as well as 1 week, 6 months,
and 1 year postoperatively. These radiographic measurements were obtained utilizing the digital radiographic calibration
software inherent to our digital radiographic system. Digital dynamometric strength analysis and functional range of motion
assessments were obtained in the preoperatively as well as 6 months and 1 year post-operatively. All data obtained was
analyzed statistically to evaluate for significance.
Results: Forty-four patients (46 shoulders) received surgical treatment with functional biological augmentation. A 4%
failure rate has been observed and 86% of patients are satisfied with the surgical results. Outcome data analysis demonstrated
significant (p<0.05) improvements in pain (VAS preop 2.80 – VAS 1 year 0.8) strength (FF/ABD preop 4.5 lb/3.7 lb – FF/
ABD 1 year 9.7 lb /12.4 lb), and range of motion (FF/ABD preop 127.3°/112.0° – FF/ABD 1 year 163.0°/163.8°). There was
no statistical difference (P<0.05) at 1 year between strength and range of motion in the operative and non-operative extremity.
Radiographic analysis showed significance (P<0.05) at the 1-week, 6-month, and 1-year time points for an increase in the
acromio-humeral interval (mean 7.6mm preop – mean 8.7mm 1 year) and superior capsular distance (mean 52.8mm preop
– mean 45.2mm 1 year). Outcome data analysis demonstrated improved scores in visual analog scores (4.0 to 0.9), simple
shoulder test (45.4 to 54.2), SANE scores (35.0 to 49.3), ASES function score (14.8 to 20.7), and ASES index scores (54.8 to
80.0) at one year follow-up.
Conclusions: Functional biologic augmentation with superior capsular reconstruction and concomitant rotator cuff repair in
massive rotator cuff tears with associated advanced muscular atrophy has demonstrated promising early results in treating this
problematic patient population. The use of the acellular dermal allograft intraoperatively as a graft to reconstruct the superior
capsule allows for easier approximation of retracted rotator cuff tears to the native rotator cuff attachment site at the greater
tuberosity of the humerus and a reduction of superior capsular distance. This technique also provides a biologic scaffold that
allows host cell infiltration and enhances the healing process. Utilization of this technique in large retracted tears with poor
tissue quality has the theoretic benefit of providing a repair with less tension and restoration of superior stability. While the
short-term results have been promising in this outcome analysis and long-term benefit needs to be confirmed.


Biography
Dr. Pennington is a board certified Orthopedic Surgeon with subspecialty certification in sports medicine. He completed medical school and
orthopedic residency training at the Medical College of Wisconsin. His fellowship training in shoulder and knee reconstruction was completed at the
California Pacific Medical Center in San Francisco, CA. He is a partner in The Orthopedic Institute of Wisconsin and a founding member of Midwest
Orthopedic Specialty Hospital. His primary scope of practice is all aspects of shoulder reconstruction via arthroscopic and open reconstruction
methods. He has numerous publications and presentations pertaining to shoulder reconstruction.


Arthroscopic Superior Capsular Reconstruction for the Treatment of Massive Irreparable Rotator
Cuff Tears in the Active Patient: 1-2 year Results
William T. Pennington*, Brian A. Bartz, Joann M. Pauli, Carol E. Walker and William Schmidt
The Orthopedic Institute of Wisconsin, Milwaukee, USA
P urpose: To present our outcome analysis of 88 consecutive shoulders (86 patients) presenting with massive, retracted,
irreparable rotator cuff tears that we treated with arthroscopic superior capsular reconstruction utilizing an acellular dermal
allograft. We also present the concept of superior capsular distance to quantitatively measure the decreased distance present
upon restoration of superior capsular integrity. We believe this radiographic analytical tool, in addition to acromiohumeral
distance, can be utilized to demonstrate restoration and maintenance of superior stability.
Methods: Eighty-eight shoulders in eighty-six consecutive patients presented with massive rotator cuff tears (Cofield
classification, >5cm), retraction (>5cm), and atrophy (Goutalier Grade 3 or 4). The tears involved the supraspinatus or
both the supraspinatus and infraspinatus tendons. All failed previous treatments including surgical (n=34) and non-surgical
modalities (n=54). The patients in this series were considered too young and active (ages 27-79, mean age 59.4) for treatment
with reverse total shoulder arthroplasty. All patients were treated by a single surgeon and underwent arthroscopic superior
capsular reconstruction with an acellular dermal allograft. Outcome analysis was performed via an internet based outcome-
tracking system to evaluate visual analog score, ASES score, and simple shoulder test scores. These scores were obtained
preoperatively and at intervals of 2 weeks, 3 months, 6 months, one year, and two years postoperatively. Radiographic analysis
of standard AP radiographs was analyzed to assess acromiohumeral interval and superior capsular distance preoperatively as
well as 1 week, 6 months, and one year postoperatively. These radiographic measurements were obtained utilizing the digital
radiographic calibration software inherent to our digital radiographic system. Digital dynamometric strength analysis and
functional range of motion assessments were obtained preoperatively as well as 6 months and one year postoperatively. All
data obtained was analyzed statistically to evaluate for significance.
Results: Eighty-six patients (88 shoulders) received surgical treatment with superior capsular reconstruction. Upon follow-
up, 90% of patients report satisfaction with the surgical results. Outcome data analysis demonstrated significant (p<0.05)
improvements in pain (VAS preop 4.0 – VAS 1 year 1.2), strength (FF/ABD/EXR preop 4.8 lb/4.1 lb/7.7 lb – FF/ABD/EXR
1 year 9.8 lb/9.2 lb/12.3 lb), and range of motion (FF/ABD preop 120°/103° - FF/ABD 1 year 160°/159°). At one year, there
was no statistical difference in strength and range of motion between the operative and non-operative extremity. Radiographic
analysis showed significance (p<0.05) at the 1 week, 6 month, and one year time points for an increase in the acromiohumeral
interval (mean 7.1mm preop – mean 9.7mm 1 year) and the superior capsular distance (mean 52.9mm preop – mean 46.2mm
1 year). Outcome data analysis also demonstrated improved scores in visual analog scores (4.0 to 1.2), simple shoulder test (52
to 79), SANE Scores (32 to 70), ASES Function scores (13 to 21), and ASES Index scores (52 to 79) at one year follow-up. A
4.5% failure rate has been observed, three radiographically and one clinically, with the single clinical failure being revised to
a reverse total shoulder arthroplasty.
Conclusion: Younger, active patients with massive irreparable rotator cuff tears and pseudoparalysis have been historically
difficult to predictably treat with arthroscopic methods. Our outcome analysis demonstrates that arthroscopic superior capsular
reconstruction with acellular dermal allograft has been a successful procedure in this patient population, leading to decreasing
pain and improving function with promising early results. Radiographic analysis in these patients has also demonstrated a
consistent and lasting decrease in superior capsular distance as well as an increase in the acromiohumeral interval, indicative
of maintenance of superior capsular stability. As it is generally accepted that reverse total shoulder arthroplasty should be
avoided in this patient population, this procedure “burns no bridges” for future reconstructive procedures. Arthroscopic
superior capsular reconstruction appears to be a reproducible alternative that may delay or prevent the need for future reverse
total shoulder arthroplasty in this patient population. Longer-term follow-up will be required to demonstrate the sustainability
of these promising short-term results.
Note: This study has been published with following citation:
Arthroscopic Superior Capsular Reconstruction with Acellular Dermal Allograft for the Treatment of Massive Irreparable
Rotator Cuff Tears in short- term clinical outcomes and the radiographic parameter of superior capsular distance. William T.
Pennington, M.D., Brian A. Bartz, P.A.-C., Joann M. Pauli, P.A.-C., Carol E. Walker, B.A., William Schmidt B.S. Arthroscopy:
The Journal of Arthroscopic and Related Surgery, Vo. 34, No 6 (June), 2018: pp 1764-1773.


Biography
Dr. Pennington is a board certified Orthopedic Surgeon with subspecialty certification in sports medicine. He completed medical school and
orthopedic residency training at the Medical College of Wisconsin. His fellowship training in shoulder and knee reconstruction was completed at the
California Pacific Medical Center in San Francisco, CA. He is a partner in The Orthopedic Institute of Wisconsin and a founding member of Midwest
Orthopedic Specialty Hospital. His primary scope of practice is all aspects of shoulder reconstruction via arthroscopic and open reconstruction
methods. He has numerous publications and presentations pertaining to shoulder reconstruction.


How does a Personalized Rehabilitative Model influence the Functional Response of Different
Ankle Foot Orthoses in a Cohort of Patients Affected by Neurological Gait Pattern?
Maurizio Falso*, Eleonora Cattaneo, Elisa Foglia, Marco Zucchini and Franco Zucchini
Middle Cares Rehabilitation Unit, Fondazione Madonna del Corlo, Lonato (Bs), Italy
F ive patients affected by different neurological gait pattern and volunteered to participate to this study were recruited.
The comparative spatio-temporal and functional effect on gait pattern of 3 types of AFOs was investigated under 4 study
conditions: 1) without AFO or free-walk (FW); 2) wearing a Codivilla spring, 3) wearing a carbon unjointed AFO (“Toe-Off”);
4) wearing an innovative carbon-Kevlar dynamic joint DAFO (DAFONS=Dynamic Ankle Foot Orthoses with Neuroswing).
In line with our rehabilitative model, patients underwent to a weekly treatment session, 80 minutes duration per session, for 4
weeks. Evaluation was made before (time T3=time of recruitment) and after our individualized rehabilitative treatment course
(time T4=1 month from T3) by using: a. G-Walk sensor (by BTS) spatio-temporal measures in different gait performances;
b. clinical/functional outcome measures (Modified Ashworth Scale or MAS for the affected upper and lower limb; Medical
Research Council or MRC; orthostatic stability evaluation by using the Berg Balance Scale or BBS).
A statistical insignificant change of MRC and MAS scales at time T4, with a significance trend outcome observed at the same
time by using the Wilcoxon Signed Rank Test; a statistical significant difference between test duration (sec) by using Toe-Off
vs DAFONS and by using Codivilla spring vs. Toe-Off; a statistical significant increase of the stride length on the left side (%
cycle length) by using DAFONS compared to Toe-Off for patient P1, P3 and P5 with a parameter decrease by using DAFONS
compared to Codivilla spring and Toe-Off use for patient P2; a statistical significant correlation between BBS trend and test
duration (sec) by using Codivilla spring at time T3 and T4; a statistical significant correlation between the BBS trend and the
double gait support duration on the right side (% cycle) with number of left step cycles by using DAFONS at time T3 and T4;
in a comparative post-treatment visual gait analysis a modification of each patient’s static and dynamic postural assessment
by using 3 different types of orthoses.
Biography
Dr. Falso MV received his degree in Medicine in 1999 and his specialization in Physical Medicine and Rehabilitation in 2004 from the University of
Medicine of Verona (Italy). This was followed by a post-specialization research on the management of spasticity and movement disorders at the
Department of Neurological Sciences and Vision of the University of Verona (Italy), by using botulinum toxin and baclofen pumps and analyzing
motor patterns with video-surface EMG. He is a Professor at the Physiotherapist School of the Medicine University of Brescia (Italy) and a past-
member of the Italian Consensus Table on the use of Xeomin in adult spasticity. In his career he also promoted the use of innovative dynamic
carbon-kevlar custom made AFO (DAFONS), innovative postural devices in patients affected by neurological complex postural needs, the device
treatment of idiopathic scoliosis by using an innovative dynamic spine brace called “BRIXIA” and the device treatment of gait disorders by using
an innovative dynamic carbon Kevlar foot insole called “PRODYNAMIC”


Functional Capacity, Quality of Life and Aspects Related to the Health Conditions of Women with
Rheumatoid Arthritis
Pablo Costa Cortez*, Roberta Lin Goncalves, Ellen Kathellen SA de Souza and Fernanda Albuquerque Marinho Marciao
Federal University of Amazonas, Brazil
T o analyze aspects related to the functional capacity, quality of life (QoL) and the health conditions of women with
rheumatoid arthritis (AR). Methods: prospective study performed with 44 women diagnosed with RA. Functional
capacity was performed using the Modified Health Assessment Questionnaire (MHAQ) and the Functional Status (FS), the
ability to perform activities of daily living distance covered in the (6MWT), physical fitness status by the Duke Activity
Status Questionnaire (DASI), the hand grip strength (HGS) by dynamometry, pain by Visual Analog Scale for Pain (VAS-P),
and QoL by the questionnaire the World Health Organization Quality of Life (WHOQoL-BREF). The statistical analysis
was performed using descriptive statistics with absolute (N) and relative (%) frequencies, mean ± standard deviation (SD).
Fisher's exact test to test the dependence of two nominal categorical variables, Variance-One-Way analysis model (ANOVA)
to analyze the influence of normal continuous response variables with nominal categorical independent variables and the
Pearson correlation coefficient to evaluate the degree of relationship between two quantitative variables (p<0.05). Results: The
studied women had a mean of 48 ± 7.98 years, sedentary, with low level of physical fitness, overweight and moderate level of
pain. Most women were classified with normal functional status, the 6MWT was 486.50 ± 65.7 m, the HGS was 16.15 ± 8.02
kg on the right hand. The overall QoL was on average 60.91 ± 13.05. MHAQ and FS were correlated and correlated with QoL.
Conclusion: RA affected the functional capacity of the women studied in a multidimensional manner.
Biography
Pablo Costa Cortez has completed his MSc, from Federal University of Amazonas (UFAM)/ Brazil, PhD student from Program of Basic and Applied
Immunology of the UFAM. He is a physiotherapist and professor of Northern University Center, is specialized in physiotherapy orthopedic trauma
and intensive care units, works as a research in the lines of evaluation of the functionality, quality of life and lung function of individuals with
Rheumatoid Arthritis and Parkinson.


Features of the Imbalance of Load in the Support Contour for Patients with Damage to the Anterior
Cruciate Ligament
T.V. Serebryak1*, L.M. Smirnova1,2 and O.E. Gaevskaya1
1
Federal State Budgetary Institution of the Ministry of Labour and Social Protection of the Russian Federation, Russia
2
Saint-Petersburg Electrotechnical University Leti, Russia
T he data of biomechanical examination of 60 people before and after arthroscopic reconstruction of ACL were analyzed.
This was a prospective controlled study. The analysis of loads in the support circuit of the feet was carried out on the
balance charts obtained by the method of in-Shoe baroplantography on the diagnostic software and hardware complex
"Diasled" with matrix pressure sensors in the form of insoles. Data recording was carried out in static-in the usual orthostatic
position standing with simultaneous support on both feet. It has been revealed that patients with ACL injury are characterized
by an imbalance in the load distribution in the support loop of the feet in the form of a shift in the total center of pressure
towards the injured limb, in contrast to the vast majority of pathologies in which there is a preference for the contralateral
limb rather than the affected one. In addition, there is a diagonal skew of the support from the heel of the healthy foot to
the toe of the foot of the limb with a damaged joint. As the function of the knee joint is restored, these disorders decrease.
Reduction of bilateral asymmetry of load distribution in the sagittal plane of the reference contour is an objective indicator of
the effectiveness of treatment of damage to the ACL, especially in the long term.
Biography
T. V. Serebryak he defended his thesis at the research Institute of traumatology and orthopedics named after R. R. Vreden the doctor the
traumatologist-orthopedist, researcher at the Department of biomechanical research of the Federal state budgetary institution “Federal scientific
center of rehabilitation of the disabled named after G. A. Albrecht” of the Ministry of labor and social protection of the Russian Federation.


Effectiveness of Homoeopathic Medicine on Osgood-Schlatter Disease

Amir Ashraf
Homoeopathic Physician, Ashirvad Hospital, India
O sgood-Schlatter disease is a common cause of knee pain in growing adolescents. It is an inflammation of the area just
below the knee where the tendon from the kneecap (patellar tendon) attaches to the shinbone (tibia). Osgood-Schlatter
disease most often occurs during growth spurts, when bones, muscles, tendons, and other structures are changing rapidly.
Because physical activity puts additional stress on bones and muscles, children who participate in athletics — especially
running and jumping sports - are at an increased risk for this condition. However, less active adolescents may also experience
this problem. The bones of children and adolescents possess a special area where the bone is growing called the growth plate.
Growth plates are areas of cartilage located near the ends of bones. When a child is fully grown, the growth plates harden into
solid bone.
Some growth plates serve as attachment sites for tendons, the strong tissues that connect muscles to bones. A bony bump
called the tibial tubercle covers the growth plate at the end of the tibia. The group of muscles in the front of the thigh (called
the quadriceps) attaches to the tibial tubercle.
When a child is active, the quadriceps muscles pull on the patellar tendon which in turn, pulls on the tibial tubercle. In some
children, this repetitive traction on the tubercle leads to inflammation of the growth plate. The prominence, or bump, of the
tibial tubercle may become very pronounced.
Biography
Dr. Amir Ashraf has completed the Bachelor of Homoeopathic Medicine and Surgery (BHMS) from the Rajiv Gandhi University of Health Science,
Bangalore in 2013 and completed the Internship Training programme for one year at the father Muller Homoeopathic Medical College and
Hospital, in year of 2014 September. 6th of October 2014 Dr Joined in Ashirvad Hospital at Kannur district of Kerala under the Homoeopathic
department, Where Dr Manage both Inpatient department and Outpatient department. Dr Amir is also a visiting Consultant in Apple Homoeopathic
Specialty Clinic Kannur and thalassery, Rm Homoeopathic Multispeciality clinic Kannur, Calicut and Malappuram and also at Aihms Multispeciality
clinic at Wayanad. Dr Amir has presented the Research paper titled “Effectiveness of Homoeopathic medicine Conium Maculatum 200c for the
management of Pyuria” at International conference on traditional and alternative medicine India, and on last Dr Amir presented a case study
titled “Effectiveness of Homoeopathic Medicine on Renal Hypoplasia” and “Effectiveness of Homoeopathic medicine Conium Maculatum 200c for
the management of Pyuria” at 22nd world congress on Neonatology and Perinatology at Hong Kong. Dr Amir Recently presented Paper at IHK
December 2nd 2018 on topic of Effectiveness of Homoeopathic medicine on Status asthmatics. Dr Amir is a PRO (Public relation) for Qualified
Private Homoeopaths Association (QPHA, 2017-19), Dr also an Executive Member in “Research in Homeopathy”.


TRIA-MF Protocol as an Innovative Tool in the Comprehensive Treatment and Outcome Evaluation
of Lower Limb Amputees Before and After Prosthesis Use
Maurizio Falso*, Silvia Zani, Eleonora Cattaneo, Marco Zucchini and Franco Zucchini
Middle Cares Rehabilitation Unit, Fondazione Madonna Del Corlo, Lonato (Bs), Italy
T he aim of this study was to define the efficacy and outcome value of an innovative procedure tool (TRIA-MF protocol)
in the treatment of lower limb amputees before and after prosthesis use with the purpose to quantify the quality of the
procedure and its economic impact on the clinical patients’ recovery. 12 patients (4 women and 8 males) subjected to lower
limb amputation and admitted according to the principles of inclusion criteria of the TRIA-MF protocol at the Rehabilitation
Department of the Clinical Institute Citt a di Brescia were recruited in this study. All patients were included in an integrated
and task-specific management protocol of the amputee, which allowed following the rehabilitation process from amputation
to the final restoration, for a period of 6 months for each patient. Patients were evaluated 5 times during the study, collecting
their degree of pain (VAS), their independence profile (Barthel Index) and the cirtometry of their amputation stump. Data
on the duration of their admission to the rehabilitation unit, the inter-time between the amputation and acquisition of the
temporary prosthesis, and between temporary prosthesis acquisition and the final prosthesis acquisition were also reported.
Patients of our sample, at the end of their hospitalization, highlight a significant modification of the temporal data at 1 month
and 6 months from their hospital discharge. A statistical significant increase of the Barthel Index value was observed in all
patients recruited in this study proceeding from time T0 to time T4; in the same way, a statistical significant decrease of the
VAS scale was observed in all patients recruited proceeding from time T0 to time T4; the cirtometry of the amputation stump
(expressed in cm) showed a statistical significant decrease in all patients recruited proceeding from time T0 to time T4. We
haven’t observed a statistical significant correlation between the duration of the rehabilitative hospitalization and our clinical
data; no statistical significant correlation was observed between the amputation stump cirtometry time-related modification
and our intertime data.
Biography
Dr Falso MV received his degree in Medicine in 1999 and his specialization in Physical Medicine and Rehabilitation in 2004 from the University of
Medicine of Verona (Italy). This was followed by a post-specialization research on the management of spasticity and movement disorders at the
Department of Neurological Sciences and Vision of the University of Verona (Italy), by using botulinum toxin and baclofen pumps and analyzing
motor patterns with video-surface EMG. He is a Professor at the Physiotherapist School of the Medicine University of Brescia (Italy) and a past-
member of the Italian Consensus Table on the use of Xeomin in adult spasticity. In his career he also promoted the use of innovative dynamic
carbon-kevlar custom made AFO (DAFONS), innovative postural devices in patients affected by neurological complex postural needs, the device
treatment of idiopathic scoliosis by using an innovative dynamic spine brace called “BRIXIA” and the device treatment of gait disorders by using
an innovative dynamic carbon Kevlar foot insole called “PRODYNAMIC”.

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