Cebu Normal University

College of Nursing
Osmenia Blvd. Cebu City 6000

NAS III – Pharmacology, Therapeutics and Diagnostics

DRUG STUDY

Name of Patient Age Height

Diagnosis Sex Weight
Doctor Date of Admission Body Build

Drug Data Classification Mechanism of Action Indication

Generic Name Pharmacologic Class Inhibits activity of acid (proton) pump, and binds to General Indications
omeprazole proton pump inhibitors hydrogen-potassium adenosine triphosphatase,  Symptomatic gastroesophageal reflux disease
located at secretory surface of the gastric parietal (GERD) without esophageal lesions
Trade Name Therapeutic Class cells, to block formation of gastric acid.  Erosive esophagitis and accompanying
Losec, Prilosec Antiulcer agents symptoms caused by GERD
Pharmacokinetics  Maintenance of healing erosive esophagitis
Patient’s Dose Pregnancy Risk Category  Pathologic hypersecretory conditions (such as
C Onset Zollinger-Ellison syndrome)
 Duodenal ulcer (short-term treatment)
Minimum Dose Peak
 Helicobacter pylori infection and duodenal ulcer
disease, to eradicate H. pylori with
Duration
clarithromycin (dual therapy)
Maximum Dose
 H. pylori infection and duodenal ulcer disease,
Drug Half Life
to eradicate H. pylori with clarithromycin and
amoxicillin (triple therapy)
Contents
 Short-term treatment of active benign gastric
Availability ulcer
Capsules (delayed-release):
10 mg, 20 mg, 40 mg Patient’s Actual Indication

Routes of administration
PO
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 Contraindications
Contraindicated in:
Contraindicated in patients hypersensitive to
drug or its components.
Precaution
Use cautiously with pregnancy, lactation
Drug interaction
Drug-drug.
Ampicillin esters, iron derivatives,
ketoconazole: may exhibit poor bioavailability
in patients taking omeprazole because
optimal absorption of these drugs needs a
low gastric pH. Avoid using together.
Diazepam, phenytoin, warfarin: decreases
hepatic clearance, possibly leading to
increased serum levels. Monitor closely.
Drug-herb.
Male fern: male fern is inactivated in alkaline
environments. Patient should separate
administration.
Pennyroyal: may change rate of formation of
toxic metabolites of pennyroyal. Avoid using
together.
Source:
Adverse Reactions Nursing Responsibilities
CNS: headache, dizziness, asthenia Before
 Assess patient’s history: Hypersensitivity to omeprazole or
GI: diarrhea, abdominal pain, nausea, vomiting, any of its components; pregnancy, lactation
constipation, flatulence
 Conduct physical assessment: Skin lesions; T; reflexes,
affect; urinary output, abdominal exam; respiratory
Musculoskeletal: back pain
auscultation
Respiratory: cough, upper respiratory tract infection  Dosage adjustments aren't needed for patients with renal
or hepatic impairment.
Skin: rash  Omeprazole increases its own bioavailability with repeated
dosages. Drug is labile in gastric acid; less drug is lost to
hydrolysis because drug increases gastric pH.
 Don't confuse Prilosec with Prozac, Prilocaine, or Prinivil.
During
 Tell patient to swallow capsules whole and not to open,
crush, or chew them.
 Administer drug 30 minutes before meals.
 Administer antacids with omeprazole, if needed.

After
 Caution patient not to perform hazardous activities if
dizziness occurs
 Arrange for further evaluation of patient after 8 wks of
therapy for gastroreflux disorders; not intended for
maintenance therapy.
 Instruct patient to have regular medical follow-up visits.
 Inform patient of the possible side effects of drug and
advise to consult with your health care provider if
uncomfortable
 Advise patient to report severe headache, worsening of
symptoms, fever, and chills.
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