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Introduction to Biochemical Engineering

The Experts:
Sorada Kanokpanont: Biomaterials Applications
Kasidit Nootong: Environmental Bioprocess Engineering
Seeroong Prichanont: Biosensors
Pimporn Penpech: Computer Simulation in Bioprocess Engineering

Evaluations:
30 + 30% Midterm + Final Examinations (1/4 for each instructor)
40% Activities, Home works, Quiz

Objectives:
1) Learning basic concepts, terms, and components in Biochemical
Engineering Process
2) Identify components and mechanism of the bioprocess
3) Ready for a life-long learning
What is a Biochemical Engineering Process?

Biochemical engineering also Bioprocess Engineering, is a branch of


chemical engineering or biological engineering that mainly deals with the
design and construction of unit processes that involve biological
organisms or molecules, such as bioreactors. Its applications are in the
petrochemical industry, food, pharmaceutical, biotechnology, and water
treatment industries [Wikipedia.com]

Biochemical Engineers develop usable, tangible products, using


knowledge of biology, chemistry, or engineering. Solve problems related to
materials, systems, or processes that interact with humans, plants,
animals, microorganisms, or biological materials. [Owlguru.com]
What is a Biochemical Engineering Process?

Strictly speaking, biochemical engineering is usually defined as the


extension of chemical engineering principles to systems using a biological
catalyst to bring about desired chemical transformations. It is often
subdivided into reactor design and downstream separation…

The recent development of biochemical engineering is the direct result of


advances in molecular biology (e.g., recombinant DNA, tissue culture,
protoplast fusion, monoclonal antibodies) and protein engineering.
Biochemical engineers work in a wide cross-section of industry including;
pharmaceuticals, food, fine chemicals, wastewater treatment, mining and
energy. Hence, biochemical products vary from high volume, low coast to
very low volume and extremely high cost. [Thermopedia.com]
Concentration versus final selling price. (J. L. Dwyer, “Scaling Up Bioproduct Separation
with High Performance Liquid Chromatography,” Bio/Technology, vol. 2, p. 957, 1984.)
 Chemical (organic or inorganic)  Biological (enzymes or cells)
Catalysts Catalysts
 Pure feed inputs  Inhomogeneous inputs
 Wide ranges of reaction  Specific ranges of reaction
conditions (Temperature, conditions (Temperature,
Pressure, Flow rate etc.) Pressure, Flow rate etc.)
 Well defined variable factors  Many variable factors (some
 Well understood times)
 Complex
 Occur in nature or in the livings
Bioseparation
(Enzymes), Cell Cultivation
and Expansion
Bioseparation
(downstream processing,
Product Purification)
Bioseparation
(Raw Material Foods & Bev
Separation and Pharmaceutics
Treatment) Cosmetics
Biotech products
Environments
FEEDS Consumer
-Products

Bioreactor Design and Control


(Enzyme reactions,
Fermentation, Cell Cultivation
Process
Waste treatment
 Biomaterial (extracting high value active agents or materials from
nature for applications)
 Bioengineering, Cell Engineering (controlling cell metabolism,
Gene Editing, Genetic Engineering etc.)
 Biosensor (use cells/enzyme/genetic materials/microorganism to
detect something at high sensitivity)
 Controlled Release Systems
 Tissue Engineering (growing new 3D tissues)
 Bioprinting (2D, 3D)
 Bio-Computer interfaces
 Computer modeling and simulation in Biochemical Processes
Etc.
Examples of Products of Biochemical Engineering Process

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