TI Application Note For NIBP Meassure

TI Designs
Ultralow-Power Blood Pressure and Heart Rate Monitor
TI Designs Design Features

TI Designs provide the foundation that you need • Offers Ultralow-Power in Standby Mode
including methodology, testing, and design files to • Offers Battery Power, Portable Electronic
quickly evaluate and customize the system. TI Designs
help you accelerate your time to market. • Offers MCU with LCD Driver, One-Chip Solution
• Offers Easy-to-Use, Two Buttons, Four Operation
Design Resources Modes
• Supports Raw Data Readout
TIDM-BPM TI Design Files
• Features a Real Product (Not Only Reference
MSP430F6638 Product Folder
Design)
LMV324 Product Folder
TPS76333 Product Folder Featured Applications
• Portable BPM in Hospitals
ASK Our E2E Experts • Portable BPM in Homes
WEBENCH® Calculator Tools • Healthcare
LCD
36*4 seg Keyboard
Air
Valve
Driver Circuit MCU
Pump
V PWM
Buzzer
Pre-Amp
LM324 24C256
Pressure EEPROM
ADC
Sensor
MSP430F6638
Air
Pump
Driver Circuit
UART RS-232
Pump
M PWM2
UART to USB
Optional
Boost Power IC
Or LDO
An IMPORTANT NOTICE at the end of this TI reference design addresses authorized use, intellectual property matters and other
important disclaimers and information.
MSP430 is a trademark of Texas Instruments.

TouchPro is a trademark of Elo Touch Solutions,Inc.
MATLAB is a registered trademark of The MathWorks Inc.
All other trademarks are the property of their respective owners.
TIDU514 – October 2014 Ultralow-Power Blood Pressure and Heart Rate Monitor 1
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Copyright © 2014, Texas Instruments Incorporated
Key System Specifications www.ti.com
1 Key System Specifications
PARAMETER SPECIFICATION DETAILS

System Battery 6-V DC power Four 1.5-V AA batteries
Supply voltage: 2.7-V to 3.3-V pressure
Pressure Sensor LP3V5050
range: 0 kPa to 50 kPa
Rated voltage: 6-V rated current: <430-mA
DC Air Bump Referenced KPM27L
diameter of air tap: 4.3 mm
Rated voltage: 6-V normal open type
DC Air Valve
diameter of air tap: 3 mm
LCD Customized LCD to display special icons
2 System Description
This design is a reference design for an electronic sphygmomanometer that can get systolic, diastolic, and
heart-rate data through one measurement. This design collects data from a cuff tied to the upper arm and
then processes these data. The algorithm is designed to calculate systolic, diastolic, and heart rate data
from raw pressure data. The measured result will be stored in the E2PROM each time, which can store up
to 80 records. The latest record will overwrite the earliest record when the store range is full.
2.1 MCU-MSP430F6638
This device is selected as the system MCU and is the brain of the system. The device can perform the
following actions:
• Display the date and time in standby mode
• Support date and time settings in set mode
• Display history records in memory mode
• Measure systolic, diastolic, and heart rate in measure mode
2.2 OPA-LMV324
This device uses the signal from the pressure sensor and converts it to a level that the analog-to-digital
converter (ADC) module of the MCU can handle.
2.3 LDO-TPS76333
This device converts the input voltage from the battery (approximately 6 V) to 3.3 V and supplies it to the
MCU. The device can provide stable input voltage to the MCU. The 6-V battery output is supplied to the
pump and valve to drive them normally.
2 Ultralow-Power Blood Pressure and Heart Rate Monitor TIDU514 – October 2014
www.ti.com Block Diagram
3 Block Diagram
Figure 1 shows the block diagram.
LCD
36*4 seg Keyboard
Air
Valve
Driver Circuit MCU
Pump
V Buzzer
PWM
Pre-Amp
LM324 24C256
Pressure EEPROM
ADC
Sensor
MSP430F6638
Air
Pump
Driver Circuit
UART RS-232
Pump
M PWM2
UART to USB
Optional
Boost Power IC
Or LDO
Figure 1. System Block Diagram
3.1 Highlighted Products
3.1.1 MCU-MSP430F6638
This MCU has 256k flash, 16k RAM, and 2k USB RAM. The MCU has rich peripherals, such as a
universal serial communication interface (USCI) module, a timer module, an ADC module, a USB module,
and so forth. The USCI module supports multiple serial-communication modes with one hardware module
that has different configurations. The USCI module can be configured as inter-integrated circuit (I2C)
mode, universal asynchronous receiver and transmitter (UART) mode, or serial peripheral interface (SPI)
mode.
The TI MSP430™ family of ultralow-power microcontrollers consists of several devices featuring different
sets of peripherals targeted for various applications. The architecture, combined with five low-power
modes, is optimized to achieve extended battery life in portable measurement applications. The device
features a powerful 16-bit RISC CPU, 16-bit registers, and constant generators that contribute to
maximum code efficiency. The digitally-controlled oscillator (DCO) lets the device wake up from low-power
modes to active mode in 3 μs (typical). The MSP430F663xx series are microcontroller configurations with
a high-performance 12-bit ADC, comparator, two USCIs, USB 2.0, a hardware multiplier, DMA, four 16-bit
timers, a real-time clock module with alarm capabilities, an LCD driver, and up to 74 I/O pins.
Block Diagram www.ti.com
Typical applications for this device include analog and digital sensor systems, digital motor control, remote
controls, thermostats, digital timers, and hand-held meters. Figure 2 shows the functional block diagram
for the MSP430F6638.
XIN XOUT DVCC DVSS AVCC AVSS RST/NMI PA PB PC PD
P1.x P2.x P3.x P4.x P5.x P6.x P7.x P8.x P9.x
XT2IN I/O Ports I/O Ports

ACLK 16KB Power SYS I/O Ports I/O Ports I/O Ports
Unified P1/P2 P3/P4 P5/P6 USCI0,1
Clock 256KB RAM Management P7/P8 P9 USB
XT2OUT Watchdog 2×8 I/Os 2×8 I/Os 2×8 I/Os 1×6 I/Os
System SMCLK 192KB 1×8 I/Os Ax: UART,
+2KB RAM Interrupt Interrupt 1×8 I/Os Full-speed
128KB IrDA, SPI
USB Buffer P2 Port Capability Capability
LDO
Flash SVM/SVS Mapping PE
MCLK +8B Backup PA PB PC PD Bx: SPI, I2C
Brownout Controller 1×8 I/Os
RAM 1×16 I/Os 1×16 I/Os 1×16 I/Os 1×14 I/Os
CPUXV2
and
Working
Registers
EEM
(L: 8+2)
DMA
ADC12_A
TA1 and RTC_B LCD_B 6 Channel
TA2 DAC12_A REF
JTAG/ TA0 TB0 12 Bit
200 KSPS 160
SBW MPY32 CRC16 Comp_B 12 bit
Timer_A 2 Timer_A Timer_B Reference Segments
Interface/ 2 channels
5 CC each with 7 CC Battery 16 Channels 1.5V, 2.0V,
3 CC voltage out 2.5V
Port PJ Registers Registers Backup (12 ext/4 int)
Registers System Autoscan
PJ.x
Figure 2. Functional Block Diagram for MSP430F6638
3.1.2 OPA-LMV324
The LMV324 is a quad low-voltage (2.7 V to 5.5 V) operational amplifier with rail-to-rail output swing. The
LMV324 is the most cost-effective solution for applications where low-voltage operation, space saving,
and low cost are required. These amplifiers are designed for low-voltage (2.7 V to 5 V) operations with
performance specifications that meet or exceed the LMV324 device that operates from 5 V to 30 V.
Additional features of the LMV3xx devices are a common-mode input voltage range that includes ground,
1-MHz unity-gain bandwidth, and 1-V/μs slew rate.
VCC
VBIAS1
+ VCC
–
VBIAS2
+
Output
–
VCC VCC
VBIAS3
+
IN-
VBIAS4–
IN+ +
Figure 3. LMV324 Detailed Schematic
www.ti.com System Design Theory
3.1.3 LDO-TPS76333
The TPS763xx family of low-dropout (LDO) voltage regulators offers the benefits of low-dropout voltage,
low-power operation, and miniaturized packaging. These regulators feature low-dropout voltages and
quiescent currents compared to those of conventional LDO regulators. Offered in a 5-terminal, small-
outline integrated-circuit SOT-23 package, the TPS763xx series is ideal for cost-sensitive designs and for
applications where board space is limited.
The TPS763xx also features a logic-enabled sleep mode to shut down the regulator, reducing the
quiescent current to 1-µA maximum at TJ = 25°C. The TPS763xx is offered in 1.6-V, 1.8-V, 2.5-V, 2.7-V,
2.8-V, 3.0-V, 3.3-V, 3.8-V, and 5-V fixed-voltage versions and in a variable version (programmable over
the range of 1.5 V to 6.5 V).
IN OUT
EN
Current Limit/
Thermal
VREF Protection
GND
Figure 4. TPS76333 Detailed Schematic
4 System Design Theory

Blood pressure is an important physiological parameter of the human body that carries a lot of
physiological and pathological information. The two basic methods to get blood pressure are the Korotkoff-
Sounds method and the oscillography method.
To use the blood pressure monitor, do as follows:
1. Tie the cuff to the upper arm of the subject.
2. Aerate the cuff slowly to constrict the arm.
System Design Theory www.ti.com
Blood flows into the arm and creates pressure in the blood vessel; the blood flow changes with the heart
rate and creates a periodic waveform. The blood flow is blocked when the pressure of the cuff is greater
than systolic; after the blood flow is blocked, the waveform disappears. During the measuring period, the
pressure data from the sensor is the superposition of static pressure from the cuff and the oscillation wave
from the vessel. The oscillation wave becomes larger with the further increase of pressure in the cuff. After
reaching the maximum value, the oscillation wave lessens; after the blood vessel is blocked, the
oscillation wave disappears. The pressure of the cuff is called average pressure where the oscillation
wave has the maximum value. See Figure 5.
Figure 5. Oscillation Method to Get Blood Pressure
Obtaining the oscillation wave and its envelop is easy (see Figure 5), but systolic and diastolic parameters
are required. There are two methods get these parameters from the oscillation curve. One method is
called the proportionality coefficient method, where a proportional relationship exists between average
pressure and systolic and diastolic (the coefficients are called Ks and Kd, respectively).
SP/MP = Ks (value range: 0.3 to 0.75), DP/MP = Kd (value range: 0.45 to 0.90).
These two coefficients are obtained from a large number of statistical data. The proportionality coefficient
method is simple and suitable for MCU applications, but difference between individuals is large and
inconsistent. Sometimes large errors occur with this method.
The other method is called the eigenvalue method. This method determines whether the oscillation wave
has saltation in systolic and diastolic pressure points. The eigenvalue method must distinguish the
inflection point of a curve and build math models to analyze data; this method requires more resources
and time to calculate results than the proportionality coefficient method. The eigenvalue method is
complex and less suitable for MCU applications.
www.ti.com Getting Started Hardware
The algorithm in this system is based on the proportionality coefficient method. The proportionality
coefficients (Ks, Kd) are listed in Table 1.
Table 1. Ks, Kd Value According to Average Pressure Range (J Moraes)

AVERAGE PRESSURE AVERAGE PRESSURE
Ks Kd
RANGE (mmHg) RANGE (mmHg)
MAP > 200 0.5 MAP > 180 0.75
200 ≥ MAP > 150 0.29 180 ≥ MAP > 140 0.82
150 ≥ MAP > 135 0.45 140 ≥ MAP > 120 0.85
135 ≥ MAP > 120 0.52 120 ≥ MAP > 60 0.78
120 ≥ MAP > 110 0.57 60 ≥ MAP > 50 0.6
110 ≥ MAP > 70 0.58 50 ≥ MAP 0.5
70 ≥ MAP 0.64 50 ≥ MAP 0.5
5 Getting Started Hardware

To set up the hardware, connect all the parts of the system. Before connecting, assemble the components
to the board. See Section 5.1.
5.1 System Connection

1. Connect the gas path as shown in Figure 6 (pressure sensor, pump, valve, and cuff must be
connected).
Figure 6. Connection of Cuff, Pump, Valve, and Sensor for Gas Path
Getting Started Hardware www.ti.com
2. Connect one wire of the pump to BAT and the other wire to CN5.
3. Connect one wire of the valve to BAT and the other wire to CN6 (see Figure 7).
Figure 7. Pump and Valve Electronic Connection to the Board
4. Connect the battery to the board.

5. Connect the positive end of the battery to the VBAT pin of P1.
6. Connect the negative end of the battery to the GND pin of P1 (the date and time should appear on the
LCD after it powers up, see Figure 8).
Figure 8. Connect to the Board
www.ti.com Getting Started Hardware
To see or collect raw data, connect UART to the PC (see Figure 9).
7. Connect the TXD of H2 to the TXD of the MSP430 emulator (or another emulator).
8. Connect the GND (TouchPro™ GUI must be installed on the PC to support this function, see
http://www.ti.com/tool/msptouchprogui?keyMatch=touch_pro&tisearch=Search-EN).
Figure 9. Raw Data Readout Through UART
5.2 Running the Demo

After powering up, the system enters standby mode and shows the date and time.
1. Press the start and memory buttons simultaneously for three seconds (the system should enter time-
set mode).
NOTE: In this mode, the month position blinks.
2. Use the memory button to adjust the number in the current position.
3. Use the start button to select the next position.
4. When the minute position is blinking, press the start button to end time-set mode and enter standby
mode.
NOTE: The selection logic for the start button is month → date → hour → minute → standby mode.
5. Press the memory button in standby mode will enter the system into memory mode.
NOTE: The memory icon and total-records number appear for three seconds and the display shows
the latest record. Every record includes systolic, diastolic, heart rate, date, and time.
6. Press the memory button in this mode switch to the next record or press the start button to end this
mode and enter standby mode.
Getting Started Firmware www.ti.com
NOTE: Pressing the start button in standby mode causes the system to enter measure mode.
Before entering this mode, ensure that the cuff is correctly tied to the upper arm, otherwise
the system will report an error. In measure mode, the system takes a measurement and
shows the result on the LCD. After entering this mode, all LCD segments appear and the
buzzer works. This stage lasts three seconds, during which the system does not respond to
any action. After this stage, the system aerates the cuff and the LCD shows the pressure of
the cuff. After the pressure of the cuff reaches the goal pressure (145 mmHg set by the
system), the system stops aerating and begins deflating. The system calculates and shows
the results.
6 Getting Started Firmware

To start using the firmware, do as follows:
1. Download the firmware.
2. Compile it in CCS.
3. Download it to MCU
NOTE: The system runs as described in Section 5.2.
To collect the raw data for further analysis, use the TouchPro tool and connect the hardware as described
in Section 5.1. The raw data is pressure data collected by the sensor-ADC module.
7 Test Setup
1. Connect the system as shown in Figure 6.
2. Check the connection point and ensure there is no air leakage.
3. Connect the system as described in Section 5.1 and power it up.
NOTE: The date and time appear on the LCD. The default value is the 7th of October, 0:00. If
nothing appears on the LCD, check the battery and the LDO output
www.ti.com Test Setup
4. Run the system as described in Section 5.2.
NOTE: To get raw data in measure mode, connect the system as shown in Figure 10.
Figure 10. Measure Demo
Test Setup www.ti.com
5. Connect UART to TouchPro in PC.

6. Select the correct COM and 9600 as the baud rate (see Figure 11).
7. Click the open button to open the COM.
Figure 11. TouchPro Tool
NOTE: When the system receives the data, a curve appears on the panel of this tool.
www.ti.com Test Setup
To save the raw data in the PC for further analysis, do as follows:

1. Click File Directory.
2. Name the file.
3. Click the Record button (see Figure 12).
Figure 12. Collecting and Saving Raw Data
Test Data www.ti.com
8 Test Data
The saved data is a .txt file and its format is as shown in Figure 13. The frame headers are 0x55 and
0xaa; the following is the data length 0x04 and then channel number 0x01. The fifth and the sixth data are
the real data from the 12-bit ADC. To get the real value, use the following equation:
fifth data × 256 + sixth data
Every frame has 7 bytes and the last data is the checksum.
Figure 13. Raw Data
Use MATLAB® to process the .txt file in Figure 13 and get the related curves described in Figure 14.
These curves show the data flow process, which is saved in the MCU. This process runs automatically
after the Start button is pressed.
Figure 14. Signal Processed by Matlab
In Figure 14, the x-axis is the amount of raw data that can be converted to time (the sample rate is 100
Hz), and the y-axis is the amplitude. The upper half of this signal is the plot of raw data from Figure 13.
The blue curve in the lower half of the signal is the plot of filtered raw data. The filter is a band-pass type
with a set bandwidth of 0.3 Hz to 3.5 Hz; the order of this band-pass filter is 2. The red curve in the lower
half of the signal is the envelop of the filtered data.
www.ti.com Design Files
9 Design Files
9.1 Schematics
To download the schematics for each board, see the design files at http://www.ti.com/tool/TIDM-BPM
VBAT AVCC AVCC
buzzer
2
C1 1
2
1
0.47U D1 2 H1
U7 DVCC H2 AVCC
RXD 1
VBAT U1CON2 AVCC buzzer
MBRA320 1
AGND
P1 R3 TXD 2
1 CN5
1
1 5 47R 2 3
V+ 2 IN OUT R4 AGND DVCC VBAT
G U9
C12 3 4
3 R2 2 R1 47K DGND PUMP
G 2 GND 4 5
47R 300K C5 VBAT
2
4
BAT 1u 1 3 4 4.7uF R61K header-4p 6
C2 C3 EN NC/FB B1 CN6
RST/TDIO Q1 7
C4 CON2 button BZ VALVE
47uF 0.01uF TPS763XX NSS4020 8
0.1uF TEST/TCLK
C6 R7 9
RST/TDIO
LED1 R5 R10 10n 2K 10
1
3
200K 1R HEADER10P
R20
0R DGND AGND
GND AGND
DGND CON1
25 S0
S20 24 S1
C21 S19 23 S2
P7.3/XT2OUT
VBAT S21 S18
P5.7/RTCLK
4.7nF 26 22 S3
TEST/TCLK
P7.2/XT2IN
S21 S17
RST/TDIO
S22 27 21 S4
S23 28 S22 S16 20 S5
DVSS3
AVSS3
VBAT1
VBAT
SVSIN
S23 S15
DVCC
LDOO
VSSU
VBAK
AVCC DVCC S24 29 19 S6
LDOI
AIN0
PU.1
PU.0
P6.3
P6.2
R14
PJ.3
PJ.2
PJ.1
PJ.0
NC1
S25 30 S24 S14 18 S7
NC
VBAT VBAT S26 31 S25 S13
0R S26 17 S8
S12
2
2
S27 32 16 S9
R15 R8 U3 S27 S11
S28 33 15 S10
47R 800K 430100PIN_F6433 S28 S10
D2 D3 S29 34 14 S11
100
99
98
97
96
95
94
93
92
91
90
89
88
87
86
85
84
83
82
81
80
79
78
77
76
MBRA320 C11 C8 C9 C10 B2/P6.4 S0 S29 S9
MBRA320 S30 35 13 S12
1u 47p 10u 0.01u B3/P6.5
1 75
S1 S30 S8
CN6 CN5 S31 36 12 S13
1
1
2 74 S31 S7
SVSIN B4/P6.6 S2 S32 37 11 S14
Q2 B5/P6.7
3 73
S3 S33 38
S32 S6
VALVE R11 Q3 R12 LED2 4 72 S33 10 S15
NSS4020 PUMP S4 S34 39 S5
NSS4020 5 71 S34 9 S16
1K 1K R13 S5 S35 40 S4 8 S17
R22 R9 R16 200K 6 70 S35 S3
S6 S36 41 7 S18
100k 100k 7 69 S36 S2
S7 S37 42 6 S19
0R 8 68 S37 S1
P5.1 S8 S38 43 5 S20
9 67 S38 S0 4 COM0
DGND P5.1 S9 S39 44
COM4
AGND 10 66 S39 3 COM1
AVCC S10 S40 45 COM3
11 65 S40 2 COM2
AVSS1 DVCC COM2
12 64 1 COM3
GND XIN DVSS2 COM1
13 63
XOUT S11
14 62
AVSS2 S12
15 61 DGND
P5.6 S13
16 60 CON20*2P
RXD S14
AGND 17 59
TXD S15
18 58
PM_UCB0SCL S16
19 57
PM_UCB0SDA S17
20 56
P2.4 S18
21 55
P2.5 S19
22 54
P2.6 S20
23 53
P2.7 S21
24 52
DVCC S22
OUT+ 25 51
U4
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
AVCC 1 8
U11 N/C N/C
AVCC
1 6 2 7
V+ NC N/C JUMP1 DVCCDVCC
Vs
P5.2/R23
P1 1
LCDCAP
OUT-
TA0CLK
2 5 C16 C17
VCORE
VALVE
DVSS1
OUT+ OUT- 3
PUMP
6
COM0
COM1
COM2
COM3
1uF 0.01uF GND N/C
3 4 2 AIN0
S31
S30
S35
S34
S33
S32
S29
S28
S27
S26
S25
S24
S23
BZ
V- V- R21 R23
P1 4 5
Vout N/C 1.5K 1.5K
BP300 P2 3
C20 MP3V5050 C22
JUMP-3P C7
470pF R41
PM_UCB0SCL 470nF4.7uF
R37 R38 PM_UCB0SDA DVCC
0R
0 0 AGND JUMP2
P2 1
AGND
AGND DGND R33 R35
2 SIN
R34 R36
P1 3
100k100k
100k 100k
B2
C14 1 2 P5.6
JUMP-3P XOUT 3 4
AGND
12p
11
U2A Y1
OUT- R39 3 LMV324 DGND 32k
R24 R27
100k 1 C19 B3
2 XIN 1 2
500k 500k
AGND 3 4
12p
4
P6.3 R25 R26

R28
U2C 100k 61.9k B4
500k
R29 9 1 2
200K 8 P2 U2D U6 DVCC 3 4
10 13 1 8 B4/P6.6
R30 A0 VCC
14 AIN0 B2/P6.4
500k LMV324 SIN R18 R19 12 2
A1 WC
7
B3/P6.5 B5
33k 1 2
2
1
33k C15 LMV324 3 6 PM_UCB0SCL B5/P6.7

C18 A2 SCL 3 4
U2B 1u U8
1u
6 CON2 4 5 PM_UCB0SDA
R31 R32 AGND GND SDA
7
OUT+ R40 5 500k 500k CAT24C32
100k low pass filter 5Hz
LMV324 AGND DGND
Figure 15. Schematic of System
Design Files www.ti.com
9.2 Bill of Materials

To download the bill of materials (BOM) for each
board, see the design files at
http://www.ti.com/tool/TIDM-BPM
Table 2. BOM List

PART
ITEM QTY REFERENCE VALUE PCB FOOTPRINT
DESCRIPTION
1 1 B1 button BUTTON-4P SW-4P
2 4 B2, B3, B4, B5 button BUTTON-4P SW-4P
3 1 buzzer buzzer buzzer buzzer
4 1 C1 0.47 uF CAP C/0805/SMT1
5 1 C2 47 uF CAP C/0805/SMT1
6 2 C3, C17 0.01 uF CAP C/0805/SMT1
7 1 C4 0.1 uF CAP C/0805/SMT1
8 2 C5, C7 4.7 uF CAP, CAP/0805 C/0805/SMT1
9 1 C6 10 nF CAP C/0805/SMT1
10 1 C8 47 pF CAP C/0805/SMT1
11 1 C9 10 uF CAP C/0805/SMT1
12 1 C10 0.01 uF CAP C/0805/SMT1
13 4 C11, C12, C15, C18 1 uF CAP C/0805/SMT1
14 2 C14, C19 12 pF CAP C/0805/SMT1
15 1 C16 1 uF CAP C/0805/SMT1
16 1 C20 470 pF CAP C/0805/SMT1
17 1 C21 4.7 nF CAP/0805 C/0805/SMT1
18 1 C22 470 nF CAP/0805 C/0805/SMT1
19 1 CON1 CON20*2P CON20*2P LCD1
20 3 D1, D2, D3 MBRA320 DIODE DIODE
21 1 H1 HEADER10P HEADER10P CN10P/2.54
22 1 H2 header-4p header-4p CON4P-2.54H
23 2 JUMP1, JUMP2 JUMP-3P JUMP-3P CON3P-2.54H
24 2 LED1, LED2 LED LED_1 LED0805
25 1 P1 BAT BAT CON3P-2.54H
26 3 Q1, Q2, Q3 NSS4020 NPN_BJT SOT23-3P
27 1 R1 300 k RES R/0805/SMT1
28 3 R2, R3, R15 47 R RES R/0805/SMT1
29 1 R4 47 k RES R/0805/SMT1
30 3 R5, R13, R29 200 k RES R/0805/SMT1
31 3 R6, R11, R12 1k RES R/0805/SMT1
32 1 R7 2k RES R/0805/SMT1
33 1 R8 800 k RES R/0805/SMT1
34 9 R9, R22, R25, R33, R34, R35, R36, R39, 100 k RES R/0805/SMT1
R40
35 1 R10 1R RES C/0805/SMT1
36 3 R14, R16, R20 0R RES R/0805/SMT1
37 2 R18, R19 33 k RES R/0805/SMT1
38 2 R21, R23 1.5 k RES R/0805/SMT1
39 6 R24, R27, R28, R30, R31, R32 500 k RES R/0805/SMT1
40 1 R26 61.9 k RES R/0805/SMT1
41 2 R37, R38 0 RES R/0805/SMT1
42 1 R41 0R RES/0805 C/0805/SMT1
www.ti.com Design Files
Table 2. BOM List (continued)

PART
ITEM QTY REFERENCE VALUE PCB FOOTPRINT
DESCRIPTION
43 1 U1 TPS763XX TPS763XX SOT23-5P
44 1 U2 LMV324 LMV324 SO-G14/G3.3
45 1 U3 430100PIN_F6638 430100PIN IC-LQFP100-PZ - duplicate
46 1 U4 MP3V5050 MP3V5050 MP3V5050
47 1 U6 CAT24C32 CAT24C32 SO-G8/D7.7
48 3 U7, U8, U9 CON2 CON2 CON2P-2.54H
49 1 U11 BP300 BP300 BP300UF
50 1 Y1 32 k CRYSTAL XIAL-2*5 V
9.3 PCB Layout Recommendations

This is a low-frequency system with no special PCB layout requirements. See recommendations from the
device datasheet.
9.3.1 Layout Prints

To download the layout prints for each board, see the design files at http://www.ti.com/tool/TIDM-BPM
Figure 16. Top Silkscreen layer of PCB Figure 17. Bottom Solder Layer of PCB
Design Files www.ti.com
9.4 Altium Project

To download the Altium project files for each board, see the design files at http://www.ti.com/tool/TIDM-
BPM.
Figure 18. Multi-Layer Composite Print
9.5 Gerber files

To download the Gerber files for each board, see the design files at http://www.ti.com/tool/TIDM-BPM.
10 Software Files
To download the software files for this reference design, see the design files at
http://www.ti.com/tool/TIDM-BPM.
11 References
1. Gallardo JE, Cotta C, Ferandez AJ. On the hybridization of memetic algorithms with branch-and-bound
techniques. IEEE Transactions on Systems, Man, and Cybernetics, Part B:Cybernetics, 2007, 37(1):
77-83.
2. Texas Instruments: MSP430x5xx and MSP430x6xx Family User's Guide (SLAU208M).
www.ti.com Terminology
12 Terminology
PPG, SYSTOLIC, DIASTOLIC
13 About the Author

FIONA CHEN is a Systems Application Engineer at Texas Instruments, where she is responsible for
developing total solutions for Chinese customers. Fiona earned her Masters degree of BioMedical
Engineering from Zhejiang University in Hangzhou, Zhejiang.
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TI Designs

Ultralow-Power Blood Pressure and Heart Rate Monitor

TI Designs Design Features

MSP430 is a trademark of Texas Instruments.

1 Key System Specifications

PARAMETER SPECIFICATION DETAILS

Figure 1. System Block Diagram

3.1 Highlighted Products

XT2IN I/O Ports I/O Ports

Figure 2. Functional Block Diagram for MSP430F6638

Figure 3. LMV324 Detailed Schematic

Figure 4. TPS76333 Detailed Schematic

4 System Design Theory

Figure 5. Oscillation Method to Get Blood Pressure

Table 1. Ks, Kd Value According to Average Pressure Range (J Moraes)

5 Getting Started Hardware

5.1 System Connection

Figure 7. Pump and Valve Electronic Connection to the Board

4. Connect the battery to the board.

Figure 8. Connect to the Board

Figure 9. Raw Data Readout Through UART

5.2 Running the Demo

NOTE: In this mode, the month position blinks.

6 Getting Started Firmware

NOTE: The system runs as described in Section 5.2.

4. Run the system as described in Section 5.2.

Figure 10. Measure Demo

5. Connect UART to TouchPro in PC.

Figure 11. TouchPro Tool

To save the raw data in the PC for further analysis, do as follows:

Figure 12. Collecting and Saving Raw Data

Figure 13. Raw Data

Figure 14. Signal Processed by Matlab

P6.3 R25 R26

33k C15 LMV324 3 6 PM_UCB0SCL B5/P6.7

Figure 15. Schematic of System

9.2 Bill of Materials

Table 2. BOM List

Table 2. BOM List (continued)

9.3 PCB Layout Recommendations

9.3.1 Layout Prints

9.4 Altium Project

Figure 18. Multi-Layer Composite Print

9.5 Gerber files

13 About the Author

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