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The Journal of Maternal-Fetal & Neonatal Medicine

ISSN: 1476-7058 (Print) 1476-4954 (Online) Journal homepage: https://www.tandfonline.com/loi/ijmf20

The impact of lacto-ovo-/lacto-vegetarian and


vegan diets during pregnancy on the birth
anthropometric parameters of the newborn

Pietro Ferrara, Federica Sandullo, Federica Di Ruscio, Giulia Franceschini,


Benedetta Peronti, Valeria Blasi, Sabina Bietolini & Antonio Ruggiero

To cite this article: Pietro Ferrara, Federica Sandullo, Federica Di Ruscio, Giulia Franceschini,
Benedetta Peronti, Valeria Blasi, Sabina Bietolini & Antonio Ruggiero (2019): The impact of
lacto-ovo-/lacto-vegetarian and vegan diets during pregnancy on the birth anthropometric
parameters of the newborn, The Journal of Maternal-Fetal & Neonatal Medicine, DOI:
10.1080/14767058.2019.1590330

To link to this article: https://doi.org/10.1080/14767058.2019.1590330

Published online: 25 Mar 2019.

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THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
https://doi.org/10.1080/14767058.2019.1590330

ORIGINAL ARTICLE

The impact of lacto-ovo-/lacto-vegetarian and vegan diets during pregnancy


on the birth anthropometric parameters of the newborn
Pietro Ferraraa,b, Federica Sandullob, Federica Di Rusciob, Giulia Franceschinib, Benedetta Perontic,
Valeria Blasid, Sabina Bietolinie and Antonio Ruggieroa
a
Institute of Pediatrics, Catholic University Medical School, Rome, Italy; bService of Pediatrics, Campus Bio-Medico University, Rome,
Italy; cUnit of Food Science and Human Nutrition, Campus Bio-Medico University, Rome, Italy; dFood Sciences and Human Nutrition
Unit, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy; eNutritionist Biologist, Rome, Italy

ABSTRACT ARTICLE HISTORY


Introduction: The data in the literature on the appropriateness of vegetarian diets during preg- Received 5 October 2018
nancy and the impact on the birth anthropometric parameters of the newborn are divergent Accepted 1 March 2019
and conflicting. The aim of the present study is to compare the birth anthropometric parame-
KEYWORDS
ters of three groups of children distinguished according to the dietary pattern followed by their
Newborn; pregnancy; vegan
mothers during pregnancy. Moreover, the second aim is to study the cultural inference of diet; vegetarian diet
vegetarianism.
Materials and methods: Between September 2017 and May 2018, from the Pediatric Service of
the Campus Bio-Medico University Hospital of Rome and vegetarian-oriented societies, detailed
information have been provided to all mothers who showed interest in participating in the
study. More than 100 mothers gave their consent, but in consideration of the criteria of inclu-
sion and exclusion only 55 with the respective children (for a total of 63 kids) have been
enlisted in the study. Based on the dietary pattern followed by women during pregnancy, the
participants have been divided into three groups: vegan group, lacto-ovo-/lacto-vegetarian
group, and omnivorous group. The data necessary for the study have been collected through a
questionnaire previously created and sent electronically to 55 enrolled mothers.
Results: From our statistical analysis, it has emerged that birth weight, both when expressed in
grams and when expressed in growth percentiles, of the vegan mothers’ children is lower than
that of the omnivorous mothers’ children. No significant difference has emerged from the com-
parison for the length, cranial circumference and BMI at birth between the three groups.
Conclusion: Although from our study statistically significant differences in birth weight between
the vegan group and the omnivorous one has emerged, the values of this anthropometric par-
ameter were all included within the physiological range decided by the experts in the field.
From this, it emerges that the planning of any type of diet with experts in the field is indispens-
able to ensure a physiological development of the fetus, but given the limited number of partic-
ipants we cannot draw unequivocal and certain conclusions on this subject.

Introduction legumes and vegetables and low amount of fruit,


Vegetarianism is used to describe an ensemble of diet- dried fruit and seems [3].
ary habits, characterized by the partial or total removal According to Gallup’s Consumption Habits survey,
of food products of animal origin from the diet [1,2]. in the American population, the rate of vegetarian
Based on the types of food eliminated from the adults that considers itself vegetarian stands at about
diet, the vegetarian dietary patterns highlighted in 5 and 2% of the same population defines itself vegan
Table 1 can be distinguished at [3]. [4]. In Europe, the percentage of vegetarians is similar
In addition, there are dietary patterns that are the to the American one, around 5% with considerable
extremity of the vegan diet, such as, such as raw foods variability between the countries [5], while in India it
diet, characterized by consumption of uncooked and is significantly higher reaching 29%, mainly based on
unprocessed foods or cooked at low temperatures, religious reasons [6]. The “Report Italy 2018” of
fruitarian diet, based on intake of fruits, nuts, seeds, EURISPES (Institute of political, economic and social
bread, tofu and macrobiotic diet, based on grains, studies) has reported that about 6.2% of Italian adults

CONTACT Pietro Ferrara pietro.ferrara@unicatt.it Institute of Pediatrics, Catholic University Medical School, L.go Francesco Vito, 1, Rome
00168, Italy.
ß 2019 Informa UK Limited, trading as Taylor & Francis Group
2 P. FERRARA ET AL.

Table 1. Classification of vegetarian dietary patterns. Table 2. Nutrients deficiencies in different vegetarian diet-
Types of foods ary patterns.
Types of
Nutrients
vegetarian diet Red meat White meat Fish Eggs Milk and dairy
Semivegetarian x /x    Types of Vitamin Vitamin
LOV x x x   vegetarian diet Iron Zinc Calcium B12 D n-3 fats Protein
LV x x x x  Semivegetarian x      
Pescatarian x x    Lacto-ovo-vegetarian x x    x 
Vegan x x x x x Pescatarian x x     
LOV: lacto-ovo-vegetarian; LV: lacto-vegetarian Vegan x x x x x x x

interviewed is vegetarian and 0.9% follows a vegan growth of the fetus and to prevent adverse pregnancy
diet [7]. outcomes. Among the most important factors, it is
Religious and ethical reasons, philosophical points, essential to mention the dietary pattern followed by
healthy consideration, and environmental impact are the pregnant woman. In recent years, this factor has
the main reasons that have pushed vegetarians to fol- even been linked to birth weight, which is an indicator
low their respective dietary patterns [8–10]. of infant health and a strong predictor of future health
Foods of plant origin differ from those of animal outcomes [17].
origin with regard to the macronutrients and the In relation to this, available data in the literature
micronutrients that compose them [11]; therefore, the are divergent and conflicting to prove or invalidate
abstention from consuming foods of animal origin the appropriateness of vegetarian diets during preg-
could induce the appearance of important nutritional nancy and to assess their influence on the birth
deficits [2,3,12]. Since very different dietary patterns weight of the child.
are part of the group of vegetarian diets, it is neces- The aim of the present study is to compare the
sary to analyze them separately in order to detect birth anthropometric parameters of three groups of
deficient nutrients (Table 2) [3]. Individuals who children distinguished according to the dietary pattern
choose to follow a vegetarian diet must be aware of followed by mothers during pregnancy.
this in order to prevent adverse health effects by tak- The second aim of the present study is to explore
ing the missing nutrients through supplements or for- the cultural sphere of vegetarianism, looking into the
tified foods [2,3,11]. various dietary habits and lifestyle of mothers dur-
The health consequences of the individual second-
ing pregnancy.
ary to nutritional deficits could be serious and irrevers-
ible, and therefore among the various scientific
societies, there is a disagreement about the appropri- Materials and methods
ateness of vegetarian diets during all phases of an
Between September 2017 and May 2018, from the
individual’s life [12,13].
Pediatric Service of the Campus Bio-Medico University
In fact, while the American Dietetic Association and
Hospital of Rome and from vegetarian-oriented soci-
the Academy of Nutrition and Dietetics state that bal-
anced and well-planned vegetarian diets, including eties, detailed information has been provided to all
vegan diets, are adequate for all phases of an individ- mothers who showed interest in participating in the
ual’s life, including pregnancy, breastfeeding, and study. More than 100 mothers gave their consent, but
infancy [11,14], the German Nutrition Society and the before enlisting them, they have been subjected to a
European Society for Pediatric Gastroenterology preliminary assessment in order to check the presence
Hepatology and Nutrition advise against such dietary of inclusion criteria and the absence of exclusion ones.
patterns during the phases just mentioned since the The inclusion criteria considered have been: (i) a
consequences on the child’s development could be constant adoption by mothers, during pregnancy, of
catastrophic [15,16]. In addition, these latest scientific one of the following dietary style: omnivorous, lacto-
societies assert that if there is a desire to follow a ovo-vegetarian, lacto-vegetarian, vegan; (ii) a planning
vegetarian diet during these phases, it is necessary diet with experts in the field (biologists, nutritionists);
that an expert in the field carefully follow the subject (iii) the full-term birth of newborns between 37th and
to ensure that he makes no nutritional errors [15]. 40th week pregnant. The total or partial or occasional
Pregnancy is a delicate moment in a woman’s life: in change during pregnancy and preterm birth (before
fact, it is necessary that there are all the conditions to the 37th week pregnant) or after 40th week pregnant
guarantee the correct development and physiological have been considered exclusion criteria.
THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 3

Following the aforesaid preliminary assessment, of both on the values expressed in the respective units
the 100 mothers, 55 with the respective children (for a of measurement (weight in grams, length and cranial
total of 63 kids) have been enlisted in the study. circumference in centimeters) and those expressed in
Based on the dietary pattern followed by women growth percentiles calculated using an online calcula-
during pregnancy, the participants have been divided tor, the “Baby Infant Growth Chart Calculator” [19],
into three groups as follows: 21 mothers and 21 chil- that utilizes the percentiles tables drawn up by the
dren vegan, 19 mothers and 21 children lacto-ovo-/ World Health Organization (WHO) [20]. With regard to
lacto-vegetarian, and 15 mothers and 21 chil- the birth BMI of children, the statistical analysis has
dren omnivore. been carried out only on the values expressed in (kilo-
The data necessary for the study have been col- gram per square meter) since the online calculator
lected through a questionnaire previously created and used has not allowed calculating the growth percent-
sent by e-mails to the women. In order to draw up ile of this parameter in absolute value.
the aforementioned questionnaire, we have based on The arithmetic mean, standard deviation, median,
a validated Food Frequency Questionnaire (FFQ) pub- and interquartile range of the values of anthropomet-
lished in the scientific journal “Nutrients” in 2014 [18]. rics parameters of the mothers and of the children
The FFQ is a part of an article of Dyett et al., entitled have been calculated and statistical analysis of these
“Evaluation of a Validated Food Frequency data has been conducted through ANOVA with post-
Questionnaire for Self-Defined Vegans in the United hoc analysis in accordance with the Bonferroni
States”, as a result of a study whose aim has been to method. A p value of <.05 has been accepted as stat-
create an FFQ suitable to investigate the dietary habits
istically significant.
and lifestyle of the adult American population. The Chi-square test has been used for the statistical
FFQ consists of 316 multiple-choice or open questions,
analysis of data not related to the anthropometric
divided into three sections: Vegetarian Lifestyle & Food
parameters of the subjects of the study.
Practices, Food Consumption Patterns and Health,
Fitness & Demographical Information.
The modifications made to the validated FFQ in Results
order to draw up the appropriate questionnaire for
54% of children (34/63) were males and 46% of chil-
our study have been the following: reduction of the
dren (29/63) were females.
number of questions in the first and the third sections,
The analysis of the participants’ biographical data,
elimination of the second section and addition of a
collected through the questionnaires, has shown a
new section that includes questions related to the
geographical distribution as follows: 14 vegan mothers
birth anthropometrics parameters of the children. The
(70%), 7 lacto-ovo-/lacto-vegetarian mothers (33%),
questionnaire obtained and used by us consists of 26
questions, divided into three parts: maternal dietary and 1 omnivorous mother living in North-Italy; 4
habits, maternal auxological parameters and behavior, vegan mothers (20%), 13 lacto-ovo-/lacto-vegetarian
infant auxological parameters. ones (61.9%), and 7 omnivore mothers (33%) living in
The questionnaire obtained in this way has been Central-Italy; 2 vegan mothers (10%) and 11 omnivor-
sent electronically to 55 enrolled mothers. ous mothers (52.4%) living in Southern-Italy and in the
The data obtained from the questionnaires have Islands; finally, 1 vegan mother (4.8%) living in
been collected in a database, prepared specifically, Germany and 2 omnivorous mothers (9.5%) in
and divided into three groups according to the dietary Switzerland. Vegan mothers were not referred to by
pattern followed by the pregnant mothers and their geographic origin.
then analyzed. The analysis of the questionnaires has shown that
Regarding the anthropometric parameters, both the all omnivore mothers follow their respective dietary
maternal and the children ones have been collected patterns for more than 10 years. As regards the lacto-
and analyzed: specifically, we have analyzed weight ovo-/lacto-vegetarian mothers, 7/19 (36.9%) have said
(expressed in kilograms), height (expressed in centi- to follow this dietary pattern for more than 10 years,
meters), and BMI (expressed in kilogram per square 10/19 (52.6%) from 4–10 years, and 2/19 (10.5%) for
meter) of mothers and weight, length, cranial circum- 1–3 years. Finally, out of the 21 vegan mothers, 14
ference and BMI at the birth of children. The analysis (66.7%) have affirmed to follow veganism for 4–10
of the birth anthropometric parameters of the chil- years, 6 (28.6%) for 1–3 years, and 1 (4.8%) for less
dren, with the exception of BMI, has been carried out than 1 year.
4 P. FERRARA ET AL.

In relation to reasons for choice, we have found Table 3. Number of regular meals daily consumed by the
that 7/21 vegan mothers (33%), 5/19 lacto-ovo-/lacto- mothers of the three groups.
vegetarian mothers (26.3%) and all omnivorous ones Groups of mothers

(100%) have asserted to follow the respective dietary Lacto-ovo-/


Number of Vegan lacto-vegetarian Omnivorous
pattern for their beneficial effects on health while 7/ regular meals (21 mothers) (19 mothers) (15 mothers)
21 vegan mothers (33%) and 8/19 lacto-ovo-/lacto- 2 2 (9.5%) 4 (21.1%) 9 (60%)
vegetarian ones (42.1%) for animal welfare and envir- 3 14 (66.7%) 13 (68.4%) 6 (40%)
4 or more 5 (23.8%) 2 (10.5%) None
onmental impact. Moreover, 7/21 vegan mothers
(33%) and 6/19 lacto-ovo-/lacto-vegetarian mothers
(31.6%) have affirmed to follow a plant-based diet for
both the reasons mentioned above. Finally, 8/15 Table 4. Number of regular snacks daily consumed by the
omnivorous mothers (53.3%) have also claimed that mothers of the three groups.
Groups of mothers
diet followed by families of origin has influenced
their choices. Lacto-ovo/
Number of Vegan lacto-vegetarian Omnivorous
Regarding the cooking techniques adopted by regular snacks (21 mothers) (19 mothers) (15 mothers)
mothers, 14/21 vegan mothers (66.7%), 7/19 lacto- None 2 (9.5%) None 1 (6.7%)
ovo-/lacto-vegetarian mothers (36.8%), and 6/15 1 7 (33.3%) 9 (47.4%) 3 (20%)
2 11 (52.4%) 8 (42.1%) 10 (66.7%)
omnivorous mothers (40%) prefer boiling/steaming 3 or more 1 (4.8%) 2 (10.5%) 1 (6.7%)
while 2/19 lacto-ovo-/lacto-vegetarian mothers
(10.5%), and 3/15 omnivorous mothers (20%) baking/
microwave/grill. Moreover, 7/21 vegan mothers Table 5. Types of nutritional supplements taken by the
(33.3%), 10/19 lacto-ovo-/lacto-vegetarian mothers mothers of the three groups.
(52.6%), and 3/15 omnivorous mothers (20%) have Groups of mothers
affirmed to adopt all the cooking techniques men- Lacto-ovo-/
tioned so far. Finally, out of 21 omnivorous mothers, 1 Type of nutritional Vegan lacto-vegetarian Omnivorous
supplements (20 mothers) (16 mothers) (four mothers)
(6.7%) preferred frying and 2 (13.3%) preferred alter-
Vitamins D and B12/ 15 (75%) 9 (56.3%) 2 (50%)
nate frying with baking. Multivitamins
The number of regular meals and snacks consumed Vitamin D 1 (5%) 1 (6.3%)
Vitamin B12 3 (15%) 4 (25%) 1 (25%)
daily by the mothers of the three groups has also Vitamins D and B12/ 2 (12.5%)
been analyzed; the results obtained are shown in Multivitamins þ Iron
Iron 1 (5%) 1 (25%)
Tables 3 and 4.
From our study, it emerged that 20/21 vegan moth-
ers (95.2%), 16/19 lacto-ovo-/lacto-vegetarian mothers
(84.2%) and 4/15 omnivorous ones (26.7%) had taken Table 6. Frequency of supplement’s intake by the mothers of
nutritional supplements during pregnancy. The type of the three groups.
nutritional supplements consumed by them and the Groups of mothers
frequency of supplements’ intake are shown in Tables Lacto-ovo-/
5 and 6. Frequency of Vegan lacto-vegetarian Omnivorous
supplements’ intake (20 mothers) (16 mamme) (4 mamme)
In relation to personal physical activity level, 16
2 or more times/week 18 (90%) 9 (56.3%) 4 (100%)
vegan mothers (76.2%), 15 lacto-ovo-/lacto-vegetarian 2–5 times/month 2 (10%) 4 (25%)
mothers (78.9%), and 11 omnivorous mothers (73.3%) 1–12 times/year 3 (18.8%)
have defined its as moderate while 4 vegan mothers
(19%), 2 lacto-ovo-/lacto-vegetarian mothers (10.5%),
and 4 omnivorous mothers (26.6%) defined its as sed-
Table 7. Amount of time spent outdoors by mothers of the
entary; only, 1 vegan mother (4.8%) and 2 lacto-ovo-/ three groups.
lacto-vegetarian ones have described it as vigorous. Groups of mothers
Moreover, in our study, the amount of time spent out-
Lacto-ovo-/
doors by mothers has been analyzed; the results Time spent Vegan lacto-vegetarian Omnivorous
obtained are shown in Table 7. outdoors (21 mothers) (19 mothers) (15 mothers)
<5 hours/week 2 (9.5%) 3 (15.8%) 1 (6.7%)
Three lacto-ovo-/lacto-vegetarian mothers (15.8%) 5–6 hours/week 5 (23.8%) 7 (36.8%) 5 (33.3%)
and 2 omnivorous ones (13.4%) have affirmed to be 1–2 hours/day 12 (57.1%) 7 (36.8%) 6 (40%)
smokers. Out of 3 lacto-ovo-/lacto-vegetarian mothers, 3–5 hours/day 2 (9.5%) 2 (10.5%) 3 (20%)
THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 5

1 (5.3%) smokes occasionally, 1 (5.3%) a few times per Discussion


week and 1 (5.3%) daily, while out of two omnivorous
Currently, in the literature, there are several studies
mothers, 1 smokes occasionally and 1 daily. No vegan
investigating the appropriateness of vegetarian diets
mother smokes.
during pregnancy, taking into account the health
About of pathological anamnesis, the analysis of
effects of mothers and children. Despite this, the data
the questionnaires has shown that among vegan
are divergent and conflicting.
mothers 1 (4.8%) suffers from psoriasis, 1 (4.8%)
From a systematic review drafted by Piccoli et al. in
Hashimoto’s thyroiditis and 1 (4.8%) ulcerative colitis,
2015 [21], it has emerged that there is no increase in
while among lacto-ovo-/lacto-vegetarian mothers 1
severe adverse outcomes or malformations between
(5.3%) is diagnosed with bronchial asthma, 3 (15.8%)
newborns of vegetarian mothers and those of omniv-
with Hashimoto’s thyroiditis and 1 (5.3%) with coeliac
orous mothers, except for one study that has shown
disease. Lastly, among omnivorous mothers, 1 (6.7%)
an increase in the incidence of hypospadias among
suffers from Hashimoto’s thyroiditis and 1 (6.7%) from children of vegetarian mothers. In addition, the same
ischemic heart disease. review has proved that, during pregnancy, vegetarian
With regards to the education qualification, a bach- women are at greater risk of developing vitamin B12
elor’s degree is held by 10/21 vegan mothers (47.6%), and iron deficiency than omnivorous ones. This even-
13/19 lacto-ovo-/lacto-vegetarian mothers (68.4%) and tuality has been deepened by Koebnick et al. [22]:
6/15 omnivorous mothers (40%). Instead, 11 vegan they have shown that, during pregnancy, serum vita-
mothers (52.4%), 6 lacto-ovo-/lacto-vegetarian mothers min B12 concentrations of lacto-ovo-vegetarian
(31.6%) and 8 omnivorous mothers (53.3%) have a women and low-meat eaters were lower than that of
high secondary school diploma; only 1 omnivorous the control group consisting of omnivorous women.
mother (6.7%) has a lower secondary school diploma. These findings are in agreement with what
As regard the mothers’ average age at the time of emerged from our study: in fact, with regard to the
conception, that of vegans is 32.9 ± 3.9 years, that of intake of food supplements during pregnancy, most of
lacto-ovo-/lacto-vegetarians is 32.8 ± 3.8 years and that the vegetarian mothers, both vegan and lacto-ovo-/
of omnivores is 29.5 ± 3.7 years. lacto-vegetarian, unlike the omnivorous mothers, have
Finally, from our study, no statistically significant regularly taken vitamin B12 supplements.
differences have emerged between mothers of the Finally, from the systematic review prepared by
three groups regarding their anthropometric parame- Piccoli et al. [21] it has also emerged that the data in
ters (weight, height, and BMI). the literature about the impact of vegetarian diets
Turning to birth anthropometric parameters, from during pregnancy on newborn’s birth weight are dis-
our statistical analysis, performed by ANOVA with cordant: in fact, while some studies have shown that
Bonferroni correction, a statistically significant differ- the birth weight of vegetarian mothers’ children was
ence between birth weight of vegan mothers’ children lower than that of omnivorous mothers’ children,
(lower values) and that of omnivorous mothers’ chil- other studies have shown that it was greater. This has
dren has emerged, both when this parameter is also been demonstrated by Zulyniak et al. through a
expressed in grams (p ¼ .03) and when expressed in study published in 2017 [17] whose purpose was to
growth percentiles (p ¼ .02). No significant difference evaluate the impact of vegetarianism during preg-
regarding this anthropometric parameter, however, nancy on the birth weight of newborns of different
has emerged from the comparison between the vegan ethnic groups: specifically, it has emerged that vege-
and the lacto-ovo-/lacto-vegetarian group and tarian diets during pregnancy among white Europeans
between the latter and the omnivorous group. As are associated with lower birth weight, reduced likeli-
regard birth length and birth head circumference, the hood of large for gestational age (LGA) and increased
statistical analysis has not shown any statistically sig- likelihood of small for gestational age (SGA) while
nificant difference between children of the three among South Asians living in Canada they are associ-
groups, neither when such parameters are expressed ated with increased birth weight.
in centimeters nor when expressed in growth From our study, it has emerged that birth weight,
percentiles. Finally, comparing the children of the but not the length, the head circumference and the
three groups’ mothers for birth BMI, expressed in BMI at birth, of the vegan mothers’ children, is lower
(kilogram per square meter), from the analysis no than that of the omnivorous mothers’ children.
statistically significant differences have emerged Despite this, from the descriptive analysis of the
between them. birth anthropometric parameters, a gradual increase in
6 P. FERRARA ET AL.

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